WO1998051711A1 - Perles de chitine, perles de chitosane, leur procede de production, vehicule comprenant lesdites perles, et procede de preparation d'une spore de microsporidie - Google Patents
Perles de chitine, perles de chitosane, leur procede de production, vehicule comprenant lesdites perles, et procede de preparation d'une spore de microsporidie Download PDFInfo
- Publication number
- WO1998051711A1 WO1998051711A1 PCT/JP1997/003741 JP9703741W WO9851711A1 WO 1998051711 A1 WO1998051711 A1 WO 1998051711A1 JP 9703741 W JP9703741 W JP 9703741W WO 9851711 A1 WO9851711 A1 WO 9851711A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- beads
- chitin
- preparing
- microsporidian spore
- particle diameter
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
- C09B67/0097—Dye preparations of special physical nature; Tablets, films, extrusion, microcapsules, sheets, pads, bags with dyes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
- A23L27/72—Encapsulation
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/275—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Animal Husbandry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54901498A JP3368323B2 (ja) | 1997-05-14 | 1997-10-16 | キチンビーズ、キトサンビーズ、これらビーズの製造方法及びこれらビーズからなる担体並びに微胞子虫胞子の製造法 |
US09/214,383 US6156330A (en) | 1997-05-14 | 1997-10-16 | Chitin beads, chitosan beads, process for preparing these beads, carrier comprising said beads, and process for preparing microsporidian spore |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9/124255 | 1997-05-14 | ||
JP12425597 | 1997-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998051711A1 true WO1998051711A1 (fr) | 1998-11-19 |
Family
ID=14880811
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1997/003741 WO1998051711A1 (fr) | 1997-05-14 | 1997-10-16 | Perles de chitine, perles de chitosane, leur procede de production, vehicule comprenant lesdites perles, et procede de preparation d'une spore de microsporidie |
PCT/JP1998/002112 WO1998051712A1 (fr) | 1997-05-14 | 1998-05-13 | Billes de chitine, billes de chitosane, leurs procedes de fabrication, supports obtenus a partir de ces billes et procedes de production de spores de microsporidies |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1998/002112 WO1998051712A1 (fr) | 1997-05-14 | 1998-05-13 | Billes de chitine, billes de chitosane, leurs procedes de fabrication, supports obtenus a partir de ces billes et procedes de production de spores de microsporidies |
Country Status (8)
Country | Link |
---|---|
US (1) | US6156330A (ja) |
EP (1) | EP0913407B1 (ja) |
JP (1) | JP3368323B2 (ja) |
KR (1) | KR100321665B1 (ja) |
CN (1) | CN1176949C (ja) |
CA (1) | CA2255080C (ja) |
DE (1) | DE69828245T2 (ja) |
WO (2) | WO1998051711A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6649168B2 (en) | 1999-03-17 | 2003-11-18 | Novartis Ag | Pharmaceutical compositions comprising TGF-beta |
JP2007520430A (ja) * | 2003-06-27 | 2007-07-26 | ユニバーシティ オブ ハル | 製剤 |
JP2009502896A (ja) * | 2005-07-28 | 2009-01-29 | ユニバーシティ オブ ハル | スポロポレニンを含有する局所用配合物 |
JP2023035552A (ja) * | 2021-09-01 | 2023-03-13 | 大日精化工業株式会社 | 樹脂ビーズ、樹脂ビーズの製造方法、及び樹脂ビーズを用いた製品 |
Families Citing this family (41)
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KR100375422B1 (ko) * | 1999-12-21 | 2003-03-10 | 한국과학기술연구원 | 다공성 키토산 구슬 및 그의 제조 방법 |
US20070148770A1 (en) * | 2000-11-30 | 2007-06-28 | Korea Institute Of Science And Technology | Macroporous chitosan beads and preparation method thereof |
US8741335B2 (en) | 2002-06-14 | 2014-06-03 | Hemcon Medical Technologies, Inc. | Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as Chitosan |
ATE549996T1 (de) | 2001-06-14 | 2012-04-15 | Gregory Kenton W | Verfahren zur herstellung von chitosan- wundauflagen |
US7371403B2 (en) * | 2002-06-14 | 2008-05-13 | Providence Health System-Oregon | Wound dressing and method for controlling severe, life-threatening bleeding |
BE1014638A6 (fr) * | 2002-02-12 | 2004-02-03 | Univ Liege | Methode de preparation de derives de la paroi cellulaire a partir de biomasse. |
US6943023B2 (en) * | 2002-03-06 | 2005-09-13 | National Institute Of Agrobiological Sciences | Insect cell primary culture medium, extra cellular matrix, and process of preparing an insect culture cell line in a short period of time using the medium and matrix |
US8269058B2 (en) | 2002-06-14 | 2012-09-18 | Hemcon Medical Technologies, Inc. | Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan |
US20050137512A1 (en) * | 2003-12-23 | 2005-06-23 | Campbell Todd D. | Wound dressing and method for controlling severe, life-threatening bleeding |
US7094372B1 (en) * | 2003-06-12 | 2006-08-22 | Chung Yuan Christian University | Chitosan membrane containing nano-inorganic particles and the method for forming the same |
US7608270B2 (en) * | 2003-06-27 | 2009-10-27 | University Of Hull | Dosage form |
GB0315019D0 (en) * | 2003-06-27 | 2003-07-30 | Univ Hull | Dosage form |
BRPI0507031B1 (pt) | 2004-01-23 | 2021-01-19 | Eden Research Plc. | método para exterminar nematódeos compreendendo a aplicação de uma composição nematocida compreendendo uma partícula oca de glicano que encapsula um componente de terpeno e uso da referida composição nematocida |
PT2338332E (pt) | 2004-05-20 | 2014-05-15 | Eden Research Plc | Partícula oca de glucano ou partícula de parede celular que encapsula um componente de terpeno |
GB0427520D0 (en) * | 2004-12-16 | 2005-01-19 | Univ Hull | Magnetic resonance contrast media |
US9204957B2 (en) | 2005-03-17 | 2015-12-08 | Hemcon Medical Technologies, Inc. | Systems and methods for hemorrhage control and or tissue repair |
KR20080044238A (ko) * | 2005-07-13 | 2008-05-20 | 헴콘, 인크. | 키토산으로부터 형성된 입상 지혈제를 사용하고폴리-4-히드록시 부티레이트의 중합체 망상 물질을포함하는 지혈 조성물, 집합체, 시스템 및 방법 |
AP2901A (en) | 2005-11-30 | 2014-05-31 | Eden Research Plc | Compositions and methods comprising terpenes or terpene mixtures selected form thymol, eugenol, geraniol, citral, and L-carvone |
PL2982244T3 (pl) | 2005-11-30 | 2021-08-09 | Eden Research Plc | Kapsułki owadobójcze zawierające tymol oraz sposoby ich wytwarzania i zastosowania |
CA2653175A1 (en) | 2006-05-23 | 2007-12-06 | Providence Health System-Oregon D/B/A Providence St. Vincent Medical Cen Ter | Systems and methods for introducing and applying a bandage structure within a body lumen or hollow body organ |
US8685421B2 (en) | 2006-07-07 | 2014-04-01 | Surmodics, Inc. | Beaded wound spacer device |
CN102552967B (zh) | 2006-12-15 | 2015-08-12 | 生命连结有限公司 | 明胶-转谷氨酰胺酶止血敷料和密封材料 |
EP2279012A4 (en) * | 2008-05-02 | 2013-05-29 | Providence Health Sys Oregon | DEVICES AND METHODS OF DRESSING |
WO2009153748A2 (en) * | 2008-06-18 | 2009-12-23 | Lifebond Ltd | Methods and devices for use with sealants |
AU2009261559B2 (en) | 2008-06-18 | 2014-01-16 | Lifebond Ltd | Improved cross-linked compositions |
WO2009153751A2 (en) * | 2008-06-18 | 2009-12-23 | Lifebond Ltd | A method for enzymatic cross-linking of a protein |
GB0812513D0 (en) * | 2008-07-09 | 2008-08-13 | Univ Hull | Delivery vehicle |
WO2010042540A1 (en) | 2008-10-06 | 2010-04-15 | Providence Health System - Oregon | Foam medical devices and methods |
DE102009040624B3 (de) * | 2009-09-08 | 2011-02-03 | Bruno Gruber | Verwendung von getrockneten Wasserkefirkörnern |
CN102711853B (zh) | 2009-12-22 | 2015-05-20 | 生命连结有限公司 | 用于控制交联基质的性质的酶交联剂的改性 |
ES2567174T3 (es) | 2010-08-05 | 2016-04-20 | Lifebond Ltd | Composición seca en apósitos y adhesivos para heridas |
US9155671B2 (en) | 2012-10-16 | 2015-10-13 | Surmodics, Inc. | Wound packing device and methods |
GB201220940D0 (en) | 2012-11-21 | 2013-01-02 | Eden Research Plc | Method P |
CN103392676A (zh) * | 2013-08-23 | 2013-11-20 | 新疆师范大学 | 一种蝗虫微孢子虫接种方法 |
WO2015070194A1 (en) * | 2013-11-11 | 2015-05-14 | Dossey Aaron T | Insect products and methods of manufacture and use thereof |
FR3016882A1 (fr) | 2014-01-30 | 2015-07-31 | Sofradim Production | Procede de preparation de chitosane a haut degre d’acetylation |
US10201457B2 (en) | 2014-08-01 | 2019-02-12 | Surmodics, Inc. | Wound packing device with nanotextured surface |
CN105385601B (zh) * | 2015-12-07 | 2018-12-07 | 南京华得福生物科技有限公司 | 一种蝗虫微孢子虫及其悬浮培养方法和应用 |
US11998654B2 (en) | 2018-07-12 | 2024-06-04 | Bard Shannon Limited | Securing implants and medical devices |
KR102393124B1 (ko) * | 2021-01-13 | 2022-05-03 | 농업회사법인 (주)한국유용곤충연구소 | 동애등에와 곤충키틴을 포함하는 발효 곤충사료첨가제의 제조방법 및 그에 따라 제조된 발효 곤충사료첨가제 |
KR102661511B1 (ko) | 2021-10-20 | 2024-04-26 | 서울대학교산학협력단 | 키토산 담체 합성 장치 및 방법 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50116632A (ja) * | 1974-02-27 | 1975-09-12 | ||
JPH04132701A (ja) * | 1990-09-26 | 1992-05-07 | Fuji Spinning Co Ltd | 分子ふるい能を有する多孔質微小架橋キチン粒状体の製造方法 |
WO1993014216A1 (en) * | 1992-01-20 | 1993-07-22 | Nakamura, Tomotaka | Process for producing chitin and chitosan from dermatophyte |
JPH0725905A (ja) * | 1993-07-16 | 1995-01-27 | New Oji Paper Co Ltd | 球状キトサン微粒子およびその製造方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62151430A (ja) * | 1985-12-25 | 1987-07-06 | Dai Ichi Kogyo Seiyaku Co Ltd | キチンポ−ラスビ−ズの製造法 |
JPS62151403A (ja) * | 1985-12-25 | 1987-07-06 | Dai Ichi Kogyo Seiyaku Co Ltd | N−アシルキトサンポ−ラスビ−ズの製造法 |
JP2615444B2 (ja) * | 1995-03-15 | 1997-05-28 | 工業技術院長 | キトオリゴ糖の部分n−アシル化体又はその塩 |
US5645844A (en) * | 1995-06-07 | 1997-07-08 | Chitogenics, Inc. | Negatively charged chitosan derivative semiochemical delivery system |
US5851545A (en) * | 1995-08-25 | 1998-12-22 | Sandoz Ltd. | Insecticidal matrix and process for preparation thereof |
JP2777981B2 (ja) * | 1995-09-12 | 1998-07-23 | 工業技術院長 | キトサン含有繊維からなる中空球状素材、及びその製造法 |
-
1997
- 1997-10-16 JP JP54901498A patent/JP3368323B2/ja not_active Expired - Lifetime
- 1997-10-16 US US09/214,383 patent/US6156330A/en not_active Expired - Fee Related
- 1997-10-16 WO PCT/JP1997/003741 patent/WO1998051711A1/ja active Application Filing
-
1998
- 1998-05-13 EP EP98919581A patent/EP0913407B1/en not_active Expired - Lifetime
- 1998-05-13 CN CNB988006316A patent/CN1176949C/zh not_active Expired - Fee Related
- 1998-05-13 WO PCT/JP1998/002112 patent/WO1998051712A1/ja active IP Right Grant
- 1998-05-13 KR KR1019980710364A patent/KR100321665B1/ko not_active IP Right Cessation
- 1998-05-13 CA CA002255080A patent/CA2255080C/en not_active Expired - Fee Related
- 1998-05-13 DE DE69828245T patent/DE69828245T2/de not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50116632A (ja) * | 1974-02-27 | 1975-09-12 | ||
JPH04132701A (ja) * | 1990-09-26 | 1992-05-07 | Fuji Spinning Co Ltd | 分子ふるい能を有する多孔質微小架橋キチン粒状体の製造方法 |
WO1993014216A1 (en) * | 1992-01-20 | 1993-07-22 | Nakamura, Tomotaka | Process for producing chitin and chitosan from dermatophyte |
JPH0725905A (ja) * | 1993-07-16 | 1995-01-27 | New Oji Paper Co Ltd | 球状キトサン微粒子およびその製造方法 |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6649168B2 (en) | 1999-03-17 | 2003-11-18 | Novartis Ag | Pharmaceutical compositions comprising TGF-beta |
JP2007520430A (ja) * | 2003-06-27 | 2007-07-26 | ユニバーシティ オブ ハル | 製剤 |
JP2009502896A (ja) * | 2005-07-28 | 2009-01-29 | ユニバーシティ オブ ハル | スポロポレニンを含有する局所用配合物 |
JP2009509917A (ja) * | 2005-07-28 | 2009-03-12 | ユニバーシティ オブ ハル | スポロポレニンの使用 |
JP2023035552A (ja) * | 2021-09-01 | 2023-03-13 | 大日精化工業株式会社 | 樹脂ビーズ、樹脂ビーズの製造方法、及び樹脂ビーズを用いた製品 |
Also Published As
Publication number | Publication date |
---|---|
EP0913407A1 (en) | 1999-05-06 |
CA2255080A1 (en) | 1998-11-19 |
JP3368323B2 (ja) | 2003-01-20 |
KR100321665B1 (ko) | 2002-03-23 |
WO1998051712A1 (fr) | 1998-11-19 |
US6156330A (en) | 2000-12-05 |
CN1226900A (zh) | 1999-08-25 |
EP0913407B1 (en) | 2004-12-22 |
KR20000016757A (ko) | 2000-03-25 |
CN1176949C (zh) | 2004-11-24 |
DE69828245T2 (de) | 2005-12-08 |
EP0913407A4 (en) | 2000-03-29 |
DE69828245D1 (de) | 2005-01-27 |
CA2255080C (en) | 2004-08-31 |
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