WO1997001556A1 - Novel substituted azacyclic or azabicyclic compounds - Google Patents
Novel substituted azacyclic or azabicyclic compounds Download PDFInfo
- Publication number
- WO1997001556A1 WO1997001556A1 PCT/DK1996/000292 DK9600292W WO9701556A1 WO 1997001556 A1 WO1997001556 A1 WO 1997001556A1 DK 9600292 W DK9600292 W DK 9600292W WO 9701556 A1 WO9701556 A1 WO 9701556A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- methyl
- formula
- isoxazolyl
- methylene
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Definitions
- the present invention relates to heterocyclic compounds which are cholinergic ligands selective for neuronal nicotinic channel receptors, to methods for their preparation, to pharmaceutical compositions comprising them, and to their use in treating cognitive, neurological and mental disorders, which are characterized by decreased nicotine cholinergic function.
- the invention also relates to a method of treating Parkinson's disease by modulating the process of dopamine secretion, a method of treating or preventing withdrawal symptoms caused by cessation of chronic or long term use of tobacco products, as well as a method for treating obesity.
- Nicotinic and muscarinic receptors are the two distinct types of choliner ⁇ gic receptors named after their selectivity for muscarine and nicotine, respectively.
- the cholinergic system is the neurotransmitter system that best correlates with memory and cognitive functions.
- SDAT a cholinergic hypothesis for senile dementia of the Alzheimer type
- mAChR muscarinic acetylcholine receptors
- nAChR nicotinic acetylcholine receptors
- Parkinson's disease is a debilitating neurodegenerative disease, presently of unknown etiology, characterized by tremors and muscular rigidity.
- nicotine may also have beneficial effects in PD.
- Nicotine has also shown beneficial effects in Tourette's syndrome (Sanberg et al., Biomed. Phamacother., Vol. 43, pp. 1 9-23, (1 989)). Alleviation of negative psychotic symptoms, known as the hypofrontality syndrome in schizophrenia, by nicotinic agonists, have been suggested by data showing that nicotine stimulates dopamine release in the nucleus accumbens more potently than in stria ⁇ tum, (Rowell et al.
- EP 414394 discloses a class of methyleneazabicyclic compounds, substi ⁇ tuted with a five membered heterocyclic ring described as cholinergic compounds which enhance acetylcholine function via an action at mus- carinic receptors within the central nervous system.
- the present invention relates to novel substituted azacyclic or azabicyclic compounds of formula I selected from the following:
- k is 0, 1 , 2 or 3; and m is 0 and p is 2 and n is 2, or m is 1 and p is 1 and n is 2, or m is 0 and p is 1 and n is 0; and s is 0, 1 or 2; and t is 1 or 2; and u is 1 , 2 or 3; and
- R is hydrogen, C ⁇ -alkyl or C 3 . 6 -cycloalkyl; and wherein Y is
- R ⁇ R 2 and R 3 independently are hydrogen, halogen, -NO 2 , -CN, -NR 5 R 6 , -OR 7 , -SR 8 , -COOR 9 , -SOR 10 , -SO 2 R 11 , -SO 3 R 12 , C ⁇ -alkyl optionally substi ⁇ tuted with one, two or three fluorine
- R 4 is C ⁇ -alkyl, C 2 . 6 -alkenyl, C 2 . 6 - alkynyl, C 3 . 6 -cycloalkyl, -R l7 -O-R 18 or -R 19 -S-R 20 , wherein R 5 and R 6 inde ⁇ pendently are hydrogen, C ⁇ -alkyl, C 2 . 6 -alkenyl or C 2 .
- R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 14 , R 16 , R 18 and R 20 independently are hydrogen, C ⁇ -alkyl, C 2 . 6 -alkenyl, C 2 . 6 -alkynyl or C 3 . 7 -cycloalkyl and wherein R 13 , R 15 , R 17 and R 19 independently are C ⁇ -alkylene, C 2 . 6 -alkenylene or C 2 . 6 - alkynylene; or a pharmaceutically acceptable salt thereof.
- salts include inorganic and organic acid addition salts such as hydrochloride, hydrobromide, sulphate, phosphate, acetate, fumarate, maleate, citrate, lactate, tartrate, oxalate, or similar pharma ⁇ ceutically-acceptabie inorganic or organic acid addition salts, and include the pharmaceutically acceptable salts listed in Journal of Pharmaceutical Science, 66, 2 (1977) which are hereby incorporated by reference.
- the compounds of formula I may exist as geometric and optical isomers and all isomers and mixtures thereof are included herein. Isomers may be separated by means of standard methods such as chromatographic techniques or fractional crystallization of suitable salts.
- Alkyl, alkenyl and alkynyl as used herein mean straight or branched alkyl, alkenyl or alkynyl chains.
- the invention also relates to a method of preparing the above mentioned compounds of formula I. These methods comprise: a) reacting a compound of formula II selected from the following:
- R, k, m, n, p, s, t and u have the meanings defined above with a phosphorus ylide of formula III or a phosphonate of formula IV
- R 21 , R 22 and R 23 independently are C ⁇ -alkyl, aryl or aralkyl and
- R and R 1 have the meanings defined above.
- the pharmacological properties of the compounds of the invention can be illustrated by determining their capability to inhibit the specific binding of 3 H-methylcarbamylcholine ( 3 H-MCC) (Abood and Grassi, Biochem. Phar- macol., Vol. 35, pp. 41 99-4202, ( 1 986)).
- 3 H-MCC 3 H-methylcarbamylcholine
- 3 H-MCC labels the nicotinic receptors in the CNS.
- the inhibitory effect on 3 H-MCC binding reflects the affinity for nicotinic acetylcholine receptors.
- Fresh or frozen rat, brain tissue (hippocampus or cortex) was homoge ⁇ nized in assay buffer (50mM Tris-HCI, pH 7.4, 1 20 mM NaCl, 5 mM KCI, 2 mM CaCI 2 , 1 mM MgCI 2 ) and centrifuged for 10 min. at 40.000 x g. Pellets were subsequently reconstituted in assay buffer and an appropri ⁇ ate amount of tissue sample was mixed in tubes with 3 H-methylcarba- mylcholine (NEN, NET-951 ; final concentration 2 nM) and test drug. The tubes were incubated at 0 °C for 60 min.
- assay buffer 50mM Tris-HCI, pH 7.4, 1 20 mM NaCl, 5 mM KCI, 2 mM CaCI 2 , 1 mM MgCI 2
- Pellets were subsequently reconstituted in assay buffer and an appropri ⁇ ate amount of tissue sample was mixed in tubes with 3 H-methylcarba-
- Unbound ligand was separated from bound ligand by vacuum filtration through GF/B filters presoaked in 0.5 % polyethylenimine. Filters were washed three times with 5 ml wash buffer (50mM Tris-HCI, pH 7.4) and transferred to vials. 4 ml scintillation fluid was added and the radioactivity was measured by scintillation counting. Unspecific binding was measured with 10 ⁇ M nicotine. The IC 50 values of the test compounds were determined by nonlinear regression analyses (GraphPad InPlot).
- the pharmacological properties of the compounds of the invention can also be illustrated by determining their capability to inhibit the specific binding of 3 H-Oxotremorine-M ( 3 H-Oxo).
- 3 H-Oxo 3 H-Oxotremorine-M
- the Character of Muscarinic Receptors in Different Regions of the Rat Brain Proc. Roy. Soc. London (Series B) 207,1 .
- 3 H-Oxo labels muscarinic receptor in the CNS (with a preference for agonist domains of the receptors).
- Three different sites are labelled by 3 H- Oxo. These sites have affinity of 1 .8, 20 and 3000 nM, respectively. Using the present experimental conditions only the high and medium affinity sites are determined.
- the inhibitory effects of compounds on 3 H-Oxo binding reflects the affinity for muscarinic acetylcholine receptors.
- Fresh cortex (0.1 -1 g) from male Wistar rats (1 50-250 g) is homogenized for 5- 10 s in 10 ml 20 mM Hepes pH: 7.4, with an Ultra-Turrax homogenizer. The homogenizer is rinsed with 10 ml of buffer and the combined sus- pension centrifuged for 15 min. at 40,000 x g. The pellet is washed three times with buffer. In each step the pellet is homogenized as before in 2 x 10 ml of buffer and centrifuged for 10 min. at 40,000 x g.
- the final pellet is homogenized in 20 mM Hepes pH: 7.4 (100 ml per g of original tissue) and used for binding assay. Aliquots of 0.5 ml is added 25 ul of test solution and 25 ul of 3 H-Oxotremorine (1 .0 nM, final concentra ⁇ tion) mixed and incubated for 30 min. at 25°C. Non-specific binding is determined in triplicate using arecoline (1 ug/ml, final concentration) as the test substance. After incubation samples are added 5 ml of ice-cold buffer and poured directly onto Whatman GF/C glass fiber filters under suction and immediately washed 2 times with 5 ml of ice-cold buffer. The amount of radioactivity on the filters are determined by conventional liquid scintillation counting. Specific binding is total binding minus non specific binding.
- Test substances are dissolved in 1 0 ml water (if necessary heated on a steam-bath for less than 5 min.) at a concentration of 2.2 mg/ml. 25- 75% inhibition of specific binding must be obtained before calculation of IC 50 .
- the test value will be given as IC 50 (the concentration (nM) of the test substance which inhibits the specific binding of 3 H-Oxo by 50%).
- IC 50 (applied test substance concentration) x(C x /C 0 -C x )nM
- Table I illustrates the affinity of the compounds of the present invention for nicotinic and muscarinic receptors as determined by 3 H-MCC and 3 H- Oxo binding to rat cortical receptors.
- the compounds show selective affinity for nicotinic receptors as compared to muscarinic receptors, i.e OXO/MCC > 1 .
- Table 1 illustrates the affinity of the compounds of the present invention for nicotinic and muscarinic receptors as determined by 3 H-MCC and 3 H- Oxo binding to rat cortical receptors.
- the compounds show selective affinity for nicotinic receptors as compared to muscarinic receptors, i.e OXO/MCC > 1 .
- the compounds of the invention are effective over a wide dosage range.
- dosages from about 0.05 to about 100 mg, preferably from about 0.1 to about 100 mg, per day may be used.
- a most preferable dosage is about 10 mg to about 70 mg per day.
- the exact dosage will depend upon the mode of administration, form in which administered, the subject to be treated and the body weight of the subject to be treated, and the preference and experience of the physician or veterinarian in charge.
- the route of administration may be any route, which effectively trans ⁇ ports the active compound to the appropriate or desired site of action, such as oral or parenteral e.g. rectal, transdermal, subcutaneous, intra ⁇ venous, intraurethral, intramuscular, topical, intranasal, ophthalmic solution or an ointment, the oral route being preferred.
- oral or parenteral e.g. rectal, transdermal, subcutaneous, intra ⁇ venous, intraurethral, intramuscular, topical, intranasal, ophthalmic solution or an ointment, the oral route being preferred.
- compositions include a compound of formula I or a pharmaceuti ⁇ cally acceptable acid addition salt thereof, associated with a pharmaceuti- cally acceptable carrier.
- the active compound will usually be mixed with a carrier, or diluted by a carrier, or enclosed within a carrier which may be in the form of a ampoule, capsule, sachet, paper, or other container.
- the carrier serves as a diluent, it may be solid, semi-solid, or liquid material which acts as a vehicle, excipient, or medium for the active compound.
- the active compound can be adsorbed on a granular solid container for example in a sachet.
- suitable carriers are water, salt solutions, alcohols, polyethylene glycols, polyhydroxyethoxylated castor oil, gelatine, lactose, amylose, magnesium stearate, talc, silicic acid, fatty acid monoglycerides and diglycerides, pentaerythritol fatty acid esters, hydroxymethylcellulose and polyvinylpyrrolidone.
- the pharmaceutical preparations can be sterilized and mixed, if desired, with auxiliary agents, emulsifiers, salt for influencing osmotic pressure, buffers and/or coloring substances and the like, which do not deleteri ⁇ ously react with the active compounds.
- injectable solutions or suspensions preferably aqueous solutions with the active compound dissolved in polyhydroxylated castor oil.
- Tablets, dragees, or capsules having talc and/or a carbohydrate carrier or binder or the like are particularly suitable for oral application.
- Preferable carriers for tablets, dragees, or capsules include lactose, corn starch, and/or potato starch.
- a syrup or elixir can be used in cases where a sweetened vehicle can be employed.
- the compounds are dispensed in unit form comprising from about 1 to about 100 mg in a pharmaceutically acceptable carrier per unit dosage.
- a typical tablet, appropriate for use in this method, may be prepared by conventional tabletting techniques and contains:
- the crude compounds were separated by column chromatography (eluent: methylene chlo- ride/methanol: 9/1 ).
- the first fractions contained (Z)-3-(3-methyl-5- isoxazolyl)methylene-1 -methylpipendine which was crystallized as the oxalate salt in 40 mg (3% yield). M.p. 1 63-1 64°C. (Compound 1 ).
- the next fractions contained 3-(3-methyl-5-isoxazolyl)methyl-1 -methyl- 1 ,2,5,6-tetrahydropyridine, which was crystallized as the fumarate salt in 240 mg (1 8% yield). M.p. 145-146°C. (Compound 2).
- the reaction mixture was warmed to 4 °C and kept at this temperature overnight.
- the reaction mixture was evaporated to half volume in vacuo and water (25 ml) was added.
- the water phase was extracted with ethylacetate (3 x 25 ml).
- the organic extracts were dried over magnesiumsulfate and evaporated.
- the crude compound was separated by column chromatography on silica (eluent: ethylacetate/methanol/ammoniumhydroxide, 25 % in water: 3/1 /0.5%).
- the first fractions contained the (Z) 3-(3-methyl-5- isoxazolyl)methylene-1 -methylpipendine which was crystallized as the oxalate salt in 450 mg yield.
- the crude material was purified by column chromatogaphy on silica (eluent: ethylacetate/methanol/ammo- niumhydroxide, 25 % in water: 3/1 /0.5%).
- the first fractions contained the (Z) 3-(3-methyl-5-isoxazolyl)methylenepiperidine which was crystal ⁇ lized as the hydrochloride salt from ethylacetate in 1 20 mg yield.
- the next fractions contained (E) 3-(3-methyl-5- isoxazolyDmethylene-piperidine, which was crystallized as the hydro- choride salt from ethylacetate in 1 90 mg yield.
- Compound 7. Mp 21 9-20
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU62993/96A AU6299396A (en) | 1995-06-29 | 1996-06-28 | Novel substituted azacyclic or azabicyclic compounds |
EP96921917A EP0842172A1 (en) | 1995-06-29 | 1996-06-28 | Novel substituted azacyclic or azabicyclic compounds |
JP9504109A JPH11508540A (en) | 1995-06-29 | 1996-06-28 | New substituted azacyclic or azabicyclic compounds |
US08/973,847 US6022868A (en) | 1995-06-29 | 1996-06-28 | Substituted azacyclic or azabicyclic compounds |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK75695 | 1995-06-29 | ||
DK0756/95 | 1995-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997001556A1 true WO1997001556A1 (en) | 1997-01-16 |
Family
ID=8097188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK1996/000292 WO1997001556A1 (en) | 1995-06-29 | 1996-06-28 | Novel substituted azacyclic or azabicyclic compounds |
Country Status (5)
Country | Link |
---|---|
US (1) | US6022868A (en) |
EP (1) | EP0842172A1 (en) |
JP (1) | JPH11508540A (en) |
AU (1) | AU6299396A (en) |
WO (1) | WO1997001556A1 (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999051602A1 (en) * | 1998-04-02 | 1999-10-14 | R.J. Reynolds Tobacco Company | Azatricyclo[3.3.1.1] decane derivatives and pharmaceutical compositions containing them |
WO2000034276A1 (en) * | 1998-12-11 | 2000-06-15 | R.J. Reynolds Tobacco Company | Pyridyl-bridgehead derivatives and their analogues, pharmaceutical compositions and their use as inhibitors of nicotinic cholinergic receptors |
FR2805818A1 (en) * | 2000-03-03 | 2001-09-07 | Aventis Pharma Sa | New 3-substituted 1-(di-((hetero)aryl)-methyl)-azetidine derivatives having cannabinoid CB1 receptor antagonist activity, useful e.g. for treating central nervous system, respiratory or gastrointestinal disorders |
FR2805817A1 (en) * | 2000-03-03 | 2001-09-07 | Aventis Pharma Sa | Pharmaceutical compositions containing new or known 3-amino-azetidine derivatives having cannabinoid CB1 receptor antagonist activity, useful e.g. for treating central nervous system, respiratory or gastrointestinal disorders |
WO2001064633A1 (en) * | 2000-03-03 | 2001-09-07 | Aventis Pharma S.A. | Pharmaceutical compositions containing 3-amino-azetidine derivatives, novel derivatives and preparation thereof |
US6566356B2 (en) | 2000-03-03 | 2003-05-20 | Aventis Pharma S.A. | Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation |
US6953855B2 (en) | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
US7056910B2 (en) | 2000-11-28 | 2006-06-06 | Astellas Pharma Inc. | 1,4,5.6-tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof |
US7101896B2 (en) | 1999-11-01 | 2006-09-05 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
US7981906B2 (en) | 2007-08-02 | 2011-07-19 | Targacept, Inc. | (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl-benzofuran-2-carboxamide, novel salt forms, and methods of use thereof |
US8193372B2 (en) | 2009-03-04 | 2012-06-05 | Idenix Pharmaceuticals, Inc. | Phosphothiophene and phosphothiazole HCV polymerase inhibitors |
US8901151B2 (en) | 2009-01-26 | 2014-12-02 | Targacept, Inc. | Preparation and therapeutic applications of (2S, 3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]OCT-3-yl)-3,5-difluorobenzamide |
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US20060189569A1 (en) * | 2000-01-10 | 2006-08-24 | Saul Yedgar | Use of lipid conjugates in the treatment of infection |
US6479479B2 (en) * | 2000-03-03 | 2002-11-12 | Aventis Pharma S.A. | Azetidine derivatives, their preparation and pharmaceutical compositions containing them |
ATE292636T1 (en) | 2000-05-25 | 2005-04-15 | Targacept Inc | HETEROARYLDIAZABICYCLOALKANES AS LIGANDS FOR THE NICOTINIC ACETYLCHOLINE RECEPTOR |
US6579878B1 (en) | 2000-07-07 | 2003-06-17 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
US6624167B1 (en) | 2000-08-04 | 2003-09-23 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
NZ537214A (en) * | 2002-07-05 | 2007-08-31 | Targacept Inc | N-Aryl diazaspiracyclic compounds capable of affecting nicotinic cholinergic receptors and methods of preparation and use thereof |
JP2008510711A (en) * | 2004-08-20 | 2008-04-10 | ターガセプト,インコーポレイテッド | Use of N-aryl diazaspira cyclic compounds in the treatment of addiction |
US7384929B2 (en) * | 2004-09-20 | 2008-06-10 | Targacept, Inc. | N-aryl azaspiroalkene and azaspiroalkane compounds and methods of preparation and use thereof |
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EP0330353A1 (en) * | 1988-02-19 | 1989-08-30 | Eli Lilly And Company | Tetrazole excitatory amino acid receptor antagonists |
EP0414394A2 (en) * | 1989-08-05 | 1991-02-27 | Beecham Group Plc | Azabicyclic Derivatives having muscarinic receptor affinity |
WO1993012108A1 (en) * | 1991-12-18 | 1993-06-24 | Schering Corporation | Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring |
-
1996
- 1996-06-28 EP EP96921917A patent/EP0842172A1/en not_active Withdrawn
- 1996-06-28 WO PCT/DK1996/000292 patent/WO1997001556A1/en not_active Application Discontinuation
- 1996-06-28 US US08/973,847 patent/US6022868A/en not_active Expired - Fee Related
- 1996-06-28 AU AU62993/96A patent/AU6299396A/en not_active Abandoned
- 1996-06-28 JP JP9504109A patent/JPH11508540A/en active Pending
Patent Citations (3)
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EP0330353A1 (en) * | 1988-02-19 | 1989-08-30 | Eli Lilly And Company | Tetrazole excitatory amino acid receptor antagonists |
EP0414394A2 (en) * | 1989-08-05 | 1991-02-27 | Beecham Group Plc | Azabicyclic Derivatives having muscarinic receptor affinity |
WO1993012108A1 (en) * | 1991-12-18 | 1993-06-24 | Schering Corporation | Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring |
Non-Patent Citations (1)
Title |
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CHEMICAL ABSTRACTS, Volume 110, No. 16, 17 April 1989, (Columbus, Ohio, USA), HELAK, BERND et al., "Formation of Furylpyrrolidines and -Piperidines on Heating L-Proline with Reducing Sugars and Furancarbox Aldehydes", page 761, the Abstract No. 135678n; & J. AGRIC. FOOD CHEM. 1989, 37 (2), 405-410. * |
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WO1999051602A1 (en) * | 1998-04-02 | 1999-10-14 | R.J. Reynolds Tobacco Company | Azatricyclo[3.3.1.1] decane derivatives and pharmaceutical compositions containing them |
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US7754189B2 (en) | 1998-12-11 | 2010-07-13 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
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Also Published As
Publication number | Publication date |
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US6022868A (en) | 2000-02-08 |
EP0842172A1 (en) | 1998-05-20 |
JPH11508540A (en) | 1999-07-27 |
AU6299396A (en) | 1997-01-30 |
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