WO1998004517A1 - Arylcycloalkane carboxylic esters, their use, pharmaceutical compositions and preparation - Google Patents
Arylcycloalkane carboxylic esters, their use, pharmaceutical compositions and preparation Download PDFInfo
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- WO1998004517A1 WO1998004517A1 PCT/SE1997/001310 SE9701310W WO9804517A1 WO 1998004517 A1 WO1998004517 A1 WO 1998004517A1 SE 9701310 W SE9701310 W SE 9701310W WO 9804517 A1 WO9804517 A1 WO 9804517A1
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/12—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Definitions
- the present invention relates to arylcycloalkane carboxylic esters having pharmacological properties, and to processes for their preparation.
- the invention also relates to pharmaceutical compositions containing arylcycloalkane carboxylic esters, methods of treating disorders related to urinary incontinence and irritable bowel syndrome (IBS) , respectively, by administering an arylcycloalkane carboxylic ester, as well as methods for the manufacture of pharmaceutical compositions for treating disorders related to urinary incontinence and irritable bowel syndrome (IBS) , respectively.
- IBS urinary incontinence and irritable bowel syndrome
- arylcycloalkane carboxylic esters including arylcyclopropane, arylcyclobutane, arylcyclopentane and arylcyclohexane carboxylic acid esters, are known to possess anticholinergic activity. Some of them have a pronounced spasmolytic or anticonvulsant activity and have therefore been proposed to be used as substitutes for atropine in the treatment of sarin poisoning (sarin is an organophosphorous anticholinesterase agent acting as a nerve gas) . Other activities related to that type of compounds are antipsychotic, anti-ischemic, anti-stroke and antidementia.
- Arylcyclobutane carboxylic esters having anticholinergic activities are, for example, described in Bannard, R. A. B. , et al . , Can. J. Phys . Pharm. 47 (1969) 1036 (2 ' -diisopropylaminoethyl 1-phenylcyclobutane- carboxylate, 1 ' -methylpiperidyl-4 ' 1-phenylcyclobutane- carboxylate) ; CH-B-240160 (diethylaminoethyl 1- phenylcyclobutylcarboxylate) ; Parkkari, J. H., et al . , Can. J. Chem.
- Arylcyclopentane carboxylic esters having anticholinergic activities are, for example, described in Bannard, R. A. B., et al . , Can. J. Chem. 40 (1962) 1909- 1916; Stubbins, J. F., et al, Med. Chem. Res. 2 (1992) 384- 393; JP-A-02062823; US-A-3 , 317 , 526 ; FR-A-1461314 ; FR-A- 2155927; DD-A-289411 and FR-A-2168881.
- Arylcyclohexane carboxylic esters having anticholinergic activities are, for example, described in Zbigniew, J., et al., Pol. J. Pharmacol. Pharm. 35 (1983) 103-107; Tsung-Ping Su et al., Pharmacology and Exp. Therapeutics 259 (1991) 543-550; Wolinski, J., and Cessak, M., Acta Pol. Pharm. 36 (1979) 635-40; WO 92/02481 and FR-A-2155927.
- arylcyclopropane, arylcyclobutane, arylcyclopentane and arylcyclohexane carboxylic esters possess a selective antimuscarinic activity on the urinary bladder smooth muscle, and on the small intestine muscle, and are therefore indicated for the treatment of disorders of the urinary bladder, such as urge incontinence, as well as for the treatment of disorders of the small intestine, such as irritable bowel syndrome (IBS) .
- IBS irritable bowel syndrome
- the present invention provides novel arylcycloalkane carboxylic esters of the general Formula I:
- A is an optionally substituted cycloalkane ring having 3 to 6 carbon atoms and attached at a single ring carbon atom thereof
- Ar is phenyl or heteroaryl having 5 or 6 ring members
- Rl and R2 independently are hydrogen, lower alkyl, lower alkoxy, halo, hydroxy, trifluoromethyl , nitro or amino, or R]_ and R2 together form lower alkylenedioxy or optionally substituted benzo
- R'3 is ( i) - (CH2) n NR 10' R ll ⁇ ⁇ n which n is 2 or 3 and R]_0 ano ⁇ R ll eac ⁇ are lower alkyl or R ⁇ Q and R ⁇ together with the nitrogen atom form a saturated azacyclic or azabicyclic ring system; or (ii) -(CH2) ⁇ Q' i n which m is 0 or 1 and Q is the residue of a saturated azacyclic or azabicyclic
- the cycloalkane ring A may be substituted at one or more ring carbons (mono- or di-substituted at each carbon) , preferably with a substituent or substituents independently selected from lower alkyl, lower alkoxy, lower alkoxy-lower alkyl, cycloalkyi, lower alkenyl, lower hydroxyalkyl, benzyloxy-lower alkyl, trifluoromethyl , hydroxy, oxo or spiro-coupled lower alkylene or lower alkylenedioxy .
- A. is a group of the general Formula II, III, IV or V:
- R4, R5, R , R , R3 and Rg independently are hydrogen, lower alkyl, lower alkoxy, lower alkoxy-lower alkyl, cycloalkyl, lower alkenyl, lower hydroxyalkyl , benzyloxy- lower alkyl, trifluoromethyl or hydroxy, or either R4 and R5 or Rs and R7 or R ⁇ and R9 together form lower alkylene, lower alkylenedioxy or oxo.
- Provisos (i) to (viii) given above for Formula I are then defined as: (i) when A is a group of Formula II, Ar is phenyl, R'3 is - ( CH2 ) n NR ⁇ )' R ll- 10 an ⁇ - R ll are lower alkyl, and one of R4 and R5 is hydrogen and the other is hydrogen, lower alkyl or lower alkenyl, then R ⁇ g a "d Rn contain together at least six carbon atoms; (ii) when A is a group of Formula II, Ar is phenyl, R'3 is - ( CH2 ) n NR_0 ' R ll ⁇ n is 2, and R o and R ll together with the nitrogen atom form a pyrrolidine ring, or R'3 is - (CH2) -Q, m is 0 and Q is a tropanyl ring, then at least one of R4 and R5 is other than hydrogen; (iii) when A is a group of
- One subgroup of compounds of Formula I is comprised of arylcyclopropane carboxylic esters of the general Formula I (II) (i.e. where the group A in Formula I is a group of Formula II above) :
- Rl Q and R11 are lower alkyl of together at least six carbon atoms .
- at least one of R4 and R5 is other than hydrogen.
- Another subgroup of compounds of Formula I is comprised of arylcyclobutane carboxylic esters of the general Formula I (III) (i.e. where the group A in Formula I is a group of Formula III above) :
- At least one of R4, R5 , Rg and R7 is other than hydrogen.
- R'3 is -(CH2) m -Q- m is 0 or 1, and Q is a saturated azabicyclic ring.
- R'3 is -(CH2) m -Q, and m is 1.
- R'3 is - (CH2 ) n NR 10 R ll ' R 10 and R ll are lower alkyl of together at least six carbon atoms.
- Another subgroup of compounds of Formula I is comprised of arylcyclopentane carboxylic esters of the general Formula I (IV) (i.e. where the group A in Formula I is a group of Formula IV above) :
- R O and Rn are lower alkyl of together at least six carbon atoms .
- Yet another subgroup of compounds of Formula I is comprised of arylcyclohexane carboxylic esters of the general Formula I(V) (i.e. the group A in Formula I is a group of Formula V above) : wherein Ar , R , R2 , R '3 ⁇ a nd R4 to Rg , including provisions (vii) and (viii), are as defined above.
- At least one of R4 , R5, Rg , R7 , Rg and R9 is other than hydrogen.
- R'3 is - ( CH2 ) n NR 10 R ll ' R 10 and R ll are lower alkyl of together at least six carbon atoms.
- the present invention provides the compounds having the general Formula I above for therapeutical use, particularly for antagonizing muscarinic receptors, and especially for the treatment of urinary incontinence related disorders, or for the treatment of irritable bowel syndrome (IBS) .
- the present invention provides a pharmaceutical composition comprising one or more compounds of the general Formula I above as the active ingredient, preferably together with a pharmaceutically acceptable carrier and, if desired, other pharmacologically active agents.
- the present invention provides a method of treating a living body suffering from a disorder related to urinary incontinence, which method comprises the step of administering to the said living body an effective amount of a compound having the general Formula IA:
- A is an optionally substituted cycloalkane ring having 3 to 6 carbon atoms and attached at a single ring carbon atom thereof
- Ar is phenyl or heteroaryl having 5 or 6 ring members
- Rl and R2 independently are hydrogen, lower alkyl, lower alkoxy, halo, hydroxy, trifluoromethyl , nitro or amino, or Ri and R2 together form lower alkylenedioxy or optionally substituted benzo
- R3 is ( i ) - ( CH2 ) n NR 10' R ll' in which n is 2 or 3 and RlO and Rn each are lower alkyl or RI Q and Rn together with the nitrogen atom form a saturated azacyclic or azabicyclic ring system; or (ii) -(CH2) m ⁇ Q' i n which m is 0 or 1 and Q is the residue of a saturated azacyclic or azabicyclic ring system coupled via a carbon atom thereof
- the cycloalkane ring A may be substituted at one or more ring carbons (mono- or di-substituted at each carbon) , preferably v/ith a substituent or substituents independently selected from lower alkyl, lower alkoxy, lower alkoxy-lower alkyl, cycloalkyl, lower alkenyl, lower hydroxyalkyl , benzyloxy-lower alkyl, trifluoromethyl, hydroxy, oxo or spiro-coupled lower alkylene or lower alkylenedioxy.
- the group A in Formula IA is a group of the general Formula II, III, IV or V:
- R4 , R5 , Rg , R7 , Rg and R9 independently are hydrogen, lower alkyl, lower alkoxy, lower alkoxy-lower alkyl, cycloalkyl, lower alkenyl, lower hydroxyalkyl , benzyloxy-lower alkyl, trifluoromethyl or hydroxy, or either R4 and R5 or Rg and R7 or Rg and R9 together form lower alkylene, lower alkylenedioxy or oxo.
- the present invention provides a method of treating a living body suffering from a disorder related to irritable bowel syndrome (IBS), which method comprises the step of administering to the said living body an effective amount of a compound having the general Formula IA as defined above.
- IBS irritable bowel syndrome
- the present invention provides a pharmaceutical composition for treating a disorder related to urinary incontinence, which composition comprises one or more compounds of the general Formula IA above as the active ingredient, preferably together with a pharmaceutically acceptable carrier and, if desired, other pharmacologically active agents.
- a pharmaceutical composition for treating irritable bowel syndrome (IBS) which composition comprises one or more compounds of the general Formula IA above as the active ingredient, preferably together with a pharmaceutically acceptable carrier and, if desired, other pharmacologically active agents
- the present invention provides the use of the compounds having the general Formula IA above for the manufacture of a medicament for the treatment of urinary incontinence related disorders .
- the present invention provides the use of the compounds having the general Formula IA above for the manufacture of a medicament for the treatment of irritabel bowel syndrome (IBS) .
- IBS irritabel bowel syndrome
- the present invention provides processes for preparing compounds having the general Formula I above .
- lower alkyl separately and in combinations (as well as in alkylene) , is meant to include straight and branched, saturated hydrocarbon groups having from one to six carbon atoms, particularly from one to five, and preferably from one to four carbon atoms.
- alkyl groups are methyl, ethyl, n-propyl , iso- propyl , n-butyl , n-pentyl, n-hexyl and isomeric forms thereof .
- lower alkenyl is meant to include straight and branched hydrocarbon groups having from two to six carbon atoms, particularly from two to five, and preferably from two to four carbon atoms, and containing one or more unsaturations .
- Exemplary alkenyl groups are ethenyl, propenyl , butenyl , pentenyl, hexenyl , methylpropenyl, ethylbutenyl and isomeric forms thereof.
- lower alkoxy is meant to include straight and branched, saturated alkoxy groups having from one to six carbon atoms, particularly from one to five, and preferably from one to four carbon atoms.
- Exemplary alkoxy groups are ethoxy, ethoxy, n- propyloxy, iso-propyloxy, n-butyloxy, n-pentyloxy, n- hexyloxy and isomeric forms thereof.
- Cycloalkyl is preferably C3_gcycloalkyl , such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl.
- heteroaryl groups are thiophene, furan, thiazole, isothiazole, oxazole, isoxazole, pyridine, pyrazine, pyrimidine, pyridazine.
- Preferred heteroaryl groups are 2- or 3-thienyl, 2- or 3-furanyl, and 2-, 3- or 4-pyridine .
- Halo includes fluoro, chloro, bromo and iodo, and is preferably fluoro, chloro or bromo.
- Lower alkylenedioxy is preferably methylenedioxy .
- Benzo is preferably 2,3-benzo or 3,-4-benzo. When benzo is substituted, it may be substituted in one or more of the ortho-, metha- or para-positions. Preferably, it is di- or mono-substituted, more preferably mono-substituted.
- R'3 or R3 comprises a saturated azacyclic or azabicyclic ring system
- the nitrogen atom thereof will have tertiary nature, either by being a bridge end or by substitution, preferred N-substituents being lower alkyl and lower alkenyl.
- Exemplary azacyclic and azabicyclic rings are piperidine, pyrrolidine, azanorbornane, azacycloheptane, quinuclidine, isoquinuclidine, tropane, azabicyclo [3.2.1] octane, azabicyclo[2.2.1] heptane, 2- azabicyclo [3.2.1] octane, azabicyclo [3.2.1] octane, azabicyclo [3.3.0] octane, azabicyclo [3.2.2] nonane, azabicyclo [3.3.1] nonane .
- the azacyclic or azabicyclic rings may be mono- or independently di-substituted at a carbon atom in any position by lower alkyl, lower alkenyl, halo, lower alkoxy or hydroxy, preferably by methyl, methoxy or hydroxy.
- R'3 or R3 is - (CH2 ) n NR 10 R ll' n ⁇ s
- the nitrogen atom of the azabicyclic ring is preferably spaced from the coupling carbon atom by one carbon atom.
- R4 , R5 , Rg, R7 , Rg and R9 are separate groups, they are preferably selected from hydrogen, lower alkyl, lower alkoxy, methoxymethyl, benzyloxymethyl, ethenyl, propenyl and trifluoromethyl .
- R4 and R5 , Rg and R7 , or Rg and R9 together form lower alkylene or lower alkylenedioxy they are preferably selected from dimethylene, trimethylene and ethylenedioxy.
- Ar is phenyl, 2- or 3-thienyl, 2- or 3-furanyl or 2-, 3- or 4-pyridine; and/or Ri and R2 are independently hydrogen, fluoro, chloro, bromo, C ⁇ _4alkyl, C ⁇ _ alkoxy, methoxymethyl, phenoxymethyl, vinyl, allyl, trifluormethyl ; and/or
- R4, R5, Rg, R7 , Rg and R9 are independently hydrogen, C ⁇ _4alkyl, C ⁇ _4alkoxy, methoxymethyl, benzyloxymethyl, vinyl, allyl, trifluoromethyl , or either R4 and R5 , or Rg and R7 , or Rg and R9 together form dimethylene, trimethylene, tetramethylene or ethylenedioxy.
- the general Formulae I and IA include the enantiomeric and racemic forms .
- the compounds of Formulae I and IA may also be in the form of salts suitable for pharmacological use. They may form salts with physiologically acceptable acids, organic and inorganic, and the invention comprises the free bases as well as the salts thereof. Examples of such salts include the hydrochloride, hydrobromide, hydrogen fumarate and the like.
- Exemplary compounds of Formulae I and IA include:
- R3 is as defined above, or with a compound of the general Formula Villa:
- R3 is as defined above, and A', R' and R'2 represent A, Ri and R2 , respectively, as defined above, or a group that can be converted to A, Ri and R2 , respectively, at least one of A', R' and R'2 is converted to a group A,
- the conversion of the group A' to a group A usually comprises converting one or more substituents on the cycloalkane ring.
- A' is a group of the general Formula Ila, Ilia, IVa or Va:
- R'4, R'5- R '6> R ⁇ 7- R '8 and R '9 represent R4 , R5 , Rg , R7, Rg and Rg, respectively, or a group that can be converted to R4, R5 , R , R7 , Rg and Rg , respectively, one or more of groups R'4, R'5, R'g, R'7, R'g and R'9 are converted to a group R4, R5 , R , R , Rg and R9 , respectively.
- the compound of Formula VI is preferably transformed to a reactive derivative, such as the anhydride or acid chloride.
- a reactive derivative such as the anhydride or acid chloride.
- the reaction may be carried out in an inert organic solvent or mixture of solvents, such as benzene or toluene.
- a suitable temperature range for the reaction is between between room temperature and about 100 °C .
- the resulting product may be isolated by conventional procedures.
- An acid chloride of a compound of Formula VI above may be prepared by reacting the compound VI with thionyl chloride. The resulting acid chloride does not need to be isolated but may be added directly to the reaction mixture.
- the reaction of a compound of Formula VI with a compound of Formula Villa may be carried out in a dipolar aprotic organic solvent or mixture of solvents, such as dimethylformamide, acetonitril or dimethyl sulphoxide.
- a dipolar aprotic organic solvent or mixture of solvents such as dimethylformamide, acetonitril or dimethyl sulphoxide.
- strong base sodium hydride or potassium tert . -butylate may be used.
- a suitable temperature range for the reaction is between about 0 and about 100 °C .
- the resulting product may be isolated by conventional procedures .
- the reaction between a compound of Formula VI in acid form and a compound of Formula Vila is carried out in the presence of a dehydrating agent, preferably a carbodiimide, such as dicyclohexylcarbodiimide (DCC) and a base as catalyst.
- a dehydrating agent preferably a carbodiimide, such as dicyclohexylcarbodiimide (DCC) and a base as catalyst.
- Method b) (which is further illustrated in, e.g., Example 9 below) , for example, a compound of Formula I or IA having a hydroxy-containing substituent may be obtained by hydrogenating a corresponding benzyloxy compound.
- Method b) also includes the conversion of one or more of the groups R4, R5, R , R7 , Rg and Rg to another group or groups R4 , R5 , R , R7 , Rg and Rg , respectively, for example the conversion of a nitro group to an amino group by hydrogenation, or the reduction of an oxo group to a hydroxy group .
- a trans-substituted starting material of Formula VI may be prepared by reacting a corresponding arylacetic ester with a suitable chloroepoxyalkane to form a compound of Formula II having a hydroxyl-containing trans-substituent, and optionally etherifying the hydroxyl group, route A (see e.g. Example 1 below) .
- route A see e.g. Example 1 below
- a corresponding arylnitrile is substituted for the arylphenylcarboxylic ester in the above procedure, route B (see e.g. Example 3 below) .
- the above reaction routes A and B are outlined in Reaction Scheme I provided at the end of the description.
- An arylcyclopropane carboxylic acid of Formula VI may be converted to another arylcyclopropane carboxylic acid of Formula VI by converting one or more substituents on the cyclopropane ring, such as substituents R4 or R5 as defined above .
- starting materials of Formula VI may e.g. be prepared by any of routes A to E shown in Reaction Scheme II.
- route A an arylacetonitrile is reacted with a 1,3- dibromopropane to give an arylcyclobutaneacetonitrile, which is then hydrolyzed to form the arylcyclobutane- carboxylic acid of Formula VI (illustrated in Examples 9 to 26 below) .
- routes B and C an arylacetonitrile is reacted with a di-O-p-toluenesulfonyl-1 , 3-propanediol (route B) or 3- bromo-O-p-toluenesulfonyl-l-propanol (route C) to give a 1- phenylcyclobutaneacetonitrile, which is then hydrolyzed to form the arylcyclobutanecarboxylic acid of Formula VI.
- Route B is illustrated in Examples 27-28, and route C in Examples 29-31 below
- route D an arylacetic ester is reacted with a 1,3- dibromopropane to give a 1-phenylcyclobutanecarboxylic ester, which is then hydrolyzed to form the arylcyclobutanecarboxylic acid of Formula VI (illustrated in Examples 32-33 below) .
- route E a l-cyano-l-phenyl-3-oxycyclobutane is reacted with an alkyltriphenylphosphoniumbromide (Wittig reaction) to give a l-phenyl-3-alkylenecyclobutane- acetonitrile, which is then hydrolyzed to form the arylcyclobutanecarboxylic acid of Formula VI (illustrated in Example 34) .
- An arylcyclobutanecarboxylic acid of Formula VI may be converted to another arylcyclobutanecarboxylic acid of
- Formula VI by converting one or more substituents on the cyclobutane ring, such as Ri , R2 , R4 , R5 , Rg or R7 (illustrated in Example 35) as defined above.
- starting materials of Formula VI may e.g. be prepared by route A or B shown in Reaction Scheme III.
- route A an arylacetonitrile is reacted with a 1,4- dibromobutane to give an arylcyclopentaneacetonitrile, which is then hydrolyzed to form the arylcyclopentane- carboxylic acid of Formula VI (illustrated in Examples 94 and 95 below) .
- route B an arylacetonitrile is reacted with a di- O-p-toluenesulfonyl-1, 4-butanediol to give a 1- phenylcyclopentaneacetonitrile, which is then hydrolyzed to form the arylcyclopentanecarboxylic acid of Formula VI (illustrated in Example 96 below) .
- An arylcyclopentanecarboxylic acid of Formula VI may be converted to another arylcyclopentanecarboxylic acid of Formula VI by converting one or more substituents on the cyclopentane ring, such as R , R2 , R4 , R5 , Rg or R7 as defined above.
- starting materials of Formula VI may e.g. be prepared by any of routes A to C shown in Reaction Scheme IV.
- route B the oxo group of an arylcyclohexanonecarbonitrile is first protected by rection with ethyleneglycol . The nitrile is then hydrolyzed to carboxylic acid, whereupon the oxo group is deprotected to form an arylcyclohexanecarboxylic acid of Formula VI (illustrated in Example 114 below) .
- an arylacetonitrile is reacted with a di- O-p-toluenesul onyl-l, 5-pentanediol to give a 1- phenylcyclohexaneacetonitrile, which is then hydrolyzed to form an arylcyclohexanecarboxylic acid of Formula VI (illustrated in Examples 115 and 116 below).
- An arylcyclohexanecarboxylic acid of Formula VI may be converted to another arylcyclohexanecarboxylic acid of
- Formula VI by converting one or more substituents on the cyclohexane ring, such as Ri, R2 , R4, R5 , Rg , R7 , Rg or Rg as defined above.
- racemic compounds of the general Formulae I and IA may be resolved using known methods, such as various resolving acids. Crystallization of a resolving acid salt of compounds of the general Formulae I and IA may be effected in any suitable conventional inert organic solvent, and preferably at a temperature from the boiling point of the solvent to -20 °C .
- exemplary solvents are ethanol, 1-propanol, 2-propanol, acetone, diethyl ether and ethyl acetate. Water and mixtures of solvents may also be employed.
- racemates can also be achieved by various chromatographic techniques, such as separation of diastereomeric mixtures, separation on chiral stationary phases or with chiral counter ion in the mobile phase. All the above described methods, including the resolution of racemates, may optionally be carried out in the presence of a catalyst known to be useful therein.
- the compounds of the invention are generally characterized by the pharmacological activity stated above, making them useful for counteracting the indicated physiological abnormalities in a living human or animal body.
- Effective quantities of a pharmacologically active compound of the invention may be administered to a living human or animal body in any one of various ways, e.g. orally as in capsules or tablets, parenterally in the form of sterile solutions, suspensions, emulsions, pellet implantation or by pumps.
- routes of parenteral administration are intravenous, sublingual, subcutaneous, intramuscular, intraperitoneal , intradermal, intravesical , intraurethral and intranasal administration.
- Other modes of administration are vaginal, rectal and topical administrations, e.g.
- compositions are usually prepared from a predetermined quantity of one or more of the compounds of the Formulae I or IA above.
- Such formulations may take the form of powders, syrups, suppositories, ointments, solutions, pills, capsules, pellets or tablets, suspensions, emulsions, oil solutions, etc. with or without, but preferably with any one of a large variety of pharmaceutically acceptable vehicles or carriers .
- the active ingredient When in a mixture with a pharmaceutical vehicle or carrier, the active ingredient usually comprises from about 0.01 to about 75 %, normally about 0.05 to about 15 % by weight of the composition.
- Carriers such as starch, sugar, talc, commonly used synthetic and natural gums, water and the like may be used in such formulations.
- Binders such as polyvinylpyrrolidone, and lubricants, such as sodium stearate, may be used to form tablets.
- Disintegrating agents such as sodium carbonate may also be included in tablets .
- unit dosages are preferably 2 milligrams or above, and preferably 10, 20, 50 or 100 milligrams, or even higher depending, of course, upon the subject treated and the particular result desired, as will be apparent to one skilled in the art. Broader ranges would be from 1 to 1000 milligrams per unit dose.
- the present compounds of Formulae I and IA may thus be administered in a quantity of 1 to 1000 milligrams, preferred ranges being 2 to 250 milligrams per day per subject or patie ⁇ r divided into one to four doses over a suitable period and depending upon the subject and the type of subject being treated.
- Ethyl l-phenyl-2- trans-hydroxymethylcyclopropane- carboxylate (6.8 mmol), obtained in Example 1 above, was dissolved in DMF (10 mL) together with benzylchloride (8 mmol) and added to NaH (60% dispersion in mineral oil, 10 mmol) at ambient temperature during 15 min. After 1 h of stirring, excess hydride was decomposed by addition of EtOH and the reaction mixture was partitioned between toluene and H 2 O . The organic layer was dried (MgS0 4 ) and evaporated.
- EXAMPLE 6 3-Quinuclidinyl 1-phenylcyclopropanecarboxylate hydrochloride The title compound was prepared in analogous manner to that in Example 4. The 1-phenylcyclopropanecarbonyl chloride obtained after the chlorination step was reacted with 3-quinuclidinol at 80 °C for 21 h. The reaction mixture was filtered and chromatographed on silica gel using toluene-Et 3 N 95:5 as eluent.
- EXAMPLE 9 (starting material) 1- (2-bro ophenyl) cyclobutanecarboxylic acid NaH (80% dispersion in mineral oil, 127 mmol) was washed several times with n-pentane and suspended in DMF (50 mL) . A mixture of 2-bromophenylacetonitrile (51 mmol) and 1 , 3-dibromopropane (51 mmol) in DMF (50 mL) was added dropwise to the ice-cold mixture. The reaction mixture was stirred at room temperature for 3 h. Excess hydride was then decomposed by the cautious addition of H 2 O.
- EXAMPLE 11 (starting material) 1- (3, 4-Methylenedioxyphenyl) cyclobutanecarboxylic acid
- the title compound was prepared in an analogous manner to that in Example 9 from 3 , 4-methylenedioxyphenyl- acetonitrile and 1, 3-dibromopropane .
- 2.1 eq of NaH and 1.1 eq of 1 , 3-dibromopropane were used.
- the mixture of 3,4- methylenedioxyphenylacetonitrile and 1 , 3-dibromopropane was added at 0 °C.
- the title compound was prepared in an analogous manner to that in Example 9 from phenylacetonitrile and 1,3- dibromo-1-methylpropane .
- the reaction with NaH was stirred overnight.
- the afforded l-phenyl-2-methylcyclobutane- acetonitrile was a mixture of cis and trans isomers .
- the isomers were separated by chromatography on silica gel using hexane-toluene 85:15 as eluent.
- EXAMPLE 14 (starting material) 1- ( 1-Naphthyl ) cyclobutanecarboxylic acid
- the title compound was prepared in an analogous manner to that in Example 9 from 1-naphthylacetonitrile and 1,3- dibromopropane .
- the reaction mixture with NaH was stirred overnight.
- 1- (1-Naphthyl) cyclobutaneacetonitrile was refluxed with KOH overnight.
- EXAMPLE 15 (starting material) 1- (2-Naphtyl) cyclobutanecarboxylic acid
- the title compound was prepared in an analogous manner to that in Example 9 from 2-naphthylacetonitrile and 1,3- dibromopropane .
- the yield was 3.0 g (44%).
- EXAMPLE 16 (starting material) 1- (3-M ⁇ thylphenyl) cyclobutanecarboxylic acid
- EXAMPLE 18 1- (4-Methylphenyl) cyclobutanecarboxylic acid The title compound was prepared in an analogous manner to that in Example 9 from 4-methylphenylacetonitrile and 1, 3-dibromopropane . The crude was washed with petroleumether-toluene 90:10. The yield was 82%; X H NMR (CDCI 3 ) ⁇ 1.86 (m, IH) , 2.05 (m, IH) , 2.32 (s, 3H) , 2.49 (m, 2H) , 2.82 ( , 2H) , 7.17 (m, 4H) , 9.6 (br, IH) .
- EXAMPLE 19 (starting material)
- EXAMPLE 20 (starting material) 1- (4-Fluorophenyl) cyclobutanecarboxylic acid
- the title compound was prepared in an analogous manner to that in Example 9 from 4-fluorophenylacetonitrile and 1 , 3-dibromopropane .
- the crude was washed with petroleumether-toluene 90:10 as eluent; 1 H NMR (CDCI 3 ) ⁇ 1 . 86 (m, IH ) , 2 . 06 (m, IH ) , 2 . 47 (m, 2H ) , 2 . 83 (m , 2H ) , 7 . 00 (m , 2H ) , 7 . 26 (m, 2H ) , 11 . 1 ( br , IH) .
- EXAMPLE 21 (starting material) 1- (2-Fluorophenyl) cyclobutanecarboxylic acid
- the title compound was prepared in an analogous manner to that in Example 9 from 2-fluorophenylacetonitrile and 1, 3-dibromopropane .
- the crude was chromatographed on silica gel using petroleumether-EtOAc-HOAc 90:8:2 as eluent. The yield was 86%;
- EXAMPLE 26 (starting material) 1- ( 3-Thienyl) cyclobutanecarboxylic acid The title compound was prepared in an analogous manner to that in Example 9 from 3 - thienylacetonitrile and 1,3- dibromopropane. 1- (3 -Thienyl ) cyclobutaneacetonitrile was chromatographed on silica gel using petroleumether-EtOAc 96:4 as eluent).
- EXAMPLE 29 (starting material) l-Phenyl-3, 3-dimethylcyclobutanecarboxylic acid NaH (60% dispersion in mineral oil, 77.8 mmol) was washed several times with n-pentane and suspended in DMF. Phenylacetonitrile (31 mmol) in DMF was added followed by
- the allylester of the acid was prepared.
- l-Phenyl-3-methylcyclobutanecarboxylic acid 24 mmol was refluxed with neat SOCI 2 (25 mL) for 1 h.
- S0C1 was then evaporated, the residue was dissolved in toluene and allylalcohol (26 mmol) and pyridine (26 mmol) were added.
- EXAMPLE 31 (starting material) l-Phenyl-3-cis-methylcyclobutanecarboxylic acid
- the fractions containing allyl l-phenyl-3 - cis- methylcyclobutane-carboxylate afforded in preparation of 1- phenyl-3- trans-methylcyclobutanecarboxylic acid in Example 30 above were pooled and further chromatographed on silica gel using a gradient of pecroleumether up to petroleumether-toluene 60:40 as eluent. Hydrolysis of the allyl ester gave the desired product that contained less than 2% of the trans isomer. The total yield was 0.18 g (1%); *H NMR (CDCI 3 ) ⁇ 1.03 (d, 3H) , 2.02-2.10 (m, 2H) ,
- EXAMPLE 34 (starting material) l-Phenyl-3-methylenecyclobutanecarboxylic acid Methyltriphenylphosphoniumbromide (41 mmol) was added to a suspension of KOtBu (41 mmol) in toluene (200 mL) . After stirring at 65 °C for 45 min, l-cyano-l-phenyl-3- oxycyclobutane (34 mmol) was added. The reaction mixture was stirred for another 5 min. The mixture was allowed to cool to room temperature and was then washed twice with H 2 O . The organic layer was dried ( a 2 S0 4 ) and evaporated.
- EXAMPLE 37 3- (Diethylamino)propyl 1-phenylcyclobutanecarboxylate hydrochloride
- the title compound was prepared in an analogous manner to that in Example 36 by reacting 1-phenylcyclobutane- carbonyl chloride with 3-diethylaminopropanol at 80 °C for 5 h.
- the reaction mixture was filtered and chromatographed on silica gel using toluene-Et 3 N 95:5 as eluent.
- Example 36 The title compound was prepared in an analogous manner to that in Example 36 from the compound prepared in Example 27 and 2-diethylaminoethanol .
- the crude was chromatographed on silica gel using toluene-Et 3 N 90:10 as eluent.
- Example 36 The title compound was prepared in an analogous manner to that in Example 36 from the compound prepared in Example 27 and 2-diisopropylaminoethanol .
- the crude was chromatographed using hexane-Et 3 N 90:10 as eluent.
- Example 36 The title compound was prepared in an analogous manner to that in Example 36 from the compound prepared in Example 28 and 2-diisopropylaminoethanol .
- the crude was chromatographed on silica gel using toluene-Et 3 N 92:8 as eluent. Fumaric acid (1 eq) was added to the pure amine .
- Example 36 The title compound was prepared in an analogous manner to that in Example 36 from the compound prepared in Example 32 and 2-diisopropylaminoethanol .
- the crude was chromatographed twice on silica gel using hexane-Et 3 N 90:10 and toluene-EtOAc 90:10 as eluent.
- EXAMPLE 52 2- (Diisopropylamino) ethyl l-(3,4- methylenedioxyphenyl) cyclobutanecarboxylate hydrochloride The title compound was prepared in an analogous manner to that in Example 36 from the compound prepared in Example 11 and 2-diisopropylaminoethanol . The amine salt was recrystallized from acetone-ether.
- EXAMPLE 64 3-Quinuclidinyl 1-phenylcyclobutanecarboxylate hydrochloride The title compound was prepared in an analogous manner to that in Example 36 by reacting 1-phenylcyclobutan- carbonyl chloride with 3-quinuclidinol at 80 °C for 15 h. The yield was 0.4 g (22%); mp 163-168 °C; X H NMR (D 2 0) ⁇
- Example 36 The title compound was prepared in an analogous manner to that in Example 36 by reacting 1-phenylcyclobutane- carbonyl chloride with R( -) -3-quinuclidinol at 80 °C for 30 h. The yield was 0.43 g (31%); mp 219-223 °C; X H NMR (D 2 0) ⁇ 1.80 (m, 2H) , 1.88-2.02 (m, 2H) , 2.04-2.17 (m, 2H) , 2.38 (m, IH) , 2.59-2.70 (m, 2H) , 2.90 (m, 2H) , 3.08 (q, IH) ,
- Example 36 The title compound was prepared in an analogous manner to that in Example 36 from the compound prepared in Example 29 and 3-quinuclidinol .
- the crude was chromatographed on silica gel using EtOAc-Et 3 N 90:10 as eluent.
- EXAMPLE 70 3-Quinuclidinyl 1- (4-methylphenyl)cyclobutanecarboxylate hydrochloride The title compound was prepared in an analogous manner to that in Example 36 from the compound prepared in Example 18 and 3-quinuclidinol . The yield was 0.45 g (23%); mp 209- 211 °C; ⁇ K NMR (CDCI 3 ) ⁇ 1.57 (m, 2H) , 1.88 (m, 4H) , 2.33 (s, 3H) , 2.55 (m, 2H) , 2.83 (m, 5H) , 3.23 (m, 3H), 3.55 (ddd, IH) , 5.02 (br, IH) , 7.14 (s, 4H) . Anal. (Ci 9 H 25 0 2 -HCl) C, H, N.
- Example 36 The title compound was prepared in an analogous manner to that in Example 36 from the compound prepared in Example 22 and 3-quinuclidinol .
- the crude was chromatographed on silica gel using toluene-Et 3 N 94:6 as eluent.
- EXAMPLE 76 3 -Quinuclidinyl 1- (4-fluorophenyl) cyclobutanecarboxylate hydrochloride The title compound was prepared in an analogous manner to that in Example 36 from the compound prepared in Example 20 and 3-quinuclidinol . The crude was chromatographed on silica gel using toluene-Et 3 N 94:6 as eluent.
- Example 36 The title compound was prepared in an analogous manner to that in Example 36.
- the crude was chromatographed on silica gel using Et0Ac-Et 3 N 90:10 as eluent. The yield was 0.2 g (6%); mp 194-200 °C; X H NMR (CD 3 OD) ⁇ 1.47-1.74 (m, 2H) , 1.82-2.50 (m, 3H) ,
- Example 36 The title compound was prepared in an analogous manner to that in Example 36.
- the crude was chromatographed on silica gel using Et0Ac-Et 3 N
- EXAMPLE 86 2-endo-Methyl-3-quinuclidinyl 1- phenylcyclobutanecarboxylate hydrochloride
- the title compound was prepared in an analogous manner to that in Example 36 by reacting 1-phenylcyclobutane- carbonyl chloride with 2-methyl-3-quinuclidinol at 80 °C for 30 h.
- the reaction mixture was filtered and chromatographed on silica gel using toluene- ⁇ tjN 95:5 as eluent in order to separate the two afforded isomers.
- the endo isomer eluted earlier than the exo isomer.
- EXAMPLE 90 3-Methylidenequinuclidinyl 1-phenylcyclobutanecarboxylate hydrochloride
- the title compound was prepared in an analogous manner to that in Example 36 by reacting 1-phenylcyclobutane- carboxylate hydrochloride with 3-methylidenequinuclidinol .
- the esterification was carried out in CH 2 CI 2 .
- the crude was chromatographed on silica gel using toluene-Et 3 N 88:12 as eluent.
- the crude oxocarboxylic acid was dissolved in DMF (30 L) and then added to NaH (60% dispersion in mineral oil, 20 mmol, washed twice with hexane) at ambient temperature. After 30 min N,N- diisopropyl-2-chloroethylamine (1.8 mmol) was added. After 2 h, the reaction mixture was partitioned between H 2 O and toluene. The crude product was chromatographed on silica gel using toluene-Et 3 N 98:2 as eluent.
- the crude isomer mixture was chromatographed on silica using CHCl 3 -MeOH-conc . ammonia 98:2:0.2 as eluent.
- the pure cis isomer fractions were pooled and the solvent was evaporated.
- the residue was dissolved in ' E 2 ⁇ and HCl(g)/Et 2 ⁇ was added whereby the product was collected as a colourless oil.
- the yield was
- EXAMPLE 96 (starting material) l-Phenyl-3, 3-dimethylcyclopentanecarboxylic acid
- the title compound was produced in an analogous manner to that in Example 94 from 1-phenylacetonitrile and di-O-p- toluene-sulfonyl-2-dimethyl-l, 4-butanediol .
- Example 97 The title compound was produced in an analogous manner to that in Example 97 by reacting 1-phenylcyclopentane- carbonyl chloride with 2-diisopropylaminoetha ⁇ ol at 80 °C for 8 h. The reaction mixture was filtered and chromatographed on silica gel using toluene-Et 3 N 95:5 as eluent.
- EXAMPLE 101 2- (Diisopropylamino) ethyl 1- (3-thienyl) cyclopentane- carboxylate
- the title compound was produced in an analogous manner to that in Example 97 from 1- (3- thienyl) cyclopentane- carboxylic acid, prepared in Example 95, and 2- diisopropylaminoethanol .
- the crude was chromatographed on silica gel using toluene-Et 3 N 97:3 as eluent.
- EXAMPLE 102 (1-Methyl-3-piperidino)methyl 1- (2-thienyl) cyclopentane- carboxylate hydrochloride
- the title compound was produced in an analogous manner to that in Example 97 from 1- (2- hienyl) cyclopentane- carboxylic acid, prepared in Example 94, and (l-methyl-3- piperidino)methanol .
- the crude was chromatographed on silica gel using toluene-Et 3 N 95:5 as eluent.
- EXAMPLE 103 (1-Methyl-3-piperidino)methyl 1- (3-thienyl)cyclopentane- carboxylate hydrochloride
- the title compound was produced in an analogous manner to that in Example 97 from 1- (3-thienyl) cyclopentane- carboxylic acid, prepared in Example 95, and (l-methyl-3- piperidino)methanol .
- the crude was chromatographed on silica gel using toluene-Et 3 N 97:3 as eluent. The yield was 0.82 g (57%); mp 156-157 °C; X H NMR (CDCI 3 ) ⁇ 0.
- Example 97 The title compound was produced in an analogous manner to that in Example 97 from 1- (2-thienyl ) cyclopentane- carboxylic acid, prepared in Example 94, and l-methyl-4- hydroxypiperidine .
- the crude was chromatographed on silica gel using toluene-Et 3 N 96:4 as eluent.
- Example 97 The title compound was produced in an analogous manner to that in Example 97 by reacting 1-phenylcyclopentane carbonyl chloride with 3-quinuclidinol at 80 °C for 22 h. The reaction mixture was filtered and chromatographed on silica gel using toluene-Et 3 N 95:5 as eluent.
- Example 97 The title compound was produced in an analogous manner to that in Example 97 from 1- (3-thienyl) cyclopentane- carboxylic acid, prepared in Example 95, and 3- quinuclidinol .
- the arylcyclopentanecarbonylchloride was refluxed with 3-quinuclidinol for three days.
- the crude was chromatographed on silica gel using toluene-Et 3 N 89:11 as eluent. The yield was 1.73 g (40%); mp 213-215 °C; !
- EXAMPLE 109 3-Endo- (l-azabicyclo[3.3. l]nonyl 1- phenylcyclopentanecarboxylate hydrochloride
- the title compound was produced in an analogous manner to that in Example 97 by reacting 1-phenylcyclopentane- carbonyl chloride with 3 -hydroxy-1-azabicyclo [3.3.1] nonane at 80 °C for 18 h.
- the reaction mixture was filtered and chromatographed on silica gel using toluene-Et 3 N 95:5 as eluent in order to separate the two afforded isomers.
- the endo isomer eluted earlier than the exo isomer.
- EXAMPLE 111 3-Tropanyl 1- (2-thienyl) cyclopentanecarboxylate hydrochloride
- the title compound was produced in an analogous manner to that in Example 97 from 1- (2-thienyl) cyclopentane- carboxylic acid, prepared in Example 94, and 3-tropanol.
- the crude was chromatographed on silica using toluene-Et 3 N 93:7 as eluent.
- Example 97 The title compound was produced in an analogous manner to that in Example 97 from l-phenyl-3 , 3-dimethyl- cyclopentanecarboxylic acid, prepared in Example 96, and 2- diisopropylaminoethanol .
- the crude was chromatographed on silica gel using toluene-Et 3 N 98:2 as eluent.
- EXAMPLE 115 (starting material) l-Phenyl-3 , 3 -dimethylcyclohexanecarboxylic acid NaH (60% dispersion in mineral oil, 72.3 mmol) was washed several times with n-hexane and suspended in DMF. A mixture of phenylacetonitrile (24.1 mmol) and di-O-p- toluene-sulfonyl-2-dimethyl-l , 5-pentanediol (24.1 mmol) in DMF was added dropwise. The reaction mixture was stirred at 70 °C for 3 h and DMF was evaporated under reduced pressure. Excess hydride was then decomposed by the cautious addition of H 0.
- EXAMPLE 116 (starting material) l-Phenyl-4,4-dimethylcyclohexanecarboxylic acid
- the title compound was produced in an analogous manner to that in Example 113.
- l-Phenyl-4 4-dimethylcyclohexane- acetonitrile was refluxed with KOH in ethyleneglycol for 2 days.
- the yield of the desired carboxylic acid was 0.55 g (12%) X H NMR (CDC1 3 ) ⁇ 0.94 (s, 3H) , 1.00 (s, 3H) , 1.49 (m, 2H) , 1.74 (m, 2H) , 1.92 ( , 4H) , 7.44 (m, 5H) .
- EXAMPLE 118 2- (Diisopropylamino) ethyl l-phenyl-4- methoxycyclohexanecarboxylate hydrochloride The title compound was produced in an analogous manner to that in Example 117 from l-phenyl-4-methoxycyclohexane- carboxylic acid, prepared in Example 113, and 2- diisopropylaminoethanol . The reaction with S0C1 2 was refluxed for 2 h.
- Example 117 The title compound was produced in an analogous manner to that in Example 117 from l-phenyl-4-oxocyclohexane- carboxylic acid, prepared in Example 114, and 2- diisopropylaminoethanol .
- the amine salt was recrystallized from acetone/Et 2 0.
- EXAMPLE 120 3-Quinuclidinyl 1-phenylcyclohexanecarboxylate hydrochloride
- the title compound was produced in an analogous manner to that in Example 117 by reacting 1-phenylcyclohexane- carbonyl chloride with 3-quinuclidinol at 80 °C for 25 h.
- the reaction mixture was filtered and chromatographed on silica gel using toluene-Et 3 N 95:5 as eluent.
- EXAMPLE 121 3 Quinuclidinyl l-phenyl-4-methoxycyclohexanecarboxylate hydrochloride
- the title compound was produced in an analogous manner to that in Example 117 from l-phenyl-4-methoxycyclohexane- carboxylic acid, prepared in Example 113, and 3- quinuclidinol.
- the reaction with S0C1 2 was refluxed for 2 h.
- l-Phenyl-4-methoxycyclohexanecarbonyl chloride was reacted with the 3-quinuclidinol at 50°C for 15 h.
- Example 117 The title compound was produced in an analogous manner to that in Example 117 by reacting l-phenyl-4- oxocyclohexanecarboxylic acid, prepared in Example 114, with 3-quinuclidinol at 50°C for 15 h.
- Example 117 The title compound was produced in an analogous manner to that in Example 117 by reacting 1-phenylcyclohexane- carbonyl chloride (2.45 mmol) with BOC-protected isopropylaminoethanol (2.69 mmol) and pyridine (2.69 mmol) at room temperature overnight. The solvent was then evaporated and the residue was dissolved in EtOAc. 3 M HCl was added and the reaction mixture was stirred overnight. The mixture was then treated with NaOH and extracted with Et 2 ⁇ and EtOAc . The combined organic layers were dried (MgS0 ) and concentrated in vacuo.
- Example 117 The title compound was produced in an analogous manner to that in Example 117 from l-phenyl-4 , 4-dimethyl- cyclohexanecarboxylic acid, prepared in Example 116, and 2- diisopropylaminoethanol .
- the crude was chromatographed on silica gel using toluene-Et 3 N 99:1.
- Weight of 1 tablet 325 mg * The mesh standard is according to the international system of code DIN 4189/1968.
- EXAMPLE G 5 mg sterile powder to be dissolved in water for injection
- the substances are dissolved in distilled water.
- the solution is dispensed in vials and freeze-dried.
- the Active Compounds are those covered by the general Formulae I and IA above or their addition salts with pharmaceutically acceptable inorganic or organic acids.
- Water-soluble Active Compounds are such addition salts or salts with a pharmaceutically acceptable inorganic or organic cation.
- two or more Active Compounds of the invention may be used in combination in the composition illustrated, and also, if desired, in combination with other pharmacologically active agents. BIOLOGICAL EVALUATION
- Dissected tissues were homogenised in an ice-cold sodium-potassium phosphate buffer (50 mM, pH 7.4) containing 1 mM PMSF, using a Polytron PT-10 instrument (heart, parotid) and a Potter-Elvehjem Teflon homogeniser (cortex) . All homogenates were finally diluted with the ice-cold phosphate/PMSF buffer to a final protein concentration of ⁇ 0.3 mg/ml and immediately used in the receptor binding assays. Protein was determined by the method of Lowry et al . (1951) , us ing bovine serum albumin as the standard.
- the muscarinic receptor affinities of unlabelled compounds of the Examples were derived from competition experiments in which the ability to inhibit the receptor specific binding of (-) 3 H-QNB ( 1-quinuclidinyl [phenyl-4- 3 H]benzilate, 32-52 Ci/mmole) was monitored as previously described 3 ' 5 . Each sample contained 10 ⁇ l of (-) 3 H-QNB
- the method has been changed from centrifugation assay to filtration assay.
- the K ⁇ -values for atropine, AF-DX 116, 4-DAMP and pirenzepine were compared with those previously determined using centrifugation assays.
- the Kj_-values of these two methods were almost identical (within the experimental error) .
- the time of incubation was prolonged by 20-40 minutes due to the slower process of gaining 25°C in the present samples. Functional in vitro studies
- the tested compounds exhibit high activity and specificity as antagonists for muscarinic receptor mediated bladder contraction. They also show a high affinity and specificity to intestinal muscle.
- Nilvebrant, L; Sparf, B. Dicyclomine, benzhexol and oxybutynin distinguish between sub-classes of muscarinic binding-sites. Eur . J. Pharmacol. 1986, 123, 133-143.
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Abstract
Description
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Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ333798A NZ333798A (en) | 1996-07-29 | 1997-07-23 | Arylcycloalkane carboxylic esters, their use for the treatment of urinary incontinence or irritable bowel syndrome, and method of manufacture. |
EP97934832A EP0923536A1 (en) | 1996-07-29 | 1997-07-23 | Arylcycloalkane carboxylic esters, their use, pharmaceutical compositions and preparation |
US09/230,164 US6124354A (en) | 1996-07-29 | 1997-07-23 | Arylcycloalkane carboxylic esters, their use, pharmaceutical compositions and preparation |
IL12809697A IL128096A0 (en) | 1996-07-29 | 1997-07-23 | Arylcycloalkane carboxylic esters their use pharmaceutical compositions and preparation |
SK46-99A SK4699A3 (en) | 1996-07-29 | 1997-07-23 | Arylcycloalkane carboxylic esters, their use, pharmaceutical compositions and preparation |
AU37905/97A AU724563B2 (en) | 1996-07-29 | 1997-07-23 | Arylcycloalkane carboxylic esters, their use, pharmaceutical compositions and preparation |
JP10508739A JP2000515881A (en) | 1996-07-29 | 1997-07-23 | Arylcycloalkanecarboxylates, their use, pharmaceutical compositions and preparation |
BR9710614-3A BR9710614A (en) | 1996-07-29 | 1997-07-23 | Carboxylic arylcycloalkane esters, their use, pharmaceutical composition and preparation. |
EEP199900034A EE9900034A (en) | 1996-07-29 | 1997-07-23 | Arylcycloalkanecarboxylic esters, their use, pharmaceutical compositions and their preparation |
NO990335A NO990335L (en) | 1996-07-29 | 1999-01-25 | Arylic cycloalkanecarboxyl esters, their use, pharmaceutical compositions and preparation |
BG103207A BG103207A (en) | 1996-07-29 | 1999-02-25 | Esters of the arylcycloalkanecarboxylic acids, their application, pharmaceutical compositions and their preparation |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9602890-7 | 1996-07-29 | ||
SE9602887A SE9602887D0 (en) | 1996-07-29 | 1996-07-29 | Carboxylic esters, their use and preparation |
SE9602887-3 | 1996-07-29 | ||
SE9602890A SE9602890D0 (en) | 1996-07-29 | 1996-07-29 | Carboxylic esters, their use and preparation |
SE9602888-1 | 1996-07-29 | ||
SE9602888A SE9602888D0 (en) | 1996-07-29 | 1996-07-29 | Carboxylic esters, their use and preparation |
SE9602889-9 | 1996-07-29 | ||
SE9602889A SE9602889D0 (en) | 1996-07-29 | 1996-07-29 | Carboxylic esters, their use and preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998004517A1 true WO1998004517A1 (en) | 1998-02-05 |
Family
ID=27484794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1997/001310 WO1998004517A1 (en) | 1996-07-29 | 1997-07-23 | Arylcycloalkane carboxylic esters, their use, pharmaceutical compositions and preparation |
Country Status (17)
Country | Link |
---|---|
US (1) | US6124354A (en) |
EP (1) | EP0923536A1 (en) |
JP (1) | JP2000515881A (en) |
KR (1) | KR20000029703A (en) |
CN (1) | CN1226886A (en) |
AU (1) | AU724563B2 (en) |
BG (1) | BG103207A (en) |
BR (1) | BR9710614A (en) |
CA (1) | CA2261692A1 (en) |
EE (1) | EE9900034A (en) |
IL (1) | IL128096A0 (en) |
NO (1) | NO990335L (en) |
NZ (1) | NZ333798A (en) |
PL (1) | PL331384A1 (en) |
SK (1) | SK4699A3 (en) |
TR (1) | TR199900185T2 (en) |
WO (1) | WO1998004517A1 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008059239A1 (en) * | 2006-11-14 | 2008-05-22 | Astrazeneca Ab | Novel compounds 514 |
WO2008059245A1 (en) | 2006-11-14 | 2008-05-22 | Astrazeneca Ab | Quiniclidine derivatives of (hetero) arylcycloheptanecarboxylic acid as muscarinic receptor antagonists |
WO2009139708A1 (en) * | 2008-05-13 | 2009-11-19 | Astrazeneca Ab | PHARMACEUTICAL PRODUCT COMPRISING A MUSCARINIC RECEPTOR ANTAGONIST AND A β2-ADRENOCEPTOR AGONIST |
US8329729B2 (en) | 2008-05-13 | 2012-12-11 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic M3 receptor antagonists |
WO2012145234A3 (en) * | 2011-04-21 | 2012-12-13 | Emory University | Cyclopropyl derivatives and methods of use |
US10456390B2 (en) | 2013-07-25 | 2019-10-29 | Almirall, S.A. | Combinations comprising MABA compounds and corticosteroids |
US11008316B2 (en) | 2012-09-11 | 2021-05-18 | Genzyme Corporation | Glucosylceramide synthase inhibitors |
US11857512B2 (en) | 2020-07-24 | 2024-01-02 | Genzyme Corporation | Pharmaceutical compositions comprising venglustat |
US12083115B2 (en) | 2020-02-03 | 2024-09-10 | Genzyme Corporation | Methods for treating neurological symptoms associated with lysosomal storage diseases |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20020547A1 (en) | 2000-10-24 | 2002-06-12 | Upjohn Co | USE OF TOLTERODINE IN ASTHMA TREATMENTS |
JP2005511582A (en) * | 2001-11-05 | 2005-04-28 | ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー | Antimuscarinic aerosol |
EP1589968A4 (en) * | 2003-01-16 | 2009-05-06 | Univ Rochester | Quaternary antimuscarinic compounds for the treatment of bladder diseases |
TW201617343A (en) * | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | New bicyclic derivatives having [beta]2 adrenergic agonist and M3 muscarinic antagonist activities |
CN106083615B (en) * | 2016-06-08 | 2019-03-08 | 山东省药学科学院 | A kind of preparation method of cyclopentolate hydrochloride |
EP3643703A4 (en) | 2017-06-21 | 2020-12-23 | Daiichi Sankyo Co., Ltd. | Ep300/crebbp inhibitor |
Citations (3)
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FR2168881A1 (en) * | 1972-01-25 | 1973-09-07 | Synthelabo | Tropanol 1-phenylcycloalkane carboxylic ester salts - spasmolytics and cholinergics |
EP0382687A2 (en) * | 1989-02-06 | 1990-08-16 | BOEHRINGER INGELHEIM ITALIA S.p.A. | Benzofused-N-containing heterocycle derivatives |
DD289411A7 (en) * | 1984-06-29 | 1991-05-02 | Arzneimittelwerk Dresden Gmbh,De | PROCESS FOR PREPARING ANTIDOS FOR PHOSPHORORGANIC COMPOUNDS |
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US4418202A (en) * | 1981-12-21 | 1983-11-29 | Emery Industries, Inc. | 2-Vinyl- and 2-ethylcyclopropane monocarboxylates |
US5086054A (en) * | 1990-07-31 | 1992-02-04 | Sri International | Novel arylcycloalkanepolyalkylamines |
US5064850A (en) * | 1991-04-08 | 1991-11-12 | Marion Merrell Dow Inc. | Dihydro-3,3-diphenyl-5-(1H-pyrazol-1-ylmethyl-2(3H)-furanone and dihydro-5-((substituted-1H-pyrazol-1-yl)methyl)-3,3-diphenyl-2(3H)-furanone derivatives |
US5817679A (en) * | 1993-04-01 | 1998-10-06 | University Of Virginia | 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands |
-
1997
- 1997-07-23 IL IL12809697A patent/IL128096A0/en unknown
- 1997-07-23 CN CN97196892A patent/CN1226886A/en active Pending
- 1997-07-23 AU AU37905/97A patent/AU724563B2/en not_active Ceased
- 1997-07-23 EP EP97934832A patent/EP0923536A1/en not_active Withdrawn
- 1997-07-23 KR KR1019997000803A patent/KR20000029703A/en not_active Application Discontinuation
- 1997-07-23 US US09/230,164 patent/US6124354A/en not_active Expired - Fee Related
- 1997-07-23 PL PL97331384A patent/PL331384A1/en unknown
- 1997-07-23 BR BR9710614-3A patent/BR9710614A/en unknown
- 1997-07-23 JP JP10508739A patent/JP2000515881A/en active Pending
- 1997-07-23 SK SK46-99A patent/SK4699A3/en unknown
- 1997-07-23 WO PCT/SE1997/001310 patent/WO1998004517A1/en not_active Application Discontinuation
- 1997-07-23 TR TR1999/00185T patent/TR199900185T2/en unknown
- 1997-07-23 NZ NZ333798A patent/NZ333798A/en unknown
- 1997-07-23 CA CA002261692A patent/CA2261692A1/en not_active Abandoned
- 1997-07-23 EE EEP199900034A patent/EE9900034A/en unknown
-
1999
- 1999-01-25 NO NO990335A patent/NO990335L/en not_active Application Discontinuation
- 1999-02-25 BG BG103207A patent/BG103207A/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2168881A1 (en) * | 1972-01-25 | 1973-09-07 | Synthelabo | Tropanol 1-phenylcycloalkane carboxylic ester salts - spasmolytics and cholinergics |
DD289411A7 (en) * | 1984-06-29 | 1991-05-02 | Arzneimittelwerk Dresden Gmbh,De | PROCESS FOR PREPARING ANTIDOS FOR PHOSPHORORGANIC COMPOUNDS |
EP0382687A2 (en) * | 1989-02-06 | 1990-08-16 | BOEHRINGER INGELHEIM ITALIA S.p.A. | Benzofused-N-containing heterocycle derivatives |
Non-Patent Citations (3)
Title |
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CANADIAN JOURNAL OF CHEMISTRY, Volume 40, 1962, R.A.B. BANNARD et al., "Preparation of Antidotes for Anticholinesterase Poisoning I. Parpanit Analogues", pages 1909-1916. * |
EUROPEAN JOURNAL OF PHARMACOLOGY, Volume 231, 1993, ROBERT L. HUDKINS et al., "Caramiphen, Iodocaramiphen and Nitrocaramiphen are Potent, Competitive, Muscarinic M1 Receptor-Selective Agents", pages 485-488. * |
MED. CHEM. RES., Volume 2, 1992, JAMES F. STUBBINS et al., "Muscarinic M1 and M2 Binding Affinity of Cyclic Amine Derivatives of Caramiphen and Dicyclomine", pages 384-393. * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8207193B2 (en) | 2006-11-14 | 2012-06-26 | Astrazeneca Ab | Quiniclidine derivatives of (hetero) arylcycloheptanecarboxylic acid as muscarinic receptor antagonists |
WO2008059245A1 (en) | 2006-11-14 | 2008-05-22 | Astrazeneca Ab | Quiniclidine derivatives of (hetero) arylcycloheptanecarboxylic acid as muscarinic receptor antagonists |
WO2008059239A1 (en) * | 2006-11-14 | 2008-05-22 | Astrazeneca Ab | Novel compounds 514 |
EP2256117A1 (en) | 2006-11-14 | 2010-12-01 | AstraZeneca AB | Quiniclidine derivatives of (hetero) arylcycloheptanecarboxylic acid as muscarinic receptor antagonists |
US8329729B2 (en) | 2008-05-13 | 2012-12-11 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic M3 receptor antagonists |
AU2009247021B2 (en) * | 2008-05-13 | 2012-06-07 | Astrazeneca Ab | Pharmaceutical product comprising a muscarinic receptor antagonist and a beta2-adrenoceptor agonist |
WO2009139708A1 (en) * | 2008-05-13 | 2009-11-19 | Astrazeneca Ab | PHARMACEUTICAL PRODUCT COMPRISING A MUSCARINIC RECEPTOR ANTAGONIST AND A β2-ADRENOCEPTOR AGONIST |
CN102088976B (en) * | 2008-05-13 | 2012-12-26 | 阿斯利康(瑞典)有限公司 | Pharmaceutical product comprising a muscarinic receptor antagonist and a beta2-adrenoceptor agonist |
WO2012145234A3 (en) * | 2011-04-21 | 2012-12-13 | Emory University | Cyclopropyl derivatives and methods of use |
US10207984B2 (en) | 2011-04-21 | 2019-02-19 | Emory University | Cyclopropyl derivatives and methods of use |
US11008316B2 (en) | 2012-09-11 | 2021-05-18 | Genzyme Corporation | Glucosylceramide synthase inhibitors |
US12060349B2 (en) | 2012-09-11 | 2024-08-13 | Genzyme Corporation | Glucosylceramide synthase inhibitors |
US10456390B2 (en) | 2013-07-25 | 2019-10-29 | Almirall, S.A. | Combinations comprising MABA compounds and corticosteroids |
US12083115B2 (en) | 2020-02-03 | 2024-09-10 | Genzyme Corporation | Methods for treating neurological symptoms associated with lysosomal storage diseases |
US11857512B2 (en) | 2020-07-24 | 2024-01-02 | Genzyme Corporation | Pharmaceutical compositions comprising venglustat |
Also Published As
Publication number | Publication date |
---|---|
CN1226886A (en) | 1999-08-25 |
PL331384A1 (en) | 1999-07-05 |
EP0923536A1 (en) | 1999-06-23 |
IL128096A0 (en) | 1999-11-30 |
NO990335D0 (en) | 1999-01-25 |
SK4699A3 (en) | 2000-04-10 |
NO990335L (en) | 1999-03-29 |
JP2000515881A (en) | 2000-11-28 |
AU724563B2 (en) | 2000-09-28 |
KR20000029703A (en) | 2000-05-25 |
CA2261692A1 (en) | 1998-02-05 |
AU3790597A (en) | 1998-02-20 |
BG103207A (en) | 1999-10-29 |
EE9900034A (en) | 1999-08-16 |
TR199900185T2 (en) | 1999-04-21 |
US6124354A (en) | 2000-09-26 |
BR9710614A (en) | 2000-01-11 |
NZ333798A (en) | 2000-08-25 |
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