WO1997015550A1 - Fluoro-substituted benzoylpropionic acid derivatives - Google Patents
Fluoro-substituted benzoylpropionic acid derivatives Download PDFInfo
- Publication number
- WO1997015550A1 WO1997015550A1 PCT/EP1996/004321 EP9604321W WO9715550A1 WO 1997015550 A1 WO1997015550 A1 WO 1997015550A1 EP 9604321 W EP9604321 W EP 9604321W WO 9715550 A1 WO9715550 A1 WO 9715550A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- formula
- amino
- acid
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
Definitions
- the scope of the present invention encompasses both the individual optical isomers and the racemic mixture of the formula (I) compounds.
- R are hydroxy, amino, hydroxylamino or OR' in which R' is C 1 -C 6 alkyl and benzyl .
- the term C x -C 6 alkyl includes, for example C 1 -C 1 alkyl such as methyl, ethyl, n-propyl, isopropyl and n- butyl; preferably, it is methyl, ethyl or n-propyl.
- R-, in the above formulae (III) and (IV) is trifluoromethyl, methoxy or ethoxy.
- the reaction of a compound of formula (II) with a compound of formula (III) , as described under step a) may be carried out according to known methods (see, for example, J.E. Nordlander, J. Org. Chem., 5_0_, 3619-22,
- the reaction mixture of a total volume of 100 ml was constituted of 44 mg of suspended extract, 100 mM Tris/Cl " buffer pH 8.1, 10 mM EDTA, 100 mM KCl, 0.8 mM NADPH, 0.025 mM L-kynurenine, 0.5 mCi L- (3, 5- 3 H) Kynurenine (10 Ci/mmol) and 10 ml of different concentration of inhibitor solutions. After the incubation the reaction was terminated by the addition of 1 mL of 7.5% (w/v) activated charcoal, vortexed and centrifugated for 7 min. A 500 ml aliquot of supernatant was counted by scintillation spectroscopy in 5 ml of liquid scintillation.
- the compounds of the present invention were constituted of 44 mg of suspended extract, 100 mM Tris/Cl " buffer pH 8.1, 10 mM EDTA, 100 mM KCl, 0.8 mM NADPH
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT96934537T ATE193522T1 (en) | 1995-10-20 | 1996-10-04 | FLUOROUS SUBSTITUTED BENZOYLPROPIONIC ACID DERIVATIVES |
DK96934537T DK0862551T3 (en) | 1995-10-20 | 1996-10-04 | Fluoro-substituted benzoyl propionic acid derivatives |
JP9516233A JPH11513694A (en) | 1995-10-20 | 1996-10-04 | Fluoro-substituted benzoylpropionic acid derivatives |
US09/051,486 US5973006A (en) | 1995-10-20 | 1996-10-04 | Fluoro-substituted benzoylpropionic acid derivatives |
EP96934537A EP0862551B1 (en) | 1995-10-20 | 1996-10-04 | Fluoro-substituted benzoylpropionic acid derivatives |
SI9630227T SI0862551T1 (en) | 1995-10-20 | 1996-10-04 | Fluoro-substituted benzoylpropionic acid derivatives |
DE69608699T DE69608699T2 (en) | 1995-10-20 | 1996-10-04 | Fluorosubstituted benzoylpropionic acid derivatives |
AU72852/96A AU7285296A (en) | 1995-10-20 | 1996-10-04 | Fluoro-substituted benzoylpropionic acid derivatives |
GR20000401940T GR3034253T3 (en) | 1995-10-20 | 2000-08-23 | Fluoro-substituted benzoylpropionic acid derivatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9521486.2 | 1995-10-20 | ||
GBGB9521486.2A GB9521486D0 (en) | 1995-10-20 | 1995-10-20 | Fluoro-substituted benzoylpropionic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997015550A1 true WO1997015550A1 (en) | 1997-05-01 |
Family
ID=10782602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1996/004321 WO1997015550A1 (en) | 1995-10-20 | 1996-10-04 | Fluoro-substituted benzoylpropionic acid derivatives |
Country Status (14)
Country | Link |
---|---|
US (1) | US5973006A (en) |
EP (1) | EP0862551B1 (en) |
JP (1) | JPH11513694A (en) |
AT (1) | ATE193522T1 (en) |
AU (1) | AU7285296A (en) |
CA (1) | CA2233075A1 (en) |
DE (1) | DE69608699T2 (en) |
DK (1) | DK0862551T3 (en) |
ES (1) | ES2148800T3 (en) |
GB (1) | GB9521486D0 (en) |
GR (1) | GR3034253T3 (en) |
PT (1) | PT862551E (en) |
WO (1) | WO1997015550A1 (en) |
ZA (1) | ZA968795B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998009938A1 (en) * | 1996-09-03 | 1998-03-12 | Pharmacia & Upjohn S.P.A. | N-substituted-2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity |
WO1999006375A1 (en) * | 1997-07-30 | 1999-02-11 | Pharmacia & Upjohn S.P.A. | Fused heterocyclic compounds and their use as kynurenine-3-hydroxylase inhibitors |
US6858602B2 (en) * | 2001-06-12 | 2005-02-22 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
WO2016027757A1 (en) * | 2014-08-18 | 2016-02-25 | 国立大学法人大阪大学 | Novel 2-aminbenzoyl derivative |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009065906A2 (en) * | 2007-11-20 | 2009-05-28 | Cognis Oleochemicals Gmbh | Method for producing an organic composition containing an n-nonyl ether |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0501378A1 (en) * | 1991-02-28 | 1992-09-02 | Merrell Dow Pharmaceuticals Inc. | NMDA Antagonists |
WO1995003271A1 (en) * | 1993-07-23 | 1995-02-02 | Pharmacia S.P.A. | 2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity |
WO1995004714A1 (en) * | 1993-08-06 | 1995-02-16 | University Of Maryland At Baltimore | Substituted kynurenines, a process for their preparation, and use as medicaments |
-
1995
- 1995-10-20 GB GBGB9521486.2A patent/GB9521486D0/en active Pending
-
1996
- 1996-10-04 DK DK96934537T patent/DK0862551T3/en active
- 1996-10-04 PT PT96934537T patent/PT862551E/en unknown
- 1996-10-04 DE DE69608699T patent/DE69608699T2/en not_active Expired - Fee Related
- 1996-10-04 ES ES96934537T patent/ES2148800T3/en not_active Expired - Lifetime
- 1996-10-04 EP EP96934537A patent/EP0862551B1/en not_active Expired - Lifetime
- 1996-10-04 CA CA002233075A patent/CA2233075A1/en not_active Abandoned
- 1996-10-04 AU AU72852/96A patent/AU7285296A/en not_active Abandoned
- 1996-10-04 AT AT96934537T patent/ATE193522T1/en not_active IP Right Cessation
- 1996-10-04 US US09/051,486 patent/US5973006A/en not_active Expired - Fee Related
- 1996-10-04 WO PCT/EP1996/004321 patent/WO1997015550A1/en active IP Right Grant
- 1996-10-04 JP JP9516233A patent/JPH11513694A/en active Pending
- 1996-10-18 ZA ZA968795A patent/ZA968795B/en unknown
-
2000
- 2000-08-23 GR GR20000401940T patent/GR3034253T3/en not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0501378A1 (en) * | 1991-02-28 | 1992-09-02 | Merrell Dow Pharmaceuticals Inc. | NMDA Antagonists |
WO1995003271A1 (en) * | 1993-07-23 | 1995-02-02 | Pharmacia S.P.A. | 2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity |
WO1995004714A1 (en) * | 1993-08-06 | 1995-02-16 | University Of Maryland At Baltimore | Substituted kynurenines, a process for their preparation, and use as medicaments |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998009938A1 (en) * | 1996-09-03 | 1998-03-12 | Pharmacia & Upjohn S.P.A. | N-substituted-2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity |
WO1999006375A1 (en) * | 1997-07-30 | 1999-02-11 | Pharmacia & Upjohn S.P.A. | Fused heterocyclic compounds and their use as kynurenine-3-hydroxylase inhibitors |
US6858602B2 (en) * | 2001-06-12 | 2005-02-22 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
WO2016027757A1 (en) * | 2014-08-18 | 2016-02-25 | 国立大学法人大阪大学 | Novel 2-aminbenzoyl derivative |
Also Published As
Publication number | Publication date |
---|---|
DE69608699T2 (en) | 2000-11-23 |
DK0862551T3 (en) | 2000-10-02 |
EP0862551B1 (en) | 2000-05-31 |
GB9521486D0 (en) | 1995-12-20 |
ES2148800T3 (en) | 2000-10-16 |
EP0862551A1 (en) | 1998-09-09 |
US5973006A (en) | 1999-10-26 |
JPH11513694A (en) | 1999-11-24 |
PT862551E (en) | 2000-11-30 |
ZA968795B (en) | 1997-05-20 |
AU7285296A (en) | 1997-05-15 |
GR3034253T3 (en) | 2000-12-29 |
ATE193522T1 (en) | 2000-06-15 |
CA2233075A1 (en) | 1997-05-01 |
DE69608699D1 (en) | 2000-07-06 |
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