WO1998023219A1 - Dental bleaching composition and method - Google Patents
Dental bleaching composition and method Download PDFInfo
- Publication number
- WO1998023219A1 WO1998023219A1 PCT/US1997/021273 US9721273W WO9823219A1 WO 1998023219 A1 WO1998023219 A1 WO 1998023219A1 US 9721273 W US9721273 W US 9721273W WO 9823219 A1 WO9823219 A1 WO 9823219A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- laser
- bleaching composition
- particles
- dental bleaching
- hydrogen peroxide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C19/00—Dental auxiliary appliances
- A61C19/06—Implements for therapeutic treatment
- A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
- A61C19/066—Bleaching devices; Whitening agent applicators for teeth, e.g. trays or strips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
- A61K2800/434—Luminescent, Fluorescent; Optical brighteners; Photosensitizers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
Definitions
- the present invention relates to dental bleaching compositions and methods, and more particularly to dental bleaching compositions and methods utilizing a laser to enhance the bleaching action.
- the invention more particularly relates to dental bleaching compositions and methods with enhanced removal of both extrinsic and intrinsic discolorants from the dentition and with reduced pain or sensitivity associated with the bleaching process.
- Extrinsic discolorations are on the outer surface of the dentition and can be removed from the surface by dental instruments or polishing abrasives.
- Intrinsic discolorations, or stains located within the crystalline matrix of the enamel and dentin and cannot be removed by the use of dental instruments or polishing abrasives.
- Extrinsic discolorations or stains are usually superficial stains of the tooth surface resulting from the deposition of a film, pigments or calculus on the teeth. Many agents can cause such extrinsic discolorations including common substances such as coffee, tea, artificial food colorations, grapes, berries, smoking or chewing of tobacco, and the like. Stain intensity, and consequently ease of removal of the stains, are worsened by the penetration of the stain into tooth surface irregularities such as pits, cracks, grooves, exposed dentin, and bared root surfaces resulting from recession. The degree of difficulty of removal of the stain increases the deeper the penetration of the stain, with some stains penetrating to such a depth that the removal is extremely difficult or virtually impossible using current methods of stain removal.
- Intrinsic discolorations can have many causes of either an endogenous or exogenous origin and may occur during or after odontogenesis.
- the teeth may become discolored from changes in the quality or quantity of enamel or dentin, or from incorporation of discoloring agents in the hard tissues, and may be caused by many diseases and medications, such as tetracycline.
- Post-eruption discolorations occur when discoloring agents enter the dental hard tissues from either the pulp cavity or tooth surface and can be caused by trauma, aging, metals, dental materials, and contact with or ingestion of certain foods and beverages.
- a commonly practiced technique for removing discoloration is the practice of external bleaching, often with hydrogen peroxide.
- bleaching agents are able only to remove discoloring agents located within five to seven microns from the enamel surface due to the high inorganic content and limited permeability of the enamel. Thus intrinsic discolorations and deeply penetrating extrinsic discolorations are left untouched.
- cold bleaching systems were developed. These systems used longer room temperature reaction times instead of shorter heat activated reaction times. In these cold bleaching systems, the hydrogen peroxide is thickened or gelled to allow the hydrogen peroxide to form a coating capable of remaining in contact with the teeth for extended period of time. Although the cold bleaching systems eliminated the side effects of the application of heat, a number of office visits were still required to achieve satisfactory results and post-bleaching sensitivity still occurred. Recently, as disclosed in U.S. Patent No.
- the dental bleaching composition of the present invention can be used in conjunction with a laser to provide enhanced effectiveness of the bleaching action while reducing post-bleaching sensitivity.
- the dental bleaching composition comprises a bleaching agent such as hydrogen peroxide, carbamine peroxide and the like; an inert gelling compound such as a silicon dioxide compound; a pH modifier such as sodium hydroxide; and a discrete inert particulate laser enhancing material such as beads having a color complementary to the color of the laser light.
- a bleaching agent such as hydrogen peroxide, carbamine peroxide and the like
- an inert gelling compound such as a silicon dioxide compound
- a pH modifier such as sodium hydroxide
- a discrete inert particulate laser enhancing material such as beads having a color complementary to the color of the laser light.
- These materials are admixed to form a translucent or transparent gel with a pH of about 9 to 11, more preferably from about 9.5 to about 10.5, and most preferably from about 10 to 10.5.
- the discrete particles are capable of absorbing the light energy from the wavelength of light emitted from the laser and retransmitting it as thermal energy.
- the dental bleaching composition of the present invention is used in the process of the present invention by placing it on the tooth surfaces to be bleached to coat the area to be bleached.
- the coated tooth surfaces are exposed to laser energy, and then the coating is removed from the tooth surfaces, preferably by rinsing.
- the process is then repeated for one or more cycles until the desired degree of bleaching of the dental surface is achieved.
- Neutral sodium fluoride is then applied to the bleached teeth for at least 10 minutes to reduce or eliminate post-bleaching sensitivity.
- a kit containing the ingredients allows single dose applications to be mixed immediately before use.
- the present invention is directed to a novel dental bleaching composition and its method of use which results in enhanced bleaching action while reducing or eliminating post- bleaching sensitivity.
- the topical dental bleaching composition of the present invention comprises a gel formed from admixing a bleaching agent with an inert gelling compound. The pH of the gel is modified or adjusted at least 9.0 to reduce post-bleeding sensitivity. To enhance the effectiveness of the bleaching composition, discrete inert laser enhancing particles are dispersed throughout the composition.
- the bleaching agent may be any bleaching agent suitable for use on dentition in living patients. Preferably the bleaching agent hydrogen peroxide or carbamine peroxide.
- bleaching agents may include sodium perborate, oxalic acid (for iron stains) , chlorine (for silver and copper stains) , and ammonia (for iodine-containing stains) .
- the bleaching agent is hydrogen peroxide in concentrations ranging from about 5% to about 70% by volume, more preferably from about 25% to about 60% by volume, and most preferably from about 35% to about 50% by volume.
- the amount of hydrogen peroxide present is about 90 to 95% by weight of the total mixture.
- any suitable inert gelling compound may be used that is capable of forming a gel or thickened mixture when admixed with the bleaching agent.
- suitable compositions include silica compounds, sodium stearate, and long chain hydrocarbons such as CarbopolTM, TrolamineTM and PolyoxTM.
- an inert silica compound is used and suitable silica compounds include silicon dioxide, fumed silica and the like.
- the silica compound is in a finely divided form that enhances the gelling reaction with the bleaching agent, such as hydrogen peroxide.
- the preferred concentration of the silica gelling agent is approximately 5 to 10% by weight.
- Bleaching agents such as hydrogen peroxide, are concentration-dependant pulpal irritants. The higher the concentration of bleaching agent placed on the surface of a tooth, the more rapidly the concentration of the bleaching agent rises within the enamel and dentin of the tooth. Even at lower concentrations, bleaching agents can irritate the pulp causing pulpitis and at higher concentrations, can cause pulpal death.
- One embodiment of the present invention is directed to the discovery that even with very high concentrations of hydrogen peroxide and other bleaching agents, post-bleaching tooth and dental sensitivity can be significantly decreased by maintaining hydration of the dental tissues during the bleaching process and thus eliminating pulpitis and its attendant sensitivity. It has been discovered that there is a significant difference in pain both during and after bleaching teeth with a hydrogen peroxide/silicon dioxide gel and an argon laser when the teeth were rinsed with water every 3 to 5 minutes during the bleaching procedure to keep them hydrated. In these tests, patients had a hydrogen peroxide and silicon dioxide gel placed on six maxillary anterior teeth, canine to canine. The teeth were exposed, in turn, to 40 seconds of argon laser light per tooth.
- the bleaching gel was wiped away with a cotton gauze and on the other three teeth, the bleaching gel was rinsed away and the teeth were bathed in water for approximately 20 seconds. The bleaching gel was then replaced and the cycle was repeated for a total of six cycles. Patients reported significantly less pain during and after the bleaching procedure on the teeth that were hydrated. When the sides were switched and the teeth that had been bathed in water were wiped clean instead, while the teeth that were wiped were hydrated, the patients reported that the teeth that were sensitive had switched as well.
- adjusting or modifying the pH of the bleaching composition results in a significant reduction in post-bleaching sensitivity.
- Any suitable pH modifier can be used that does not adversely affect the bleaching action of the bleaching agent such as disassociation of a peroxide bleaching agent.
- sodium hydroxide (NaOH) or sodium polysilicate is used to adjust the pH.
- a laser capable of increasing the bleaching action of a bleaching agent on a tooth surface such as an argon laser, is used to enhance the bleaching action of the dental bleaching composition of the present invention.
- the laser light enhances the speed by which enamel and dentin can be bleached by any or all of the following mechanisms: i) lowering the energy needed to break down the stain molecules within the teeth, ii) pushing the bleaching gel into the tooth more rapidly, and iii) interacting with the bleaching gel to enhance its reactivity. It has been discovered that teeth coated with a hydrogen peroxide and fumed silica gel and exposed to argon laser light bleach lighter than teeth of the same shade bleached with the gel alone.
- This effect is dependent on the strength of the argon laser, with a laser yielding a power density of 550-700 milliwatts/cm 2 bleaching the coated tooth surfaces more effectively than a laser yielding a power density of 350-550 milliwatts/cm 2 but at the cost of increased sensitivity during and following the bleaching process. This may be due to one or both of the following mechanisms. i) The laser energy "pushes" the hydrogen peroxide into the tooth more rapidly — the concentration of hydrogen peroxide at any distance from the surface of the tooth may be greater when the tooth is bathed in argon laser light than in the absence of the laser. ii) The laser energy may contribute directly to pulpal irritation.
- the bleaching action of the dental bleaching composition is enhanced by the inclusion into the bleaching composition of a discrete inert particulate material that absorbs the wavelength of light emitted by the laser.
- the discrete inert particulate matter is pigmented or colored in a color complement to the laser light, thus resulting in efficient absorption of the laser light wavelength.
- an argon laser utilizes a blue light with a wavelength in the range of 470 nm to 520 nm.
- the color complement to blue is orange, and thus an orange or red-orange particulate material that reflects light in the 600 nm to 650 nm range and absorbs at all other wavelengths would enhance the action of the laser and would be preferred since orange is the color complement to blue.
- Other colors or compositions that absorb at the wavelength that laser light is emitted are also suitable.
- a black particulate material would absorb all wavelengths of emitted light.
- Particulate material made from compositions of matter that absorb emitted laser light in the desired wavelength ranges are also suitable.
- an inert plastic material that absorbs light at a of 470 nm to 520 nm can be used as the discrete particulate material of the present invention for use with an argon laser.
- the discrete inert colored particulate material can be made of any suitable material that will not react with the hydrogen peroxide or other bleaching agent and that will not leach its color into the tooth surface during the bleaching process.
- suitable materials include colored or coated porcelain, ceramic, thermoplastic or polymeric resins such as acrylic resins, cellulosic resins, ceramic fiber compounds, fluoroplastic resins, polyamide resins, polycarbonate resins, phenolic resins, polyethelene resins, polyester resins, polymethylpentene resins, polyoxymethylene resins, polyphenylene resins, polypropylene resins, polystryrene resins, polyvinyl resins, nitrile resins, terephthalic resins, or glass fiber compounds.
- plastics and polymeric materials known to those in the art may be used provided that they do not react.
- the particles can be coated or colored by any suitable means and such coating and coloring processes are well known in the art.
- the discrete laser enhancing particles are made of a material that absorbs the wavelength of the emitted laser light and retransmits it as thermal energy. Suitable materials are known to those of ordinary skill in the art.
- the size of the particles can vary and preferably range from about 50 microns to about 400 microns, more preferably from about 75 microns to about 200 microns, and most preferably from about 90 microns to 125 microns.
- the discrete particulate material enhances the laser's action by increasing the thermal energy, and thus the reactivity of the bleaching agent.
- the amount or density of the particles in the bleaching gel is sufficient to allow the laser to enhance the reactivity of the hydrogen peroxide.
- the particulate density or amount is not so great that it blocks the laser light from reaching the surface of the tooth. As described above, it is necessary for the laser light to reach the tooth in order to enhance the bleaching action of the bleaching agent since this appears to be the more important part and thus the density of the particulate matter needs to be adjusted accordingly.
- post- bleaching sensitivity is further reduced by the application of neutral sodium fluoride to the bleached teeth for at least ten minutes.
- Fluoride has been used in dentistry to reduce sensitivity for many years. Often, when the root surface of teeth are exposed to the oral cavity due to gingival recession, these teeth become sensitive to hot, cold and sometimes sweets. Fluoride has been shown to reduce this sensitivity by combining with the crystalline structure of the tooth to form fluorapatite and by blocking dentinal tubuals.
- the dental bleaching composition of the present invention can be supplied to dental practitioners in the form of a kit containing ingredients sufficient for either individual or multiple treatments.
- the ingredients can be supplied individually in separate containers or vials, or can have multiple ingredients premixed so that the hydrogen peroxide containing mixture can be admixed by the dental professional with the silicon compound at the point of use.
- the dental professional will be supplied with a kit containing the ingredients making up the bleaching composition of the present invention so that the bleaching composition can be mixed "chairside" and immediately used.
- the kit may contain 2 premeasured containers, one containing a bleaching agent such as hydrogen peroxide with glycerin, and the other containing a pH modifier such as sodium hydroxide or sodium polysilicate, with a premixed quantity of the inert gelling agent such as silica or fumed silica and the discrete laser enhancing particulate matter.
- a bleaching agent such as hydrogen peroxide with glycerin
- a pH modifier such as sodium hydroxide or sodium polysilicate
- the inert gelling agent such as silica or fumed silica
- the discrete laser enhancing particulate matter for an argon laser, the particulate matter is preferably orange. All items are packaged with a protocol by which safe and effective use of the materials can be achieved.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Dentistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97950645A EP1006922A4 (en) | 1996-11-27 | 1997-11-26 | Dental bleaching composition and method |
AU53596/98A AU5359698A (en) | 1996-11-27 | 1997-11-26 | Dental bleaching composition and method |
JP52474498A JP2001506602A (en) | 1996-11-27 | 1997-11-26 | Dental bleaching compositions and methods |
CA002272286A CA2272286A1 (en) | 1996-11-27 | 1997-11-26 | Dental bleaching composition and method |
US09/114,166 US6846182B1 (en) | 1996-11-27 | 1998-07-13 | Dental bleaching composition and method |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/757,248 | 1996-11-27 | ||
US08/757,248 US5766011A (en) | 1996-11-27 | 1996-11-27 | Dental bleaching composition and method |
US75724897A | 1997-11-26 | 1997-11-26 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/757,248 Continuation-In-Part US5766011A (en) | 1996-11-27 | 1996-11-27 | Dental bleaching composition and method |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/114,166 Continuation-In-Part US6846182B1 (en) | 1996-11-27 | 1998-07-13 | Dental bleaching composition and method |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998023219A1 true WO1998023219A1 (en) | 1998-06-04 |
Family
ID=27116356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/021273 WO1998023219A1 (en) | 1996-11-27 | 1997-11-26 | Dental bleaching composition and method |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1998023219A1 (en) |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002022097A1 (en) * | 2000-09-14 | 2002-03-21 | High Tech Laser | Method and composition for dental bleaching |
US6365134B1 (en) * | 1999-07-07 | 2002-04-02 | Scientific Pharmaceuticals, Inc. | Process and composition for high efficacy teeth whitening |
US7067115B2 (en) | 1999-07-07 | 2006-06-27 | Scientific Pharmaceuticals, Inc. | Process and composition for high efficacy teeth whitening |
US7845039B2 (en) | 2003-09-09 | 2010-12-07 | The Procter & Gamble Company | Toothbrush with severable electrical connections |
US8075875B2 (en) | 2005-11-09 | 2011-12-13 | Klox Technologies Inc. | Teeth whitening composition and methods |
US8632822B2 (en) | 2008-11-07 | 2014-01-21 | Klox Technologies Inc. | Combination of an oxidant and a photoactivator for the healing of wounds |
US8685466B2 (en) | 2009-07-17 | 2014-04-01 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
US9345648B2 (en) | 2006-11-09 | 2016-05-24 | Klox Technologies Inc. | Photoactivatable oxygen-evolving compositions and methods for teeth whitening |
US9655829B2 (en) | 2012-09-14 | 2017-05-23 | Valeant Pharmaceuticals International, Inc. | Compositions and methods for teeth whitening |
US9877801B2 (en) | 2013-06-26 | 2018-01-30 | Sonendo, Inc. | Apparatus and methods for filling teeth and root canals |
US10010388B2 (en) | 2006-04-20 | 2018-07-03 | Sonendo, Inc. | Apparatus and methods for treating root canals of teeth |
US10130706B2 (en) | 2013-03-14 | 2018-11-20 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
US10207029B2 (en) | 2014-04-01 | 2019-02-19 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
US10363120B2 (en) | 2012-12-20 | 2019-07-30 | Sonendo, Inc. | Apparatus and methods for cleaning teeth and root canals |
US10376455B2 (en) | 2012-04-20 | 2019-08-13 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
US10420630B2 (en) | 2009-11-13 | 2019-09-24 | Sonendo, Inc. | Liquid jet apparatus and methods for dental treatments |
US10631962B2 (en) | 2012-04-13 | 2020-04-28 | Sonendo, Inc. | Apparatus and methods for cleaning teeth and gingival pockets |
US10702355B2 (en) | 2010-10-21 | 2020-07-07 | Sonendo, Inc. | Apparatus, methods, and compositions for endodontic treatments |
US10722325B2 (en) | 2013-05-01 | 2020-07-28 | Sonendo, Inc. | Apparatus and methods for treating teeth |
US10806544B2 (en) | 2016-04-04 | 2020-10-20 | Sonendo, Inc. | Systems and methods for removing foreign objects from root canals |
US10835355B2 (en) | 2006-04-20 | 2020-11-17 | Sonendo, Inc. | Apparatus and methods for treating root canals of teeth |
US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
US11173019B2 (en) | 2012-03-22 | 2021-11-16 | Sonendo, Inc. | Apparatus and methods for cleaning teeth |
US11213375B2 (en) | 2012-12-20 | 2022-01-04 | Sonendo, Inc. | Apparatus and methods for cleaning teeth and root canals |
US11350993B2 (en) | 2006-08-24 | 2022-06-07 | Pipstek, Llc | Dental and medical treatments and procedures |
US11421349B2 (en) | 2014-10-31 | 2022-08-23 | Klox Technologies Inc. | Photoactivatable fibers and fabric media |
USD997355S1 (en) | 2020-10-07 | 2023-08-29 | Sonendo, Inc. | Dental treatment instrument |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5713738A (en) * | 1995-12-12 | 1998-02-03 | Britesmile, Inc. | Method for whitening teeth |
US5766011A (en) | 1996-11-27 | 1998-06-16 | Sibner; Jeffrey A. | Dental bleaching composition and method |
-
1997
- 1997-11-26 WO PCT/US1997/021273 patent/WO1998023219A1/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5713738A (en) * | 1995-12-12 | 1998-02-03 | Britesmile, Inc. | Method for whitening teeth |
US5766011A (en) | 1996-11-27 | 1998-06-16 | Sibner; Jeffrey A. | Dental bleaching composition and method |
Non-Patent Citations (1)
Title |
---|
See also references of EP1006922A4 * |
Cited By (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6365134B1 (en) * | 1999-07-07 | 2002-04-02 | Scientific Pharmaceuticals, Inc. | Process and composition for high efficacy teeth whitening |
US7067115B2 (en) | 1999-07-07 | 2006-06-27 | Scientific Pharmaceuticals, Inc. | Process and composition for high efficacy teeth whitening |
WO2002022097A1 (en) * | 2000-09-14 | 2002-03-21 | High Tech Laser | Method and composition for dental bleaching |
AU2000272625B2 (en) * | 2000-09-14 | 2006-06-29 | High Tech Laser | Method and composition for dental bleaching |
KR100768352B1 (en) * | 2000-09-14 | 2007-10-18 | 하이 테크 레이저 | Composition for dental bleaching |
US7845039B2 (en) | 2003-09-09 | 2010-12-07 | The Procter & Gamble Company | Toothbrush with severable electrical connections |
US8075875B2 (en) | 2005-11-09 | 2011-12-13 | Klox Technologies Inc. | Teeth whitening composition and methods |
US8986719B2 (en) | 2005-11-09 | 2015-03-24 | Klox Technologies Inc. | Teeth whitening compositions and methods |
US10617498B2 (en) | 2006-04-20 | 2020-04-14 | Sonendo, Inc. | Apparatus and methods for treating root canals of teeth |
US11918432B2 (en) | 2006-04-20 | 2024-03-05 | Sonendo, Inc. | Apparatus and methods for treating root canals of teeth |
US10039625B2 (en) | 2006-04-20 | 2018-08-07 | Sonendo, Inc. | Apparatus and methods for treating root canals of teeth |
US10016263B2 (en) | 2006-04-20 | 2018-07-10 | Sonendo, Inc. | Apparatus and methods for treating root canals of teeth |
US10835355B2 (en) | 2006-04-20 | 2020-11-17 | Sonendo, Inc. | Apparatus and methods for treating root canals of teeth |
US10010388B2 (en) | 2006-04-20 | 2018-07-03 | Sonendo, Inc. | Apparatus and methods for treating root canals of teeth |
US11350993B2 (en) | 2006-08-24 | 2022-06-07 | Pipstek, Llc | Dental and medical treatments and procedures |
US11426239B2 (en) | 2006-08-24 | 2022-08-30 | Pipstek, Llc | Dental and medical treatments and procedures |
US11684421B2 (en) | 2006-08-24 | 2023-06-27 | Pipstek, Llc | Dental and medical treatments and procedures |
US9345648B2 (en) | 2006-11-09 | 2016-05-24 | Klox Technologies Inc. | Photoactivatable oxygen-evolving compositions and methods for teeth whitening |
US8911791B2 (en) | 2008-11-07 | 2014-12-16 | Klox Technologies Inc. | Method for acne treatment using an oxidative-photoactivated composition |
US10384072B2 (en) | 2008-11-07 | 2019-08-20 | Klox Technologies Inc. | Combination of an oxidant and a photoactivator for the healing of wounds |
US9597349B2 (en) | 2008-11-07 | 2017-03-21 | Klox Technologies Inc. | Combination of an oxidant and a photoactivator for the healing of wounds |
US11691025B2 (en) | 2008-11-07 | 2023-07-04 | Klox Technologies Inc. | Methods and compositions for reversing or mitigating skin aging |
US9375446B2 (en) | 2008-11-07 | 2016-06-28 | Klox Technologies Inc. | Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin |
US11020609B2 (en) | 2008-11-07 | 2021-06-01 | Klox Technologies Inc. | Methods and compositions for treatment of pigmented lesions |
US8986745B2 (en) | 2008-11-07 | 2015-03-24 | Klox Technologies Inc. | Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin |
US8974833B2 (en) | 2008-11-07 | 2015-03-10 | Klox Technologies Inc. | Combination of an oxidant and a photoactivator for the healing of wounds |
US10149985B2 (en) | 2008-11-07 | 2018-12-11 | Klox Technologies Inc. | Methods and compositions for treating rosacea |
US8632822B2 (en) | 2008-11-07 | 2014-01-21 | Klox Technologies Inc. | Combination of an oxidant and a photoactivator for the healing of wounds |
US10758744B2 (en) | 2008-11-07 | 2020-09-01 | Klox Technologies Inc. | Combination of an oxidant and a photoactivator for the wounds |
US8637086B2 (en) | 2008-11-07 | 2014-01-28 | Klox Technologies Inc. | Method for acne treatment using an oxidative-photoactivated composition |
US8658219B2 (en) | 2008-11-07 | 2014-02-25 | Klox Technologies Inc. | Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin |
US10485986B2 (en) | 2008-11-07 | 2019-11-26 | Klox Technologies Inc. | Methods and compositions for treatment of pigmented lesions |
US10322179B2 (en) | 2009-07-17 | 2019-06-18 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
US10471147B2 (en) | 2009-07-17 | 2019-11-12 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
US9603929B2 (en) | 2009-07-17 | 2017-03-28 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfecton and treatment of oral disease |
US8685466B2 (en) | 2009-07-17 | 2014-04-01 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
US8986746B2 (en) | 2009-07-17 | 2015-03-24 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
US11141482B2 (en) | 2009-07-17 | 2021-10-12 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
US11160645B2 (en) | 2009-11-13 | 2021-11-02 | Sonendo, Inc. | Liquid jet apparatus and methods for dental treatments |
US10420630B2 (en) | 2009-11-13 | 2019-09-24 | Sonendo, Inc. | Liquid jet apparatus and methods for dental treatments |
US10806543B2 (en) | 2010-10-21 | 2020-10-20 | Sonendo, Inc. | Apparatus, methods, and compositions for endodontic treatments |
US10702355B2 (en) | 2010-10-21 | 2020-07-07 | Sonendo, Inc. | Apparatus, methods, and compositions for endodontic treatments |
US11173019B2 (en) | 2012-03-22 | 2021-11-16 | Sonendo, Inc. | Apparatus and methods for cleaning teeth |
US11284978B2 (en) | 2012-04-13 | 2022-03-29 | Sonendo, Inc. | Apparatus and methods for cleaning teeth and gingival pockets |
US10631962B2 (en) | 2012-04-13 | 2020-04-28 | Sonendo, Inc. | Apparatus and methods for cleaning teeth and gingival pockets |
US10376455B2 (en) | 2012-04-20 | 2019-08-13 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
US11331257B2 (en) | 2012-04-20 | 2022-05-17 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
US11723854B2 (en) | 2012-04-20 | 2023-08-15 | Fle International S.R.L. | Biophotonic compositions and methods for providing biophotonic treatment |
US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
US9655829B2 (en) | 2012-09-14 | 2017-05-23 | Valeant Pharmaceuticals International, Inc. | Compositions and methods for teeth whitening |
US10363120B2 (en) | 2012-12-20 | 2019-07-30 | Sonendo, Inc. | Apparatus and methods for cleaning teeth and root canals |
US11213375B2 (en) | 2012-12-20 | 2022-01-04 | Sonendo, Inc. | Apparatus and methods for cleaning teeth and root canals |
US11103333B2 (en) | 2012-12-20 | 2021-08-31 | Sonendo, Inc. | Apparatus and methods for cleaning teeth and root canals |
US11324823B2 (en) | 2013-03-14 | 2022-05-10 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
US10130706B2 (en) | 2013-03-14 | 2018-11-20 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
US10722325B2 (en) | 2013-05-01 | 2020-07-28 | Sonendo, Inc. | Apparatus and methods for treating teeth |
US9877801B2 (en) | 2013-06-26 | 2018-01-30 | Sonendo, Inc. | Apparatus and methods for filling teeth and root canals |
US11701202B2 (en) | 2013-06-26 | 2023-07-18 | Sonendo, Inc. | Apparatus and methods for filling teeth and root canals |
US10772990B2 (en) | 2014-04-01 | 2020-09-15 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
US10207029B2 (en) | 2014-04-01 | 2019-02-19 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
US11421349B2 (en) | 2014-10-31 | 2022-08-23 | Klox Technologies Inc. | Photoactivatable fibers and fabric media |
US10806544B2 (en) | 2016-04-04 | 2020-10-20 | Sonendo, Inc. | Systems and methods for removing foreign objects from root canals |
USD997355S1 (en) | 2020-10-07 | 2023-08-29 | Sonendo, Inc. | Dental treatment instrument |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5766011A (en) | Dental bleaching composition and method | |
WO1998023219A1 (en) | Dental bleaching composition and method | |
US6846182B1 (en) | Dental bleaching composition and method | |
AU743641B2 (en) | Light-activated tooth whitening composition and method of using same | |
US6162055A (en) | Light activated tooth whitening composition and method of using same | |
US20070237728A1 (en) | Method and Composition for Dental Bleaching | |
CA2632187C (en) | Teeth whitening compositions and methods | |
US6416319B1 (en) | Tooth whitening device and method of using same | |
KR101869109B1 (en) | Photoactivatable oxygen-evolving compositions and methods for teeth whitening | |
AU2000272625A1 (en) | Method and composition for dental bleaching | |
US20080131843A1 (en) | Light-Activated Tooth Whitening Method | |
MXPA00007810A (en) | Light-activated tooth whitening composition and method of using same | |
Paul¹ et al. | TOOTH BLEACHING A CRITICAL REVIEW | |
AU2320702A (en) | Light-activated tooth whitening composition and method of using same | |
CZ20002944A3 (en) | Light-activatible tooth whitening composition and method of using the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 09114166 Country of ref document: US |
|
CFP | Corrected version of a pamphlet front page |
Free format text: ADD INID NUMBER (63) "RELATED BY CONTINUATION (CON) OR CONTINUATION-IN-PART (CIP) TO EARLIER APPLICATION" WHICH WAS INADVERTENTLY OMITTED FROM THE FRONT PAGE |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
ENP | Entry into the national phase |
Ref document number: 2272286 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref country code: JP Ref document number: 1998 524744 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1997950645 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1997950645 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1997950645 Country of ref document: EP |