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WO1998014222A1 - Procedes et compositions de programmation d'une matrice organique en vue d'un remodelage au sein d'un tissu cible - Google Patents

Procedes et compositions de programmation d'une matrice organique en vue d'un remodelage au sein d'un tissu cible

Info

Publication number
WO1998014222A1
WO1998014222A1 PCT/US1997/017530 US9717530W WO1998014222A1 WO 1998014222 A1 WO1998014222 A1 WO 1998014222A1 US 9717530 W US9717530 W US 9717530W WO 1998014222 A1 WO1998014222 A1 WO 1998014222A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
matrix
bone
growth
composition
tissue
Prior art date
Application number
PCT/US1997/017530
Other languages
English (en)
Inventor
Samy Ashkar
Anthony Atala
Original Assignee
Children's Medical Center Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3695Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1875Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005Ingredients of undetermined constitution or reaction products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057Ingredients of undetermined constitution or reaction products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608Bone, e.g. demineralised bone matrix [DBM], bone powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents

Abstract

Cette invention se rapporte à des procédés permettant de programmer une matrice non immunogène en vue d'un remodelage au sein d'un tissu cible. L'invention se rapporte également à des compositions qui favorisent la croissance de types de tissus sélectionnés chez un sujet. Elle se rapporte aussi à des procédés de préparation desdites compositions. Ces procédés et compositions sont utiles pour traiter des défauts tissulaires dans des tissus du type os, cartilage et muscle.
PCT/US1997/017530 1996-09-30 1997-09-29 Procedes et compositions de programmation d'une matrice organique en vue d'un remodelage au sein d'un tissu cible WO1998014222A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US2712396 true 1996-09-30 1996-09-30
US60/027,123 1996-09-30

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA 2267111 CA2267111A1 (fr) 1996-09-30 1997-09-29 Procedes et compositions de programmation d'une matrice organique en vue d'un remodelage au sein d'un tissu cible
EP19970944567 EP0929322A1 (fr) 1996-09-30 1997-09-29 Procedes et compositions de programmation d'une matrice organique en vue d'un remodelage au sein d'un tissu cible
JP51676898A JP2001501934A (ja) 1996-09-30 1997-09-29 標的組織にリモデリングするよう有機マトリックスをプログラムするための方法及び組成物
US09058048 US6165487A (en) 1996-09-30 1998-04-09 Methods and compositions for programming an organic matrix for remodeling into a target tissue

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09058048 Continuation US6165487A (en) 1996-09-30 1998-04-09 Methods and compositions for programming an organic matrix for remodeling into a target tissue

Publications (1)

Publication Number Publication Date
WO1998014222A1 true true WO1998014222A1 (fr) 1998-04-09

Family

ID=21835826

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/017530 WO1998014222A1 (fr) 1996-09-30 1997-09-29 Procedes et compositions de programmation d'une matrice organique en vue d'un remodelage au sein d'un tissu cible

Country Status (4)

Country Link
EP (1) EP0929322A1 (fr)
JP (1) JP2001501934A (fr)
CA (1) CA2267111A1 (fr)
WO (1) WO1998014222A1 (fr)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045972A2 (fr) * 1998-03-09 1999-09-16 Stichting Voor De Technische Wetenschappen Substitut de peau et composition topique pour plaies de la peau
WO1999052572A1 (fr) * 1998-04-09 1999-10-21 Children's Medical Center Corporation Procedes et compositions pour la regeneration tissulaire
EP1043963A1 (fr) * 1997-12-31 2000-10-18 Depuy Orthopaedics, Inc. Compositions a base d'osteopontine activant la reparation osseuse
WO2001002030A2 (fr) * 1999-07-06 2001-01-11 Ramot University Authority For Applied Research & Industrial Development Ltd. Matrice d'echafaudage et systemes de conservation de tissu
EP1084719A1 (fr) * 1999-09-17 2001-03-21 Depuy Orthopaedics, Inc. Compositions à base de sialoprotéine osseuse activant la réparation du tissu conjonctif
EP1127581A1 (fr) * 1998-02-27 2001-08-29 Musculoskeletal Transplant Foundation Pâte malléable pour remplir de défauts osseux
US6326018B1 (en) 1998-02-27 2001-12-04 Musculoskeletal Transplant Foundation Flexible sheet of demineralized bone
EP1198235A1 (fr) * 1999-07-26 2002-04-24 Orquest, Inc. Methode d'aide a la croissance osseuse avec de l'acide hyaluronique et des facteurs de croissance
EP1203074A1 (fr) * 1999-06-29 2002-05-08 J. Alexander Marchosky Compositions et procede de formation et de renforcement des os
US6437018B1 (en) 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
US6458375B1 (en) 1998-02-27 2002-10-01 Musculoskeletal Transplant Foundation Malleable paste with allograft bone reinforcement for filling bone defects
WO2002080995A1 (fr) * 2001-04-04 2002-10-17 Ramot At Tel-Aviv University Ltd. Matrice de support et systemes de conservation des tissus
WO2003059296A2 (fr) * 2001-12-28 2003-07-24 Angiotech International Ag. Compositions a base de collagene et procedes d'utilisation
USRE38522E1 (en) 1998-02-27 2004-05-25 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6831178B2 (en) 2000-04-19 2004-12-14 Shionogi & Co., Ltd. Process for preparation of sulfonamide derivatives and crystals thereof
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
USRE42208E1 (en) 2003-04-29 2011-03-08 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US8563040B2 (en) 2002-02-07 2013-10-22 Marfly 2, Lp Compositions and methods for forming and strengthening bone
US9701940B2 (en) 2005-09-19 2017-07-11 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2175506A (en) * 1985-05-29 1986-12-03 American Hospital Supply Corp Methods of producing prostheses for replacement of articular cartilage and prostheses so produced
EP0251695A2 (fr) * 1986-06-25 1988-01-07 Collagen Corporation Composition d'implantation injectable à pouvoir d'intrusion modifié
WO1989004646A1 (fr) * 1987-11-13 1989-06-01 Jefferies Steven R Materiaux de reparation des os et administration de medicaments retardee
EP0321277A2 (fr) * 1987-12-16 1989-06-21 Collagen Corporation Composition injectable pour la réparation des tissus osseux
WO1990001955A1 (fr) * 1988-08-19 1990-03-08 Ed Geistlich Söhne Ag Für Chemische Industrie Composes chimiques
EP0419275A1 (fr) * 1989-09-21 1991-03-27 Osteotech, Inc., Composition de poudre d'os fluide et déminéralisée et son utilisation pour la réparation de l'os
EP0495284A1 (fr) * 1991-01-17 1992-07-22 Osteotech, Inc., Composition ostéogénique et implant le contenant
EP0585168A2 (fr) * 1992-08-21 1994-03-02 Bristol-Myers Squibb Company Composition et méthode pour la génération d'os
US5314476A (en) * 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
WO1995015776A1 (fr) * 1993-12-09 1995-06-15 Osteotech, Inc. Materiaux façonnes a partir de particules osseuses de forme allongee et procede de preparation de ces materiaux
US5531791A (en) * 1993-07-23 1996-07-02 Bioscience Consultants Composition for repair of defects in osseous tissues, method of making, and prosthesis

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2175506A (en) * 1985-05-29 1986-12-03 American Hospital Supply Corp Methods of producing prostheses for replacement of articular cartilage and prostheses so produced
EP0251695A2 (fr) * 1986-06-25 1988-01-07 Collagen Corporation Composition d'implantation injectable à pouvoir d'intrusion modifié
WO1989004646A1 (fr) * 1987-11-13 1989-06-01 Jefferies Steven R Materiaux de reparation des os et administration de medicaments retardee
EP0321277A2 (fr) * 1987-12-16 1989-06-21 Collagen Corporation Composition injectable pour la réparation des tissus osseux
WO1990001955A1 (fr) * 1988-08-19 1990-03-08 Ed Geistlich Söhne Ag Für Chemische Industrie Composes chimiques
EP0419275A1 (fr) * 1989-09-21 1991-03-27 Osteotech, Inc., Composition de poudre d'os fluide et déminéralisée et son utilisation pour la réparation de l'os
EP0495284A1 (fr) * 1991-01-17 1992-07-22 Osteotech, Inc., Composition ostéogénique et implant le contenant
US5314476A (en) * 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
EP0585168A2 (fr) * 1992-08-21 1994-03-02 Bristol-Myers Squibb Company Composition et méthode pour la génération d'os
US5531791A (en) * 1993-07-23 1996-07-02 Bioscience Consultants Composition for repair of defects in osseous tissues, method of making, and prosthesis
WO1995015776A1 (fr) * 1993-12-09 1995-06-15 Osteotech, Inc. Materiaux façonnes a partir de particules osseuses de forme allongee et procede de preparation de ces materiaux

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1043963A1 (fr) * 1997-12-31 2000-10-18 Depuy Orthopaedics, Inc. Compositions a base d'osteopontine activant la reparation osseuse
EP1043963A4 (fr) * 1997-12-31 2001-02-07 Depuy Orthopaedics Inc Compositions a base d'osteopontine activant la reparation osseuse
USRE39587E1 (en) 1998-02-27 2007-04-24 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6326018B1 (en) 1998-02-27 2001-12-04 Musculoskeletal Transplant Foundation Flexible sheet of demineralized bone
EP1127581A1 (fr) * 1998-02-27 2001-08-29 Musculoskeletal Transplant Foundation Pâte malléable pour remplir de défauts osseux
USRE38522E1 (en) 1998-02-27 2004-05-25 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6458375B1 (en) 1998-02-27 2002-10-01 Musculoskeletal Transplant Foundation Malleable paste with allograft bone reinforcement for filling bone defects
US6437018B1 (en) 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
WO1999045972A3 (fr) * 1998-03-09 1999-10-14 Stichting Tech Wetenschapp Substitut de peau et composition topique pour plaies de la peau
WO1999045972A2 (fr) * 1998-03-09 1999-09-16 Stichting Voor De Technische Wetenschappen Substitut de peau et composition topique pour plaies de la peau
US9254301B2 (en) 1998-03-30 2016-02-09 Marfly2, LP Compositions and methods for forming and strengthening bone
WO1999052572A1 (fr) * 1998-04-09 1999-10-21 Children's Medical Center Corporation Procedes et compositions pour la regeneration tissulaire
EP1203074A1 (fr) * 1999-06-29 2002-05-08 J. Alexander Marchosky Compositions et procede de formation et de renforcement des os
EP1203074A4 (fr) * 1999-06-29 2003-09-10 J Alexander Marchosky Compositions et procede de formation et de renforcement des os
WO2001002030A3 (fr) * 1999-07-06 2001-08-23 Zvi Nevo Matrice d'echafaudage et systemes de conservation de tissu
WO2001002030A2 (fr) * 1999-07-06 2001-01-11 Ramot University Authority For Applied Research & Industrial Development Ltd. Matrice d'echafaudage et systemes de conservation de tissu
US6632651B1 (en) 1999-07-06 2003-10-14 Ramot At Tel Aviv University Ltd. Tissue maintenance system that applies rhythmic pulses of pressure
US6652872B2 (en) 1999-07-06 2003-11-25 Ramat At Tel Aviv University Ltd. Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
EP1198235A1 (fr) * 1999-07-26 2002-04-24 Orquest, Inc. Methode d'aide a la croissance osseuse avec de l'acide hyaluronique et des facteurs de croissance
EP1198235A4 (fr) * 1999-07-26 2006-04-05 Depuy Spine Inc Methode d'aide a la croissance osseuse avec de l'acide hyaluronique et des facteurs de croissance
EP1084719A1 (fr) * 1999-09-17 2001-03-21 Depuy Orthopaedics, Inc. Compositions à base de sialoprotéine osseuse activant la réparation du tissu conjonctif
US6458763B1 (en) 1999-09-17 2002-10-01 Depuy Orthopeadics Bone sialoprotein-based compositions for enhancing connective tissue repair
US6831178B2 (en) 2000-04-19 2004-12-14 Shionogi & Co., Ltd. Process for preparation of sulfonamide derivatives and crystals thereof
WO2002080995A1 (fr) * 2001-04-04 2002-10-17 Ramot At Tel-Aviv University Ltd. Matrice de support et systemes de conservation des tissus
WO2003059296A3 (fr) * 2001-12-28 2003-09-18 Angiotech Pharm Inc Compositions a base de collagene et procedes d'utilisation
WO2003059296A2 (fr) * 2001-12-28 2003-07-24 Angiotech International Ag. Compositions a base de collagene et procedes d'utilisation
US8563040B2 (en) 2002-02-07 2013-10-22 Marfly 2, Lp Compositions and methods for forming and strengthening bone
USRE42208E1 (en) 2003-04-29 2011-03-08 Musculoskeletal Transplant Foundation Glue for cartilage repair
US8221500B2 (en) 2003-05-16 2012-07-17 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US9701940B2 (en) 2005-09-19 2017-07-11 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US8906110B2 (en) 2007-01-24 2014-12-09 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects

Also Published As

Publication number Publication date Type
CA2267111A1 (fr) 1998-04-09 application
EP0929322A1 (fr) 1999-07-21 application
JP2001501934A (ja) 2001-02-13 application

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