WO1997000601A3 - Polypeptides with interleukin-8 receptor binding - Google Patents
Polypeptides with interleukin-8 receptor binding Download PDFInfo
- Publication number
- WO1997000601A3 WO1997000601A3 PCT/US1996/010537 US9610537W WO9700601A3 WO 1997000601 A3 WO1997000601 A3 WO 1997000601A3 US 9610537 W US9610537 W US 9610537W WO 9700601 A3 WO9700601 A3 WO 9700601A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polypeptides
- receptor binding
- interleukin
- receptor
- modulating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5421—IL-8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
The present invention presents sequences of polypeptides capable of modulating IL8 receptor binding and IL8 receptor-mediated biological response. Also, polynucleotides encoding the instant polypeptides and methods of producing the polypeptides are also described.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU62839/96A AU6283996A (en) | 1995-06-20 | 1996-06-18 | Polypeptides with interleukin-8 receptor binding |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US277495P | 1995-06-20 | 1995-06-20 | |
US60/002,774 | 1995-06-20 | ||
US538595P | 1995-10-18 | 1995-10-18 | |
US60/005,385 | 1995-10-18 | ||
US92845596A | 1996-04-05 | 1996-04-05 | |
US08/928,455 | 1996-04-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997000601A2 WO1997000601A2 (en) | 1997-01-09 |
WO1997000601A3 true WO1997000601A3 (en) | 1997-03-13 |
Family
ID=27357239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/010537 WO1997000601A2 (en) | 1995-06-20 | 1996-06-18 | Polypeptides with interleukin-8 receptor binding |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU6283996A (en) |
WO (1) | WO1997000601A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002070565A2 (en) * | 2001-03-01 | 2002-09-12 | University Of Saskatchewan Technologies Inc. | High-affinity antagonists of elr-cxc chemokines |
CN100366637C (en) * | 2005-11-17 | 2008-02-06 | 中国人民解放军第四军医大学 | Human interleukin 8 antagonist protein and preparation method thereof |
HUE026447T2 (en) | 2009-10-16 | 2016-05-30 | Novartis Ag | Biomarkers of tumor pharmacodynamic response |
US20150224190A1 (en) | 2012-07-06 | 2015-08-13 | Mohamed Bentires-Alj | Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the IL-8/CXCR interaction |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993011159A1 (en) * | 1991-12-04 | 1993-06-10 | The Biomedical Research Centre Limited | Human interleukin-8 analogs |
-
1996
- 1996-06-18 WO PCT/US1996/010537 patent/WO1997000601A2/en active Application Filing
- 1996-06-18 AU AU62839/96A patent/AU6283996A/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993011159A1 (en) * | 1991-12-04 | 1993-06-10 | The Biomedical Research Centre Limited | Human interleukin-8 analogs |
Non-Patent Citations (7)
Title |
---|
CLARK-LEWIS I.: "Structural requirements for interleukin-8 function identified by design of analogs and CXC chemokine hybrids", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 23, 10 June 1994 (1994-06-10), pages 16075 - 16081, XP002018167 * |
DATABASE EMBL Heidelberg, BRD; 1 March 1989 (1989-03-01) * |
DATABASE EMBL Heidelberg, BRD; 14 April 1996 (1996-04-14), XP002018323 * |
HBERT C.: "Scanning mutagenesis of Interleukin-8 identifies a cluster of residues required for receptor binding", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 28, 5 October 1991 (1991-10-05), pages 18989 - 18994, XP002018437 * |
SCHMID J.: "Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes", THE JOURNAL OF IMMUNOLOGY, vol. 139, no. 1, 1 July 1987 (1987-07-01), pages 250 - 256, XP002018164 * |
TAKEDA J., UNBUBLISHED * |
WERNETTE HAMMOND M.E.: "Receptor recognition and specificity of interleukin-8 is determined by residues that cluster near a surface-accessible hydrophobic pocket", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 14, 5 April 1996 (1996-04-05), pages 8228 - 8235, XP002018166 * |
Also Published As
Publication number | Publication date |
---|---|
WO1997000601A2 (en) | 1997-01-09 |
AU6283996A (en) | 1997-01-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1997007198A3 (en) | Dna sequences and secreted proteins encoded thereby | |
CA2258502A1 (en) | Modified factor viii | |
WO1998007859A3 (en) | Secreted proteins and polynucleotides encoding them | |
EP1162264A3 (en) | Chimeric hormone receptor | |
WO1998021343A8 (en) | Genes encoding telomerase proteins | |
WO1998017687A3 (en) | Secreted proteins and polynucleotides encoding them | |
EP1571216A3 (en) | Phosphodiesterase 8A | |
ZA9710288B (en) | Novel genes encoding telomerase proteins. | |
WO1998033916A8 (en) | Secreted proteins and polynucleotides encoding them | |
WO1997027284A3 (en) | Human rad50 and septin-2 genes and methods of use | |
WO2000015798A3 (en) | Mammalian transforming growth factor beta - 9 (ztgfss9) | |
WO1998004693A3 (en) | Secreted proteins and polynucleotides encoding them | |
WO1998057983A3 (en) | Mammalian neuro-growth factor like protein | |
WO1998017810A3 (en) | Multi-functional chimeric hematopoietic receptor agonists | |
WO1998040486A3 (en) | Secreted proteins and polynucleotides encoding them | |
WO1997000601A3 (en) | Polypeptides with interleukin-8 receptor binding | |
WO1998005776A3 (en) | Secreted proteins and polynucleotides encoding them | |
WO1998027205A3 (en) | Secreted proteins and polynucleotides encoding them | |
WO1998037094A3 (en) | Secreted proteins and polynucleotides encoding them | |
WO1998032853A3 (en) | Secreted proteins and polynucleotides encoding them | |
CA2199403A1 (en) | Novel PKA-Binding Proteins and Uses Thereof | |
WO2000024771A3 (en) | Nucleic acids encoding osteoprotegerin-like proteins and methods of using same | |
WO1998040404A3 (en) | Secreted proteins and polynucleotides encoding them | |
WO1998030589A3 (en) | Secreted proteins and polynucleotides encoding them | |
WO1999029720A3 (en) | Mammalian alpha helical protein-1 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AU CA CN IL JP MX US US US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
NENP | Non-entry into the national phase |
Ref country code: CA |
|
122 | Ep: pct application non-entry in european phase |