WO1999005919A1 - Slow sinking pellets or granules for use in fish breeding - Google Patents

Slow sinking pellets or granules for use in fish breeding Download PDF

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Publication number
WO1999005919A1
WO1999005919A1 PCT/EP1998/004551 EP9804551W WO9905919A1 WO 1999005919 A1 WO1999005919 A1 WO 1999005919A1 EP 9804551 W EP9804551 W EP 9804551W WO 9905919 A1 WO9905919 A1 WO 9905919A1
Authority
WO
WIPO (PCT)
Prior art keywords
granules
pellets
wt
anspr
che
Prior art date
Application number
PCT/EP1998/004551
Other languages
German (de)
French (fr)
Inventor
Gunther Berndl
Jörg Breitenbach
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19733504A priority Critical patent/DE19733504A1/en
Priority to DE19733504.7 priority
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of WO1999005919A1 publication Critical patent/WO1999005919A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/80Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K40/00Shaping or working-up of animal feeding-stuffs
    • A23K40/10Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K40/00Shaping or working-up of animal feeding-stuffs
    • A23K40/20Shaping or working-up of animal feeding-stuffs by moulding, e.g. making cakes or briquettes
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K40/00Shaping or working-up of animal feeding-stuffs
    • A23K40/25Shaping or working-up of animal feeding-stuffs by extrusion

Abstract

The invention relates to slow sinking, porous granules or pellets with a density of greater than 1 g/cm3 for use in fish breeding. The inventive granules or pellets are obtained by solvent-free melt extrusion of mixtures consisting of biologically active substances, matrix support substances and a solid gas producer.

Description

Slowly sinking pellets or granules for fish farming

description

The present invention relates to slow sinking pellets or granules for use in fish farming with a density of greater than 1 g / cm3, obtainable by solvent-free melt extrusion of mixtures of one or more active compounds, customary excipients and a solid matrix gas developers. Furthermore, the invention relates to a method for producing such pellets or granules.

The production of solvent-free drug formulations according to the melt extrusion method is known for example from EP-A 240 906 or EP-A 358 105th

In EP-A 689 387 the production of fish feed by extrusion of fish feed containing pellets containing polyvinyl pyrrolidone as a binder is described. By

Extrusion of a wet mass occurs while after extrusion to an expansion of the pellets by evaporation of moisture, which leads to a reduction in the density of the pellets.

ACCORDING TO US-A 4,393,087 floating fish feed pellets are obtained with a curable carbohydrate matrix gain by a proportion of expanded cereal particles, their buoyancy.

From US-A 5,171,588 is known to influence the rate of sedimentation of pellets for fish farming by use of specific surfactants. However, the use of surfactants is disadvantageous in terms of environmental issues.

In JP-A 4267852 pellets are described for the fish-breeding, which are obtained by extrusion of aqueous starch slurries in the presence of an expanding agent such as sodium bicarbonate. In this method, the strength of gelatinized and by the influence of water and heat it comes to form gas in decomposition of the expanding agent. The resulting shapes are greatly expanded and soft.

For the purposes of animal feed or feed additives in fish farming, the floating or sinking behavior is of great importance. Sinking the forms quickly, they are often too quickly removed from the feeding area of ​​many held in culture fish such as salmon or trout, there will no longer be eaten on the floor overall sunkenes material. This not only feed intake is negatively affected, but negatively affected by rotting of the forage on the ground ecological Gleichgwicht the waters. Shapes that float on the surface are, however, not accepted by many culture fish.

The object of the present invention is to find forms that have a favorable for use in fish farming Sinkgeschwin- speed.

Accordingly, the pellets or granules defined at the outset were found.

As biologically active substances for the purposes of this invention apply to veterinary therapeutics, particularly those such as are suitable for use in the fish farm, such as antibiotics, antifungal agents, anthelmintics, antiparasitic agents, further tion hormones and growth promoters, as well as substances for Immunstimula-, for example, ß - 1.3 - 1.6 glucans, vitamins such as vitamins C, e or A and their physiologically acceptable salts or esters, the vitamins of the B series, carotenoids such as beta-carotene, astaxanthin, canthaxanthin or zeaxanthin, further minerals and / or trace elements. It can also be used any mixtures of said classes of substance. The biologically active substances can be used in amounts of from 0.1 to 95, preferably 5 to 70, particularly preferably contain from 20 to 60 wt .-%.

The biologically active substances are homogeneously dispersed in a matrix of excipients. As matrix excipient, at least one thermoplastically processable binder is contained. As melt-processable binder according to the invention celluloses or cellulose derivatives such as cellulose ethers or Celluloseester come into consideration, for example hydroxyalkylcelluloses such as hydroxypropyl celluloses, further unsaponified or partially saponified polyvinyl acetate having a K value according to Fikentscher of 10 to 150, preferably 20 to 90, particularly preferably 30 to 80, at 20 ° C measured in acetone (for determining the K value, see. Fikentscher, cellulose Chemie 13 (1932) 58-64 and 71-74), polyvinyl alcohol, homopolymers or copolymers of N-vinylpyrrolidone with Fikentscher K values ​​in the after range of 20 to 90, for example, polyvinylpyrrolidone copolymers with vinyl acetate as a comonomer Vinylestern like, as well as pectins, xanthans, guar and locust bean gum, said binder starches, starch derivatives, dextrins, polyfructosans, gelatin, carrageenans or mixtures thereof. Furthermore, suitable degradable biologically polyester as described 44 40 858, DE-A m, for example, polyester based on butanediol, Adipmsaure and Terephtalsaure. Polyvmylacetat or mixtures of Polyvmylacetat and starch are used. The poly older binders may _r amounts from 1 to 99.5, preferably from 2 to 80 wt .-%, are oesonders preferably 5 to 60 wt .-%, are used.

Furthermore, the matrix can hold as auxiliary fusible sugar alcohols such as sorbitol, xylitol, mannitol, isomalt or Maicitol corresponds, or scnmelzbare sugars such as sucrose or glucose, or fats and waxes. These excipients may be used m amounts of from 0 to 50 wt .-%.

By use of fillers such as chalk which can Smkge- schwmdigkeit the shapes] e can be set by application.

Optionally, also for pharmaceuticals and food or feed SDrengmittel conventional adjuvants such as, dyes, release agents, antioxidants, flow agents or sorbents, for example, W m nochdisperses silica are added to the usual quantities for this purpose e

The inventive shaped pellets or granules is added em Gasent- winder m solid form. As gas developers According to the invention alkali metal or alkaline earth metal such as Natnum-, Kaliumcarbona suitable carbonate, magnesiu carbonate or calcium carbonate, alkali metal bicarbonate continue carbonate also as Natriumhyαrogen- or Kaliumnydrogencarbonat. The Gasentwιcκler are used in amounts of 0.1 to 20, preferably 1 to 10, particularly preferably 2 to 5 wt .-%.

preferably the erfmdungsgenassen forms also contain natural or synthetic flavoring agents, for example, fish meal, Fischmehlhydrolysate, soluble fish protein concentrates and hydrolysates or other animal meal, or, particularly fruit flavors mixtures, m amounts of from 0.1 to 20 wt .-%.

The production of the inventive pellets or granules ER followed by a solvent-free melt extrusion. Losungsmittelfr ei means that the mixtures to be extruded no water or organic solvents are added. The processing of the mixtures takes place in particular m single or multi-screw extruders, preferably twin screw extruders m. The components can be introduced as a masterbatch into the extruder, but it is also possible first of all the thermoplastically processable binder gegebenenfals melted with other adjuvants and to meter the biologically active substance to the melt. This is especially useful in the processing of thermolabile biologically active substances. The components in the extruder at temperatures in the range from 50 to 180 ° C, preferably 80 to 140 ° C are mixed. Here, able to melt all the components, or even for its thermoplastic binder. By the action of shear forces a homogeneous mixture of all components produced in any case. Depending on the nature of the biologically active substance, it can also as so-called "solid solution", that is molecularly present in the matrix of excipients. The term "solid solution" is known to the expert (cf. Chiou and Riegelman, J. Pharm Be 60 (9), 1281 -... 1301 (1971)).

The melt is extruded through a nozzle or perforated plate and subjecting the still plastic mass to a shaping step. The shaping can be done, for example by calendering, cold-cut or, preferably, by hot cutting.

The granules or pellets according to the invention obtained have densities of greater than 1 to 3 g / cm3, preferably 1.1 to 1.8 g / cm 3. By using a gas generator which decomposes under the processing conditions all or part of it have a porous or foam-like structure. However, in contrast to conventional foams, they have a greater density. In water, the shapes fall slowly. The sink rate at 21 ° C in 4 parts by weight aqueous sodium chloride solution are in the range of 0.2 m / min to 10 m / min, preferably 0.5 to 7 m / min, particularly preferably 0.7 to 5 m / min , speeds in these Sinkge- done the best shot of the granules or pellets by the fish. The sink rate can be specifically controlled by the amounts of added gas developers. The novel shapes are free of surfactants, such as surfactants.

The pellets or granules may lengths of 0.5 to 50 mm, preferably 1 to 15 mm, and widths of 0.2 to 20 mm, preferably having from 1 to 10 mm. Which particle size is chosen in each individual case depends on the type of fish.

The pellets or granules are in principle for all farmed fish or crustaceans, especially for the rearing of trout, salmon trout or salmon. Examples

The mixtures described in the Examples below were processed in a twin-screw extruder (ZSK-30 of Werner & Pfleiderer) at a product flow rate of 7 kg / h. The shaping of the still plastic extrudate to granules was carried out by hot cutting.

As biologically active substance in the following examples play a vitamin premix following composition is used:

Vitamin A 500,000 IU / g 7.92 g

Vitamin Ξ-500 mg / g 396.04 g

Vitamin C 396.04 g inositol 198.02 g fumed Siliciu dioxide 1.98 g

example 1

A mixture of 14.15 wt .-% of a copolymer of 60 wt -. N-vinylpyrrolidone and 40 wt .-% vinyl acetate with a K value of 30, 19.0 wt .-% of potato starch, 2 wt .-% sodium hydrogen - carbonate, 9.25 wt .-% of hydroxypropyl methylcellulose, 5 wt .-% fish meal, 0.1 wt .-% butylated hydroxytoluene (BHT) and 50.5 wt .-% vitamin premix were mixed and extruded.

Temperatures of the shots: 83, 92, 101, 100, 100, 105 ° C Temperature nozzle: 111 ° C

The granules had a particle size of 3 mm × 5 mm. Sink rate: 3.3 m / min

example 2

A mixture of 20.5 wt .-% of polyvinyl acetate with a K value of 63, 22 wt .-% of potato starch, 5 wt .-% sodium hydrogencarbonate, 2 wt .-% silica and 50.5 wt .- hochdisperεes% vitamin premix were mixed and extruded.

Temperatures of the shots: 80, 100, 103, 101, 101, 105 ° C Temperature nozzle: 111 ° C

The granules had a particle size of 3 mm × 5 mm. Settling velocity: 3.5 m / min Example 3

A mixture of 5 wt .-% Polyvinylaceta, 39.2 wt .-% of potato starch, 2 wt .-% sodium bicarbonate, 3 wt .-% highly dispersed silica, 0.1 wt .-% BHT, 50.5 wt. -% vitamin premix, and 0.2 wt .-% of a fruit flavor mixture based on strawberry and raspberry flavors were mixed and extruded.

Temperature shots: 45, 80, 101, 101, 102, 120 ° C Temperature nozzle: 130 ° C

The granules had a particle size of 3 mm × 5 mm. Sink rate: 3.1 m / min

Claims

Patentanspr├╝che
1. slowly sinking poröse granules or pellets with a density of grösser 1 g / cm3 für use in fish farming, erhältlich lösungsmittelfreie by melt extrusion of a mixture of biologically active substances, matrix adjuvants and a solid gas generator.
2. granules or pellets according to claim 1, having a settling velocity of 0.2 m / min to 10 m / min in a 4 wt .-% aqueous sodium chloride wässrigen Lösung at 21°C.
3. granules or pellets according to claim 1 or 2, containing as solid gas developer alkali or alkaline earth metal carbonates in amounts of from 0.1 to 20 wt .-%.
4. granules or pellets according to one of Anspr├╝che 1 to 3, comprising, as matrix excipient, at least one thermoplastically processable polymeric binder.
5. pellets or granules according to one of Ansprüche 1 to 4, containing, as thermoplastically processable binder polyvinyl acetate or mixtures of polyvinyl acetate and Stärken.
6. granules or pellets according to one of Anspr├╝che 1 to 5, comprising, as biologically active substances vitamins.
7. A process for the production of granules or pellets ACCORDANCE the Anspr├╝chen 1 to 6 by mixing the components in the melt without added L├╢sungsmitteln in an extruder and subsequent shaping, characterized in that by the addition of solid gas developers por ├╢se forms having a density of gr├╢sser 1 to 3 g / cm3 produced.
PCT/EP1998/004551 1997-08-01 1998-07-21 Slow sinking pellets or granules for use in fish breeding WO1999005919A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19733504A DE19733504A1 (en) 1997-08-01 1997-08-01 Slowly sinking pellets or granules for fish farming
DE19733504.7 1997-08-01

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
BR9810852-2A BR9810852A (en) 1997-08-01 1998-07-21 Granular or porous pellets, slow sinking, and process for producing the same
EP98943754A EP0999756A1 (en) 1997-08-01 1998-07-21 Slow sinking pellets or granules for use in fish breeding
CA002298440A CA2298440A1 (en) 1997-08-01 1998-07-21 Slow sinking pellets or granules for use in fish breeding
JP2000504750A JP2001511365A (en) 1997-08-01 1998-07-21 Pellets or granules settle slowly for fish farming
AU91551/98A AU9155198A (en) 1997-08-01 1998-07-21 Slow sinking pellets or granules for use in fish breeding
NO20000486A NO20000486L (en) 1997-08-01 2000-01-31 Slow sinking pellets or granules for use in aquaculture

Publications (1)

Publication Number Publication Date
WO1999005919A1 true WO1999005919A1 (en) 1999-02-11

Family

ID=7837826

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/004551 WO1999005919A1 (en) 1997-08-01 1998-07-21 Slow sinking pellets or granules for use in fish breeding

Country Status (10)

Country Link
EP (1) EP0999756A1 (en)
JP (1) JP2001511365A (en)
CN (1) CN1265565A (en)
AR (1) AR016562A1 (en)
AU (1) AU9155198A (en)
BR (1) BR9810852A (en)
CA (1) CA2298440A1 (en)
DE (1) DE19733504A1 (en)
NO (1) NO20000486L (en)
WO (1) WO1999005919A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10359530B4 (en) * 2003-12-17 2006-07-06 Thomas Becken baits
US20120204801A1 (en) * 2011-02-14 2012-08-16 Addison Lawrence System and Method of Shrimp Aquaculture Using Floating Feed

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57139511A (en) * 1981-02-13 1982-08-28 Mitsui Petrochem Ind Ltd Preparation of monofilament
US4393087A (en) * 1981-05-04 1983-07-12 Ralston Purina Company Process for the production of a floating aquatic food pellet
DE3306027A1 (en) * 1983-02-22 1984-08-23 Edmund Mueller Feedstuff base and foodstuff base for aquatic animals and process for production thereof
EP0240906A2 (en) * 1986-04-11 1987-10-14 BASF Aktiengesellschaft Continuous pelleting-process
JPH04267852A (en) * 1991-02-21 1992-09-24 Dai Ichi Kogyo Seiyaku Co Ltd Production of dry pellet for fish farming
US5573792A (en) * 1993-06-03 1996-11-12 Isp Investments Inc. Method of growing fish or crustaceans at increased conversion, growth and survival rates

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57139511A (en) * 1981-02-13 1982-08-28 Mitsui Petrochem Ind Ltd Preparation of monofilament
US4393087A (en) * 1981-05-04 1983-07-12 Ralston Purina Company Process for the production of a floating aquatic food pellet
DE3306027A1 (en) * 1983-02-22 1984-08-23 Edmund Mueller Feedstuff base and foodstuff base for aquatic animals and process for production thereof
EP0240906A2 (en) * 1986-04-11 1987-10-14 BASF Aktiengesellschaft Continuous pelleting-process
JPH04267852A (en) * 1991-02-21 1992-09-24 Dai Ichi Kogyo Seiyaku Co Ltd Production of dry pellet for fish farming
US5573792A (en) * 1993-06-03 1996-11-12 Isp Investments Inc. Method of growing fish or crustaceans at increased conversion, growth and survival rates

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8240, Derwent World Patents Index; Class A17, AN 82-84674E, XP002087849 *
PATENT ABSTRACTS OF JAPAN vol. 017, no. 055 (C - 1023) 3 February 1993 (1993-02-03) *

Also Published As

Publication number Publication date
CA2298440A1 (en) 1999-02-11
EP0999756A1 (en) 2000-05-17
DE19733504A1 (en) 1999-02-04
AU9155198A (en) 1999-02-22
NO20000486L (en) 2000-01-31
AR016562A1 (en) 2001-07-25
BR9810852A (en) 2000-07-25
CN1265565A (en) 2000-09-06
JP2001511365A (en) 2001-08-14
NO20000486D0 (en) 2000-01-31

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