WO1998017342A2 - System and method for delivery of neutron beams for medical therapy - Google Patents
System and method for delivery of neutron beams for medical therapy Download PDFInfo
- Publication number
- WO1998017342A2 WO1998017342A2 PCT/US1997/019503 US9719503W WO9817342A2 WO 1998017342 A2 WO1998017342 A2 WO 1998017342A2 US 9719503 W US9719503 W US 9719503W WO 9817342 A2 WO9817342 A2 WO 9817342A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- neutron
- delivery system
- target
- producing
- proton
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K5/00—Irradiation devices
- G21K5/04—Irradiation devices with beam-forming means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H3/00—Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
- H05H3/06—Generating neutron beams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1095—Elements inserted into the radiation path within the system, e.g. filters or wedges
Definitions
- This invention relates to apparatus and methods for delivery of neutron beams for medical therapy. More particularly, it concerns a neutron delivery system with a bimodal energy spectrum that can be used for both fast-neutron therapy and for fast-neutron therapy augmented by boron neutron capture therapy.
- NCT Neutron capture therapy
- fast neutron therapy neutrons having relatively high energy (approximately 30-50 MeV) are generated by a suitable neutron source and used directly for irradiation of the treatment volume, just as is done with standard photon (x-ray) therapy.
- Delivery of fast- neutron therapy for cancer is typically accomplished using accelerator based fast neutron sources that generally involve targeting a proton or deuteron beam onto beryllium.
- a neutron capture agent which in current practice is boron-10 (yielding Boron NCT, or BNCT) is selectively taken into the malignant tissue following the administration of a suitable boronated pharmaceutical, preferably into the bloodstream of the patient.
- boron-10 yielding Boron NCT, or BNCT
- the treatment volume is exposed to a field of thermal neutrons produced by application of an external neutron beam.
- the thermal neutrons interact with the boron-10, which has a very high capture cross section in thermal energy range and which, ideally, is present only in the malignant cells.
- Each boron-neutron interaction produces an alpha particle and a lithium ion.
- These highly-energetic charged particles deposit their energy within a geometric volume that is comparable to the size of the malignant cell, leading to a high probability of cell inactivation by direct DNA damage.
- the NCT process offers the possibility of highly selective destruction of malignant tissue, with cellular-level separating of neighboring normal tissue since the neutron sources used for NCT are, themselves, designed to produce a minimal level of damage of normal tissue.
- BNCT When BNCT is administered as a primary therapy, an epithermal - neutron beam (neutrons having energies in the range of 1 eV to 10 keV) is used to produce the required thermal neutron flux at depth, since these somewhat higher-energy neutrons will penetrate deeper into the irradiation volume before thermalizing, yet they are still not of sufficient energy to inflict unacceptable damage to intervening normal tissue.
- a third form of neutron therapy which is basically a hybrid that combines the features of fast neutron therapy and NCT is also currently a subject of research interest, and constitutes the field of application where this invention is useful.
- a neutron capture agent is introduced preferentially into the malignant tissue prior to the administration of standard fast neutron therapy.
- the present invention provides a potentially compact, user friendly, field-deployable neutron delivery system with dual capabilities for fast neutron therapy alone, or for fast neutron therapy with neutron capture therapy augmentation, with much improved capability for tumor control during neutron beam treatment.
- the present invention is a neutron delivery system that provides improved capability for tumor control by producing a specially tailored neutron beam.
- the specially tailored neutron beam has a bimodal energy spectrum and provides dramatically enhanced tumor control during medical therapy by allowing neutron therapy to be enhanced with neutron capture therapy.
- the system includes: a structure for producing a proton beam; at least one target; and a magnet arrangement for directing the proton beam into the at least one target.
- the target includes layers for producing, when impacted by the proton beam, at least one neutron beam having a bimodal energy spectrum for use with both fast-neutron therapy and boron neutron capture therapy.
- FIG. 1 is a side view of a self-contained gantry mounted neutron delivery system.
- FIG. 2 is an end view of a self-contained gantry mounted neutron delivery system.
- FIG. 3 is a side view of a gantry mounted neutron delivery system with a superconducting cyclotron located just behind the rotating wheel assembly.
- FIG. 4 shows a side view of a target of the present invention where divisions between layers of the target are indicated with dotted lines.
- FIG. 5 illustrates a partial front view of a neutron delivery system mounted in a wall, the partial view focusing on the bearings between the housing of the delivery system and the wall, and the ring gear and motor for rotating the housing.
- FIG. 1 A sketch of a proposed system for neutron delivery is shown in FIG. 1.
- a superconducting cyclotron produces a proton beam, which is subsequently directed through a system of bending magnets to a target assembly where neutrons are produced.
- This target assembly is laminated and has other design features to enhance the production of neutrons having a spectrum that will simultaneously induce a desired fast-neutron dose-depth profile in hydrogenous tissue at the isocenter as well as a desired thermal -neutron flux profile in the same hydrogenous target volume at the isocenter.
- This specially tailored neutron beam is achieved in the present invention by a specially designed accelerator target and/or by selective neutron filtering downstream from the target itself, but within the target assembly shown in FIG. 1.
- the preferred target assembly has several elements: first is a proton-neutron conversion region composed in the currently- preferred embodiment of laminated beryllium and tungsten, followed by a neutron filtering subasse bly composed of a suitable material having neutron cross-section characteristics such that the downstream spectrum emerging from the filter has an operator adjustable bimodal shape as a function of energy as the result of the action of the target and/or filter.
- the target filter assembly is followed in turn by suitable flattening and wedge filters, composed in the currently preferred embodiment of tungsten or iron.
- Downstream of the target-filter assembly is a multi -segment collimator to further tailor the neutron beam prior to delivery to the patient at the isocenter.
- all major components of the system are preferably housed within a balanced rotating structure that can be mounted in a large circular opening in the interior wall of the building where the systems is installed.
- the mounting wall will generally be quite thick, in order to provide the necessary level of neutron shielding.
- the device can be mounted on roller bearings, with a ring gear wrapped circumferentially around the periphery of the housing or circumferentially within the opening within the wall where the system is installed. Either way, small drive motors engage the large ring gear to facilitate rotation of the entire assembly about the isocenter to within the required precision.
- FIG. 3 An alternative embodiment of this invention is illustrated in FIG. 3.
- the cyclotron itself is located just behind the rotating assembly. This is a less-preferred embodiment at this time because somewhat more space is required. Additionally, the cyclotron could not be used to counterbalance the weight of the target and collimator assembly. Thus, this embodiment requires the installation of additional counterweights in the rotating structure itself.
- An alternate approach within this invention is to sequentially expose the target volume of the patient with two or more neutron beams having different energy levels to cumulatively achieve the same result as that achieved by a tailored beam. Ease of treatment will normally make a system having a tailored neutron beam the system of choice.
- a neutron delivery system 10 provides improved capability for tumor control during medical therapy.
- the neutron delivery system 10 includes the following parts: a cyclotron 14 for producing a proton beam 16; magnets 18; and at least one target 22.
- the magnets 18 are for directing the proton beam 16 into the target 22 so that the target produces at least one neutron beam 26 when impacted by the proton beam.
- the neutron beam 26 has a bimodal energy spectrum that can be used with both fast-neutron therapy and boron neutron capture therapy.
- the delivery system 10 also includes a collimator 30 to further tailor the neutron beam 26 prior to delivery to a patient.
- the delivery system 10 is housed on a balanced rotating structure 34.
- the neutron delivery system 10 of FIG. 1 shows a cyclotron 14, the delivery system may have various embodiments. More specifically, the cyclotron 14 of FIG. 1, may be replaced by a compact superconducting cyclotron, or other means for producing a proton or deuteron beam.
- the neutron delivery system 10 should enable a user to produce proton beams with various energy levels.
- a preferred energy range of a proton beam is in the 50-70 MeV range.
- the neutron delivery system 10 typically uses magnets 18 to create a bending magnet system that directs the proton beam 16 into the target 22.
- the target 22 is capable of producing at least one neutron beam having a high energy component in the 30-60 MeV range and a low-energy component in the
- the target 22 is composed of a plurality of layers. Although in a preferred embodiment the target 22 has two layers, i.e., a layer of beryllium 40 and a layer of tungsten 44, in another embodiment, the target has a third layer of carbon 48.
- the layer of beryllium 40 is about five millimeters thick and the layer of tungsten 44 is about four millimeters thick.
- the layer of carbon may be placed between the two other layers.
- the layer may be made of lithium or other material to produce a neutron beam. Different targets and projectiles will produce different types of neutron sources.
- the bimodal effect of the target 22 can be accomplished with a target that has the following combination of layers: a proton-neutron conversion region; a neutron filtering subassembly; a spectral filter for modifying the neutron beam; and a plurality of filters for flattening and wedging purposes.
- the proton-neutron conversion region is often made up of a layer of beryllium operably attached to a layer of tungsten.
- the layer of beryllium can have a thickness of between about 3 to about 10 millimeters while the layer of tungsten can have a thickness of between about 1 to about 7 millimeters.
- the system may be used in a particular case for fast-neutron therapy without neutron capture augmentation it may be desirable to preferably attenuate the low-energy component of the bimodal spectrum by use of a filtering subassembly composed of a hydrogeneous material such as polyethylene.
- the spectral filter for producing a neutron beam from the neutron filtering subassembly can be adjustable by an operator. The operator has the option of producing a spectrum having a bimodal shape or otherwise.
- the tailored neutron beam is typically collimated to transverse dimensions of from 5 to 30 centimeters by from 5 to 30 centimeters.
- the half-value depth of the fast-neutron dose profile is typically from 17 to 21 centimeters, and a scalar thermal -neutron fluency field of from 2 to 5 x 10 10 neutron per square centimeter (2200 meters per second equivalent) per 100 centigrays of fast neutron dose is simultaneously generated at a 5 centimeter depth on-axis.
- the spectral filter means may also be made of tungsten, bismuth, and/or iron, depending on the desired effect.
- the bimodal shape of the spectrum is a function of energy as the result of the action of the target and/or filter.
- the filters for flattening and wedging purposes are such that the neutron beam is flattened and tilted.
- the plurality of filters for flattening and wedging purposes may be composed of tungsten or iron.
- the filters may also include a hydrogenous material for reducing the low-energy component of the spectrum. This hydrogenous material is commonly polyethylene.
- the collimator 30 of FIG. 1, to further tailor the neutron beam prior to delivery to a patient, may be a multi -segment collimator wherein the neutron beam may be further tailored prior to delivery to the patient.
- the beam should be delivered to the patient at an isocenter 18.
- the collimator 30 may be made of iron and/or bismuth.
- the neutron delivery system is housed in a balanced rotating structure 34.
- a balanced rotating structure 34 One possible embodiment for housing the system is a rotating isocentric gantry structure.
- the gantry structure contains all system components. These components are held in a manner such that the tailored neutron beam from the collimator is easily moved for exposing the target to be treated in different directions.
- the balanced rotating structure for housing the system has numerous parts that must work together.
- the structure has a housing 50 that is mounted in a large circular opening in an interior wall 54 of the building where the system is installed.
- This interior wall 54 is quite thick so that it is capable of neutron shielding and able to support the weight of the structure.
- the housing 50 is mounted on roller bearings to assist the housing to rotate within the wall 54.
- Rotating the housing 50 on the bearings 56 is accomplished with a ring gear 58.
- the ring gear 58 is wrapped circumferentially around a periphery of the housing 50.
- the ring gear 58 is operated by at least one drive motor 59.
- the drive motor 59 is mechanically coupled to the ring gear 58 to engage the ring gear and facilitate rotation of the balanced rotating structure.
- the structure as a whole can then be easily rotated about an isocenter 38 (see FIG. 1).
- One skilled in art and viewing the housing of the present invention would be enabled to make and use the above described ring gear and drive motor for rotating the housing.
- the method for using a neutron delivery system to provide improved tumor control capability during medical therapy is accomplished through the following steps: producing a proton beam; directing the proton beam into at least one target; creating at least one neutron beam having a bimodal energy spectrum for use with both fast-neutron therapy and boron neutron capture therapy; tailoring the at least one neutron beam by means of a filter collimator system; delivering the tailored at least one neutron beam to a patient; and housing the system in a balanced rotating structure for ease of adjustment.
- This method may be further defined to specify that the step of producing a proton beam comprises producing a proton beam in the
- This proton beam may be produced with any particle accelerator, e.g., a typical cyclotron or a superconducting cyclotron.
- the proton beam is then used to create at least one neutron beam when the proton beam impacts with at least one target.
- This collision produces a neutron beam that has a bimodal energy spectrum because of the properties of the material in the target.
- the bimodal energy spectrum is a neutron beam(s) that has neutrons with various energy levels.
- at least one neutron beam has a high energy component in the 30-60 MeV range and a low-energy component in the 10 KeV to 2 MeV range.
- the method described above may be accomplished by creating a single tailored neutron beam.
- This single tailored neutron beam is created by exposing a specially designed target with the neutron beam and/or by the use of spectral filters to eliminate or enhance neutrons of certain energies.
Landscapes
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- High Energy & Nuclear Physics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Plasma & Fusion (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97946333A EP0894017A2 (en) | 1996-10-25 | 1997-10-23 | System and method for delivery of neutron beams for medical therapy |
AU51525/98A AU5152598A (en) | 1996-10-25 | 1997-10-23 | System and method for delivery of neutron beams for medical therapy |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2923496P | 1996-10-25 | 1996-10-25 | |
US60/029,234 | 1996-10-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998017342A2 true WO1998017342A2 (en) | 1998-04-30 |
WO1998017342A3 WO1998017342A3 (en) | 1998-06-11 |
Family
ID=21847967
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/019503 WO1998017342A2 (en) | 1996-10-25 | 1997-10-23 | System and method for delivery of neutron beams for medical therapy |
Country Status (5)
Country | Link |
---|---|
US (1) | US5920601A (en) |
EP (1) | EP0894017A2 (en) |
AU (1) | AU5152598A (en) |
WO (1) | WO1998017342A2 (en) |
ZA (1) | ZA979551B (en) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007093965A1 (en) * | 2006-02-14 | 2007-08-23 | Accelerators For Industrial & Medical Applications. Engineering Promotions Society. Aima.Eps | A neutron therapy target and installation, and a method of producing neutrons |
KR101500247B1 (en) * | 2013-12-31 | 2015-03-06 | 가톨릭대학교 산학협력단 | Neutron therapy equipment with PET and SPECT collimator |
US9622335B2 (en) | 2012-09-28 | 2017-04-11 | Mevion Medical Systems, Inc. | Magnetic field regenerator |
US9661736B2 (en) | 2014-02-20 | 2017-05-23 | Mevion Medical Systems, Inc. | Scanning system for a particle therapy system |
US9681531B2 (en) | 2012-09-28 | 2017-06-13 | Mevion Medical Systems, Inc. | Control system for a particle accelerator |
US9706636B2 (en) | 2012-09-28 | 2017-07-11 | Mevion Medical Systems, Inc. | Adjusting energy of a particle beam |
US9723705B2 (en) | 2012-09-28 | 2017-08-01 | Mevion Medical Systems, Inc. | Controlling intensity of a particle beam |
US9730308B2 (en) | 2013-06-12 | 2017-08-08 | Mevion Medical Systems, Inc. | Particle accelerator that produces charged particles having variable energies |
US9925395B2 (en) | 2005-11-18 | 2018-03-27 | Mevion Medical Systems, Inc. | Inner gantry |
US9950194B2 (en) | 2014-09-09 | 2018-04-24 | Mevion Medical Systems, Inc. | Patient positioning system |
US9962560B2 (en) | 2013-12-20 | 2018-05-08 | Mevion Medical Systems, Inc. | Collimator and energy degrader |
US10155124B2 (en) | 2012-09-28 | 2018-12-18 | Mevion Medical Systems, Inc. | Controlling particle therapy |
US10254739B2 (en) | 2012-09-28 | 2019-04-09 | Mevion Medical Systems, Inc. | Coil positioning system |
US10258810B2 (en) | 2013-09-27 | 2019-04-16 | Mevion Medical Systems, Inc. | Particle beam scanning |
US10646728B2 (en) | 2015-11-10 | 2020-05-12 | Mevion Medical Systems, Inc. | Adaptive aperture |
US10653892B2 (en) | 2017-06-30 | 2020-05-19 | Mevion Medical Systems, Inc. | Configurable collimator controlled using linear motors |
USRE48047E1 (en) | 2004-07-21 | 2020-06-09 | Mevion Medical Systems, Inc. | Programmable radio frequency waveform generator for a synchrocyclotron |
US10675487B2 (en) | 2013-12-20 | 2020-06-09 | Mevion Medical Systems, Inc. | Energy degrader enabling high-speed energy switching |
USRE48317E1 (en) | 2007-11-30 | 2020-11-17 | Mevion Medical Systems, Inc. | Interrupted particle source |
US10925147B2 (en) | 2016-07-08 | 2021-02-16 | Mevion Medical Systems, Inc. | Treatment planning |
US11103730B2 (en) | 2017-02-23 | 2021-08-31 | Mevion Medical Systems, Inc. | Automated treatment in particle therapy |
US11291861B2 (en) | 2019-03-08 | 2022-04-05 | Mevion Medical Systems, Inc. | Delivery of radiation by column and generating a treatment plan therefor |
EP4379038A2 (en) | 2022-12-02 | 2024-06-05 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Method and device for porating and loading cells, especially immunocompetent cells |
EP4379051A2 (en) | 2022-12-02 | 2024-06-05 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Method and device for porating and loading cells, especially immunocompetent cells |
DE102022132082A1 (en) | 2022-12-02 | 2024-06-13 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Process for the preparation of immunocompetent cells genetically transfected and loaded with nanoparticles and/or a cytotoxic substance, as well as immunocompetent cells and medical composition. |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6130926A (en) * | 1999-07-27 | 2000-10-10 | Amini; Behrouz | Method and machine for enhancing generation of nuclear particles and radionuclides |
WO2002090933A2 (en) | 2001-05-08 | 2002-11-14 | The Curators Of The University Of Missouri | Method and apparatus for generating thermal neutrons |
DE10203591B4 (en) * | 2002-01-23 | 2008-09-18 | Helmholtz-Zentrum Berlin Für Materialien Und Energie Gmbh | Neutron optical component arrangement for the targeted spectral design of neutron beams or pulses |
US7957507B2 (en) | 2005-02-28 | 2011-06-07 | Cadman Patrick F | Method and apparatus for modulating a radiation beam |
US8232535B2 (en) | 2005-05-10 | 2012-07-31 | Tomotherapy Incorporated | System and method of treating a patient with radiation therapy |
JP2009502251A (en) | 2005-07-22 | 2009-01-29 | トモセラピー・インコーポレーテッド | System and method for evaluating dose delivered by a radiation therapy system |
CA2616304A1 (en) | 2005-07-22 | 2007-02-01 | Tomotherapy Incorporated | System and method of delivering radiation therapy to a moving region of interest |
CA2616292A1 (en) * | 2005-07-22 | 2007-02-01 | Tomotherapy Incorporated | Method and system for evaluating quality assurance criteria in delivery of a treament plan |
US8442287B2 (en) | 2005-07-22 | 2013-05-14 | Tomotherapy Incorporated | Method and system for evaluating quality assurance criteria in delivery of a treatment plan |
KR20080039916A (en) | 2005-07-22 | 2008-05-07 | 토모테라피 인코포레이티드 | System and method of delivering radiation therapy to a moving region of interest |
EP3175886B1 (en) * | 2005-07-23 | 2018-06-27 | TomoTherapy, Inc. | Radiation therapy imaging and delivery utilizing coordinated motion of gantry and couch |
DE102007032025A1 (en) * | 2007-07-10 | 2008-12-18 | Siemens Ag | Particle therapy installation for treating patients with cancer comprises a cylindrical gantry rotating about a rotary axis with a rotating beam generator and a beam channel for guiding the particle beam produced |
US8003964B2 (en) | 2007-10-11 | 2011-08-23 | Still River Systems Incorporated | Applying a particle beam to a patient |
US8933650B2 (en) | 2007-11-30 | 2015-01-13 | Mevion Medical Systems, Inc. | Matching a resonant frequency of a resonant cavity to a frequency of an input voltage |
AU2009212487B2 (en) * | 2008-02-05 | 2014-03-27 | The Curators Of The University Of Missouri | Radioisotope production and treatment of solution of target material |
RU2494484C2 (en) | 2008-05-02 | 2013-09-27 | Шайн Медикал Текнолоджис, Инк. | Production device and method of medical isotopes |
US20100169134A1 (en) * | 2008-12-31 | 2010-07-01 | Microsoft Corporation | Fostering enterprise relationships |
US8624502B2 (en) * | 2009-05-15 | 2014-01-07 | Alpha Source Llc | Particle beam source apparatus, system and method |
WO2012003009A2 (en) | 2010-01-28 | 2012-01-05 | Shine Medical Technologies, Inc. | Segmented reaction chamber for radioisotope production |
US10734126B2 (en) | 2011-04-28 | 2020-08-04 | SHINE Medical Technologies, LLC | Methods of separating medical isotopes from uranium solutions |
JP2013206726A (en) * | 2012-03-28 | 2013-10-07 | High Energy Accelerator Research Organization | Composite target, neutron generation method using composite target, and neutron generator using composite target |
WO2013187974A2 (en) | 2012-04-05 | 2013-12-19 | Shine Medical Technologies, Inc. | Aqueous assembly and control method |
JP6254600B2 (en) | 2012-09-28 | 2017-12-27 | メビオン・メディカル・システムズ・インコーポレーテッド | Particle accelerator |
CN104813748B (en) | 2012-09-28 | 2019-07-09 | 梅维昂医疗系统股份有限公司 | Focused particle beam |
EP2901824B1 (en) | 2012-09-28 | 2020-04-15 | Mevion Medical Systems, Inc. | Magnetic shims to adjust a position of a main coil and corresponding method |
WO2014133849A2 (en) | 2013-02-26 | 2014-09-04 | Accuray Incorporated | Electromagnetically actuated multi-leaf collimator |
US8791656B1 (en) | 2013-05-31 | 2014-07-29 | Mevion Medical Systems, Inc. | Active return system |
RU2526244C1 (en) * | 2013-08-28 | 2014-08-20 | Федеральное государственное бюджетное учреждение "Медицинский радиологический научный центр" Министерства здравоохранения РФ (ФГБУ МРНЦ Минздрава России) | Apparatus for remote neutron therapy |
US11239003B2 (en) | 2016-04-21 | 2022-02-01 | Kaneka Corporation | Support substrate for radioisotope production, target plate for radioisotope production, and production method for support substrate |
CN109074890B (en) * | 2016-04-21 | 2023-07-04 | 株式会社钟化 | Target, method for producing target, and neutron generator |
US11177116B2 (en) | 2016-04-28 | 2021-11-16 | Kaneka Corporation | Beam intensity converting film, and method of manufacturing beam intensity converting film |
EP3456381B1 (en) | 2016-07-04 | 2020-04-08 | Neuboron Medtech Ltd. | Neutron therapy device |
CN109925611B (en) * | 2017-12-18 | 2024-04-16 | 南京中硼联康医疗科技有限公司 | Neutron capture therapeutic device |
CN111821583A (en) * | 2019-04-22 | 2020-10-27 | 苏州雷泰医疗科技有限公司 | Accelerator treatment device and treatment method |
US11517769B2 (en) * | 2019-07-10 | 2022-12-06 | Ricoh Company, Ltd. | Neutron beam transmission adjusting device comprising a neutron beam transmission unit including a neutron reactant, method for producing neutron beam transmission adjusting device, and neutron beam adjusting method |
CN111888664A (en) * | 2020-08-05 | 2020-11-06 | 合肥中科离子医学技术装备有限公司 | Neutron capture treatment system based on superconducting cyclotron |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3715597A (en) | 1969-09-26 | 1973-02-06 | Licentia Gmbh | Rotatable neutron therapy irradiating apparatus |
US3781564A (en) | 1973-02-28 | 1973-12-25 | Elliott Bros | Neutron beam collimators |
US4112306A (en) | 1976-12-06 | 1978-09-05 | Varian Associates, Inc. | Neutron irradiation therapy machine |
US4139777A (en) | 1975-11-19 | 1979-02-13 | Rautenbach Willem L | Cyclotron and neutron therapy installation incorporating such a cyclotron |
US4666651A (en) | 1982-04-08 | 1987-05-19 | Commissariat A L'energie Atomique | High energy neutron generator |
US5392319A (en) | 1992-12-22 | 1995-02-21 | Eggers & Associates, Inc. | Accelerator-based neutron irradiation |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE440600B (en) * | 1979-05-17 | 1985-08-12 | Scanditronix Instr | DEVICE FOR IRRATION OF A MATERIAL VOLUME WITH A RADIATION OF LOADED PARTICLES |
US5433693A (en) * | 1992-12-31 | 1995-07-18 | Ott; Karl O. | Neutron-capture therapy apparatus and method |
US5630786A (en) * | 1994-06-27 | 1997-05-20 | Ionix Corporation | Boron neutron capture enhancement of fast neutron therapy |
US5658233A (en) * | 1995-09-19 | 1997-08-19 | Battelle Memorial Institute | Neutron capture therapy with deep tissue penetration using capillary neutron focusing |
-
1997
- 1997-10-21 US US08/955,194 patent/US5920601A/en not_active Expired - Fee Related
- 1997-10-23 WO PCT/US1997/019503 patent/WO1998017342A2/en not_active Application Discontinuation
- 1997-10-23 EP EP97946333A patent/EP0894017A2/en not_active Withdrawn
- 1997-10-23 AU AU51525/98A patent/AU5152598A/en not_active Abandoned
- 1997-10-24 ZA ZA9709551A patent/ZA979551B/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3715597A (en) | 1969-09-26 | 1973-02-06 | Licentia Gmbh | Rotatable neutron therapy irradiating apparatus |
US3781564A (en) | 1973-02-28 | 1973-12-25 | Elliott Bros | Neutron beam collimators |
US4139777A (en) | 1975-11-19 | 1979-02-13 | Rautenbach Willem L | Cyclotron and neutron therapy installation incorporating such a cyclotron |
US4112306A (en) | 1976-12-06 | 1978-09-05 | Varian Associates, Inc. | Neutron irradiation therapy machine |
US4666651A (en) | 1982-04-08 | 1987-05-19 | Commissariat A L'energie Atomique | High energy neutron generator |
US5392319A (en) | 1992-12-22 | 1995-02-21 | Eggers & Associates, Inc. | Accelerator-based neutron irradiation |
Cited By (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE48047E1 (en) | 2004-07-21 | 2020-06-09 | Mevion Medical Systems, Inc. | Programmable radio frequency waveform generator for a synchrocyclotron |
US9925395B2 (en) | 2005-11-18 | 2018-03-27 | Mevion Medical Systems, Inc. | Inner gantry |
US10279199B2 (en) | 2005-11-18 | 2019-05-07 | Mevion Medical Systems, Inc. | Inner gantry |
US10722735B2 (en) | 2005-11-18 | 2020-07-28 | Mevion Medical Systems, Inc. | Inner gantry |
WO2007093965A1 (en) * | 2006-02-14 | 2007-08-23 | Accelerators For Industrial & Medical Applications. Engineering Promotions Society. Aima.Eps | A neutron therapy target and installation, and a method of producing neutrons |
USRE48317E1 (en) | 2007-11-30 | 2020-11-17 | Mevion Medical Systems, Inc. | Interrupted particle source |
US9681531B2 (en) | 2012-09-28 | 2017-06-13 | Mevion Medical Systems, Inc. | Control system for a particle accelerator |
US9723705B2 (en) | 2012-09-28 | 2017-08-01 | Mevion Medical Systems, Inc. | Controlling intensity of a particle beam |
US9706636B2 (en) | 2012-09-28 | 2017-07-11 | Mevion Medical Systems, Inc. | Adjusting energy of a particle beam |
US10155124B2 (en) | 2012-09-28 | 2018-12-18 | Mevion Medical Systems, Inc. | Controlling particle therapy |
US10254739B2 (en) | 2012-09-28 | 2019-04-09 | Mevion Medical Systems, Inc. | Coil positioning system |
US9622335B2 (en) | 2012-09-28 | 2017-04-11 | Mevion Medical Systems, Inc. | Magnetic field regenerator |
US10368429B2 (en) | 2012-09-28 | 2019-07-30 | Mevion Medical Systems, Inc. | Magnetic field regenerator |
US9730308B2 (en) | 2013-06-12 | 2017-08-08 | Mevion Medical Systems, Inc. | Particle accelerator that produces charged particles having variable energies |
US10456591B2 (en) | 2013-09-27 | 2019-10-29 | Mevion Medical Systems, Inc. | Particle beam scanning |
US10258810B2 (en) | 2013-09-27 | 2019-04-16 | Mevion Medical Systems, Inc. | Particle beam scanning |
US9962560B2 (en) | 2013-12-20 | 2018-05-08 | Mevion Medical Systems, Inc. | Collimator and energy degrader |
US10675487B2 (en) | 2013-12-20 | 2020-06-09 | Mevion Medical Systems, Inc. | Energy degrader enabling high-speed energy switching |
KR101500247B1 (en) * | 2013-12-31 | 2015-03-06 | 가톨릭대학교 산학협력단 | Neutron therapy equipment with PET and SPECT collimator |
US11717700B2 (en) | 2014-02-20 | 2023-08-08 | Mevion Medical Systems, Inc. | Scanning system |
US10434331B2 (en) | 2014-02-20 | 2019-10-08 | Mevion Medical Systems, Inc. | Scanning system |
US9661736B2 (en) | 2014-02-20 | 2017-05-23 | Mevion Medical Systems, Inc. | Scanning system for a particle therapy system |
US9950194B2 (en) | 2014-09-09 | 2018-04-24 | Mevion Medical Systems, Inc. | Patient positioning system |
US10786689B2 (en) | 2015-11-10 | 2020-09-29 | Mevion Medical Systems, Inc. | Adaptive aperture |
US11213697B2 (en) | 2015-11-10 | 2022-01-04 | Mevion Medical Systems, Inc. | Adaptive aperture |
US11786754B2 (en) | 2015-11-10 | 2023-10-17 | Mevion Medical Systems, Inc. | Adaptive aperture |
US10646728B2 (en) | 2015-11-10 | 2020-05-12 | Mevion Medical Systems, Inc. | Adaptive aperture |
US10925147B2 (en) | 2016-07-08 | 2021-02-16 | Mevion Medical Systems, Inc. | Treatment planning |
US11103730B2 (en) | 2017-02-23 | 2021-08-31 | Mevion Medical Systems, Inc. | Automated treatment in particle therapy |
US10653892B2 (en) | 2017-06-30 | 2020-05-19 | Mevion Medical Systems, Inc. | Configurable collimator controlled using linear motors |
US11311746B2 (en) | 2019-03-08 | 2022-04-26 | Mevion Medical Systems, Inc. | Collimator and energy degrader for a particle therapy system |
US11717703B2 (en) | 2019-03-08 | 2023-08-08 | Mevion Medical Systems, Inc. | Delivery of radiation by column and generating a treatment plan therefor |
US11291861B2 (en) | 2019-03-08 | 2022-04-05 | Mevion Medical Systems, Inc. | Delivery of radiation by column and generating a treatment plan therefor |
EP4379038A2 (en) | 2022-12-02 | 2024-06-05 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Method and device for porating and loading cells, especially immunocompetent cells |
EP4379051A2 (en) | 2022-12-02 | 2024-06-05 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Method and device for porating and loading cells, especially immunocompetent cells |
DE102022132082A1 (en) | 2022-12-02 | 2024-06-13 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Process for the preparation of immunocompetent cells genetically transfected and loaded with nanoparticles and/or a cytotoxic substance, as well as immunocompetent cells and medical composition. |
DE102022132083A1 (en) | 2022-12-02 | 2024-06-13 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Device for porating and loading cells and method therefor |
DE102022132084A1 (en) | 2022-12-02 | 2024-06-13 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Device for porating and loading cells and method therefor |
EP4385526A1 (en) | 2022-12-02 | 2024-06-19 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Method for loading immunocompetent cells with nanoparticles and/or a cytotoxic substance and immunocompetent cells for use in theranostic treatment |
DE102022132082B4 (en) | 2022-12-02 | 2024-08-08 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Process for the preparation of immunocompetent cells genetically transfected and loaded with nanoparticles and/or a cytotoxic substance, as well as immunocompetent cells and medical composition. |
DE102022132084B4 (en) | 2022-12-02 | 2024-08-22 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Device for porating and loading cells and method therefor |
DE102022132083B4 (en) | 2022-12-02 | 2024-08-22 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Device for porating and loading cells and method therefor |
Also Published As
Publication number | Publication date |
---|---|
AU5152598A (en) | 1998-05-15 |
EP0894017A2 (en) | 1999-02-03 |
ZA979551B (en) | 1998-06-10 |
US5920601A (en) | 1999-07-06 |
WO1998017342A3 (en) | 1998-06-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5920601A (en) | System and method for delivery of neutron beams for medical therapy | |
US10603516B2 (en) | Neutron source for neutron capture therapy | |
Chu et al. | Instrumentation for treatment of cancer using proton and light‐ion beams | |
US8109865B2 (en) | Antiproton production and delivery for imaging and termination of undesirable cells | |
US7826593B2 (en) | Collimator | |
US10556127B2 (en) | Neutron therapy apparatus | |
EP3666337B1 (en) | Neutron capture therapy system | |
RU2707651C1 (en) | Apparatus for neutron therapy | |
CN105120954A (en) | Compact proton therapy system with energy selection onboard a rotatable gantry | |
WO2011091104A1 (en) | Method for biological modulation of radiation therapy | |
JP2008022920A (en) | Medical apparatus for boron neutron capture therapy | |
JP3079346B2 (en) | 3D particle beam irradiation equipment | |
Orton | Uses of therapeutic X-rays in medicine | |
CN107569779B (en) | Neutron therapeutic device | |
CN206167654U (en) | Neutron treatment device | |
Kawachi et al. | Radiation oncological facilities of the HIMAC | |
CN206081353U (en) | Neutron treatment device | |
JPH1157042A (en) | Radiation irradiator | |
Nigg | Neutron Sources and Applications in Radiotherapy-A Brief History, and Current Trends | |
CN107569778B (en) | Neutron therapeutic device | |
Svensson et al. | Design of a fast multileaf collimator for radiobiological optimized IMRT with scanned beams of photons, electrons, and light ions | |
Alonso | Hadron particle therapy | |
Brahme et al. | Development of a center for light ion therapy and accurate tumor diagnostics at karolinska institutet and hospital | |
Madey | The potential of negative pions for cancer radiation therapy | |
Nunan | Neutron irradiation therapy machine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1997946333 Country of ref document: EP |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWP | Wipo information: published in national office |
Ref document number: 1997946333 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
NENP | Non-entry into the national phase |
Ref country code: JP Ref document number: 1998519715 Format of ref document f/p: F |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1997946333 Country of ref document: EP |