WO1998002149A3 - Use of idebenone and analogues against beta amyloid induced cytotoxicity - Google Patents

Use of idebenone and analogues against beta amyloid induced cytotoxicity Download PDF

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Publication number
WO1998002149A3
WO1998002149A3 PCT/JP1997/002391 JP9702391W WO9802149A3 WO 1998002149 A3 WO1998002149 A3 WO 1998002149A3 JP 9702391 W JP9702391 W JP 9702391W WO 9802149 A3 WO9802149 A3 WO 9802149A3
Authority
WO
WIPO (PCT)
Prior art keywords
idebenone
optionally substituted
beta amyloid
induced cytotoxicity
against beta
Prior art date
Application number
PCT/JP1997/002391
Other languages
French (fr)
Other versions
WO1998002149A2 (en
Inventor
Masaomi Miyamoto
Keisuke Hirai
Giichi Goto
Original Assignee
Takeda Chemical Industries Ltd
Masaomi Miyamoto
Keisuke Hirai
Giichi Goto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd, Masaomi Miyamoto, Keisuke Hirai, Giichi Goto filed Critical Takeda Chemical Industries Ltd
Priority to US09/180,463 priority Critical patent/US6271266B1/en
Priority to EP97930746A priority patent/EP0915696B1/en
Priority to DE69712888T priority patent/DE69712888D1/en
Priority to AT97930746T priority patent/ATE218060T1/en
Priority to AU34589/97A priority patent/AU3458997A/en
Publication of WO1998002149A2 publication Critical patent/WO1998002149A2/en
Publication of WO1998002149A3 publication Critical patent/WO1998002149A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A compound of formula (I) or (II) wherein R1 represents a lower alkyl; R2 represents H, an optionally substituted alkyl or an optionally substituted alkenyl; R?3 and R4¿ each represents an optionally substituted lower alkyl or a lower alkoxy, or R?3 and R4¿ form, taken together, an optionally substituted butadienylene; and X?1 and X2¿ each represents an optionally esterified or etherified hydroxy, or a salt thereof is useful for protecting cells from the cytotoxicity of β-amyloid protein.
PCT/JP1997/002391 1996-07-11 1997-07-10 Use of idebenone and analogues against beta amyloid induced cytotoxicity WO1998002149A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US09/180,463 US6271266B1 (en) 1996-07-11 1997-07-10 Use of idebenone and analogues against β amyloid induced cytotoxicity
EP97930746A EP0915696B1 (en) 1996-07-11 1997-07-10 ANTI-beta-AMYLOID PROTEIN-INDUCED CYTOTOXICITY COMPOSITION
DE69712888T DE69712888D1 (en) 1996-07-11 1997-07-10 COMPILATIONS THAT PREVENT beta-AMYLOID PROTEIN CONDITIONAL CYTOTOXICITY
AT97930746T ATE218060T1 (en) 1996-07-11 1997-07-10 COMPOSITIONS THAT PREVENT BETA-AMYLOID PROTEIN RELATED CYTOTOXICITY
AU34589/97A AU3458997A (en) 1996-07-11 1997-07-10 Anti-beta-amyloid protein-induced cytotoxicity composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18209596 1996-07-11
JP8/182095 1996-07-11

Publications (2)

Publication Number Publication Date
WO1998002149A2 WO1998002149A2 (en) 1998-01-22
WO1998002149A3 true WO1998002149A3 (en) 1998-06-04

Family

ID=16112269

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/002391 WO1998002149A2 (en) 1996-07-11 1997-07-10 Use of idebenone and analogues against beta amyloid induced cytotoxicity

Country Status (7)

Country Link
US (1) US6271266B1 (en)
EP (1) EP0915696B1 (en)
AT (1) ATE218060T1 (en)
AU (1) AU3458997A (en)
CA (1) CA2252519A1 (en)
DE (1) DE69712888D1 (en)
WO (1) WO1998002149A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1888059T3 (en) * 2005-06-01 2015-03-30 Edison Pharmaceuticals Inc Redox-active therapeutic products for the treatment of mitochondrial diseases and other conditions as well as modulation of energy biomarkers
JP2009508867A (en) * 2005-09-15 2009-03-05 エジソン ファーマシューティカルズ， インコーポレイテッド Tail variants of redox-active therapeutic agents for the treatment of mitochondrial diseases and related aspects and for modulation of energy biomarkers
US9278085B2 (en) 2006-02-22 2016-03-08 Edison Pharmaceuticals, Inc. Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
EP1891946A1 (en) * 2006-08-14 2008-02-27 Santhera Pharmaceuticals (Schweiz) AG Transmucosal administration of 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone
US7968746B2 (en) 2007-11-06 2011-06-28 Edison Pharmaceuticals, Inc. 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases
CA2736250C (en) 2008-09-10 2016-12-20 Edison Pharmaceuticals, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
US8263094B2 (en) * 2008-09-23 2012-09-11 Eastman Chemical Company Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof
SI2605769T1 (en) * 2010-08-16 2016-10-28 Santhera Pharmaceuticals (Schweiz) Ag Benzoquinone derivatives for the treatment of mitchondrial eye diseases
WO2014035356A1 (en) * 2012-08-31 2014-03-06 Mahmut Bilgic Tablet formulations comprising a quinone derivative active agent
BR112017012988B1 (en) 2014-12-16 2023-10-03 Ptc Therapeutics, Inc POLYMORAPHIC AND AMORPHOUS FORMS OF (R)-2-HYDROXY-2- METHYL-4- (2,4,5-TRIMETHYL-3,6-DIOXOCYCLOHEXA-1,4-DIENYL) BUTANAMIDE
EP3389646A1 (en) 2015-12-17 2018-10-24 BioElectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
EP3615502B1 (en) 2017-04-21 2023-06-21 University Of Tasmania Therapeutic compounds and methods
CN113365616A (en) 2018-10-17 2021-09-07 Ptc医疗公司 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1, 4-diones for the inhibition and treatment of alpha-synucleinopathies, tauopathies and other diseases
KR20240032997A (en) 2021-07-08 2024-03-12 피티씨 테라퓨틱스, 인크. Pharmaceutical composition comprising 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0629400A1 (en) * 1993-06-18 1994-12-21 Takeda Chemical Industries, Ltd. Idebenone compositions for treating Alzheimer's disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08768B2 (en) 1989-08-24 1996-01-10 武田薬品工業株式会社 Nerve growth factor secretion inducer
JP2849286B2 (en) * 1992-07-09 1999-01-20 三菱電機株式会社 Method for manufacturing semiconductor device

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0629400A1 (en) * 1993-06-18 1994-12-21 Takeda Chemical Industries, Ltd. Idebenone compositions for treating Alzheimer's disease

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
G. WEYER ET AL.: "Efficacy and safety of idebenone in the long-term treatment of Alzheimer's disease: a double-blind, placebo-controlled multicentre study.", HUM. PSYCHOPHARMACOL., vol. 11, no. 1, 1996, pages 53 - 65, XP002047720 *
N.G. RANEN ET AL.: "A controlled trial of idebenone in Huntington's disease.", MOV. DISORD., vol. 11, no. 5, 1996, pages 549 - 554, XP002047721 *
T. NABESHIMA: "Nerve growth factor strategy and preparation of animal model for Alzheimer-type senile dementia.", J. PHARM. SOC. JPN, vol. 115, no. 7, 1995, pages 499 - 512, XP002047725 *
U. SENIN ET AL.: "Idebenone in senile dementia of alzheimer type.", ARCH. GERONTOL. GERIATR., vol. 15, no. 3, 1992, pages 249 - 260, XP002047722 *

Also Published As

Publication number Publication date
ATE218060T1 (en) 2002-06-15
AU3458997A (en) 1998-02-09
EP0915696B1 (en) 2002-05-29
DE69712888D1 (en) 2002-07-04
EP0915696A2 (en) 1999-05-19
US6271266B1 (en) 2001-08-07
CA2252519A1 (en) 1998-01-22
WO1998002149A2 (en) 1998-01-22

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