WO1997026016A3 - Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores - Google Patents
Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores Download PDFInfo
- Publication number
- WO1997026016A3 WO1997026016A3 PCT/EP1997/000208 EP9700208W WO9726016A3 WO 1997026016 A3 WO1997026016 A3 WO 1997026016A3 EP 9700208 W EP9700208 W EP 9700208W WO 9726016 A3 WO9726016 A3 WO 9726016A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- application
- gas bubble
- contrast medium
- ultrasound contrast
- bubble suspensions
- Prior art date
Links
- 239000002961 echo contrast media Substances 0.000 title abstract 2
- 239000000725 suspension Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
- C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
- C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
- C08J9/143—Halogen containing compounds
- C08J9/147—Halogen containing compounds containing carbon and halogen atoms only
- C08J9/148—Halogen containing compounds containing carbon and halogen atoms only perfluorinated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
- C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
- C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
- C08J9/143—Halogen containing compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2300/00—Characterised by the use of unspecified polymers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9525697A JP2000504317A (ja) | 1996-01-18 | 1997-01-16 | 気泡懸濁物と超音波造影剤への応用 |
EP97902178A EP0874644A2 (fr) | 1996-01-18 | 1997-01-16 | Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores |
AU15925/97A AU1592597A (en) | 1996-01-18 | 1997-01-16 | Gas bubble suspensions and their application as an ultrasound contrast medium |
NO983332A NO983332L (no) | 1996-01-18 | 1998-07-17 | Gassboblesuspensjoner og deres anvendelse som ultralydkontrastmiddel |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19602930.9 | 1996-01-18 | ||
DE19602930A DE19602930A1 (de) | 1996-01-18 | 1996-01-18 | Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997026016A2 WO1997026016A2 (fr) | 1997-07-24 |
WO1997026016A3 true WO1997026016A3 (fr) | 1997-10-23 |
Family
ID=7783852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1997/000208 WO1997026016A2 (fr) | 1996-01-18 | 1997-01-16 | Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0874644A2 (fr) |
JP (1) | JP2000504317A (fr) |
AU (1) | AU1592597A (fr) |
CA (1) | CA2243174A1 (fr) |
DE (1) | DE19602930A1 (fr) |
NO (1) | NO983332L (fr) |
WO (1) | WO1997026016A2 (fr) |
ZA (1) | ZA97414B (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0619036A2 (pt) * | 2005-11-28 | 2011-09-20 | Vernon D Rowe | composições úteis para reduzir a nefrotoxicidade, e uso destas |
JP5196896B2 (ja) * | 2007-07-13 | 2013-05-15 | 花王株式会社 | 微細気泡前駆体の製造方法 |
JP2010005512A (ja) * | 2008-06-25 | 2010-01-14 | Kao Corp | 微細気泡前駆体組成物 |
KR101927614B1 (ko) | 2017-03-30 | 2018-12-10 | 숭실대학교산학협력단 | 초음파 영상을 위한 안정한 생체적합 산소-나노버블 조영제 제조방법 |
JP7211699B2 (ja) * | 2017-09-11 | 2023-01-24 | バイエル ファーマ アクチエンゲゼルシャフト | 超音波診断用造影剤 |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0122624A2 (fr) * | 1983-04-15 | 1984-10-24 | Schering Aktiengesellschaft | Microparticules et milieu de contraste pour l'exploration ultrasonique contenant des bulles de gaz |
EP0123235A2 (fr) * | 1983-04-15 | 1984-10-31 | Schering Aktiengesellschaft | Microparticules et milieu de contraste pour l'exploration ultrasonique contenant des bulles de gaz |
EP0365467A2 (fr) * | 1988-10-07 | 1990-04-25 | Schering Aktiengesellschaft | Agent de contraste ultrasonique à base de bulles de gaz et de microparticules contenant des acides gras |
US5147631A (en) * | 1991-04-30 | 1992-09-15 | Du Pont Merck Pharmaceutical Company | Porous inorganic ultrasound contrast agents |
US5160725A (en) * | 1987-03-24 | 1992-11-03 | Silica Gel Gesellschaft Mbh Adsorptions-Technik, Apparatebau | Magnetic liquid compositions |
WO1992021382A1 (fr) * | 1991-06-03 | 1992-12-10 | Holmes, Michael, John | Ameliorations apportees a ou concernant des agents contrastants |
WO1993000933A1 (fr) * | 1991-07-05 | 1993-01-21 | University Of Rochester | Particules poreuses non agregees ultra-petites piegant des bulles gazeuses |
WO1993013808A2 (fr) * | 1992-01-09 | 1993-07-22 | Holmes, Michael, John | Perfectionnements apportes aux agents de contraste |
WO1995003835A1 (fr) * | 1993-07-30 | 1995-02-09 | Alliance Pharmaceutical Corp. | Compositions a mocrobulles stabilisees pour applications mettant en ×uvre des ultrasons |
WO1995021631A1 (fr) * | 1994-02-15 | 1995-08-17 | Nycomed Imaging As | Perfectionnements relatifs a des agents de contraste |
WO1996026746A1 (fr) * | 1995-02-28 | 1996-09-06 | Alliance Pharmaceutical Corp. | Emulsions gazeuses stabilisees contenant des phospholipides renforçant les contrastes dans les techniques d'imagerie par ultrasons |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3141641A1 (de) * | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
JPH06510758A (ja) * | 1991-07-05 | 1994-12-01 | ニユコメド・イメージング・アクシエセルカペト | 造影剤におけるまたは造影剤に関する改良 |
ES2145011T5 (es) * | 1991-09-17 | 2008-02-01 | Ge Healthcare As | Medios de contraste gaseoso para ecografias. |
IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
AU679295B2 (en) * | 1993-12-15 | 1997-06-26 | Bracco Suisse S.A. | Gas mixtures useful as ultrasound contrast media |
DE4406474A1 (de) * | 1994-02-23 | 1995-08-24 | Schering Ag | Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel |
-
1996
- 1996-01-18 DE DE19602930A patent/DE19602930A1/de not_active Withdrawn
-
1997
- 1997-01-16 EP EP97902178A patent/EP0874644A2/fr not_active Withdrawn
- 1997-01-16 AU AU15925/97A patent/AU1592597A/en not_active Abandoned
- 1997-01-16 CA CA002243174A patent/CA2243174A1/fr not_active Abandoned
- 1997-01-16 WO PCT/EP1997/000208 patent/WO1997026016A2/fr not_active Application Discontinuation
- 1997-01-16 JP JP9525697A patent/JP2000504317A/ja active Pending
- 1997-01-17 ZA ZA97414A patent/ZA97414B/xx unknown
-
1998
- 1998-07-17 NO NO983332A patent/NO983332L/no not_active Application Discontinuation
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0122624A2 (fr) * | 1983-04-15 | 1984-10-24 | Schering Aktiengesellschaft | Microparticules et milieu de contraste pour l'exploration ultrasonique contenant des bulles de gaz |
EP0123235A2 (fr) * | 1983-04-15 | 1984-10-31 | Schering Aktiengesellschaft | Microparticules et milieu de contraste pour l'exploration ultrasonique contenant des bulles de gaz |
US5160725A (en) * | 1987-03-24 | 1992-11-03 | Silica Gel Gesellschaft Mbh Adsorptions-Technik, Apparatebau | Magnetic liquid compositions |
EP0365467A2 (fr) * | 1988-10-07 | 1990-04-25 | Schering Aktiengesellschaft | Agent de contraste ultrasonique à base de bulles de gaz et de microparticules contenant des acides gras |
US5147631A (en) * | 1991-04-30 | 1992-09-15 | Du Pont Merck Pharmaceutical Company | Porous inorganic ultrasound contrast agents |
WO1992021382A1 (fr) * | 1991-06-03 | 1992-12-10 | Holmes, Michael, John | Ameliorations apportees a ou concernant des agents contrastants |
WO1993000933A1 (fr) * | 1991-07-05 | 1993-01-21 | University Of Rochester | Particules poreuses non agregees ultra-petites piegant des bulles gazeuses |
WO1993013808A2 (fr) * | 1992-01-09 | 1993-07-22 | Holmes, Michael, John | Perfectionnements apportes aux agents de contraste |
WO1995003835A1 (fr) * | 1993-07-30 | 1995-02-09 | Alliance Pharmaceutical Corp. | Compositions a mocrobulles stabilisees pour applications mettant en ×uvre des ultrasons |
US5605673A (en) * | 1993-07-30 | 1997-02-25 | Alliance Pharmaceutical Corp. | Stabilized microbubble compositions for ultrasound |
WO1995021631A1 (fr) * | 1994-02-15 | 1995-08-17 | Nycomed Imaging As | Perfectionnements relatifs a des agents de contraste |
WO1996026746A1 (fr) * | 1995-02-28 | 1996-09-06 | Alliance Pharmaceutical Corp. | Emulsions gazeuses stabilisees contenant des phospholipides renforçant les contrastes dans les techniques d'imagerie par ultrasons |
Also Published As
Publication number | Publication date |
---|---|
JP2000504317A (ja) | 2000-04-11 |
NO983332D0 (no) | 1998-07-17 |
ZA97414B (en) | 1997-07-17 |
AU1592597A (en) | 1997-08-11 |
WO1997026016A2 (fr) | 1997-07-24 |
NO983332L (no) | 1998-07-17 |
CA2243174A1 (fr) | 1997-07-24 |
DE19602930A1 (de) | 1997-07-24 |
EP0874644A2 (fr) | 1998-11-04 |
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