WO1998047892A1 - Substituted imidazoles useful in the treatment of inflammatory diseases - Google Patents
Substituted imidazoles useful in the treatment of inflammatory diseases Download PDFInfo
- Publication number
- WO1998047892A1 WO1998047892A1 PCT/US1998/007910 US9807910W WO9847892A1 WO 1998047892 A1 WO1998047892 A1 WO 1998047892A1 US 9807910 W US9807910 W US 9807910W WO 9847892 A1 WO9847892 A1 WO 9847892A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- compound
- group
- substituted
- fluorophenyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Abstract
Description
Claims
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69816109T DE69816109T2 (en) | 1997-04-24 | 1998-04-17 | SUBSTITUTED IMIDAZOLES FOR TREATING INFLAMMABLE DISEASES |
CA002297176A CA2297176A1 (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles useful in the treatment of inflammatory diseases |
HU0002842A HUP0002842A3 (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles, process for producing them, pharmaceutical compositions containing them, their use and their intermediates |
KR1019997009785A KR100568438B1 (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles useful in the treatment of inflammatory diseases, a process for the preparation thereof and pharmaceutical compositions containing the same |
PL336758A PL191111B1 (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles useful in the treatment of inflammatory diseases |
AT98918463T ATE244234T1 (en) | 1997-04-24 | 1998-04-17 | SUBSTITUTED IMIDAZOLES FOR THE TREATMENT OF INFLAMMATORY DISEASES |
UA99105811A UA65572C2 (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles, intermediate compounds for the preparation thereof, a method for the preparation of substituted imidazoles and a method for the treatment of inflammatory diseases |
EP98918463A EP1028954B1 (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles useful in the treatment of inflammatory diseases |
IL13231898A IL132318A0 (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles useful in the treatment of inflammatory diseases |
JP54623198A JP2001522357A (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles useful for treating inflammatory diseases |
NZ500447A NZ500447A (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles that inhibit cytokine production and are useful in the treatment of inflammatory disease |
BR9808998-6A BR9808998A (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles useful in the treatment of inflammatory diseases |
AU71382/98A AU7138298A (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles useful in the treatment of inflammatory diseases |
DK98918463T DK1028954T3 (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles suitable for the treatment of inflammatory diseases |
NO19995095A NO318937B1 (en) | 1997-04-24 | 1999-10-19 | Substituted imidazoles, a pharmaceutical composition comprising one of them, their use for the preparation of preparations and a method for the preparation of the imidazoles |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4425297P | 1997-04-24 | 1997-04-24 | |
US60/044,252 | 1997-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998047892A1 true WO1998047892A1 (en) | 1998-10-29 |
Family
ID=21931339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/007910 WO1998047892A1 (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles useful in the treatment of inflammatory diseases |
Country Status (24)
Country | Link |
---|---|
US (3) | US5965583A (en) |
EP (1) | EP1028954B1 (en) |
JP (1) | JP2001522357A (en) |
KR (1) | KR100568438B1 (en) |
CN (1) | CN1211381C (en) |
AR (1) | AR012594A1 (en) |
AT (1) | ATE244234T1 (en) |
AU (1) | AU7138298A (en) |
BR (1) | BR9808998A (en) |
CA (1) | CA2297176A1 (en) |
DE (1) | DE69816109T2 (en) |
DK (1) | DK1028954T3 (en) |
ES (1) | ES2202840T3 (en) |
HU (1) | HUP0002842A3 (en) |
IL (1) | IL132318A0 (en) |
NO (1) | NO318937B1 (en) |
NZ (1) | NZ500447A (en) |
PL (1) | PL191111B1 (en) |
PT (1) | PT1028954E (en) |
RU (1) | RU2222534C2 (en) |
TR (1) | TR199902622T2 (en) |
UA (1) | UA65572C2 (en) |
WO (1) | WO1998047892A1 (en) |
ZA (1) | ZA983451B (en) |
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US6251914B1 (en) | 1997-07-02 | 2001-06-26 | Smithkline Beecham Corporation | Cycloalkyl substituted imidazoles |
EP1119254A1 (en) * | 1998-10-07 | 2001-08-01 | SmithKline Beecham Corporation | Novel treatment for stroke management |
US6300347B1 (en) | 1997-06-30 | 2001-10-09 | Novartis Ag | 2-substituted 4,5-diaryl imidazoles |
EP1163910A1 (en) * | 1999-03-25 | 2001-12-19 | Welfide Corporation | Preventives/remedies for interstitial pneumonia and pulmonary fibrosis |
US6362193B1 (en) | 1997-10-08 | 2002-03-26 | Smithkline Beecham Corporation | Cycloalkenyl substituted compounds |
EP1196169A1 (en) * | 1999-07-01 | 2002-04-17 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
US6414150B1 (en) | 1996-08-21 | 2002-07-02 | Smithkline Beecham Corporation | 4,5-disubstituted imidazole compounds |
US6489325B1 (en) | 1998-07-01 | 2002-12-03 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US6548503B1 (en) | 1998-11-04 | 2003-04-15 | Smithkline Beecham Corporation | Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines |
US6548520B1 (en) | 1998-05-22 | 2003-04-15 | Smithkline Beecham Corporation | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
US6562832B1 (en) | 1997-07-02 | 2003-05-13 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US6610695B1 (en) | 1997-06-19 | 2003-08-26 | Smithkline Beecham Corporation | Aryloxy substituted pyrimidine imidazole compounds |
US6645989B2 (en) | 1992-01-13 | 2003-11-11 | Smithkline Beecham Corporation | Compounds |
US6730683B2 (en) | 1997-12-19 | 2004-05-04 | Smithkline Beecham Corporation | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses |
US6759410B1 (en) | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
US6774127B2 (en) | 1997-06-13 | 2004-08-10 | Smithkline Beecham Corporation | Pyrazole and pyrazoline substituted compounds |
US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US7067671B2 (en) | 2001-03-26 | 2006-06-27 | Ortho-Mcneil Pharmaceutical, Inc. | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof |
EP1676574A2 (en) | 2004-12-30 | 2006-07-05 | Johnson & Johnson Vision Care, Inc. | Methods for promoting survival of transplanted tissues and cells |
EP1707205A2 (en) | 2002-07-09 | 2006-10-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
US7166583B2 (en) | 2002-05-23 | 2007-01-23 | Pliva-Istrazivacki Institut D.O.O. | 1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
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TR199902622T2 (en) | 2000-05-22 |
EP1028954B1 (en) | 2003-07-02 |
RU2222534C2 (en) | 2004-01-27 |
UA65572C2 (en) | 2004-04-15 |
KR100568438B1 (en) | 2006-04-07 |
NO995095L (en) | 1999-12-09 |
HUP0002842A3 (en) | 2002-01-28 |
DK1028954T3 (en) | 2003-10-27 |
US6521655B1 (en) | 2003-02-18 |
PL191111B1 (en) | 2006-03-31 |
US5965583A (en) | 1999-10-12 |
NO318937B1 (en) | 2005-05-30 |
AU7138298A (en) | 1998-11-13 |
ZA983451B (en) | 1999-10-25 |
JP2001522357A (en) | 2001-11-13 |
PT1028954E (en) | 2003-11-28 |
EP1028954A1 (en) | 2000-08-23 |
CN1253558A (en) | 2000-05-17 |
ES2202840T3 (en) | 2004-04-01 |
AR012594A1 (en) | 2000-11-08 |
NZ500447A (en) | 2001-09-28 |
PL336758A1 (en) | 2000-07-17 |
BR9808998A (en) | 2000-08-08 |
DE69816109D1 (en) | 2003-08-07 |
CN1211381C (en) | 2005-07-20 |
ATE244234T1 (en) | 2003-07-15 |
NO995095D0 (en) | 1999-10-19 |
KR20010020204A (en) | 2001-03-15 |
CA2297176A1 (en) | 1998-10-29 |
HUP0002842A2 (en) | 2001-06-28 |
DE69816109T2 (en) | 2004-04-22 |
IL132318A0 (en) | 2001-03-19 |
US6214830B1 (en) | 2001-04-10 |
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