WO1997043437A3 - Isopentenyl pyrophosphate isomerase (ipi) and/or prenyl transferase inhibitors - Google Patents

Isopentenyl pyrophosphate isomerase (ipi) and/or prenyl transferase inhibitors Download PDF

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Publication number
WO1997043437A3
WO1997043437A3 PCT/GB1997/001302 GB9701302W WO9743437A3 WO 1997043437 A3 WO1997043437 A3 WO 1997043437A3 GB 9701302 W GB9701302 W GB 9701302W WO 9743437 A3 WO9743437 A3 WO 9743437A3
Authority
WO
WIPO (PCT)
Prior art keywords
ipi
prenyl transferase
isopentenyl pyrophosphate
transferase inhibitors
pyrophosphate isomerase
Prior art date
Application number
PCT/GB1997/001302
Other languages
French (fr)
Other versions
WO1997043437A2 (en
Inventor
Richard John Brown
Donald Jeremy Watts
Robert Graham Goodwin Russel
Michael John Rogers
Original Assignee
Univ Sheffield
Richard John Brown
Donald Jeremy Watts
Robert Graham Goodwin Russel
Michael John Rogers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9610174.6A external-priority patent/GB9610174D0/en
Priority claimed from GBGB9708329.9A external-priority patent/GB9708329D0/en
Application filed by Univ Sheffield, Richard John Brown, Donald Jeremy Watts, Robert Graham Goodwin Russel, Michael John Rogers filed Critical Univ Sheffield
Priority to AU27833/97A priority Critical patent/AU2783397A/en
Priority to EP97921954A priority patent/EP0952834A2/en
Publication of WO1997043437A2 publication Critical patent/WO1997043437A2/en
Publication of WO1997043437A3 publication Critical patent/WO1997043437A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/533—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving isomerase

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Prenyl transferase (farnesyl pyrophosphate synthase) and/or isopentenyl pyrophosphate isomerase inhibitors find application in various forms of the therapy and prophylaxis. The use of such inhibitors in the treatment of various diseases and disorders of bone metabolism in the screening, isolation, synthesis and the valuation of osteoactive drugs as hypolipidaemic and as anti-cancer agents is also described.
PCT/GB1997/001302 1996-05-15 1997-05-12 Isopentenyl pyrophosphate isomerase (ipi) and/or prenyl transferase inhibitors WO1997043437A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU27833/97A AU2783397A (en) 1996-05-15 1997-05-12 Isopentenyl pyrophosphate isomerase (ipi) and/or prenyl transferase inhibitors
EP97921954A EP0952834A2 (en) 1996-05-15 1997-05-12 Isopentenyl pyrophosphate isomerase (ipi) and/or prenyl transferase inhibitors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9610174.6A GB9610174D0 (en) 1996-05-15 1996-05-15 Prenyl transferase inhibitors
GB9610174.6 1996-05-15
GBGB9708329.9A GB9708329D0 (en) 1997-04-25 1997-04-25 Isopentenyl pyrophosphate iosmerase (IPI) and/or prenyl transferase inhibitors
GB9708329.9 1997-04-25

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09180814 A-371-Of-International 1999-01-27
US66064200A Continuation 1996-05-15 2000-09-13

Publications (2)

Publication Number Publication Date
WO1997043437A2 WO1997043437A2 (en) 1997-11-20
WO1997043437A3 true WO1997043437A3 (en) 1998-02-26

Family

ID=26309338

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/001302 WO1997043437A2 (en) 1996-05-15 1997-05-12 Isopentenyl pyrophosphate isomerase (ipi) and/or prenyl transferase inhibitors

Country Status (3)

Country Link
EP (1) EP0952834A2 (en)
AU (1) AU2783397A (en)
WO (1) WO1997043437A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053071A1 (en) 1998-04-14 1999-10-21 Kyowa Hakko Kogyo Co., Ltd. Process for producing isoprenoid compounds by using microorganisms and method for detecting compounds having antibacterial or herbicidal activity
IL125336A0 (en) * 1998-07-14 1999-03-12 Yissum Res Dev Co Compositions for inhibition and treatment of restinosis
US6984400B2 (en) * 1998-07-14 2006-01-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treating restenosis using bisphosphonate nanoparticles
US7008645B2 (en) 1998-07-14 2006-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of inhibiting restenosis using bisphosphonates
US6423519B1 (en) 1998-07-15 2002-07-23 Gpc Biotech Inc. Compositions and methods for inhibiting fungal growth
BR9916850A (en) * 1998-12-23 2001-10-16 Jomaa Pharmaka Gmbh Use of bisphosphonates for the prophylaxis and treatment of infectious processes
WO2000052198A1 (en) * 1999-03-05 2000-09-08 Merck & Co., Inc. Methods for identifying compounds useful for inhibiting farnesyl diphosphate synthase
KR100906018B1 (en) * 2001-07-20 2009-07-06 바이오에이전시 아게 Organo-phosphorous compounds for activating gamma/delta t cells
DE10242940A1 (en) * 2002-09-16 2004-03-18 Bayer Cropscience Ag Method of identifying fungicidally active compounds
US10517883B2 (en) 2003-06-27 2019-12-31 Zuli Holdings Ltd. Method of treating acute myocardial infarction
DE102005025191A1 (en) * 2005-06-01 2006-12-14 Bayer Cropscience Ag A method of identifying fungicidally active compounds based on isopentenyl pyrophosphate isomerases
KR101034300B1 (en) 2008-12-02 2011-05-16 고려대학교 산학협력단 A compound for inhibiting TRPV3 function and use thereof
KR101034299B1 (en) * 2008-12-02 2011-05-16 고려대학교 산학협력단 A compound for modulating TRPV3 function and use threrof
WO2011147038A1 (en) 2010-05-28 2011-12-01 The Royal Institution For The Advancement Of Learning/Mcgill University Heterocyclyl-pyridinyl-based biphosphonic acid, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof
US9290526B2 (en) 2010-05-28 2016-03-22 The Royal Institution For The Advancement Of Learning/Mcgill University Heterocyclyl-pyridinyl-based biphosphonic acid, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
CN112980809B (en) * 2021-03-17 2023-04-11 云南中烟工业有限责任公司 Tobacco farnesyl pyrophosphate synthase gene and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0339237A2 (en) * 1988-03-31 1989-11-02 Symphar S.A. Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them
WO1993024660A1 (en) * 1992-05-29 1993-12-09 The Regents Of The University Of California Method for inhibition of viral morphogenesis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0339237A2 (en) * 1988-03-31 1989-11-02 Symphar S.A. Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them
WO1993024660A1 (en) * 1992-05-29 1993-12-09 The Regents Of The University Of California Method for inhibition of viral morphogenesis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AMIN ET AL: "Bisphosphonates used for the treatment of bone disorders inhibit squalene and cholesterol biosynthesis", J LIPID RES., vol. 33, 1992, pages 1657 - 63, XP002040841 *
PARKER ET AL: "Alkylphosphonates and phosphophonates....", FEDERATION PROCEEDINGS, vol. 35, no. n7, 1976, pages p1697, XP002040844 *
POPJAK ET AL: "Analogues of geranyl pyrophosphate as inhibitors of prenyltransferase", BIOCHEM. J., vol. 111, 1969, pages 333 - 43, XP002040842 *

Also Published As

Publication number Publication date
WO1997043437A2 (en) 1997-11-20
EP0952834A2 (en) 1999-11-03
AU2783397A (en) 1997-12-05

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