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Peptide natriuretique cerebral (bnp) specifique pour un recepteur

Info

Publication number
WO1998017690A1
WO1998017690A1 PCT/US1997/018384 US9718384W WO1998017690A1 WO 1998017690 A1 WO1998017690 A1 WO 1998017690A1 US 9718384 W US9718384 W US 9718384W WO 1998017690 A1 WO1998017690 A1 WO 1998017690A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
arg
ser
gly
id
lys
Prior art date
Application number
PCT/US1997/018384
Other languages
English (en)
Inventor
David G. Lowe
Jill R. Schoenfeld
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/58Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Abstract

Composés apparentés à BNP présentant une affinité limitée de fixation au récepteur C du peptide natriurétique, mais possédant une affinité améliorée ou équivalent par rapport au BNP de type sauvage pour le récepteur A du peptide natriurétique. Ces composés peuvent être utilisés avantageusement pour le traitement ou la prophylaxie de différents états pathologiques associés au déséquilibre aqueux ou électrolytique.
PCT/US1997/018384 1996-10-22 1997-10-09 Peptide natriuretique cerebral (bnp) specifique pour un recepteur WO1998017690A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US73188096 true 1996-10-22 1996-10-22
US08/731,880 1996-10-22

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19970910899 EP0939770A1 (fr) 1996-10-22 1997-10-09 Peptide natriuretique cerebral (bnp) specifique pour un recepteur
CA 2269656 CA2269656A1 (fr) 1996-10-22 1997-10-09 Peptide natriuretique cerebral (bnp) specifique pour un recepteur
JP51943698A JP2001503256A (ja) 1996-10-22 1997-10-09 レセプター選択的bnp

Publications (1)

Publication Number Publication Date
WO1998017690A1 true true WO1998017690A1 (fr) 1998-04-30

Family

ID=24941306

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/018384 WO1998017690A1 (fr) 1996-10-22 1997-10-09 Peptide natriuretique cerebral (bnp) specifique pour un recepteur

Country Status (4)

Country Link
JP (1) JP2001503256A (fr)
CA (1) CA2269656A1 (fr)
EP (1) EP0939770A1 (fr)
WO (1) WO1998017690A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7662773B2 (en) 2002-11-26 2010-02-16 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US9266939B2 (en) 2010-12-27 2016-02-23 Alexion Pharmaceuticals, Inc. Compositions comprising natriuretic peptides and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013296A1 (fr) * 1993-11-12 1995-05-18 Genentech, Inc. Peptides natriuretiques auriculaires specifiques d'un recepteur

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013296A1 (fr) * 1993-11-12 1995-05-18 Genentech, Inc. Peptides natriuretiques auriculaires specifiques d'un recepteur

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CUNNINGHAM ET AL: "Production of an atrial natriuretic peptide variant that is specific for type A receptor", EMBO JOURNAL, vol. 13, no. 11, 1994, pages 2508 - 2515, XP002055646 *
J. SCHOENFELD ET AL: "Mutations in B-type natriuretic peptide mediating receptor-A selectivity", FEBS LETTERS, vol. 414, September 1997 (1997-09-01), pages 263 - 267, XP002055366 *
M. MIMEAULT ET AL: "Evaluation of conformational and binding characteristics of various natriuretic peptides and related analogs", BIOCHEMISTRY, vol. 34, 1995, pages 955 - 964, XP002055367 *
TETSUJI SUDOH ET AL: "A NEW NATRIURETIC PEPTIDE IN PORCINE BRAIN", NATURE, vol. 332, no. 6159, 3 March 1988 (1988-03-03), pages 78 - 81, XP000025601 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7662773B2 (en) 2002-11-26 2010-02-16 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US9266939B2 (en) 2010-12-27 2016-02-23 Alexion Pharmaceuticals, Inc. Compositions comprising natriuretic peptides and methods of use thereof

Also Published As

Publication number Publication date Type
JP2001503256A (ja) 2001-03-13 application
CA2269656A1 (fr) 1998-04-30 application
EP0939770A1 (fr) 1999-09-08 application

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