WO1998002149A3 - Use of idebenone and analogues against beta amyloid induced cytotoxicity - Google Patents
Use of idebenone and analogues against beta amyloid induced cytotoxicity Download PDFInfo
- Publication number
- WO1998002149A3 WO1998002149A3 PCT/JP1997/002391 JP9702391W WO9802149A3 WO 1998002149 A3 WO1998002149 A3 WO 1998002149A3 JP 9702391 W JP9702391 W JP 9702391W WO 9802149 A3 WO9802149 A3 WO 9802149A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- idebenone
- optionally substituted
- beta amyloid
- induced cytotoxicity
- against beta
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/180,463 US6271266B1 (en) | 1996-07-11 | 1997-07-10 | Use of idebenone and analogues against β amyloid induced cytotoxicity |
EP97930746A EP0915696B1 (en) | 1996-07-11 | 1997-07-10 | ANTI-beta-AMYLOID PROTEIN-INDUCED CYTOTOXICITY COMPOSITION |
DE69712888T DE69712888D1 (en) | 1996-07-11 | 1997-07-10 | COMPILATIONS THAT PREVENT beta-AMYLOID PROTEIN CONDITIONAL CYTOTOXICITY |
AT97930746T ATE218060T1 (en) | 1996-07-11 | 1997-07-10 | COMPOSITIONS THAT PREVENT BETA-AMYLOID PROTEIN RELATED CYTOTOXICITY |
AU34589/97A AU3458997A (en) | 1996-07-11 | 1997-07-10 | Anti-beta-amyloid protein-induced cytotoxicity composition |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18209596 | 1996-07-11 | ||
JP8/182095 | 1996-07-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998002149A2 WO1998002149A2 (en) | 1998-01-22 |
WO1998002149A3 true WO1998002149A3 (en) | 1998-06-04 |
Family
ID=16112269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1997/002391 WO1998002149A2 (en) | 1996-07-11 | 1997-07-10 | Use of idebenone and analogues against beta amyloid induced cytotoxicity |
Country Status (7)
Country | Link |
---|---|
US (1) | US6271266B1 (en) |
EP (1) | EP0915696B1 (en) |
AT (1) | ATE218060T1 (en) |
AU (1) | AU3458997A (en) |
CA (1) | CA2252519A1 (en) |
DE (1) | DE69712888D1 (en) |
WO (1) | WO1998002149A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1888059T3 (en) * | 2005-06-01 | 2015-03-30 | Edison Pharmaceuticals Inc | Redox-active therapeutic products for the treatment of mitochondrial diseases and other conditions as well as modulation of energy biomarkers |
JP2009508867A (en) * | 2005-09-15 | 2009-03-05 | エジソン ファーマシューティカルズ, インコーポレイテッド | Tail variants of redox-active therapeutic agents for the treatment of mitochondrial diseases and related aspects and for modulation of energy biomarkers |
US9278085B2 (en) | 2006-02-22 | 2016-03-08 | Edison Pharmaceuticals, Inc. | Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
EP1891946A1 (en) * | 2006-08-14 | 2008-02-27 | Santhera Pharmaceuticals (Schweiz) AG | Transmucosal administration of 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone |
US7968746B2 (en) | 2007-11-06 | 2011-06-28 | Edison Pharmaceuticals, Inc. | 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
CA2736250C (en) | 2008-09-10 | 2016-12-20 | Edison Pharmaceuticals, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
US8263094B2 (en) * | 2008-09-23 | 2012-09-11 | Eastman Chemical Company | Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof |
SI2605769T1 (en) * | 2010-08-16 | 2016-10-28 | Santhera Pharmaceuticals (Schweiz) Ag | Benzoquinone derivatives for the treatment of mitchondrial eye diseases |
WO2014035356A1 (en) * | 2012-08-31 | 2014-03-06 | Mahmut Bilgic | Tablet formulations comprising a quinone derivative active agent |
BR112017012988B1 (en) | 2014-12-16 | 2023-10-03 | Ptc Therapeutics, Inc | POLYMORAPHIC AND AMORPHOUS FORMS OF (R)-2-HYDROXY-2- METHYL-4- (2,4,5-TRIMETHYL-3,6-DIOXOCYCLOHEXA-1,4-DIENYL) BUTANAMIDE |
EP3389646A1 (en) | 2015-12-17 | 2018-10-24 | BioElectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
EP3615502B1 (en) | 2017-04-21 | 2023-06-21 | University Of Tasmania | Therapeutic compounds and methods |
CN113365616A (en) | 2018-10-17 | 2021-09-07 | Ptc医疗公司 | 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1, 4-diones for the inhibition and treatment of alpha-synucleinopathies, tauopathies and other diseases |
KR20240032997A (en) | 2021-07-08 | 2024-03-12 | 피티씨 테라퓨틱스, 인크. | Pharmaceutical composition comprising 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0629400A1 (en) * | 1993-06-18 | 1994-12-21 | Takeda Chemical Industries, Ltd. | Idebenone compositions for treating Alzheimer's disease |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08768B2 (en) | 1989-08-24 | 1996-01-10 | 武田薬品工業株式会社 | Nerve growth factor secretion inducer |
JP2849286B2 (en) * | 1992-07-09 | 1999-01-20 | 三菱電機株式会社 | Method for manufacturing semiconductor device |
-
1997
- 1997-07-10 DE DE69712888T patent/DE69712888D1/en not_active Expired - Lifetime
- 1997-07-10 EP EP97930746A patent/EP0915696B1/en not_active Expired - Lifetime
- 1997-07-10 US US09/180,463 patent/US6271266B1/en not_active Expired - Fee Related
- 1997-07-10 AU AU34589/97A patent/AU3458997A/en not_active Abandoned
- 1997-07-10 CA CA002252519A patent/CA2252519A1/en not_active Abandoned
- 1997-07-10 WO PCT/JP1997/002391 patent/WO1998002149A2/en active IP Right Grant
- 1997-07-10 AT AT97930746T patent/ATE218060T1/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0629400A1 (en) * | 1993-06-18 | 1994-12-21 | Takeda Chemical Industries, Ltd. | Idebenone compositions for treating Alzheimer's disease |
Non-Patent Citations (4)
Title |
---|
G. WEYER ET AL.: "Efficacy and safety of idebenone in the long-term treatment of Alzheimer's disease: a double-blind, placebo-controlled multicentre study.", HUM. PSYCHOPHARMACOL., vol. 11, no. 1, 1996, pages 53 - 65, XP002047720 * |
N.G. RANEN ET AL.: "A controlled trial of idebenone in Huntington's disease.", MOV. DISORD., vol. 11, no. 5, 1996, pages 549 - 554, XP002047721 * |
T. NABESHIMA: "Nerve growth factor strategy and preparation of animal model for Alzheimer-type senile dementia.", J. PHARM. SOC. JPN, vol. 115, no. 7, 1995, pages 499 - 512, XP002047725 * |
U. SENIN ET AL.: "Idebenone in senile dementia of alzheimer type.", ARCH. GERONTOL. GERIATR., vol. 15, no. 3, 1992, pages 249 - 260, XP002047722 * |
Also Published As
Publication number | Publication date |
---|---|
ATE218060T1 (en) | 2002-06-15 |
AU3458997A (en) | 1998-02-09 |
EP0915696B1 (en) | 2002-05-29 |
DE69712888D1 (en) | 2002-07-04 |
EP0915696A2 (en) | 1999-05-19 |
US6271266B1 (en) | 2001-08-07 |
CA2252519A1 (en) | 1998-01-22 |
WO1998002149A2 (en) | 1998-01-22 |
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