WO1998024928A3 - Detection d'anomalies chromosomiques - Google Patents

Detection d'anomalies chromosomiques Download PDF

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Publication number
WO1998024928A3
WO1998024928A3 PCT/DK1997/000556 DK9700556W WO9824928A3 WO 1998024928 A3 WO1998024928 A3 WO 1998024928A3 DK 9700556 W DK9700556 W DK 9700556W WO 9824928 A3 WO9824928 A3 WO 9824928A3
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WO
WIPO (PCT)
Prior art keywords
nucleic acid
mutually distinct
primers
distinct primers
characteristic
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PCT/DK1997/000556
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English (en)
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WO1998024928A2 (fr
Inventor
Niels Pallisgaard
Peter Hokland
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Niels Pallisgaard
Peter Hokland
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Application filed by Niels Pallisgaard, Peter Hokland filed Critical Niels Pallisgaard
Priority to EP97946747A priority Critical patent/EP0943013A2/fr
Priority to CA002274315A priority patent/CA2274315A1/fr
Priority to AU51877/98A priority patent/AU737190B2/en
Priority to JP52509098A priority patent/JP2001505428A/ja
Publication of WO1998024928A2 publication Critical patent/WO1998024928A2/fr
Publication of WO1998024928A3 publication Critical patent/WO1998024928A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Testing Or Measuring Of Semiconductors Or The Like (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Oscillators With Electromechanical Resonators (AREA)

Abstract

L'invention concerne une méthode de détection de l'absence ou de la présence d'anomalies chromosomiques associées à un état chez un individu, chacune d'elles étant définie par au moins une séquence nucléotidique caractéristique. En général, ladite méthode consiste à soumettre un échantillon d'acides nucléiques à une procédure d'amplification moléculaire multiplex, laquelle consiste à utiliser au moins 7 amorces différentes dans un seul mélange réactionnel. Chacune des amorces différentes au nombre minimum de 7 définit une extrémité d'au moins une séquence nucléotidique caractéristique, et au moins une des amorces définit les premières extrémités d'au moins deux séquences nucléotidiques caractéristiques, lesquelles sont définies dans leurs extrémités opposées par des amorces distinctes choisies parmi les amorces restantes. Le nombre de séquences nucléotidiques caractéristiques amplifiées pouvant être détectées à la fin de la réaction d'amplification est d'au moins 1/2xn+1, n étant le nombre correspondant aux amorces distinctes, soit au moins 7. Dans un mode de réalisation, l'utilisation d'un étalon positif contenant I) un fragment d'acide nucléique présent dans l'échantillon, et (II) des amorces pour l'amplification d'une séquence nucléotidique dudit fragment d'acide nucléique fait partie de la procédure.
PCT/DK1997/000556 1996-12-06 1997-12-08 Detection d'anomalies chromosomiques WO1998024928A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP97946747A EP0943013A2 (fr) 1996-12-06 1997-12-08 Detection d'anomalies chromosomiques
CA002274315A CA2274315A1 (fr) 1996-12-06 1997-12-08 Detection d'anomalies chromosomiques
AU51877/98A AU737190B2 (en) 1996-12-06 1997-12-08 Detection of chromosomal abnormalities
JP52509098A JP2001505428A (ja) 1996-12-06 1997-12-08 染色体異常の検出

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK140196 1996-12-06
DK1401/96 1996-12-06

Publications (2)

Publication Number Publication Date
WO1998024928A2 WO1998024928A2 (fr) 1998-06-11
WO1998024928A3 true WO1998024928A3 (fr) 1999-03-25

Family

ID=8104448

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1997/000556 WO1998024928A2 (fr) 1996-12-06 1997-12-08 Detection d'anomalies chromosomiques

Country Status (5)

Country Link
EP (1) EP0943013A2 (fr)
JP (1) JP2001505428A (fr)
AU (1) AU737190B2 (fr)
CA (1) CA2274315A1 (fr)
WO (1) WO1998024928A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105838793A (zh) * 2016-04-22 2016-08-10 上海荻硕贝肯生物科技有限公司 用于定性检测白血病融合基因的引物、试剂盒及方法

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US6969518B2 (en) 1998-12-28 2005-11-29 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
US7598226B2 (en) 1998-12-28 2009-10-06 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
EP1272673B1 (fr) * 2000-03-24 2007-03-14 Olympus Corporation Analyse multiplex specifique d'acides nucleiques
CA2404978A1 (fr) * 2000-04-03 2001-10-11 Corixa Corporation Methodes, compositions et necessaires correspondants servant au depistage et a la surveillance du cancer du sein
US7087414B2 (en) 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
AU2002366179A1 (en) 2001-11-20 2003-06-10 The Regents Of The University Of California Early leukemia diagnostics using microsphere arrays
US7301017B2 (en) * 2002-05-30 2007-11-27 Kolesnick Richard N Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
FR2842534B1 (fr) * 2002-07-19 2006-01-20 Inst Nat Sante Rech Med Amplification multiplex quantitative a l'echelle d'un genome, et applications a la detection de remaniements genomiques
JP2006508662A (ja) 2002-12-04 2006-03-16 アプレラ コーポレイション ポリヌクレオチドの多重増幅
WO2014164594A1 (fr) * 2013-03-11 2014-10-09 Meso Scale Technologies, Llc. Procédés améliorés pour conduire des dosages multiplexés

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WO1994026930A1 (fr) * 1993-05-14 1994-11-24 Thomas Jefferson University Procedes pour depister et traiter des leucemies resultant d'anomalies chromosomiques de la region all-1
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105838793A (zh) * 2016-04-22 2016-08-10 上海荻硕贝肯生物科技有限公司 用于定性检测白血病融合基因的引物、试剂盒及方法
CN105838793B (zh) * 2016-04-22 2019-07-12 上海荻硕贝肯生物科技有限公司 用于定性检测白血病融合基因的引物、试剂盒及方法

Also Published As

Publication number Publication date
AU737190B2 (en) 2001-08-09
JP2001505428A (ja) 2001-04-24
WO1998024928A2 (fr) 1998-06-11
EP0943013A2 (fr) 1999-09-22
CA2274315A1 (fr) 1998-06-11
AU5187798A (en) 1998-06-29

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