WO1998049130A3 - Hydroxynaphthoic acids and derivatives - Google Patents

Hydroxynaphthoic acids and derivatives Download PDF

Info

Publication number
WO1998049130A3
WO1998049130A3 PCT/US1998/008544 US9808544W WO9849130A3 WO 1998049130 A3 WO1998049130 A3 WO 1998049130A3 US 9808544 W US9808544 W US 9808544W WO 9849130 A3 WO9849130 A3 WO 9849130A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
hydroxynaphthoic acids
8alkynyl
8alkenyl
8alkyl
Prior art date
Application number
PCT/US1998/008544
Other languages
French (fr)
Other versions
WO1998049130A2 (en
Inventor
Jagt David L Vander
Lorraine M Deck
Robert E Royer
Original Assignee
Univ New Mexico
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/988,472 external-priority patent/US5936120A/en
Application filed by Univ New Mexico filed Critical Univ New Mexico
Priority to CA002288199A priority Critical patent/CA2288199A1/en
Priority to EP98918831A priority patent/EP0980350A4/en
Publication of WO1998049130A2 publication Critical patent/WO1998049130A2/en
Publication of WO1998049130A3 publication Critical patent/WO1998049130A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/66—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems and singly-bound oxygen atoms, bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/29—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with halogen-containing compounds which may be formed in situ
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

In one embodiment, the present invention provides a compound comprising formula (I), wherein A = H or OH, X = OH, a halogen, OR, NHR, NR', R'' where R, R', and R'' = H, C1-8alkyl, C2-8alkenyl, or C2-8alkynyl, cycloalkyl, cycloalkenyl, aryl, aralkyl or heterocyclic, substituted or unsubstituted; and R1,R2,R3,R4,R5 = H, C1-8alkyl, C2-8alkenyl, or C2-8alkynyl, cycloalkyl, cycloalkenyl, aryl or heterocyclic, substituted or unsubstituted, wherein R1 includes at least one methylene spacer through which R1 is attached to said compound. The present invention also provides methods for making hydroxynaphthoic acids.
PCT/US1998/008544 1997-04-29 1998-04-28 Hydroxynaphthoic acids and derivatives WO1998049130A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002288199A CA2288199A1 (en) 1997-04-29 1998-04-28 Hydroxynaphthoic acids and derivatives
EP98918831A EP0980350A4 (en) 1997-04-29 1998-04-28 Hydroxynaphthoic acids and derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4508397P 1997-04-29 1997-04-29
US60/045,083 1997-04-29
US08/988,472 1997-12-10
US08/988,472 US5936120A (en) 1997-12-10 1997-12-10 Deoxygossylic compounds

Publications (2)

Publication Number Publication Date
WO1998049130A2 WO1998049130A2 (en) 1998-11-05
WO1998049130A3 true WO1998049130A3 (en) 1999-01-28

Family

ID=26722357

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/008544 WO1998049130A2 (en) 1997-04-29 1998-04-28 Hydroxynaphthoic acids and derivatives

Country Status (3)

Country Link
EP (1) EP0980350A4 (en)
CA (1) CA2288199A1 (en)
WO (1) WO1998049130A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB647997A (en) * 1948-04-05 1950-12-28 Eric Berkeley Higgins Improvements in the manufacture of 2:3 hydroxynaphthoic acid
US4137272A (en) * 1976-05-04 1979-01-30 Hoechst Aktiengesellschaft Process for the manufacture of 2-alkoxy-6-bromo-naphthalenes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8897391A (en) * 1990-12-12 1992-06-18 Mitsubishi Kasei Corporation Electrostatic image-developing toner
DE4440141A1 (en) * 1994-11-10 1996-05-15 Hoechst Ag Novel crystalline cephem acid addition salts and process for their preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB647997A (en) * 1948-04-05 1950-12-28 Eric Berkeley Higgins Improvements in the manufacture of 2:3 hydroxynaphthoic acid
US4137272A (en) * 1976-05-04 1979-01-30 Hoechst Aktiengesellschaft Process for the manufacture of 2-alkoxy-6-bromo-naphthalenes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FRASER A. D., CLARK S. J., WOTIZ H. H.: "DEMETHYLATION OF LABILE ARYL ETHERS.", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 41., no. 01., 1 January 1976 (1976-01-01), US, pages 170/171., XP002916656, ISSN: 0022-3263, DOI: 10.1021/jo00863a048 *
See also references of EP0980350A4 *

Also Published As

Publication number Publication date
EP0980350A4 (en) 2003-01-02
EP0980350A2 (en) 2000-02-23
CA2288199A1 (en) 1998-11-05
WO1998049130A2 (en) 1998-11-05

Similar Documents

Publication Publication Date Title
EP1019389A4 (en) Epothilone derivatives
CA2276455A1 (en) Phthalazinones
CA2192289A1 (en) Substituted Heterocyclic Derivatives
CA2316310A1 (en) Gamma-glutamyl and beta-aspartyl containing immunomodulator compounds and methods therewith
DE69628276D1 (en) PREPARATION OF XANTHINE DERIVATIVES AS A FIXED DISPERSION
MY138525A (en) Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
CA2018704A1 (en) N-phenylpyrazole derivatives
EP0758653A4 (en) Imidazoquinazoline derivatives
PT705833E (en) DERIVED FROM DC-89
IL148516A (en) Retroviral protease inhibiting compound
CA2252543A1 (en) Benzene derivatives substituted by heterocycles and herbicides
AU1507199A (en) Novel pyrimidine-5-carboxamide derivatives
CA2196271A1 (en) Quinolone- or naphthyridonecarboxylic acid derivative or salt thereof
CA2219675A1 (en) Pentacyclic compound
EP0358190A3 (en) Polysiloxanes with sterically hindered moiety
CA2337098A1 (en) Anthranilic acid derivatives
AU3981095A (en) Antifungal sordaridin derivatives
KR20050042829A (en) Agent for inhibition of cell adhesion
CA2275253A1 (en) Method for producing n-substituted 3-hydroxypyrazoles
CA2300069A1 (en) Naphthalimidobenzamide derivatives
WO1998049130A3 (en) Hydroxynaphthoic acids and derivatives
WO2001010861A3 (en) Substituted heterocyclyl-2h-chromenes
WO2000012480A3 (en) Substituted 3-aryl-pyrazoles as herbicides
AU5715894A (en) Methotrexate derivative
WO1999007718A3 (en) Substituted tetrahydropyrane derivatives, method for producing same, their use as medicine or diagnostic agent, as well as medicine containing same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): BR CA JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): BR CA JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2288199

Country of ref document: CA

Ref country code: CA

Ref document number: 2288199

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1998918831

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1998918831

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

Ref document number: 1998547292

Format of ref document f/p: F

WWW Wipo information: withdrawn in national office

Ref document number: 1998918831

Country of ref document: EP