WO1997049703A3 - Oxazolone derivatives and their use as anti-helicobacter pylori agents - Google Patents

Oxazolone derivatives and their use as anti-helicobacter pylori agents Download PDF

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Publication number
WO1997049703A3
WO1997049703A3 PCT/JP1997/002157 JP9702157W WO9749703A3 WO 1997049703 A3 WO1997049703 A3 WO 1997049703A3 JP 9702157 W JP9702157 W JP 9702157W WO 9749703 A3 WO9749703 A3 WO 9749703A3
Authority
WO
WIPO (PCT)
Prior art keywords
helicobacter pylori
substituted
group
oxazolone derivatives
pylori agents
Prior art date
Application number
PCT/JP1997/002157
Other languages
French (fr)
Other versions
WO1997049703A2 (en
Inventor
Tsuneo Kanamaru
Masafumi Nakao
Hiroyuki Tawada
Keiji Kamiyama
Original Assignee
Takeda Chemical Industries Ltd
Tsuneo Kanamaru
Masafumi Nakao
Hiroyuki Tawada
Keiji Kamiyama
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd, Tsuneo Kanamaru, Masafumi Nakao, Hiroyuki Tawada, Keiji Kamiyama filed Critical Takeda Chemical Industries Ltd
Priority to AU31913/97A priority Critical patent/AU3191397A/en
Priority to EP97927428A priority patent/EP0923577A2/en
Priority to US09/142,506 priority patent/US6169102B1/en
Publication of WO1997049703A2 publication Critical patent/WO1997049703A2/en
Publication of WO1997049703A3 publication Critical patent/WO1997049703A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings

Abstract

An anti-Helicobacter pylori agent comprising a compound represented by formula (I) wherein A represents an aromatic ring group which may be substituted; R?1 and R2¿, whether identical or not, each represents a hydrogen atom or a hydrocarbon group which may be substituted; R?3 and R4¿, whether identical or not, each represents a hydrogen atom, a hydrocarbon group which may be substituted, an acyl group, a carbamoyl group which may be substituted, or a carboxyl group which may be esterified; or a salt thereof.
PCT/JP1997/002157 1996-06-25 1997-06-24 Oxazolone derivatives and their use as anti-helicobacter pylori agents WO1997049703A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU31913/97A AU3191397A (en) 1996-06-25 1997-06-24 Oxazolone derivatives and their use as anti-(helicobacter pylori) agent
EP97927428A EP0923577A2 (en) 1996-06-25 1997-06-24 Oxazolone derivatives and their use as anti-helicobacter pylori agent
US09/142,506 US6169102B1 (en) 1996-06-25 1997-06-24 Oxazolone derivatives and their use as anti-Helicobacter pylori agent

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP16485496 1996-06-25
JP8/164854 1996-06-25
JP9/25162 1997-02-07
JP2516297 1997-02-07
ZA978876A ZA978876B (en) 1996-06-25 1997-10-03 Oxazolone derivatives and their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/708,542 Division US6414003B1 (en) 1996-06-25 2000-11-09 Oxazolone derivatives and their use as anti-helicobacter pylori agents

Publications (2)

Publication Number Publication Date
WO1997049703A2 WO1997049703A2 (en) 1997-12-31
WO1997049703A3 true WO1997049703A3 (en) 1998-02-26

Family

ID=27284916

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/002157 WO1997049703A2 (en) 1996-06-25 1997-06-24 Oxazolone derivatives and their use as anti-helicobacter pylori agents

Country Status (6)

Country Link
EP (1) EP0923577A2 (en)
CN (1) CN1077892C (en)
AU (1) AU3191397A (en)
CA (1) CA2248784A1 (en)
WO (1) WO1997049703A2 (en)
ZA (1) ZA978876B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841295B2 (en) 2005-11-04 2014-09-23 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US8865735B2 (en) 2011-02-21 2014-10-21 Hoffman-La Roche Inc. Solid forms of a pharmaceutically active substance
US9096593B2 (en) 2009-11-06 2015-08-04 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
US9169250B2 (en) 2006-11-22 2015-10-27 Plexxikon Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US9447089B2 (en) 2009-04-03 2016-09-20 Plexxikon Inc. Compositions and uses thereof
US9469640B2 (en) 2007-07-17 2016-10-18 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387687B1 (en) * 1998-07-30 2002-05-14 Takeda Chemical Industries, Ltd. Process for producing indolmycin
KR20020038759A (en) 1999-10-20 2002-05-23 다니구치 미즈오 Method for stabilizing benzimidazole compounds
CN1925855B (en) 2003-12-19 2010-06-16 普莱希科公司 Compounds and methods for development of Ret modulators
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
US7371862B2 (en) 2005-11-11 2008-05-13 Pfizer Italia S.R.L. Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
DK2672967T3 (en) 2011-02-07 2019-01-02 Plexxikon Inc RELATIONSHIPS AND METHODS FOR CHINESE MODULATION AND INDICATIONS THEREOF
WO2012158957A2 (en) 2011-05-17 2012-11-22 Plexxikon Inc. Kinase modulation and indications therefor
US9358235B2 (en) 2012-03-19 2016-06-07 Plexxikon Inc. Kinase modulation, and indications therefor
EP4083037A4 (en) * 2019-12-26 2024-01-24 Yonsei Univ Univ Industry Foundation Uif Pyrrolidine derivative, and pharmaceutical composition for preventing or treating beta-amyloid or tau protein-associated diseases containing same
CN113480544B (en) * 2021-07-09 2022-04-26 成都大学 Alkynyl imidazo [1,5-a ] indole compound and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB862685A (en) * 1956-11-02 1961-03-15 Pfizer & Co C New antibiotic designated pa 155a
US3173923A (en) * 1961-04-13 1965-03-16 Pfizer & Co C 1-(3'-indolyl)-1-[5"-(2''-methylimino)-4''-ketooxazolidinyl] ethane and acid addition salts thereof
US3320282A (en) * 1962-10-29 1967-05-16 Pfizer & Co C Process for preparing esters of 2-hydroxy-3-(3-indolyl) alkanoic acids
US4584385A (en) * 1984-03-22 1986-04-22 Pfizer Inc. Antibacterial 2-amino-oxazolinones and process therefor
WO1996001821A1 (en) * 1994-07-12 1996-01-25 Janssen Pharmaceutica N.V. Anti-helicobacter heterocyclic derivatives of azolones

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US458385A (en) * 1891-08-25 Heater

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB862685A (en) * 1956-11-02 1961-03-15 Pfizer & Co C New antibiotic designated pa 155a
US3173923A (en) * 1961-04-13 1965-03-16 Pfizer & Co C 1-(3'-indolyl)-1-[5"-(2''-methylimino)-4''-ketooxazolidinyl] ethane and acid addition salts thereof
US3320282A (en) * 1962-10-29 1967-05-16 Pfizer & Co C Process for preparing esters of 2-hydroxy-3-(3-indolyl) alkanoic acids
US4584385A (en) * 1984-03-22 1986-04-22 Pfizer Inc. Antibacterial 2-amino-oxazolinones and process therefor
WO1996001821A1 (en) * 1994-07-12 1996-01-25 Janssen Pharmaceutica N.V. Anti-helicobacter heterocyclic derivatives of azolones

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 95, no. 9, 31 August 1981, Columbus, Ohio, US; abstract no. 78399t, WERNER ROLF G ET AL.: "Directed biosynthesis of new indolmycins." page 578; XP002049064 *
J.ANTIBIOT., vol. 34, no. 5, 1981, pages 551 - 554 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841295B2 (en) 2005-11-04 2014-09-23 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US9169250B2 (en) 2006-11-22 2015-10-27 Plexxikon Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US9487515B2 (en) 2006-11-22 2016-11-08 Plexxikon Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US9469640B2 (en) 2007-07-17 2016-10-18 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US9447089B2 (en) 2009-04-03 2016-09-20 Plexxikon Inc. Compositions and uses thereof
US9096593B2 (en) 2009-11-06 2015-08-04 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US8865735B2 (en) 2011-02-21 2014-10-21 Hoffman-La Roche Inc. Solid forms of a pharmaceutically active substance
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds

Also Published As

Publication number Publication date
CN1077892C (en) 2002-01-16
CN1230958A (en) 1999-10-06
WO1997049703A2 (en) 1997-12-31
ZA978876B (en) 1999-06-30
EP0923577A2 (en) 1999-06-23
CA2248784A1 (en) 1997-12-31
AU3191397A (en) 1998-01-14

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