WO1998055507A3 - Modulators of intracellular inflammation, cell death and cell survival pathways containing a card and kinase domain - Google Patents

Modulators of intracellular inflammation, cell death and cell survival pathways containing a card and kinase domain Download PDF

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Publication number
WO1998055507A3
WO1998055507A3 PCT/IL1998/000255 IL9800255W WO9855507A3 WO 1998055507 A3 WO1998055507 A3 WO 1998055507A3 IL 9800255 W IL9800255 W IL 9800255W WO 9855507 A3 WO9855507 A3 WO 9855507A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulators
card
kinase domain
cell
survival pathways
Prior art date
Application number
PCT/IL1998/000255
Other languages
French (fr)
Other versions
WO1998055507A2 (en
Inventor
David Wallach
Mark Boldin
Nikolai Malinin
Original Assignee
Yeda Res & Dev
David Wallach
Mark Boldin
Nikolai Malinin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12101197A external-priority patent/IL121011A0/en
Priority claimed from IL12119997A external-priority patent/IL121199A0/en
Priority to EP98923042A priority Critical patent/EP0984983B1/en
Priority to EA199901117A priority patent/EA004658B1/en
Priority to DK98923042T priority patent/DK0984983T3/en
Priority to BR9809942-6A priority patent/BR9809942A/en
Priority to US09/445,223 priority patent/US7374909B1/en
Priority to UA99127250A priority patent/UA72877C2/en
Priority to AT98923042T priority patent/ATE302215T1/en
Priority to DE69831231T priority patent/DE69831231T2/en
Application filed by Yeda Res & Dev, David Wallach, Mark Boldin, Nikolai Malinin filed Critical Yeda Res & Dev
Priority to IL13328298A priority patent/IL133282A0/en
Priority to CA002289479A priority patent/CA2289479A1/en
Priority to KR10-1999-7010836A priority patent/KR100533147B1/en
Priority to AU75467/98A priority patent/AU754963B2/en
Priority to JP50199399A priority patent/JP2002502258A/en
Priority to SI9830789T priority patent/SI0984983T1/en
Publication of WO1998055507A2 publication Critical patent/WO1998055507A2/en
Publication of WO1998055507A3 publication Critical patent/WO1998055507A3/en
Priority to IL133282A priority patent/IL133282A/en
Priority to NO19995959A priority patent/NO995959L/en
Priority to US11/130,223 priority patent/US20050288225A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A B1 protein, its isoforms, analogs, fragments and derivatives, DNA encoding it and recombinant production are provided. The protein is useful in the modulation of intracellular inflammation, cell death and/or cell survival pathways.
PCT/IL1998/000255 1997-06-05 1998-06-01 Modulators of intracellular inflammation, cell death and cell survival pathways containing a card and kinase domain WO1998055507A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
JP50199399A JP2002502258A (en) 1997-06-05 1998-06-01 Regulators of intracellular inflammation, cell death and cell survival pathways
SI9830789T SI0984983T1 (en) 1997-06-05 1998-06-01 Modulators of intracellular inflammation, cell death and cell survival pathways containing a card and a kinase domain
IL13328298A IL133282A0 (en) 1997-06-05 1998-06-01 Modulators of intracellular inflammation, cell death and cell survival pathways
DK98923042T DK0984983T3 (en) 1997-06-05 1998-06-01 Modulators of intracellular inflammation, cell death, and cell survival pathways containing a CARD and a kinase domain
BR9809942-6A BR9809942A (en) 1997-06-05 1998-06-01 Modulators of intracellular pathways of inflammation, cell death and cell survival
US09/445,223 US7374909B1 (en) 1997-06-05 1998-06-01 Modulators of intracellular inflammation, cell death and cell survival pathways
UA99127250A UA72877C2 (en) 1997-06-30 1998-06-01 Modulators of metabolic ways of intracellular inflammation, cells death and survival
AT98923042T ATE302215T1 (en) 1997-06-05 1998-06-01 MODULATORS OF INTRACELLULAR INFLAMMATORY, CELL DEATH AND CELL SURVIVAL PATHWAYS INCLUDING CARD AND KINASE DOMAIN
DE69831231T DE69831231T2 (en) 1997-06-05 1998-06-01 MODULATORS OF INTRA-CELLULAR INFLAMMATORY, CELL-DATE, AND CELL-LIFE PATHS THAT CONTAIN CARD AND KINASE DOMAINS
EP98923042A EP0984983B1 (en) 1997-06-05 1998-06-01 Modulators of intracellular inflammation, cell death and cell survival pathways containing a card and a kinase domain
EA199901117A EA004658B1 (en) 1997-06-05 1998-06-01 B1 protein capable to modulate intracellular inflammation, cell death and cell survival pathways, encoding dna molecule thereof, vector containing said dna molecule, cell strain containing said vector, methods for their use and pharmaceutical composition
CA002289479A CA2289479A1 (en) 1997-06-05 1998-06-01 Modulators of intracellular inflammation, cell death and cell survival pathways containing a card and kinase domain
KR10-1999-7010836A KR100533147B1 (en) 1997-06-05 1998-06-01 Modulators of intracellular inflammation, cell death and cell survival pathways
AU75467/98A AU754963B2 (en) 1997-06-05 1998-06-01 Modulators of intracellular inflammation, cell death and cell survival pathways
IL133282A IL133282A (en) 1997-06-05 1999-12-02 Modulators of intracellular inflammation cell death and cell survival pathways
NO19995959A NO995959L (en) 1997-06-05 1999-12-03 DNA sequence, vector, transformed eukaryotic or prokaryotic host cells, processes for producing a protein, polypeptide, antibody, isolation and identification method, pharmaceutical composition and screening method.
US11/130,223 US20050288225A1 (en) 1997-06-05 2005-05-17 Modulators of intracellular inflammation, cell death and cell survival pathways

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IL12101197A IL121011A0 (en) 1996-06-06 1997-06-05 Modulators of intracellular cell death and cell survival pathways
IL121011 1997-06-05
IL12119997A IL121199A0 (en) 1997-06-05 1997-06-30 Modulators of intracellular cell death and cell survival pathways
IL121199 1997-06-30
IL12174697A IL121746A0 (en) 1997-06-05 1997-09-11 Modulators of intracellular cell death and cell survival pathways
IL121746 1997-09-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/130,223 Division US20050288225A1 (en) 1997-06-05 2005-05-17 Modulators of intracellular inflammation, cell death and cell survival pathways

Publications (2)

Publication Number Publication Date
WO1998055507A2 WO1998055507A2 (en) 1998-12-10
WO1998055507A3 true WO1998055507A3 (en) 1999-03-11

Family

ID=27271818

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1998/000255 WO1998055507A2 (en) 1997-06-05 1998-06-01 Modulators of intracellular inflammation, cell death and cell survival pathways containing a card and kinase domain

Country Status (15)

Country Link
US (2) US7374909B1 (en)
EP (1) EP0984983B1 (en)
JP (1) JP2002502258A (en)
CN (1) CN100451115C (en)
AT (1) ATE302215T1 (en)
AU (1) AU754963B2 (en)
BR (1) BR9809942A (en)
CA (1) CA2289479A1 (en)
DE (1) DE69831231T2 (en)
DK (1) DK0984983T3 (en)
EA (1) EA004658B1 (en)
ES (1) ES2244061T3 (en)
IL (1) IL121746A0 (en)
NO (1) NO995959L (en)
WO (1) WO1998055507A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6340576B1 (en) 1998-02-06 2002-01-22 Millennium Pharmaceuticals, Inc. Nucleic acid molecules related to card-4L and CARD-4S
US6469140B1 (en) 1998-02-06 2002-10-22 Millennium Pharmaceuticals, Inc. Molecules of the card-related protein family and uses thereof
US6680167B2 (en) 1998-02-06 2004-01-20 Millennium Pharmaceuticals, Inc. Molecules of the card-related protein family and uses thereof
US6033855A (en) 1998-02-06 2000-03-07 Millennium Pharmaceuticals, Inc. Genes encoding caspase recruitment domain polypeptides
US6482933B1 (en) * 1998-02-06 2002-11-19 Millennium Pharmaceuticals, Inc. Molecules of the card-related protein family and uses thereof
US6096539A (en) * 1999-06-10 2000-08-01 Zeneca Limited Protein activator of apoptosis
US6953657B2 (en) 1999-06-28 2005-10-11 Millennium Pharmaceuticals, Inc. Molecules of the CARD-related protein family and uses thereof
US6756196B2 (en) 1999-06-28 2004-06-29 Millennium Pharmaceuticals, Inc. Molecules of the card-related protein family and uses thereof
AU1243601A (en) * 1999-10-27 2001-05-08 Millennium Pharmaceuticals, Inc. Novel molecules of the card-related protein family and uses thereof
US6936450B2 (en) * 2000-04-12 2005-08-30 Compugen Ltd. Variants of protein kinases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578468A (en) * 1987-08-10 1996-11-26 Duke University Site-specific RNA cleavage
US5585479A (en) * 1992-07-24 1996-12-17 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human ELAM-I RNA
US5840708A (en) * 1992-12-14 1998-11-24 Allegheny University Of The Health Sciences Administration of oligonucleotides antisense to dopamine receptor MRNA for diagnosis and treatment of Neurological pathologies
IL111125A0 (en) * 1994-05-11 1994-12-29 Yeda Res & Dev Soluble oligomeric tnf/ngf super family ligand receptors and their use
US6033855A (en) * 1998-02-06 2000-03-07 Millennium Pharmaceuticals, Inc. Genes encoding caspase recruitment domain polypeptides

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HOFMANN K ET AL: "The CARD domain: a new apoptotic signalling motif", TIBS TRENDS IN BIOCHEMICAL SCIENCES, vol. 22, no. 5, May 1997 (1997-05-01), pages 155-156, XP004061753 *
INOHARA N ET AL: "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.", J BIOL CHEM, MAY 15 1998, 273 (20) P12296-300, UNITED STATES, XP002078582 *
MCCARTHY JV ET AL: "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.", J BIOL CHEM, JUL 3 1998, 273 (27) P16968-75, UNITED STATES, XP002078583 *
NELSON N ET AL: "Vacuolar H(+)-ATPase: from mammals to yeast and back.", EXPERIENTIA, DEC 15 1996, 52 (12) P1101-10, SWITZERLAND, XP002078581 *
STANGER B Z ET AL: "RIP: A NOVEL PROTEIN CONTAINING A DEATH DOMAIN THAT INTERACTS WITH FAS/APO-1 (CD95) IN YEAST AND CAUSES CELL DEATH", CELL, vol. 81, 19 May 1995 (1995-05-19), pages 513 - 523, XP002072216 *

Also Published As

Publication number Publication date
EP0984983A2 (en) 2000-03-15
IL121746A0 (en) 1998-02-22
NO995959D0 (en) 1999-12-03
DE69831231T2 (en) 2006-06-08
AU7546798A (en) 1998-12-21
US20050288225A1 (en) 2005-12-29
ES2244061T3 (en) 2005-12-01
DK0984983T3 (en) 2005-09-19
AU754963B2 (en) 2002-11-28
JP2002502258A (en) 2002-01-22
CA2289479A1 (en) 1998-12-10
US7374909B1 (en) 2008-05-20
WO1998055507A2 (en) 1998-12-10
NO995959L (en) 2000-01-31
CN100451115C (en) 2009-01-14
BR9809942A (en) 2000-08-01
EA004658B1 (en) 2004-06-24
CN1259165A (en) 2000-07-05
ATE302215T1 (en) 2005-09-15
DE69831231D1 (en) 2005-09-22
EP0984983B1 (en) 2005-08-17
EA199901117A1 (en) 2000-06-26

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