WO1998014387A1 - Contamination-safe multiple-dose dispensing cartridge for flowable materials - Google Patents
Contamination-safe multiple-dose dispensing cartridge for flowable materials Download PDFInfo
- Publication number
- WO1998014387A1 WO1998014387A1 PCT/US1997/017881 US9717881W WO9814387A1 WO 1998014387 A1 WO1998014387 A1 WO 1998014387A1 US 9717881 W US9717881 W US 9717881W WO 9814387 A1 WO9814387 A1 WO 9814387A1
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- WO
- WIPO (PCT)
- Prior art keywords
- dispensing
- container
- dispensing cartridge
- cartridge
- flowable material
- Prior art date
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
- B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
- B65D47/205—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure the valve being formed by a tubular flexible sleeve surrounding a rod-like element provided with at least one radial passageway which is normally closed by the sleeve
Definitions
- the field of the invention relates generally to dispensing devices for delivering flowable materials such as liquids, solutions, dispersions, suspensions, gels, pastes and other fluids. More particularly, the field of the invention relates to a dispensing system for delivering multiple doses of flowable materials and for preventing the influx of external contaminants during and between deliveries.
- the dispensing of flowable materials in a contamination-safe manner presents many difficulties.
- the main problems relate to precise flow control and prevention of back flow or reflux. In fact, external contaminants easily can enter a container with the back flow at the end of the delivery cycle.
- collapsible containers for flowable materials have a discharge port such as a hole, nozzle, spout or other type of opening.
- the contents such as pastes, liquids or other fluids exit through the discharge port propelled by internal pressure.
- a dispensing apparatus has a valve mechanism to ensure precise delivery.
- U.S. Patent 5,033,655 Brown teaches how to dispense fluid products from a non-collapsible container by employing a system with a slit valve. The system admits air to prevent the collapse of the container as fluid is delivered to the user. Thus, external contaminants borne by air are forced into the solution remaining in the container.
- Such dispensing apparatus is not suitable for contamination-safe dispensing from collapsible containers.
- a simple discharge nozzle is presented by Latham in U.S. Patent 5,398,853.
- the nozzle is adapted for the delivery of pastes, e.g., toothpaste.
- pastes e.g., toothpaste.
- Debush discloses a modification to the applicant's prior U.S. Reissue 34,243 relying on an expandable elastomeric sleeve tightly fitted about a valve body with entry and exit ports.
- Debush's improvement is aimed at simplifying the assembly.
- his solution requires more material to manufacture the valve.
- it is difficult to produce a discoid-shaped valve for this invention and adapt the apparatus to collapsible containers.
- Pardes discloses a rigid enclosing sleeve to retain the elastomeric sheath against the valve body, thus providing a seal between the sheath and the valve body. This is closely related to the applicant's teaching in U.S. Reissue 34,243. Pardes' valve operates through two sets of ports within a valve body, thus rendering the device unnecessarily complex.
- None of the known conventional dispensing devices are low-cost, simple in construction and capable of delivering a flowable material ranging from low to high viscosity. Furthermore, conventional devices can not be easily adapted to collapsible containers, i.e., containers which do not produce an internal vacuum when their contents are expelled.
- the dispensing cartridge of the invention should thwart the back flow or reflux of the flowable material. This will prevent external contaminants from entering the container through the dispensing cartridge during and after delivery of the flowable material.
- a multiple-dose dispensing cartridge is designed to dispense a flowable material from a collapsible container, i.e., from a container of the type which does not produce an internal vacuum as the flowable material is dispensed.
- the cartridge prevents external contaminants from entering the container by virtue of its construction.
- the cartridge has a housing and an attaching mechanism for attaching the housing to the delivery port of the container in an airtight manner.
- a delivery block located inside the housing has an input port for receiving the flowable material exiting the container through the delivery port.
- An internal channel commencing at the input port and terminating in at least one output port runs through the delivery block.
- a flexible sheath envelops the delivery block such that a portion of the sheath covers the output port or ports to thus produce one or more sleeve valves permitting only the outflow of the flowable material from the output port or ports.
- the cartridge has an outlet valve formed by an end of the flexible sheath downstream of the one or more sleeve valves.
- the outlet valve also permits only the outflow of the flowable material.
- the outlet valve formed by the end of the sheath is a duck bill valve, a slit valve or a flapper valve.
- the outlet is formed by the end of the flexible sheath without creating an actual valve.
- the cartridge of the invention has a dispensing port in the housing for dispensing the flowable material exiting from the outlet valve or outlet created by the flexible sheath.
- the cartridge of the invention can be mounted on collapsible containers such as tubes, bags, infusion containers, syringes, pouches, collapsible reservoirs, bellows- type containers and the like.
- the attachment mechanism will depend on the type of container and may generally be constituted by an adhesive seal, a screw-on neck, a press-fit neck, a bonding seal, a heat seal or other joining material or element.
- the housing is preferably made of a moldable material and is rigid. This is necessary to arrest the expansion of the flexible sheath and prevent abrasion of the sheath as the flowable material is being dispensed.
- the flexible sheath is preferably made of a moldable thermoplastic elastomer. Exemplary materials which can be utilized in making the sheath include styrene-butadiene styrene, silicone, urethane, rubber and the like.
- the sheath is affixed on the delivery block to prevent slip-off and ensure proper operation of the sleeve valve or valves.
- the sheath is pinched between the delivery block and the housing.
- the inner diameter of the sheath in undistended state is smaller than the outer diameter of the delivery block.
- the preferred range of inner diameters is 0.5 to 0.8 times the outer diameter of the delivery block.
- the cartridge of the invention 1 is effective in preventing the entry of air and its constituents, oxygen, nitrogen, water vapor and other atmospheric gases as well as other air-borne contaminants including smoke, dust, pollen and microorganisms.
- the contents of the collapsible container is protected from degradation due to these types of external contaminants.
- the dispensing cartridge can be permanently bonded to the container, e.g., by the manufacturer such "that the container and cartridge constitute an integrated dispensing system.
- Fig. 1 is a three dimensional sectional view of a dispensing cartridge according to the invention.
- Fig. 2 is a cross sectional view of the dispensing cartridge of Fig. 1 before delivery.
- F Fiigg.. 33 is a cross sectional view of the dispensing cartridge of Fig. 1 during delivery.
- Fig. 4 is a three dimensional view of the tip portion of the cartridge of
- Fig. 5 is a three dimensional view of a portion of the outlet valve.
- F Fiigg.. 66 is a three dimensional view of a delivery block for the cartridge of the invention.
- Fig. 7 is a plan sectional view of a dispensing cartridge according to the invention mounted on a tube.
- Fig. 8 is a plan sectional view of a dispensing cartridge according to the invention mounted on a syringe.
- Fig. 9 is a cross sectional view of a dispensing cartridge according to the invention without an outlet valve.
- Fig. 10 is a cross sectional view of another dispensing cartridge without an outlet valve.
- Fig. 11 is a cross sectional view of yet another dispensing cartridge according to the invention mounted on a bellows-type container
- FIG. 1 A preferred embodiment of a dispensing cartridge 10 assembled in a housing 12 is shown in Fig. 1.
- housing 12 is made of a moldable material which is rigid and inert.
- cartridge 10 is mounted on a collapsible container 14, of which only the top portion is shown.
- neck 16 In practice it will be oftentimes desirable to considerably reduce the dimensions of cartridge 10, e.g., to constitute a small extension of neck 16 or protmde into or be embedded in neck 16.
- neck 16 has a neck threading 18 which cooperates with a cartridge threading 20 on the lower portion of housing 12.
- cartridge 10 is mounted on container 14 in an air-tight manner by screwing housing 12 onto neck 16.
- a flowable material 22 is stored in container 14.
- material 22 is a liquid or fluid which requires careful dispensing and protection from external contaminants 26.
- contaminants 26 can be broken down into particulates or other matter 28 such as air and its constituents, oxygen, nitrogen, water vapor and other atmospheric gases as well as other airborne contaminants including smoke, dust, pollen and microorganisms.
- the last group consists of yeasts, molds, bacteria, protozoa and diverse viruses.
- Many flowable products, such as medicines, chemicals, health-care materials, personal hygiene materials, edibles and other flowable goods require protection from at least one of the above-listed contaminants 26. These products are encountered in domestic, commercial and industrial settings.
- Neck 16 terminates in an opening or delivery port 24.
- Flowable material 22 exits container 14 through port 24 to enter dispensing cartridge 10.
- cartridge 10 has a delivery block 30 whose lower po ⁇ ion exhibits an input port 32 for receiving material 22.
- Delivery port 24 is pressed firmly and tightly against the bottom of delivery block 30 when cartridge 10 is mounted on container 14. In this way delivery port 24 feeds directly into input port 32.
- Delivery block 30 has an internal channel 34 commencing at input port 32 and terminating in two output ports 36 and 38. In fact, channel 34 splits into two branches 40 and 42 leading to output ports 36 and 38 respectively. In this embodiment output ports 36 and 38 are arranged on diametrically opposite faces of delivery block 30. This geometrical placement of ports 36 and 38 is preferred because it is easily manufactured and ensures their largest circumferential separation.
- a flexible sheath 44 stretches over or envelops delivery block 30.
- the material of flexible sheath 44 is a moldable thermoplastic elastomer.
- the most preferred ones include styrene-butadiene styrene, silicone, urethane and rubber.
- the inner diameter of sheath 44 should most preferably range from 0.5 to 0.8 times the outer diameter of delivery block 30.
- Another provision for securing sheath 44 in place over delivery block 30 includes an inward bulge or protrusion 50 extending circumferentially around delivery
- delivery block 30 has a groove 52 for receiving protrusion 50.
- Sheath 44 is securely fixed when protrusion 50 is lodged or seated in groove 52 along the circumference of delivery block 30.
- protrusion 50 serves the role of an attaching means for affixing sheath 44 to delivery block 30 below output ports 36 and 38.
- sheath 44 When properly mounted, sheath 44 extends over the sides of delivery block 30 thus covering both output ports 36 and 38. This produces two sleeve valves 46 and 48 at the locations where ports 36 and 38 are covered. By their nature, sleeve valves 46 and 48 are one-way and operate when forced open by pressure at ports
- sheath 44 Downstream of sleeve valves 46 and 48 and generally above delivery block 30 sheath 44 constricts and terminates with an end 54. In fact, in the preferred embodiment illustrated in Fig. 1 end 54 of sheath 44 forms an outlet valve 56.
- outlet valve 56 is a one-way, normally closed valve. In other words, outlet valve 56 will only permit the outflow of flowable material 22 when pressure causes the adhering walls at end 54 to open up outlet valve 56.
- this type of one-way valve is well known and encompasses three particular types: a duck bill valve, a slit valve and a flapper valve. Any one of these can be used as outlet valve 56.
- Housing 12 has a dispensing port 58 in the form of a circular opening at the point of exit of outlet valve 56.
- dispensing port may surround outlet valve 56 and protect end 54 of sheath 44 from contact with external objects. It is also possible for end 54 to protrude beyond the walls of
- housing 12 is such as to conform to the shape of-sheath 44 when delivering flowable material 22. That is because one of the functions of housing 12, besides general protection of the elements of cartridge 10 from the external environmental hazards, is to arrest the expansion of sheath 44. This is necessary to prevent sheath 44 from rupturing and to ensure proper flow delivery characteristics of flowable material 22.
- the inner diameter of housing 12 is chosen to be greater than the outer diameter of delivery block 30 by an amount which depends on the desired rate of delivery of flowable material 22 from outlet valve 56. This choice will also take into consideration the viscosity of flowable material 22 and the elasticity and rupture point of sheath 44. Adequate doses of flowable material 22 are possible with expansion in the diameter of sheath 44 of as little as 500 ⁇ m. It will be obvious to one skilled in the art that smaller or larger expansions in the diameter of sheath 44 may be chosen in specific instances.
- housing 12 also protects sheath 44 from abrasion which could occur if housing 12 were absent as well as when flowable material 22 is being delivered.
- the internal walls of housing 12 are smooth.
- dispensing cartridge 10 The operation of dispensing cartridge 10 is best explained by Figs. 2 and 3.
- Fig. 2 cartridge 10 is disabled, although flowable material 22 is present in internal channel 34 and branches 40 and 42.
- flowable material 22 has passed through neck 16 and delivery port 24 into internal channel 34 through input port 32.
- Sleeve valves 46 and 48 at ports 36 and 38 are closed as sheath 44 tightly envelops delivery block 30.
- the magnified view of sleeve valve 46 shows flowable material 22 wetting sheath 44. Due to insufficient pressure, flowable material 22 is unable to open sleeve valve 46 or 48 Meanwhile, outlet valve 56 remains closed and there is no flowable material 22 downstream of outlet valve 56
- pressure is exerted either on container 14 or on flowable material 22.
- the former can be accomplished by compressing container 14 by manual or mechanical means including a peristaltic pump and the latter by pumping or other internal means of pressure delivery. Under this pressure both sleeve valves 46 and 48 are forced open by flowable material 22. Sheath 44 expands as flowable material 22 fills the space downstream of sleeve valves 46 and 48. Meanwhile, housing 12 prevents excessive expansion of sheath 44 and its rupture or abrasion
- dispensing cartridge 10 is the same during subsequent cycles, since all flowable material 22 trapped downstream of sleeve valves 46 and 48 will always be expelled through outlet valve 56. Dispensing cartridge 10 is thus fit for delivering multiple-doses.
- dispensing cartridge 10 can be mounted on container 14 by the manufacturer or consumer.
- flowable material 22 is a paste, medicinal fluid or edible substance intended for the general consumer market
- cartridge 10 is conveniently factory-installed. Otherwise, the end user can decide when cartridge 10 is required to dispense a particular liquid or fluid.
- dispensing cartridge 10 ensures its operation with materials spanning a wide range of viscosities. Consequently, dispensing cartridge 10 is highly effective and universal. Its contamination-safe operation renders it useful in preserving the purity of virtually any flowable material which is delivered from a container that does not produce an internal vacuum when its contents are expelled.
- dispensing cartridge 10 The construction and materials required to produce dispensing cartridge 10 are low-cost and straightforward to assemble, and the finished product can be easily mounted on or even in any collapsible or reducible container. In the last case, dispensing cartridge 10 can be modified for air-tight seating inside neck 16. The mechanical modifications required are straightforward and easily implemented by a person of average skill in the art.
- dispensing cartridge 10 and container 14 form a highly effective integrated dispensing system.
- Such system is of great value in dispensing flowable materials intended for domestic or commercial consumption. That is because the consumer can be offered a ready-to-use product for delivering multiple-doses in a contamination-free manner.
- Figs. 1-3 can be modified in several ways to render it more suitable for specific applications.
- Fig. 4 illustrates the tip portion of housing 12 with a dispensing port 60. In this case, an outlet valve 62 formed by an end 64 of sheath 44 is completely protected by the high wall of dispensing port 60. This embodiment is more suitable for applications where outlet valve 62 should remain inaccessible from the exterior.
- Fig. 5 affords a more detailed view of an end 66 of a sheath 68 forming an outlet valve 70.
- sheath 68 narrows down to a rectangular opening constituting a slit valve.
- valve 66 will produce different valves with differing flow characteristics.
- the three general classes of valves produced by end 66 of sheath 68 include duck bill valves, slit valves and flapper valves. A person with average skill in the art will be able to determine which particular valve type is best suited for the flowable to be delivered and the dispensing conditions.
- Fig. 6 illustrates a delivery block 72 with numerous output ports 74.
- output ports 74 are located circumferentially at equal spacings along a top portion 76 of delivery block 72.
- Below top portion 76 is located a groove 78 for attaching flexible sheath 44 (not shown).
- Delivery block 72 has a lower portion
- delivery block 72 This particular version of delivery block 72 is well- suited for higher throughput of flowables.
- Fig. 7 shows another embodiment of a dispensing cartridge 90 mounted on a neck 92 of a tube 94.
- This arrangement is designed to dispense a paste 96, e.g., toothpaste.
- a paste 96 e.g., toothpaste.
- the actual size of dispensing cartridge 90 for mounting on a toothpaste tube would be preferably much smaller.
- dispensing cartridge 90 has a housing 98 inside which a flexible sheath 100 envelops a delivery block 102
- sheath 100 is fixed by pinching it in an air-tight manner between housing 98 and delivery block 102
- the bottom of housing 98 has a press-fit neck 104 which fits inside neck 92 of tube 94
- An additional adhesive seal 106, e g , an adhesive agent, can be provided around press-fit neck 104
- Delivery block 102 has an internal channel 106 which commences an input port 108 and splits into two branches 110 and 112 The latter terminate in output ports 114 and 116, forming two sleeve valves 118 and 120 An end 122 of sheath 100 forms an outlet valve 124 Housing 98 has a dispensing port 126 which protects outlet valve 124 from the external environment
- Fig 7 shows dispensing cartridge 90 in the delivery mode
- Sleeve valves 118, 120 and outlet valve 124 are open Paste 96 is being dispensed from dispensing port 126.
- the additional advantage of the embodiment shown in Fig 7 resides in its simplicity
- the pinching of sheath 100 to keep it in place around delivery block 106 is a low-cost solution
- the press-fit established between neck 92 and press-fit neck 104 renders this embodiment suitable for pre-mounting of delivery cartridge 90 by the manufacturer
- Fig 8 shows cartridge 90 of Fig 7 mounted on a syringe 130
- cartridge 90 is attached to a neck 132 of syringe 130 by a bonding seal 134
- the latter is preferably applied-from a dispensing unit (not shown) once cartridge 90 is slid into place on neck 132
- I ⁇ PUBLICVMH3 ⁇ 0103349 01 material of the bonding seal can include any adhesive agent or even an epoxide.
- a heat seal could also be applied, where the bonding material is melted around neck 134.
- a superior connection is achieved in the event neck 134 is itself made of a plastic or other material which can partially melt together with the bonding material.
- a plunger 136 causes a flowable material 97 to be dispensed by cartridge 90 as described above.
- This embodiment is well-suited for delivering medicinal fluids in household and hospital settings.
- Fig. 9 illustrates yet another embodiment of the invention.
- a housing 152 of dispensing cartridge 150 holds a delivery block 154 enveloped by a flexible sheath 156.
- two sleeve valves 158 and 160 are formed at output ports 162 and 164 of delivery block 154.
- An end 166 of sheath 156 in this embodiment produces an outlet 168.
- outlet 168 does not produce a valve.
- sleeve valves 158 and 160 act as before, and outlet 168 allows all flowable material to exit through a dispensing port 170. After dispensing the flowable sheath 156 constricts tightly around delivery block 154.
- Fig. 10 shows yet another embodiment of a dispensing cartridge 170 without an outlet valve.
- branches 174 and 176 of an internal channel 172 form a Y-shape in a delivery block 171.
- a flexible sheath 178 covers up output ports 180 and 182 producing sleeve valves 184 and 186 respectively
- Sheath 178 has a groove 188 for seating a protrusion 189 of delivery block 171. This method of affixing sheath 178 on delivery block 171 is different from the other embodiments where the groove is found in the delivery block.
- FIG. 11 shows a dispensing cartridge 190 mounted on a bellows-type container 192.
- a housing 194 protects a delivery block 196 and a flexible sheath 198 enveloping the former.
- a seat 200 is provided for mounting delivery block 196 inside housing 194 and for providing an air-tight seal against a neck 202 of container 192.
- Sheath 198 has an O-ring 204 and delivery block 196 has a corresponding groove 206 for seating O-ring 204. Attachment of sheath 198 using O-ring 204 is more secure that in the previous embodiments. Therefore, dispensing cartridge 190 is especially well-suited for dispensing flowables under conditions which put a high stress on sheath 198.
- the foregoing aspects of the invention provide a system for dispensing and delivering a wide range of flowable media including liquids, solutions, mixtures, suspensions, dispersions, lotions, creams, gels and salves.
- These flowable media can be either volatile or nonvolatile, aqueous or nonaqueous, and classified as inorganic or organic fluids as well as combinations of these.
- the present invention has application as a dispensing and delivery system for fluids for any industry.
- Said dispensing and delivery ' system advantageously protects said flowable materials from the adverse effects of evaporation, oxidation, and hydrolysis and advantageously prohibits the entry into said flowable media within said dispensing and delivery system of (1) microorganisms such as protozoa, yeast, molds, bacteria, and viruses; or (2) air and one or more of its constituent parts such as nitrogen, oxygen, caron dioxide, and water; or (3) dust, smokes, pollens and filamentous or other particulates; or (4) the evaporation of said flowable material or of one or more of its constituents.
- microorganisms such as protozoa, yeast, molds, bacteria, and viruses
- air and one or more of its constituent parts such as nitrogen, oxygen, caron dioxide, and water
- dust, smokes, pollens and filamentous or other particulates or (4) the evaporation of said flowable material or of one or more of its constituents.
- Examples of said flowable materials that can benefit from the present invention include (1) Human and veterinary pharmaceutical preparations, both ethical and over-the-counter products, including eye and lens care solutions; (2) In vitro and in vivo diagnostic agents, (3) Biologicals, (4) Personal care preparations including cosmetics and fragrances; toiletries; products for the care and treatment of skin, hair and nails; shampoos; hair colorants; health and beauty care products; (3) Hot or cold foods, beverages, nutritional supplements and vitamins; (4) Commercial, institutional, laboratory and industrial chemicals, including but not limited to chemical reagents, detergents, photographic solutions, adhesives, paints, varnishes, lubricants and fuels.
- said dispensing and delivery system enables said flowable media to be reformulated free of preservatives or other protective additives facilitating the therapeutic effect of a human and veterinary pharmaceutical product.
- preservatives can have harmful side effects.
- Preservatives presently in use in eye and lens care solutions cause toxicity reactions and/or allergic reactions in eye tissues.
- Preservatives in prescription eye care products are known to adversely affect the post-surgery healing rate of eye tissues.
- the foregoing advantages of the inventions are not limited to pharmaceuticals, but rather provide other benefits in the dispensing of industrial chemical fluids, photographic solutions, soaps and detergents, paints, varnishes, adhesives and the like substances as well.
- the present system advantageously maintains fluids free from contamination by air, airborne particulates such as dust, fibers, etc. and airborne microbes.
- Protective filters, antimicrobial preservatives, antioxidants and hygroscopic agents are not needed. Therefore, if handled properly, said dispensing and delivery system provides substantial benefits to a fluid by enabling increased purity, increased ease and efficiency of formulation and production, reduction in cost, and a reduction in harmful side reactions.
- the reformulation of photographic development agents without antioxidants, for example would provide substantial benefits in efficiency and in more cost effective formulations.
- the present system advantageously maintains photographic solutions free from contamination by airborne particulates such as dust, fibers, etc. as well making unnecessary the need for mechanical filters or to add antimicrobial preservatives, antioxidants and hygroscopic agents.
- Cleaners used in institutional and restaurant settings are known to be susceptible to the growth of yeasts and molds, even when preservatives are used. Naturally occurring mutations make some specimens resistant to the action of the preservative resulting in preservative-resistant strains.
- the foregoing advantages of the present system make the use of preservatives unnecessary providing the needed sanitation and freedom from contamination by microorganisms.
- Tomato catsup is an acidic medium and a poor nutrient for the growth of microbes. Therefore it is unnecessary to add preservatives.
- tomato catsup oxidizes and turns black.
- the catsup also evaporates forming unsanitary encrustation around the lip of the container.
- Edible oils and wines are additional examples of the damaging effects of oxidation on foods and beverages. Oxygen in air causes the oils to turn rancid and the alcohol to oxidize to acetic acid, i.e., vinegar.
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Pens And Brushes (AREA)
- Packages (AREA)
- Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Control And Other Processes For Unpacking Of Materials (AREA)
- Closures For Containers (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69722227T DE69722227D1 (en) | 1996-10-03 | 1997-10-03 | CARTRIDGE FOR PORTIONAL DISPENSING OF FLOWABLE MEDIA WITHOUT A CLEANING RISK |
EP97910784A EP0929463B1 (en) | 1996-10-03 | 1997-10-03 | Contamination-safe multiple-dose dispensing cartridge for flowable materials |
BR9713252-7A BR9713252A (en) | 1996-10-03 | 1997-10-03 | "multi-dose, contamination-proof dispensing cartridge for flow materials" |
AU48072/97A AU4807297A (en) | 1996-10-03 | 1997-10-03 | Contamination-safe multiple-dose dispensing cartridge for flowable materials |
IL12924797A IL129247A (en) | 1996-10-03 | 1997-10-03 | Contaminatin-safe multiple-dose dispensing cartridge for flowable materials |
AT97910784T ATE240879T1 (en) | 1996-10-03 | 1997-10-03 | CARTRIDGE FOR DISPENSING FLOWABLE MEDIA IN PORTIONS WITHOUT RISK OF COLLECTION |
JP51690798A JP2001504063A (en) | 1996-10-03 | 1997-10-03 | Multi-load dispensing cartridge without contamination of the flow material |
CA002267120A CA2267120A1 (en) | 1996-10-03 | 1997-10-03 | Contamination-safe multiple-dose dispensing cartridge for flowable materials |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/724,975 | 1996-10-03 | ||
US08/724,975 US5836484A (en) | 1996-10-03 | 1996-10-03 | Contamination-safe multiple-dose dispensing cartridge for flowable materials |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998014387A1 true WO1998014387A1 (en) | 1998-04-09 |
Family
ID=24912629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/017881 WO1998014387A1 (en) | 1996-10-03 | 1997-10-03 | Contamination-safe multiple-dose dispensing cartridge for flowable materials |
Country Status (12)
Country | Link |
---|---|
US (1) | US5836484A (en) |
EP (2) | EP0929463B1 (en) |
JP (1) | JP2001504063A (en) |
CN (1) | CN1237137A (en) |
AT (2) | ATE310679T1 (en) |
AU (1) | AU4807297A (en) |
BR (1) | BR9713252A (en) |
CA (1) | CA2267120A1 (en) |
DE (2) | DE69734741T2 (en) |
IL (1) | IL129247A (en) |
TW (1) | TW410210B (en) |
WO (1) | WO1998014387A1 (en) |
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WO2000029192A2 (en) * | 1998-11-16 | 2000-05-25 | Waterfall Company, Inc. | A cartridge for contamination-free dispensing and delivery systems |
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FR2806388A1 (en) * | 2000-01-17 | 2001-09-21 | Gabriel Bouzaglo | Seal for outlet of flexible container such as tube of cosmetic product comprises valve with conical seat and flexible membrane |
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CN101274683B (en) * | 2002-08-13 | 2011-11-23 | 因斯蒂尔医学技术有限公司 | Distributing device and filling method |
US8763655B2 (en) | 2008-05-20 | 2014-07-01 | Grinon Industries | Fluid transfer assembly and methods of fluid transfer |
US8777182B2 (en) | 2008-05-20 | 2014-07-15 | Grinon Industries | Fluid transfer assembly and methods of fluid transfer |
US9284174B2 (en) | 2008-05-20 | 2016-03-15 | Grinon Industries | Fluid transfer assembly and methods of fluid transfer |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2749830B1 (en) * | 1996-06-13 | 1998-09-11 | Bouzaglo Gabriel | PLUG WITH FLAP FOR CONTAINER |
US6443373B1 (en) * | 1996-11-29 | 2002-09-03 | Daniel Oswaldo Portugues | Flexible outlet channel stopper membrane |
US6286725B1 (en) * | 1997-09-19 | 2001-09-11 | Waterfall Company, Inc. | Contamination-safe multi-dose dispensing and delivery system for flowable materials |
GB9725192D0 (en) * | 1997-11-29 | 1998-01-28 | Cross David E | Filtration |
CH693413A5 (en) * | 1998-02-10 | 2003-07-31 | Mrp Medical Res & Promotion Es | Mehrfachdosierflasche with Dosierungsausguss for products, in particular medicine. |
FR2778173B1 (en) * | 1998-04-29 | 2000-06-30 | Jean Charles Nickels | HERMETIC FLUID DELIVERY DEVICE |
US6079449A (en) * | 1999-02-01 | 2000-06-27 | Waterfall Company, Inc. | System for delivering and maintaining the sterility and integrity of flowable materials |
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WO2000029192A2 (en) * | 1998-11-16 | 2000-05-25 | Waterfall Company, Inc. | A cartridge for contamination-free dispensing and delivery systems |
WO2000029192A3 (en) * | 1998-11-16 | 2000-11-09 | Waterfall Company Inc | A cartridge for contamination-free dispensing and delivery systems |
EP1512510A2 (en) * | 1998-11-16 | 2005-03-09 | Waterfall Company, Inc. | A cartridge for contamination-free dispensing and delivery systems |
EP1512510A3 (en) * | 1998-11-16 | 2005-04-06 | Waterfall Company, Inc. | A cartridge for contamination-free dispensing and delivery systems |
FR2803831A1 (en) * | 2000-01-17 | 2001-07-20 | Gabriel Bouzaglo | Seal for outlet of flexible container such as tube of cosmetic product comprises valve with conical seat and flexible membrane |
WO2001053164A2 (en) | 2000-01-17 | 2001-07-26 | Gabriel Bouzaglo | Sealing device for container |
FR2806388A1 (en) * | 2000-01-17 | 2001-09-21 | Gabriel Bouzaglo | Seal for outlet of flexible container such as tube of cosmetic product comprises valve with conical seat and flexible membrane |
FR2806387A1 (en) * | 2000-01-17 | 2001-09-21 | Gabriel Bouzaglo | Seal for outlet of flexible container such as tube of cosmetic product comprises valve with conical seat and flexible membrane |
WO2001053164A3 (en) * | 2000-01-17 | 2002-04-11 | Gabriel Bouzaglo | Sealing device for container |
US6827241B2 (en) * | 2000-01-17 | 2004-12-07 | Gabriel Bouzaglo | Sealing device for container |
CN101274683B (en) * | 2002-08-13 | 2011-11-23 | 因斯蒂尔医学技术有限公司 | Distributing device and filling method |
EP1973792A2 (en) * | 2006-01-05 | 2008-10-01 | Medical Instill Technologies, Inc. | One-way valve and apparatus and method of using the valve |
EP1973792A4 (en) * | 2006-01-05 | 2011-08-31 | Medical Instill Tech Inc | One-way valve and apparatus and method of using the valve |
WO2007120791A3 (en) * | 2006-04-13 | 2008-03-20 | Johnson & Son Inc S C | Heated flowable product dispenser |
US8061918B2 (en) | 2006-04-13 | 2011-11-22 | S.C. Johnson & Son, Inc. | Heated flowable product dispenser |
WO2007120791A2 (en) * | 2006-04-13 | 2007-10-25 | S. C. Johnson & Son, Inc. | Heated flowable product dispenser |
US8240933B2 (en) | 2006-04-13 | 2012-08-14 | S.C. Johnson & Son, Inc. | Heated flowable product dispenser |
US8777182B2 (en) | 2008-05-20 | 2014-07-15 | Grinon Industries | Fluid transfer assembly and methods of fluid transfer |
US8763655B2 (en) | 2008-05-20 | 2014-07-01 | Grinon Industries | Fluid transfer assembly and methods of fluid transfer |
US9284174B2 (en) | 2008-05-20 | 2016-03-15 | Grinon Industries | Fluid transfer assembly and methods of fluid transfer |
US9440835B2 (en) | 2008-05-20 | 2016-09-13 | Grinon Industries | Fluid transfer assembly and methods of fluid transfer |
US9663264B2 (en) | 2008-05-20 | 2017-05-30 | Grinon Industries | Fluid transfer assembly and methods of fluid transfer |
US9694931B2 (en) | 2008-05-20 | 2017-07-04 | Grinon Industries | Fluid transfer assembly and methods of fluid transfer |
US10207910B2 (en) | 2008-05-20 | 2019-02-19 | Grinon Industries | Fluid transfer assembly and methods of fluid transfer |
US10696530B2 (en) | 2008-05-20 | 2020-06-30 | Grinon Industries | Fluid transfer assembly and methods of fluid transfer |
Also Published As
Publication number | Publication date |
---|---|
DE69734741D1 (en) | 2005-12-29 |
AU4807297A (en) | 1998-04-24 |
US5836484A (en) | 1998-11-17 |
CA2267120A1 (en) | 1998-04-09 |
EP0929463A1 (en) | 1999-07-21 |
EP0929463B1 (en) | 2003-05-21 |
DE69722227D1 (en) | 2003-06-26 |
CN1237137A (en) | 1999-12-01 |
DE69734741T2 (en) | 2006-09-07 |
IL129247A0 (en) | 2000-02-17 |
ATE310679T1 (en) | 2005-12-15 |
EP1155968A1 (en) | 2001-11-21 |
TW410210B (en) | 2000-11-01 |
ATE240879T1 (en) | 2003-06-15 |
BR9713252A (en) | 2000-01-18 |
IL129247A (en) | 2001-05-20 |
EP1155968B1 (en) | 2005-11-23 |
JP2001504063A (en) | 2001-03-27 |
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