WO1997030156A3 - Nucleotides and peptides corresponding to the canine ige heavy chain constant region and related methods - Google Patents

Nucleotides and peptides corresponding to the canine ige heavy chain constant region and related methods Download PDF

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Publication number
WO1997030156A3
WO1997030156A3 PCT/US1997/002322 US9702322W WO9730156A3 WO 1997030156 A3 WO1997030156 A3 WO 1997030156A3 US 9702322 W US9702322 W US 9702322W WO 9730156 A3 WO9730156 A3 WO 9730156A3
Authority
WO
WIPO (PCT)
Prior art keywords
heavy chain
canine ige
disclosed
constant region
chain constant
Prior art date
Application number
PCT/US1997/002322
Other languages
French (fr)
Other versions
WO1997030156A2 (en
Inventor
Brion Mermer
Rachel A Harris
Ann E Siefring
Original Assignee
Idexx Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idexx Lab Inc filed Critical Idexx Lab Inc
Priority to AU21256/97A priority Critical patent/AU2125697A/en
Publication of WO1997030156A2 publication Critical patent/WO1997030156A2/en
Publication of WO1997030156A3 publication Critical patent/WO1997030156A3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Abstract

Recombinant DNA molecules encoding complete canine IgE heavy chain constant region and the DNA sequence for all six exons of canine IgE are disclosed. The canine IgE heavy chain constant region DNA sequence was isolated using a nested walking procedure that is also disclosed. Also disclosed are peptides encoded by said sequences, including recombinant canine IgE heavy chain peptides produced by prokaryotic or eukaryotic cells. Such peptides are used in methods to treat the manifestation of allergy in dogs. Disclosed are antibodies that bind to peptides disclosed herein, as well as such antibodies for use to treat the manifestations of allergy in dogs.
PCT/US1997/002322 1996-02-14 1997-02-14 NUCLEOTIDES AND PEPTIDES CORRESPONDING TO THE CANINE IgE HEAVY CHAIN CONSTANT REGION AND RELATED METHODS WO1997030156A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU21256/97A AU2125697A (en) 1996-02-14 1997-02-14 Nucleotides and peptides corresponding to the canine ige heavy chain constant region and related methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60119796A 1996-02-14 1996-02-14
US08/601,197 1996-02-14

Publications (2)

Publication Number Publication Date
WO1997030156A2 WO1997030156A2 (en) 1997-08-21
WO1997030156A3 true WO1997030156A3 (en) 1997-10-09

Family

ID=24406583

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/002322 WO1997030156A2 (en) 1996-02-14 1997-02-14 NUCLEOTIDES AND PEPTIDES CORRESPONDING TO THE CANINE IgE HEAVY CHAIN CONSTANT REGION AND RELATED METHODS

Country Status (2)

Country Link
AU (1) AU2125697A (en)
WO (1) WO1997030156A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537781B1 (en) 1999-08-10 2003-03-25 Idexx Laboratories, Inc. Methods and compositions concerning canine interleukin 5
EP1967205B1 (en) 2000-08-30 2012-10-10 Pfizer Products Inc. Anti-IgE vaccines
US10017762B2 (en) * 2010-11-24 2018-07-10 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Compositions and methods for treating or preventing lupus

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018114A1 (en) * 1990-05-22 1991-11-28 Medical Research Council Polynucleotide amplification
WO1993010138A1 (en) * 1991-11-18 1993-05-27 Tanox Biosystems, Inc. Anti-sense oligonucleotides for isotype-specific suppression of immunoglobulin production
WO1994020533A1 (en) * 1993-03-11 1994-09-15 Tanox Biosystems, Inc. PEPTIDES REPRESENTING ANTIGENIC EPITOPES OF IgE PRESENT ON B CELL BUT NOT BASOPHIL SURFACE
US5514776A (en) * 1987-12-31 1996-05-07 Tanox Biosystems, Inc. Peptides representing antigenic epitopes of dog IgE present on B cell but not basophil surface
WO1996014867A1 (en) * 1994-11-09 1996-05-23 Merck & Co., Inc. Dna encoding canine immunoglobulins

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514776A (en) * 1987-12-31 1996-05-07 Tanox Biosystems, Inc. Peptides representing antigenic epitopes of dog IgE present on B cell but not basophil surface
WO1991018114A1 (en) * 1990-05-22 1991-11-28 Medical Research Council Polynucleotide amplification
WO1993010138A1 (en) * 1991-11-18 1993-05-27 Tanox Biosystems, Inc. Anti-sense oligonucleotides for isotype-specific suppression of immunoglobulin production
WO1994020533A1 (en) * 1993-03-11 1994-09-15 Tanox Biosystems, Inc. PEPTIDES REPRESENTING ANTIGENIC EPITOPES OF IgE PRESENT ON B CELL BUT NOT BASOPHIL SURFACE
WO1996014867A1 (en) * 1994-11-09 1996-05-23 Merck & Co., Inc. Dna encoding canine immunoglobulins

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
D. DEBOER ET AL.: "Production and characterization of mouse monoclonal antibodies directed against canine IgE and IgG.", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 37, no. 3-4, August 1993 (1993-08-01), AMSTERDAM, NL, pages 183 - 199, XP000647974 *
M. PATEL ET AL.: "Sequence of the dog immunoglobulin alpha and epsilon constant region genes.", IMMUNOGENETICS, vol. 41, no. 5, 22 March 1995 (1995-03-22), NEW YORK, NY, USA, pages 282 - 286, XP002037155 *
R. SNOW ET AL.: "Analysis of Ig Vh region genes encoding IgE antibodies in splenic B lymphocytes of a patient with asthma.", THE JOURNAL OF IMMUNOLOGY, vol. 154, no. 10, 15 May 1995 (1995-05-15), BALTIMORE, MD, USA, pages 5576 - 5581, XP002037158 *
T. HALL ET AL.: "Specific inhibition of IgE antibody production by an antisense olgodeoxynucleotide oligomer (Oligostick TM).", IMMUNOLOGY, vol. 77, no. 3, November 1992 (1992-11-01), OXFORD, GB, pages 462 - 464, XP002037156 *
T. HALL ET AL.: "Specific inhibition of IgE antibody production in vitro by an antisense oligodeoxynucleotide.", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 87, no. 1 part 2, 1991, ST.LOUIS, MO, USA, pages 243, XP002037157 *

Also Published As

Publication number Publication date
AU2125697A (en) 1997-09-02
WO1997030156A2 (en) 1997-08-21

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