WO1998046123A1 - Anatomical probe - Google Patents
Anatomical probe Download PDFInfo
- Publication number
- WO1998046123A1 WO1998046123A1 PCT/GB1998/001045 GB9801045W WO9846123A1 WO 1998046123 A1 WO1998046123 A1 WO 1998046123A1 GB 9801045 W GB9801045 W GB 9801045W WO 9846123 A1 WO9846123 A1 WO 9846123A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- probe
- walls
- electromagnetic radiation
- fibre optic
- illuminator
- Prior art date
Links
- 239000000523 sample Substances 0.000 title claims abstract description 69
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 37
- 239000000835 fiber Substances 0.000 claims abstract description 37
- 238000003384 imaging method Methods 0.000 claims abstract description 14
- 230000005670 electromagnetic radiation Effects 0.000 claims description 21
- 210000003484 anatomy Anatomy 0.000 claims description 11
- 230000005855 radiation Effects 0.000 claims description 9
- 238000001228 spectrum Methods 0.000 claims description 6
- 229910001220 stainless steel Inorganic materials 0.000 claims description 6
- 239000010935 stainless steel Substances 0.000 claims description 6
- 230000001419 dependent effect Effects 0.000 claims 2
- 210000001835 viscera Anatomy 0.000 abstract description 4
- 238000001514 detection method Methods 0.000 abstract description 2
- 200000000007 Arterial disease Diseases 0.000 abstract 1
- 210000001367 artery Anatomy 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- 206010003210 Arteriosclerosis Diseases 0.000 description 3
- 208000011775 arteriosclerosis disease Diseases 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 210000004013 groin Anatomy 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000208734 Pisonia aculeata Species 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
- A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
- A61B5/1076—Measuring physical dimensions, e.g. size of the entire body or parts thereof for measuring dimensions inside body cavities, e.g. using catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/104—Balloon catheters used for angioplasty
Definitions
- This invention relates to a probe for anatomical parts, and particularly, but not exclusively, to a probe for use in the detection and treatment of diseases in internal organs and blood vessels, particularly arteries.
- Probes have been developed for investigating a wide range of internal body parts.
- angioplasty has been developed as a technique for the treatment of atherosclerosis, or narrowing of blood vessels in arteries, caused by the build up of cholesterol and the like.
- the technique is particularly employed to remove plaque from the main arteries around the human heart.
- a guide wire is threaded through an artery, typically in the groin area, and up to the region of the heart.
- a first catheter, having a fluoroscope on one end, is then passed over the guide wire in the artery until the fluoroscope is located in the vicinity of any potentially constricted areas.
- the fluoroscope then generates a source of low energy X-rays, which are reflected from the arterial walls and detected.
- the detected X-rays are used to construct a picture of the interior of the artery to pinpoint particular areas of plaque build up.
- the first catheter with the fluoroscope attached is removed from the artery entirely.
- a second catheter known as a balloon catheter, is then threaded onto the guide wire and up into the area of the blood vessel which has previously been mapped by fluoroscopy.
- the balloon catheter has an expandable elastic bladder towards the end of the catheter that enters the area of interest; preferably this bladder is in turn surrounded by a wire mesh.
- the bladder of the balloon catheter is slid into a position of high plaque build up. The bladder is then expanded which crushes the plaque.
- One technique for improving the resolution would be to increase the energy of the X-rays by increasing the size of the crystal. However, this would require a new. larger diameter catheter which in turn would require approval by the relevant health authority (for example, the F.D.A. in the United States) which o can take many years.
- the relevant health authority for example, the F.D.A. in the United States
- a probe for examining the walls of anatomical parts comprising an illuminator arranged to illuminate the walls of the anatomical part with electromagnetic radiation, and a lens system for receiving electromagnetic radiation reflected from the walls of the anatomical part.
- an illuminator and a lens system allows an image of the walls to be generated which is far superior to that generated by prior art probes of a similar diameter that use ultrasound or X-ray transducers.
- the probe also comprises imaging means for receiving the reflected electromagnetic radiation from the lens system.
- imaging means for receiving the reflected electromagnetic radiation from the lens system.
- This may be one or more fibre optic wires, for example.
- the illuminator may be a fibre optic illuminator, such as a fibre optic wire. If the imaging means is also a fibre optic wire, it may preferably be located within the fibre optic illuminator. Thus, a probe with a similar diameter to those of the prior art is provided, but with substantially better resolution.
- the lens system comprises a convex reflector for guiding the electromagnetic radiation reflected from the body part walls back towards the end of the fibre optic illuminator, and a lens arranged to collimate the electromagnetic radiation from the convex reflector.
- the radiation reflected from the walls of the anatomical part tends to arrive back at the probe at an obtuse angle relative to the fibre optic illuminator.
- a convex reflector and collimating lens are therefore preferable to deflect that reflected light such that it is made generally parallel to the illuminator once more.
- the convex reflector may conveniently be a reflective ball, which may be attached to the fibre optic illuminator by a sheath substantially transparent to the electromagnetic radiation reflected from the walls of the anatomical part.
- the ball may be formed of stainless steel.
- the probe is adapted to examine blood vessel walls.
- the probe may be adapted to examine internal organs such as, for example, the stomach. It may be positioned within the organ or blood vessel by means of a conventional catheter.
- the invention also preferably extends to a system for operating the probe of o the present invention.
- the system comprises generator means for generating electromagnetic radiation, the illuminator being arranged to receive the electromagnetic radiation from the generator means; and display means for receiving the reflected electromagnetic radiation from the imaging means and displaying an image of the wall of the anatomical part. 5
- the generator means is arranged to generate electromagnetic radiation is in the infrared region of the electromagnetic spectrum particularly if the probe is adapted to examine blood vessel walls.
- the system may further comprise a frequency shifter arranged to receive the reflected infrared radiation from the fibre imaging means and shift the frequency thereof into the visible part of the electromagnetic spectrum prior to the radiation being received by the display means.
- the probe when adapted to examine blood vessel walls, may find particular application in combination with a catheter, and especially a balloon catheter which permits the removal of plaque formed on the blood vessel walls.
- the probe of the present invention provides relatively high quality images, yet is of a small enough diameter to be inserted into a 1 millimetre diameter balloon catheter. As such, it is possible to generate images of the blood vessel walls with the probe, and substantially simultaneously remove the plaque therefrom with the balloon catheter. As the balloon catheter has already been approved by the relevant health and safety commissions, approval would only need to be sought for the probe part of the combination.
- Figure 1 is a sectional view of a probe according to a preferred embodiment of the present invention.
- Figure 2a and 2b are sectional views of a detachable handle for the probe of Figure 1.
- Figure 3 shows a system for implementing the probe of Figures 1 and 2;
- Figure 4 is a section of a diseased blood vessel
- Figures 5a - 5e are schematic images obtained using the probe of the present invention when at the locations AA', BB', CC DD' and EE' respectively.
- Figure 1 shows, in section, the end of a probe, generally designated 10, located within the walls of a blood vessel 20 having arteriosclerosis or plaque build-up 30.
- the probe 10 consists of a fibre optic illuminator wire 40 of approximate diameter 380 micrometers.
- the probe is being used to investigate arteriosclerosis in the region of the human heart and is inserted through a blood vessel in the groin.
- the fibre optic illuminator wire 40 is typically a metre or more in length, and only the distal end which is used to examine the diseased area is shown in Fig. 1.
- a sheath 50 which is optically transparent, particularly in the infrared region of the electromagnetic spectrum.
- a first end of the sheath 50 is bonded or otherwise attached to the inner diameter of the fibre optic illuminator wire 40, the other end of the sheath 50 being attached to a reflective ball 60.
- the ball in this embodiment is formed of stainless steel and is approximately 350 micrometers in diameter, although any suitably reflective material could be used instead of stainless steel.
- a lens 70 is located within the sheath 50 between the ball 60 and the distal end of the fibre optic illuminator wire 40. This lens is a collimating lens, such as a plano-concave or doubly concave lens, whose purpose will be described in more detail below.
- a plurality of fibre optic detector wires 80 are located within the fibre optic illuminator wire 40.
- the probe has a removable handle 90 attached to the proximal end of the probe (i.e. the end not inserted into the blood vessel).
- the handle 90 assists in inserting the probe 10 into the blood vessel.
- the handle is shown attached to the proximal end of the probe 10 and is secured in place by a collet ring 100.
- the fibre optic illuminator wire 40 is illuminated by a source of infrared radiation, as shown in Figure 3 and explained in more detail below.
- the light from the source of infrared radiation is coupled to the fibre optic illuminator wire 40 via an annular ring 1 10. the cable from the source of infrared radiation being anchored into the handle 90 by a cable gland 120 or the like.
- the fibre optic detector wires 80 abut an optical detector system shown schematically as reference numeral 130.
- the output of this detector system 130 is connected to a frequency shifter and a monitor as described below in connection with Figure 3.
- a source of infrared radiation 140 such as a variable-frequency carbon dioxide gas laser, is connected to the fibre optic illuminator wire 40.
- the probe 10 is then inserted into a suitable blood vessel and slowly pushed up that blood vessel, with the assistance of the handle 90 of Figures 2a and 2b, until the distal end of the probe 10 reaches a region of interest.
- the distal end of the fibre optic illuminator wire 40 is bent so that infrared light emitting from the wire 40 is directed towards the walls of the blood vessel.
- the light is reflected off the walls of the blood vessel 20 and back through the transparent sheath 50 before striking the ball 60.
- the ball 60 acts as a spherical mirror and causes the light reflected off it to be directed back towards the end of the fibre optic illuminating wire 40, as shown in Fig. 1.
- the light also converges upon reflection off the stainless steel ball 60.
- the collimating lens 70 is located such that the converging light reflected off the ball 60 is collimated into a parallel beam.
- This parallel beams enters the fibre optic detector wires 80 and passes along these to a frequency shifter 150, which shifts the frequency of the infrared light that has been reflected off the walls of the blood vessel into the visible region of the electromagnetic spectrum.
- the frequency shifter 150 also processes the light and sends an output to a monitor 160 which allows a medical practitioner to view, in real time, the cross section of the blood vessel.
- the source produces spread-sprectrum IR radiation or alternatively produces a time-varying frequency.
- Figure 4 shows, in detail, a blood vessel 20 having a region of plaque build-up or arteriosclerosis 30.
- the image on the monitor 160 of Figure 2 will change as the depth of plaque on the walls of the blood vessel changes.
- Schematic representations of typical images that would be seen on the monitor 160 as the probe passes through lines AA', BB', CC, DD' and EE' are shown in Figs. 5(a) to 5(e) respectively.
- the probe of the present invention is sufficiently small in diameter, while still giving good image resolution, that it can itself be used as a guide wire with a 1 millimetre diameter balloon catheter slid around it.
- the guide wire may be anything between 0.25 mm and 3 mm in diameter. Such an arrangement is shown in Fig.3. The technique for inserting the probe will now be described, referring also to Fig. 2b.
- the probe is inserted into the blood vessel up to the region of interest.
- the handle 90 is then removed from the proximal end of the probe 10 by unscrewing the collet ring 100. Because the fibre optic illuminator wire 40 and the fibre optic detector wires 80 are not mechanically coupled to the handle, as explained above, removal and reattachment of the handle is relatively straightforward.
- a balloon catheter 200 is then slid over the fibre optic illuminator wire 40 until a balloon 210 is also located within the diseased region of interest.
- the handle 90 can then be reattached to the probe by tightening the collet ring 100 once more.
- the balloon 210 is then fixed at a given distance behind the probe, the balloon catheter 200 and probe 10 can be pushed slowly in tandem further along the blood vessel, and as the probe locates regions to be treated, the balloon 210 can be expanded, using a controller 230, to crush the plaque.
- the probe tip may repeatedly be pulled back in small steps (say 1 mm each), with a full spectal sweep made at each step. Knowing the spring between the steps, the plaque may then be reconstructed in 3 -dimensions.
- a pull-back and probe-tip location device (not shown) may be provided to assist this process.
- the balloon is surrounded by a wire mesh or stent 220 to assist in the crushing of the plaque.
- any form of convex mirror could be used instead.
- the probe is not restricted to examination of blood vessels.
- Other body parts such as internal organs, are equally susceptible to investigation by a probe employing the fibre optic imaging system described in relation to blood vessel probes.
- a probe employing the fibre optic imaging system described in relation to blood vessel probes For example, a three-dimensional image of the interior walls of the stomach may be obtained by employing the probe of the present invention as a gastroscope.
- the probe of the present invention may be used to investigate the airways or the oesophagus of the human or animal patient.
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98915020A EP0987980A1 (en) | 1997-04-11 | 1998-04-09 | Anatomical probe |
AU69309/98A AU6930998A (en) | 1997-04-11 | 1998-04-09 | Anatomical probe |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9707414.0 | 1997-04-11 | ||
GBGB9707414.0A GB9707414D0 (en) | 1997-04-11 | 1997-04-11 | Anatomical probe |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998046123A1 true WO1998046123A1 (en) | 1998-10-22 |
Family
ID=10810681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1998/001045 WO1998046123A1 (en) | 1997-04-11 | 1998-04-09 | Anatomical probe |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0987980A1 (en) |
AU (1) | AU6930998A (en) |
GB (1) | GB9707414D0 (en) |
WO (1) | WO1998046123A1 (en) |
Cited By (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6377842B1 (en) | 1998-09-22 | 2002-04-23 | Aurora Optics, Inc. | Method for quantitative measurement of fluorescent and phosphorescent drugs within tissue utilizing a fiber optic probe |
EP1411828A2 (en) * | 2001-05-31 | 2004-04-28 | Infraredx, Inc. | Multi-path optical catheter |
EP1434522A1 (en) * | 2000-10-30 | 2004-07-07 | The General Hospital Corporation | Optical methods and systems for tissue analysis |
WO2003073942A3 (en) * | 2002-02-28 | 2005-01-13 | Medtronic Inc | Improved system and method of positioning implantable medical devices |
GB2452561A (en) * | 2007-09-10 | 2009-03-11 | Sentient Medical Ltd | Bougie with illuminating and imaging means |
USRE43875E1 (en) | 2004-09-29 | 2012-12-25 | The General Hospital Corporation | System and method for optical coherence imaging |
US8838213B2 (en) | 2006-10-19 | 2014-09-16 | The General Hospital Corporation | Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s) |
US8861910B2 (en) | 2008-06-20 | 2014-10-14 | The General Hospital Corporation | Fused fiber optic coupler arrangement and method for use thereof |
US8896838B2 (en) | 2010-03-05 | 2014-11-25 | The General Hospital Corporation | Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution |
US8922781B2 (en) | 2004-11-29 | 2014-12-30 | The General Hospital Corporation | Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample |
US8928889B2 (en) | 2005-09-29 | 2015-01-06 | The General Hospital Corporation | Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures |
US8937724B2 (en) | 2008-12-10 | 2015-01-20 | The General Hospital Corporation | Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling |
US8965487B2 (en) | 2004-08-24 | 2015-02-24 | The General Hospital Corporation | Process, system and software arrangement for measuring a mechanical strain and elastic properties of a sample |
US9069130B2 (en) | 2010-05-03 | 2015-06-30 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
US9087368B2 (en) | 2006-01-19 | 2015-07-21 | The General Hospital Corporation | Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof |
US9178330B2 (en) | 2009-02-04 | 2015-11-03 | The General Hospital Corporation | Apparatus and method for utilization of a high-speed optical wavelength tuning source |
US9176319B2 (en) | 2007-03-23 | 2015-11-03 | The General Hospital Corporation | Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures |
US9186067B2 (en) | 2006-02-01 | 2015-11-17 | The General Hospital Corporation | Apparatus for applying a plurality of electro-magnetic radiations to a sample |
US9226665B2 (en) | 2003-01-24 | 2016-01-05 | The General Hospital Corporation | Speckle reduction in optical coherence tomography by path length encoded angular compounding |
US9226660B2 (en) | 2004-08-06 | 2016-01-05 | The General Hospital Corporation | Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography |
US9254089B2 (en) | 2008-07-14 | 2016-02-09 | The General Hospital Corporation | Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample |
US9254102B2 (en) | 2004-08-24 | 2016-02-09 | The General Hospital Corporation | Method and apparatus for imaging of vessel segments |
US9295391B1 (en) | 2000-11-10 | 2016-03-29 | The General Hospital Corporation | Spectrally encoded miniature endoscopic imaging probe |
US9326682B2 (en) | 2005-04-28 | 2016-05-03 | The General Hospital Corporation | Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique |
US9330092B2 (en) | 2011-07-19 | 2016-05-03 | The General Hospital Corporation | Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography |
US9332942B2 (en) | 2008-01-28 | 2016-05-10 | The General Hospital Corporation | Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging |
US9341783B2 (en) | 2011-10-18 | 2016-05-17 | The General Hospital Corporation | Apparatus and methods for producing and/or providing recirculating optical delay(s) |
US9351642B2 (en) | 2009-03-12 | 2016-05-31 | The General Hospital Corporation | Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s) |
US9364143B2 (en) | 2006-05-10 | 2016-06-14 | The General Hospital Corporation | Process, arrangements and systems for providing frequency domain imaging of a sample |
US9375158B2 (en) | 2007-07-31 | 2016-06-28 | The General Hospital Corporation | Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging |
US9377290B2 (en) | 2003-10-27 | 2016-06-28 | The General Hospital Corporation | Method and apparatus for performing optical imaging using frequency-domain interferometry |
US9415550B2 (en) | 2012-08-22 | 2016-08-16 | The General Hospital Corporation | System, method, and computer-accessible medium for fabrication miniature endoscope using soft lithography |
US9441948B2 (en) | 2005-08-09 | 2016-09-13 | The General Hospital Corporation | Apparatus, methods and storage medium for performing polarization-based quadrature demodulation in optical coherence tomography |
US9510758B2 (en) | 2010-10-27 | 2016-12-06 | The General Hospital Corporation | Apparatus, systems and methods for measuring blood pressure within at least one vessel |
US9516997B2 (en) | 2006-01-19 | 2016-12-13 | The General Hospital Corporation | Spectrally-encoded endoscopy techniques, apparatus and methods |
US9557154B2 (en) | 2010-05-25 | 2017-01-31 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
USRE46412E1 (en) | 2006-02-24 | 2017-05-23 | The General Hospital Corporation | Methods and systems for performing angle-resolved Fourier-domain optical coherence tomography |
US9664615B2 (en) | 2004-07-02 | 2017-05-30 | The General Hospital Corporation | Imaging system and related techniques |
US9668652B2 (en) | 2013-07-26 | 2017-06-06 | The General Hospital Corporation | System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography |
US9733460B2 (en) | 2014-01-08 | 2017-08-15 | The General Hospital Corporation | Method and apparatus for microscopic imaging |
US9777053B2 (en) | 2006-02-08 | 2017-10-03 | The General Hospital Corporation | Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy |
US9784681B2 (en) | 2013-05-13 | 2017-10-10 | The General Hospital Corporation | System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence |
US9795301B2 (en) | 2010-05-25 | 2017-10-24 | The General Hospital Corporation | Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images |
US10117576B2 (en) | 2013-07-19 | 2018-11-06 | The General Hospital Corporation | System, method and computer accessible medium for determining eye motion by imaging retina and providing feedback for acquisition of signals from the retina |
US10228556B2 (en) | 2014-04-04 | 2019-03-12 | The General Hospital Corporation | Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s) |
US10241028B2 (en) | 2011-08-25 | 2019-03-26 | The General Hospital Corporation | Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures |
US10285568B2 (en) | 2010-06-03 | 2019-05-14 | The General Hospital Corporation | Apparatus and method for devices for imaging structures in or at one or more luminal organs |
US10426548B2 (en) | 2006-02-01 | 2019-10-01 | The General Hosppital Corporation | Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures |
USRE47675E1 (en) | 2003-06-06 | 2019-10-29 | The General Hospital Corporation | Process and apparatus for a wavelength tuning source |
US10478072B2 (en) | 2013-03-15 | 2019-11-19 | The General Hospital Corporation | Methods and system for characterizing an object |
US10534129B2 (en) | 2007-03-30 | 2020-01-14 | The General Hospital Corporation | System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque |
US10736494B2 (en) | 2014-01-31 | 2020-08-11 | The General Hospital Corporation | System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device |
US10893806B2 (en) | 2013-01-29 | 2021-01-19 | The General Hospital Corporation | Apparatus, systems and methods for providing information regarding the aortic valve |
US10912462B2 (en) | 2014-07-25 | 2021-02-09 | The General Hospital Corporation | Apparatus, devices and methods for in vivo imaging and diagnosis |
US11123047B2 (en) | 2008-01-28 | 2021-09-21 | The General Hospital Corporation | Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood |
US11179028B2 (en) | 2013-02-01 | 2021-11-23 | The General Hospital Corporation | Objective lens arrangement for confocal endomicroscopy |
US11452433B2 (en) | 2013-07-19 | 2022-09-27 | The General Hospital Corporation | Imaging apparatus and method which utilizes multidirectional field of view endoscopy |
US11490797B2 (en) | 2012-05-21 | 2022-11-08 | The General Hospital Corporation | Apparatus, device and method for capsule microscopy |
US11490826B2 (en) | 2009-07-14 | 2022-11-08 | The General Hospital Corporation | Apparatus, systems and methods for measuring flow and pressure within a vessel |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0467459A2 (en) * | 1990-07-16 | 1992-01-22 | Eastman Kodak Company | Near infrared diagnostic method and instrument |
DE9217571U1 (en) * | 1992-12-18 | 1994-01-27 | Biotronik Mess & Therapieg | PTCA catheter |
US5411016A (en) * | 1994-02-22 | 1995-05-02 | Scimed Life Systems, Inc. | Intravascular balloon catheter for use in combination with an angioscope |
EP0650694A1 (en) * | 1993-11-01 | 1995-05-03 | Polartechnics Ltd | Method and apparatus for diseased tissue type recognition |
WO1995025460A1 (en) * | 1994-03-21 | 1995-09-28 | Societe D'etudes Et De Recherches Biologiques | Endoscopic or fiberoptic imaging device using infrared fluorescence |
-
1997
- 1997-04-11 GB GBGB9707414.0A patent/GB9707414D0/en active Pending
-
1998
- 1998-04-09 EP EP98915020A patent/EP0987980A1/en not_active Withdrawn
- 1998-04-09 WO PCT/GB1998/001045 patent/WO1998046123A1/en not_active Application Discontinuation
- 1998-04-09 AU AU69309/98A patent/AU6930998A/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0467459A2 (en) * | 1990-07-16 | 1992-01-22 | Eastman Kodak Company | Near infrared diagnostic method and instrument |
DE9217571U1 (en) * | 1992-12-18 | 1994-01-27 | Biotronik Mess & Therapieg | PTCA catheter |
EP0650694A1 (en) * | 1993-11-01 | 1995-05-03 | Polartechnics Ltd | Method and apparatus for diseased tissue type recognition |
US5411016A (en) * | 1994-02-22 | 1995-05-02 | Scimed Life Systems, Inc. | Intravascular balloon catheter for use in combination with an angioscope |
WO1995025460A1 (en) * | 1994-03-21 | 1995-09-28 | Societe D'etudes Et De Recherches Biologiques | Endoscopic or fiberoptic imaging device using infrared fluorescence |
Cited By (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6377842B1 (en) | 1998-09-22 | 2002-04-23 | Aurora Optics, Inc. | Method for quantitative measurement of fluorescent and phosphorescent drugs within tissue utilizing a fiber optic probe |
EP1434522A1 (en) * | 2000-10-30 | 2004-07-07 | The General Hospital Corporation | Optical methods and systems for tissue analysis |
EP1434522A4 (en) * | 2000-10-30 | 2007-01-03 | Gen Hospital Corp | Optical methods and systems for tissue analysis |
US9282931B2 (en) | 2000-10-30 | 2016-03-15 | The General Hospital Corporation | Methods for tissue analysis |
US9295391B1 (en) | 2000-11-10 | 2016-03-29 | The General Hospital Corporation | Spectrally encoded miniature endoscopic imaging probe |
EP1411828A2 (en) * | 2001-05-31 | 2004-04-28 | Infraredx, Inc. | Multi-path optical catheter |
EP1411828A4 (en) * | 2001-05-31 | 2008-09-10 | Infraredx Inc | Multi-path optical catheter |
WO2003073942A3 (en) * | 2002-02-28 | 2005-01-13 | Medtronic Inc | Improved system and method of positioning implantable medical devices |
US9226665B2 (en) | 2003-01-24 | 2016-01-05 | The General Hospital Corporation | Speckle reduction in optical coherence tomography by path length encoded angular compounding |
USRE47675E1 (en) | 2003-06-06 | 2019-10-29 | The General Hospital Corporation | Process and apparatus for a wavelength tuning source |
US9812846B2 (en) | 2003-10-27 | 2017-11-07 | The General Hospital Corporation | Method and apparatus for performing optical imaging using frequency-domain interferometry |
US9377290B2 (en) | 2003-10-27 | 2016-06-28 | The General Hospital Corporation | Method and apparatus for performing optical imaging using frequency-domain interferometry |
US9664615B2 (en) | 2004-07-02 | 2017-05-30 | The General Hospital Corporation | Imaging system and related techniques |
US9226660B2 (en) | 2004-08-06 | 2016-01-05 | The General Hospital Corporation | Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography |
US9763623B2 (en) | 2004-08-24 | 2017-09-19 | The General Hospital Corporation | Method and apparatus for imaging of vessel segments |
US9254102B2 (en) | 2004-08-24 | 2016-02-09 | The General Hospital Corporation | Method and apparatus for imaging of vessel segments |
US8965487B2 (en) | 2004-08-24 | 2015-02-24 | The General Hospital Corporation | Process, system and software arrangement for measuring a mechanical strain and elastic properties of a sample |
USRE45512E1 (en) | 2004-09-29 | 2015-05-12 | The General Hospital Corporation | System and method for optical coherence imaging |
USRE43875E1 (en) | 2004-09-29 | 2012-12-25 | The General Hospital Corporation | System and method for optical coherence imaging |
US8922781B2 (en) | 2004-11-29 | 2014-12-30 | The General Hospital Corporation | Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample |
US9326682B2 (en) | 2005-04-28 | 2016-05-03 | The General Hospital Corporation | Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique |
US9441948B2 (en) | 2005-08-09 | 2016-09-13 | The General Hospital Corporation | Apparatus, methods and storage medium for performing polarization-based quadrature demodulation in optical coherence tomography |
US9304121B2 (en) | 2005-09-29 | 2016-04-05 | The General Hospital Corporation | Method and apparatus for optical imaging via spectral encoding |
US9513276B2 (en) | 2005-09-29 | 2016-12-06 | The General Hospital Corporation | Method and apparatus for optical imaging via spectral encoding |
US8928889B2 (en) | 2005-09-29 | 2015-01-06 | The General Hospital Corporation | Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures |
US9516997B2 (en) | 2006-01-19 | 2016-12-13 | The General Hospital Corporation | Spectrally-encoded endoscopy techniques, apparatus and methods |
US9087368B2 (en) | 2006-01-19 | 2015-07-21 | The General Hospital Corporation | Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof |
US10987000B2 (en) | 2006-01-19 | 2021-04-27 | The General Hospital Corporation | Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof |
US9791317B2 (en) | 2006-01-19 | 2017-10-17 | The General Hospital Corporation | Spectrally-encoded endoscopy techniques and methods |
US9646377B2 (en) | 2006-01-19 | 2017-05-09 | The General Hospital Corporation | Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof |
US9186067B2 (en) | 2006-02-01 | 2015-11-17 | The General Hospital Corporation | Apparatus for applying a plurality of electro-magnetic radiations to a sample |
US10426548B2 (en) | 2006-02-01 | 2019-10-01 | The General Hosppital Corporation | Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures |
US9186066B2 (en) | 2006-02-01 | 2015-11-17 | The General Hospital Corporation | Apparatus for applying a plurality of electro-magnetic radiations to a sample |
US9777053B2 (en) | 2006-02-08 | 2017-10-03 | The General Hospital Corporation | Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy |
USRE46412E1 (en) | 2006-02-24 | 2017-05-23 | The General Hospital Corporation | Methods and systems for performing angle-resolved Fourier-domain optical coherence tomography |
US9364143B2 (en) | 2006-05-10 | 2016-06-14 | The General Hospital Corporation | Process, arrangements and systems for providing frequency domain imaging of a sample |
US10413175B2 (en) | 2006-05-10 | 2019-09-17 | The General Hospital Corporation | Process, arrangements and systems for providing frequency domain imaging of a sample |
US8838213B2 (en) | 2006-10-19 | 2014-09-16 | The General Hospital Corporation | Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s) |
US9176319B2 (en) | 2007-03-23 | 2015-11-03 | The General Hospital Corporation | Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures |
US10534129B2 (en) | 2007-03-30 | 2020-01-14 | The General Hospital Corporation | System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque |
US9375158B2 (en) | 2007-07-31 | 2016-06-28 | The General Hospital Corporation | Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging |
GB2452561A (en) * | 2007-09-10 | 2009-03-11 | Sentient Medical Ltd | Bougie with illuminating and imaging means |
US9332942B2 (en) | 2008-01-28 | 2016-05-10 | The General Hospital Corporation | Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging |
US11123047B2 (en) | 2008-01-28 | 2021-09-21 | The General Hospital Corporation | Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood |
US8861910B2 (en) | 2008-06-20 | 2014-10-14 | The General Hospital Corporation | Fused fiber optic coupler arrangement and method for use thereof |
US10835110B2 (en) | 2008-07-14 | 2020-11-17 | The General Hospital Corporation | Apparatus and method for facilitating at least partial overlap of dispersed ration on at least one sample |
US9254089B2 (en) | 2008-07-14 | 2016-02-09 | The General Hospital Corporation | Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample |
US8937724B2 (en) | 2008-12-10 | 2015-01-20 | The General Hospital Corporation | Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling |
US9178330B2 (en) | 2009-02-04 | 2015-11-03 | The General Hospital Corporation | Apparatus and method for utilization of a high-speed optical wavelength tuning source |
US9351642B2 (en) | 2009-03-12 | 2016-05-31 | The General Hospital Corporation | Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s) |
US11490826B2 (en) | 2009-07-14 | 2022-11-08 | The General Hospital Corporation | Apparatus, systems and methods for measuring flow and pressure within a vessel |
US10463254B2 (en) | 2010-03-05 | 2019-11-05 | The General Hospital Corporation | Light tunnel and lens which provide extended focal depth of at least one anatomical structure at a particular resolution |
US9642531B2 (en) | 2010-03-05 | 2017-05-09 | The General Hospital Corporation | Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution |
US9081148B2 (en) | 2010-03-05 | 2015-07-14 | The General Hospital Corporation | Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution |
US9408539B2 (en) | 2010-03-05 | 2016-08-09 | The General Hospital Corporation | Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution |
US8896838B2 (en) | 2010-03-05 | 2014-11-25 | The General Hospital Corporation | Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution |
US9069130B2 (en) | 2010-05-03 | 2015-06-30 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
US9951269B2 (en) | 2010-05-03 | 2018-04-24 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
US10939825B2 (en) | 2010-05-25 | 2021-03-09 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
US9795301B2 (en) | 2010-05-25 | 2017-10-24 | The General Hospital Corporation | Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images |
US9557154B2 (en) | 2010-05-25 | 2017-01-31 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
US10285568B2 (en) | 2010-06-03 | 2019-05-14 | The General Hospital Corporation | Apparatus and method for devices for imaging structures in or at one or more luminal organs |
US9510758B2 (en) | 2010-10-27 | 2016-12-06 | The General Hospital Corporation | Apparatus, systems and methods for measuring blood pressure within at least one vessel |
US9330092B2 (en) | 2011-07-19 | 2016-05-03 | The General Hospital Corporation | Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography |
US10241028B2 (en) | 2011-08-25 | 2019-03-26 | The General Hospital Corporation | Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures |
US9341783B2 (en) | 2011-10-18 | 2016-05-17 | The General Hospital Corporation | Apparatus and methods for producing and/or providing recirculating optical delay(s) |
US11490797B2 (en) | 2012-05-21 | 2022-11-08 | The General Hospital Corporation | Apparatus, device and method for capsule microscopy |
US9415550B2 (en) | 2012-08-22 | 2016-08-16 | The General Hospital Corporation | System, method, and computer-accessible medium for fabrication miniature endoscope using soft lithography |
US10893806B2 (en) | 2013-01-29 | 2021-01-19 | The General Hospital Corporation | Apparatus, systems and methods for providing information regarding the aortic valve |
US11179028B2 (en) | 2013-02-01 | 2021-11-23 | The General Hospital Corporation | Objective lens arrangement for confocal endomicroscopy |
US10478072B2 (en) | 2013-03-15 | 2019-11-19 | The General Hospital Corporation | Methods and system for characterizing an object |
US9784681B2 (en) | 2013-05-13 | 2017-10-10 | The General Hospital Corporation | System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence |
US11452433B2 (en) | 2013-07-19 | 2022-09-27 | The General Hospital Corporation | Imaging apparatus and method which utilizes multidirectional field of view endoscopy |
US10117576B2 (en) | 2013-07-19 | 2018-11-06 | The General Hospital Corporation | System, method and computer accessible medium for determining eye motion by imaging retina and providing feedback for acquisition of signals from the retina |
US9668652B2 (en) | 2013-07-26 | 2017-06-06 | The General Hospital Corporation | System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography |
US10058250B2 (en) | 2013-07-26 | 2018-08-28 | The General Hospital Corporation | System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography |
US9733460B2 (en) | 2014-01-08 | 2017-08-15 | The General Hospital Corporation | Method and apparatus for microscopic imaging |
US10736494B2 (en) | 2014-01-31 | 2020-08-11 | The General Hospital Corporation | System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device |
US10228556B2 (en) | 2014-04-04 | 2019-03-12 | The General Hospital Corporation | Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s) |
US10912462B2 (en) | 2014-07-25 | 2021-02-09 | The General Hospital Corporation | Apparatus, devices and methods for in vivo imaging and diagnosis |
Also Published As
Publication number | Publication date |
---|---|
GB9707414D0 (en) | 1997-05-28 |
AU6930998A (en) | 1998-11-11 |
EP0987980A1 (en) | 2000-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0987980A1 (en) | Anatomical probe | |
US6063093A (en) | Systems and methods for guiding a medical instrument through a body | |
US5131397A (en) | Imaging system for producing ultrasonic images and insonifier for such systems | |
US9295447B2 (en) | Systems and methods for identifying vascular borders | |
JP6865691B2 (en) | Dual lumen diagnostic catheter | |
JP6404829B2 (en) | Implant delivery system and implant | |
US6589164B1 (en) | Sterility barriers for insertion of non-sterile apparatus into catheters or other medical devices | |
US20140180069A1 (en) | Intraluminal imaging system | |
US7068867B2 (en) | Ultrasonic position indicator | |
US20100113919A1 (en) | Catheter arangement for insertion into a blood vessel for minimally invasive intervention | |
US20140200438A1 (en) | Intraluminal imaging system | |
US20070093703A1 (en) | System and method for non-endoscopic optical biopsy detection of diseased tissue | |
JPH03501453A (en) | Acoustic imaging system and method | |
US11344203B2 (en) | Opto acoustic device system and method | |
US20150099942A1 (en) | Vascular securement catheter with imaging | |
EP2997878A1 (en) | Endoscopic system | |
Crowley et al. | Optimized ultrasound imaging catheters for use in the vascular system | |
JP6794226B2 (en) | Diagnostic imaging device, operating method and program of diagnostic imaging device | |
US20140180119A1 (en) | Intraluminal imaging system | |
CN107713997B (en) | Flowing blood imaging device | |
US20140180168A1 (en) | Guidewire with touch sensor | |
SIEGEL et al. | Comparative studies of angioscopy and ultrasound for the evaluation of arterial disease | |
Gregory et al. | Intraluminal laser atherectomy with ultrasound and electromagnetic guidance | |
Tabbara et al. | Potential of intraluminal ultrasound for angioplasty guidance | |
JPH07155316A (en) | Tube cavity diagnosing system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 1998915020 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
NENP | Non-entry into the national phase |
Ref country code: JP Ref document number: 1998543602 Format of ref document f/p: F |
|
WWP | Wipo information: published in national office |
Ref document number: 1998915020 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: CA |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1998915020 Country of ref document: EP |