WO1998031350A1 - New formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml, comprising budesonide - Google Patents
New formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml, comprising budesonide Download PDFInfo
- Publication number
- WO1998031350A1 WO1998031350A1 PCT/SE1998/000038 SE9800038W WO9831350A1 WO 1998031350 A1 WO1998031350 A1 WO 1998031350A1 SE 9800038 W SE9800038 W SE 9800038W WO 9831350 A1 WO9831350 A1 WO 9831350A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bulk density
- composition according
- budesonide
- carrier substance
- formulation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Abstract
Description
Claims
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002277914A CA2277914C (en) | 1997-01-20 | 1998-01-13 | New formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml, comprising budesonide |
SK957-99A SK283948B6 (en) | 1997-01-20 | 1998-01-13 | New formulation for inhalation, process for preparing the formulation and the use thereof for medicament preparation |
AU57857/98A AU726916B2 (en) | 1997-01-20 | 1998-01-13 | New formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml, comprising budesonide |
HU0000841A HU228312B1 (en) | 1997-01-20 | 1998-01-13 | New formulation for inhalation having a poured bulk density of from 0,28 to 0,38 g/ml, comprising budesonide |
NZ336592A NZ336592A (en) | 1997-01-20 | 1998-01-13 | Formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml comprising finely divided budesonide and a carrier |
IL13084098A IL130840A (en) | 1997-01-20 | 1998-01-13 | Formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml comprising budesonide |
UA99074042A UA57762C2 (en) | 1997-01-20 | 1998-01-13 | Novel composition for inhalation comprising budesonide with bulk density from 0.28 to 0.38 g/ml |
EP98901616A EP1019033B1 (en) | 1997-01-20 | 1998-01-13 | New formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml, comprising budesonide |
EEP199900320A EE03998B1 (en) | 1997-01-20 | 1998-01-13 | Inhalation form containing budesonide in bulk density of 0.28 to 0.38 g / ml |
BR9806892-0A BR9806892A (en) | 1997-01-20 | 1998-01-13 | New formulation for inhalation; showing volumetric density, when poured, from 0.20 to 038 g / ml, comprising budesonide |
SI9830910T SI1019033T1 (en) | 1997-01-20 | 1998-01-13 | New formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml, comprising budesonide |
JP1998534216A JP4512202B6 (en) | 1997-01-20 | 1998-01-13 | Novel formulation for inhalation with bulk density of 0.28 to 0.38 g / ML containing budesonide |
DE69839275T DE69839275T2 (en) | 1997-01-20 | 1998-01-13 | NEW FORMULATION FOR INHALATION WITH A BULK DENSITY BETWEEN 0.28 AND 0.38 G / ML, CONTAINING BUDENSONIDES |
DK98901616T DK1019033T3 (en) | 1997-01-20 | 1998-01-13 | New formulation for inhalation having a poured bulk density of 0.28 to 0.38 g / ml which includes budesonide |
PL334493A PL191569B1 (en) | 1997-01-20 | 1998-01-13 | Novel inhalable preparation of 0.28 to 0.38 g/ml bulk density containing budesonide |
KR10-1999-7006412A KR100528418B1 (en) | 1997-01-20 | 1998-01-13 | New Formulation for Inhalation Having a Poured Bulk Density of from 0.28 to 0.38 g/㎖, Comprising Budesonide |
IS5110A IS2563B (en) | 1997-01-20 | 1999-07-06 | New inhalation mixture with a liquid concentration of 0.28 to 0.38 g / ml containing budesonide |
NO19993537A NO327451B1 (en) | 1997-01-20 | 1999-07-19 | Dry powder composition comprising budesonide as well as process for its preparation |
HK00104815A HK1025516A1 (en) | 1997-01-20 | 2000-08-01 | New formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml, comprising budesonide |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9700133A SE9700133D0 (en) | 1997-01-20 | 1997-01-20 | New formulation |
SE9700133-3 | 1997-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998031350A1 true WO1998031350A1 (en) | 1998-07-23 |
Family
ID=20405452
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1998/000038 WO1998031350A1 (en) | 1997-01-20 | 1998-01-13 | New formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml, comprising budesonide |
Country Status (35)
Country | Link |
---|---|
US (1) | US6027714A (en) |
EP (1) | EP1019033B1 (en) |
JP (1) | JP2010059179A (en) |
KR (1) | KR100528418B1 (en) |
CN (1) | CN1222282C (en) |
AT (1) | ATE389390T1 (en) |
AU (1) | AU726916B2 (en) |
BE (1) | BE1011400A5 (en) |
BR (1) | BR9806892A (en) |
CA (1) | CA2277914C (en) |
CZ (1) | CZ295083B6 (en) |
DE (1) | DE69839275T2 (en) |
DK (1) | DK1019033T3 (en) |
EE (1) | EE03998B1 (en) |
ES (2) | ES2302348T3 (en) |
FR (1) | FR2759908B1 (en) |
GR (1) | GR1003290B (en) |
HK (1) | HK1025516A1 (en) |
HU (1) | HU228312B1 (en) |
ID (1) | ID22883A (en) |
IE (1) | IE980024A1 (en) |
IL (1) | IL130840A (en) |
IS (1) | IS2563B (en) |
NL (1) | NL1008019C2 (en) |
NO (1) | NO327451B1 (en) |
NZ (1) | NZ336592A (en) |
PL (1) | PL191569B1 (en) |
PT (1) | PT1019033E (en) |
RU (1) | RU2180563C2 (en) |
SE (1) | SE9700133D0 (en) |
SI (1) | SI1019033T1 (en) |
SK (1) | SK283948B6 (en) |
TR (1) | TR199901691T2 (en) |
UA (1) | UA57762C2 (en) |
WO (1) | WO1998031350A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2809692A1 (en) | 2000-05-31 | 2001-12-07 | Ecia Equip Composants Ind Auto | Cover assembly for vehicle air bag, has rigid structural element with line of reduced resistance to outline flap, and form rupture line and hinge, formed by flexible layer stuck on to structural layer |
JP2002529402A (en) * | 1998-11-05 | 2002-09-10 | アストラゼネカ・アクチエボラーグ | Dry powder pharmaceutical formulation |
JP2003534272A (en) * | 2000-05-19 | 2003-11-18 | アストラゼネカ・アクチエボラーグ | New method |
DE102007049931A1 (en) | 2007-10-18 | 2009-04-23 | Pharmatech Gmbh | Apparatus and method for the continuous production of spherical powder agglomerates |
WO2011110852A1 (en) | 2010-03-10 | 2011-09-15 | Astrazeneca Ab | Polymorphic forms of 6- [2- (4 -cyanophenyl) - 2h - pyrazol - 3 - yl] - 5 -methyl - 3 - oxo - 4 - (trifluoromethyl - phenyl) 3,4-dihydropyrazine-2-carboxylic acid ethylamide |
EP2821061A1 (en) | 2013-07-01 | 2015-01-07 | Arven Ilac Sanayi Ve Ticaret A.S. | Novel inhalation formulations |
US9730890B2 (en) | 2003-07-10 | 2017-08-15 | Mylan Pharmaceuticals, Inc. | Bronchodilating beta-agonist compositions and methods |
WO2021058454A1 (en) | 2019-09-24 | 2021-04-01 | Chiesi Farmaceutici S.P.A. | Novel carrier particles for dry powder formulations for inhalation |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1129705A1 (en) | 2000-02-17 | 2001-09-05 | Rijksuniversiteit te Groningen | Powder formulation for inhalation |
GB0008660D0 (en) * | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
US20020141946A1 (en) * | 2000-12-29 | 2002-10-03 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
US6681768B2 (en) | 2001-06-22 | 2004-01-27 | Sofotec Gmbh & Co. Kg | Powder formulation disintegrating system and method for dry powder inhalers |
US7931022B2 (en) * | 2001-10-19 | 2011-04-26 | Respirks, Inc. | Method and apparatus for dispensing inhalator medicament |
SE0200657D0 (en) * | 2002-03-04 | 2002-03-04 | Astrazeneca Ab | Novel Formulation |
GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
US20070020298A1 (en) * | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid |
CN100333727C (en) * | 2004-11-25 | 2007-08-29 | 天津药业研究院有限公司 | Budesonide target-direction microball and preparation thereof |
ES2493641T3 (en) * | 2007-06-28 | 2014-09-12 | Cydex Pharmaceuticals, Inc. | Nasal administration of aqueous corticosteroid solutions |
EP3668505A4 (en) | 2017-08-15 | 2021-05-12 | Nephron Pharmaceuticals Corporation | Aqueous nebulization composition |
Citations (2)
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US4590206A (en) * | 1981-07-24 | 1986-05-20 | Fisons Plc | Inhalation pharmaceuticals |
US5551489A (en) * | 1993-10-01 | 1996-09-03 | Astra Aktiebolag | Agglomeration of finely divided powders |
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GB1429184A (en) * | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
GB1571629A (en) * | 1977-11-30 | 1980-07-16 | Fisons Ltd | Pharmaceutical compositions containing beclomethasone dipropionate |
SE438261B (en) * | 1981-07-08 | 1985-04-15 | Draco Ab | USE IN A DOSHALATOR OF A PERFORED MEMBRANE |
DE3274065D1 (en) * | 1981-07-08 | 1986-12-11 | Draco Ab | POWDER INHALATOR |
AU643435B2 (en) * | 1989-04-28 | 1993-11-18 | Riker Laboratories, Inc. | Dry powder inhalation device |
US5176132A (en) * | 1989-05-31 | 1993-01-05 | Fisons Plc | Medicament inhalation device and formulation |
US5192548A (en) * | 1990-04-30 | 1993-03-09 | Riker Laboratoires, Inc. | Device |
SE9100342D0 (en) * | 1991-02-04 | 1991-02-04 | Astra Ab | NOVEL STEROID ESTERS |
SE9100341D0 (en) * | 1991-02-04 | 1991-02-04 | Astra Ab | NOVEL STEROIDS |
SE9101090D0 (en) * | 1991-04-11 | 1991-04-11 | Astra Ab | PROCESS FOR CONDITIONING OF WATER-SOLUBLE SUBSTANCES |
SE9302777D0 (en) * | 1993-08-27 | 1993-08-27 | Astra Ab | Process for conditioning substances |
DE69231992T2 (en) * | 1991-06-10 | 2001-12-13 | Schering Corp | Chlorofluorocarbon free aerosol formulations |
US5736124A (en) * | 1991-12-12 | 1998-04-07 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicament |
AU673660C (en) * | 1991-12-18 | 2002-07-25 | Astrazeneca Ab | New combination of formoterol and budesonide |
US5355872B1 (en) * | 1992-03-04 | 1998-10-20 | John H Riggs | Low flow rate nebulizer apparatus and method of nebulization |
GB2269992A (en) * | 1992-08-14 | 1994-03-02 | Rh Ne Poulenc Rorer Limited | Powder inhalation formulations |
ES2180548T3 (en) * | 1992-10-16 | 2003-02-16 | Nippon Shinyaku Co Ltd | METHOD OF OBTAINING WAX MATRICES. |
IS1736B (en) * | 1993-10-01 | 1999-12-30 | Astra Ab | Methods and devices that promote increased particle aggregation |
DE4425255A1 (en) * | 1994-07-16 | 1996-01-18 | Asta Medica Ag | Formulation for inhalation application |
NZ292980A (en) * | 1994-09-29 | 1999-02-25 | Andaris Ltd | Smooth, spherical water-soluble microparticles as therapeutic or diagnostic vehicles |
US5647347A (en) * | 1994-10-21 | 1997-07-15 | Glaxo Wellcome Inc. | Medicament carrier for dry powder inhalator |
US5503869A (en) * | 1994-10-21 | 1996-04-02 | Glaxo Wellcome Inc. | Process for forming medicament carrier for dry powder inhalator |
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SE9603669D0 (en) * | 1996-10-08 | 1996-10-08 | Astra Ab | New combination |
-
1997
- 1997-01-20 SE SE9700133A patent/SE9700133D0/en unknown
-
1998
- 1998-01-09 US US09/004,894 patent/US6027714A/en not_active Expired - Lifetime
- 1998-01-13 PL PL334493A patent/PL191569B1/en unknown
- 1998-01-13 TR TR1999/01691T patent/TR199901691T2/en unknown
- 1998-01-13 RU RU99118589/14A patent/RU2180563C2/en active
- 1998-01-13 PT PT98901616T patent/PT1019033E/en unknown
- 1998-01-13 UA UA99074042A patent/UA57762C2/en unknown
- 1998-01-13 DK DK98901616T patent/DK1019033T3/en active
- 1998-01-13 WO PCT/SE1998/000038 patent/WO1998031350A1/en active IP Right Grant
- 1998-01-13 CN CNB988018985A patent/CN1222282C/en not_active Expired - Lifetime
- 1998-01-13 CA CA002277914A patent/CA2277914C/en not_active Expired - Lifetime
- 1998-01-13 EP EP98901616A patent/EP1019033B1/en not_active Expired - Lifetime
- 1998-01-13 AT AT98901616T patent/ATE389390T1/en active
- 1998-01-13 ES ES98901616T patent/ES2302348T3/en not_active Expired - Lifetime
- 1998-01-13 SI SI9830910T patent/SI1019033T1/en unknown
- 1998-01-13 ID IDW990664A patent/ID22883A/en unknown
- 1998-01-13 BR BR9806892-0A patent/BR9806892A/en not_active Application Discontinuation
- 1998-01-13 SK SK957-99A patent/SK283948B6/en not_active IP Right Cessation
- 1998-01-13 DE DE69839275T patent/DE69839275T2/en not_active Expired - Lifetime
- 1998-01-13 KR KR10-1999-7006412A patent/KR100528418B1/en active IP Right Grant
- 1998-01-13 EE EEP199900320A patent/EE03998B1/en unknown
- 1998-01-13 AU AU57857/98A patent/AU726916B2/en not_active Expired
- 1998-01-13 HU HU0000841A patent/HU228312B1/en unknown
- 1998-01-13 NZ NZ336592A patent/NZ336592A/en not_active IP Right Cessation
- 1998-01-13 CZ CZ19992555A patent/CZ295083B6/en not_active IP Right Cessation
- 1998-01-13 IL IL13084098A patent/IL130840A/en not_active IP Right Cessation
- 1998-01-13 NL NL1008019A patent/NL1008019C2/en not_active IP Right Cessation
- 1998-01-14 GR GR980100021A patent/GR1003290B/en unknown
- 1998-01-15 BE BE9800029A patent/BE1011400A5/en not_active IP Right Cessation
- 1998-01-16 FR FR9800458A patent/FR2759908B1/en not_active Expired - Lifetime
- 1998-01-16 ES ES009800078A patent/ES2148059B1/en not_active Expired - Fee Related
- 1998-01-16 IE IE980024A patent/IE980024A1/en not_active Application Discontinuation
-
1999
- 1999-07-06 IS IS5110A patent/IS2563B/en unknown
- 1999-07-19 NO NO19993537A patent/NO327451B1/en not_active IP Right Cessation
-
2000
- 2000-08-01 HK HK00104815A patent/HK1025516A1/en not_active IP Right Cessation
-
2009
- 2009-11-06 JP JP2009255051A patent/JP2010059179A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4590206A (en) * | 1981-07-24 | 1986-05-20 | Fisons Plc | Inhalation pharmaceuticals |
US5551489A (en) * | 1993-10-01 | 1996-09-03 | Astra Aktiebolag | Agglomeration of finely divided powders |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002529402A (en) * | 1998-11-05 | 2002-09-10 | アストラゼネカ・アクチエボラーグ | Dry powder pharmaceutical formulation |
JP4843140B2 (en) * | 1998-11-05 | 2011-12-21 | アストラゼネカ・アクチエボラーグ | Dry powder pharmaceutical formulation |
JP2003534272A (en) * | 2000-05-19 | 2003-11-18 | アストラゼネカ・アクチエボラーグ | New method |
JP2013040214A (en) * | 2000-05-19 | 2013-02-28 | Astrazeneca Ab | Novel process |
FR2809692A1 (en) | 2000-05-31 | 2001-12-07 | Ecia Equip Composants Ind Auto | Cover assembly for vehicle air bag, has rigid structural element with line of reduced resistance to outline flap, and form rupture line and hinge, formed by flexible layer stuck on to structural layer |
US9730890B2 (en) | 2003-07-10 | 2017-08-15 | Mylan Pharmaceuticals, Inc. | Bronchodilating beta-agonist compositions and methods |
DE102007049931A1 (en) | 2007-10-18 | 2009-04-23 | Pharmatech Gmbh | Apparatus and method for the continuous production of spherical powder agglomerates |
WO2011110852A1 (en) | 2010-03-10 | 2011-09-15 | Astrazeneca Ab | Polymorphic forms of 6- [2- (4 -cyanophenyl) - 2h - pyrazol - 3 - yl] - 5 -methyl - 3 - oxo - 4 - (trifluoromethyl - phenyl) 3,4-dihydropyrazine-2-carboxylic acid ethylamide |
EP2821061A1 (en) | 2013-07-01 | 2015-01-07 | Arven Ilac Sanayi Ve Ticaret A.S. | Novel inhalation formulations |
WO2021058454A1 (en) | 2019-09-24 | 2021-04-01 | Chiesi Farmaceutici S.P.A. | Novel carrier particles for dry powder formulations for inhalation |
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