WO1998045442A3 - Secreted f-spondin homologs - Google Patents

Secreted f-spondin homologs Download PDF

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Publication number
WO1998045442A3
WO1998045442A3 PCT/US1998/007117 US9807117W WO9845442A3 WO 1998045442 A3 WO1998045442 A3 WO 1998045442A3 US 9807117 W US9807117 W US 9807117W WO 9845442 A3 WO9845442 A3 WO 9845442A3
Authority
WO
WIPO (PCT)
Prior art keywords
secreted
zsig25
spondin
homologs
polypeptides
Prior art date
Application number
PCT/US1998/007117
Other languages
French (fr)
Other versions
WO1998045442A2 (en
Inventor
Paul O Sheppard
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU69613/98A priority Critical patent/AU6961398A/en
Publication of WO1998045442A2 publication Critical patent/WO1998045442A2/en
Publication of WO1998045442A3 publication Critical patent/WO1998045442A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to a secreted zsig25 polypeptide expressed at very high level in prostate tissue and polynucleotides encoding the same. The zsig25 polypeptides are believed to be adhesion-modulating and may be used for diagnosis of prostate adenocarcinoma or for sorting cancerous from non-cancerous cells. The present invention also includes antibodies to the zsig25 polypeptides.
PCT/US1998/007117 1997-04-10 1998-04-10 Secreted f-spondin homologs WO1998045442A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU69613/98A AU6961398A (en) 1997-04-10 1998-04-10 Secreted f-spondin homologs

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4342197P 1997-04-10 1997-04-10
US60/043,421 1997-04-10
US4928897P 1997-06-11 1997-06-11
US60/049,288 1997-06-11

Publications (2)

Publication Number Publication Date
WO1998045442A2 WO1998045442A2 (en) 1998-10-15
WO1998045442A3 true WO1998045442A3 (en) 1999-01-14

Family

ID=26720414

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/007117 WO1998045442A2 (en) 1997-04-10 1998-04-10 Secreted f-spondin homologs

Country Status (2)

Country Link
AU (1) AU6961398A (en)
WO (1) WO1998045442A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1251139A3 (en) * 1998-04-08 2002-12-18 Genentech, Inc. Human mindin-like protein and nucleic acids encoding it
CA2347085A1 (en) * 1998-10-19 2000-04-27 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating prostate cancer
US6960433B1 (en) 1998-10-19 2005-11-01 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating prostate cancer
EP1466977A1 (en) * 1999-03-08 2004-10-13 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
US6682902B2 (en) 1999-12-16 2004-01-27 Schering Aktiengesellschaft DNA encoding a novel RG1 polypeptide
DE10050274A1 (en) * 2000-10-09 2002-04-18 Henkel Kgaa In vitro assays for skin stress and skin ageing includes determination of spondin 2, cathepsin L, actin gamma 1 and vimentin fragments secreted by skin fibroblasts
CA2532394C (en) 2003-07-22 2013-09-17 Schering Aktiengesellschaft Rg1 antibodies and uses thereof
US7294704B2 (en) * 2003-08-15 2007-11-13 Diadexus, Inc. Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020196A1 (en) * 1992-04-02 1993-10-14 The Trustees Of Columbia University In The City Of New York Cloning, expression and uses of a novel secreted protein, f-spondin
WO1997029189A1 (en) * 1996-02-12 1997-08-14 Human Genome Sciences, Inc. Human neuronal attachment factor-1

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020196A1 (en) * 1992-04-02 1993-10-14 The Trustees Of Columbia University In The City Of New York Cloning, expression and uses of a novel secreted protein, f-spondin
WO1997029189A1 (en) * 1996-02-12 1997-08-14 Human Genome Sciences, Inc. Human neuronal attachment factor-1

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GOBRON S ET AL: "SCO- spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation.", JOURNAL OF CELL SCIENCE, vol. 109, no. 5, May 1996 (1996-05-01), pages 1053 - 1061, XP002059006 *

Also Published As

Publication number Publication date
AU6961398A (en) 1998-10-30
WO1998045442A2 (en) 1998-10-15

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