WO1997000601A3 - Polypeptides with interleukin-8 receptor binding - Google Patents

Polypeptides with interleukin-8 receptor binding Download PDF

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Publication number
WO1997000601A3
WO1997000601A3 PCT/US1996/010537 US9610537W WO9700601A3 WO 1997000601 A3 WO1997000601 A3 WO 1997000601A3 US 9610537 W US9610537 W US 9610537W WO 9700601 A3 WO9700601 A3 WO 9700601A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
receptor binding
interleukin
receptor
modulating
Prior art date
Application number
PCT/US1996/010537
Other languages
French (fr)
Other versions
WO1997000601A2 (en
Inventor
Mary Ellen Wernette-Hammond
Venkatakrishna Shyamala
Michael Siani
Jeff Blaney
Patrica Tekamp-Olson
Original Assignee
Chiron Corp
Wernette Hammond Mary Ellen
Venkatakrishna Shyamala
Michael Siani
Jeff Blaney
Tekamp Olson Patrica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp, Wernette Hammond Mary Ellen, Venkatakrishna Shyamala, Michael Siani, Jeff Blaney, Tekamp Olson Patrica filed Critical Chiron Corp
Priority to AU62839/96A priority Critical patent/AU6283996A/en
Publication of WO1997000601A2 publication Critical patent/WO1997000601A2/en
Publication of WO1997000601A3 publication Critical patent/WO1997000601A3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5421IL-8
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Abstract

The present invention presents sequences of polypeptides capable of modulating IL8 receptor binding and IL8 receptor-mediated biological response. Also, polynucleotides encoding the instant polypeptides and methods of producing the polypeptides are also described.
PCT/US1996/010537 1995-06-20 1996-06-18 Polypeptides with interleukin-8 receptor binding WO1997000601A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU62839/96A AU6283996A (en) 1995-06-20 1996-06-18 Polypeptides with interleukin-8 receptor binding

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US277495P 1995-06-20 1995-06-20
US60/002,774 1995-06-20
US538595P 1995-10-18 1995-10-18
US60/005,385 1995-10-18
US92845596A 1996-04-05 1996-04-05
US08/928,455 1996-04-05

Publications (2)

Publication Number Publication Date
WO1997000601A2 WO1997000601A2 (en) 1997-01-09
WO1997000601A3 true WO1997000601A3 (en) 1997-03-13

Family

ID=27357239

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/010537 WO1997000601A2 (en) 1995-06-20 1996-06-18 Polypeptides with interleukin-8 receptor binding

Country Status (2)

Country Link
AU (1) AU6283996A (en)
WO (1) WO1997000601A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070565A2 (en) * 2001-03-01 2002-09-12 University Of Saskatchewan Technologies Inc. High-affinity antagonists of elr-cxc chemokines
CN100366637C (en) * 2005-11-17 2008-02-06 中国人民解放军第四军医大学 Human interleukin 8 antagonist protein and preparation method thereof
HUE026447T2 (en) 2009-10-16 2016-05-30 Novartis Ag Biomarkers of tumor pharmacodynamic response
US20150224190A1 (en) 2012-07-06 2015-08-13 Mohamed Bentires-Alj Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the IL-8/CXCR interaction

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011159A1 (en) * 1991-12-04 1993-06-10 The Biomedical Research Centre Limited Human interleukin-8 analogs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011159A1 (en) * 1991-12-04 1993-06-10 The Biomedical Research Centre Limited Human interleukin-8 analogs

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CLARK-LEWIS I.: "Structural requirements for interleukin-8 function identified by design of analogs and CXC chemokine hybrids", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 23, 10 June 1994 (1994-06-10), pages 16075 - 16081, XP002018167 *
DATABASE EMBL Heidelberg, BRD; 1 March 1989 (1989-03-01) *
DATABASE EMBL Heidelberg, BRD; 14 April 1996 (1996-04-14), XP002018323 *
HŸBERT C.: "Scanning mutagenesis of Interleukin-8 identifies a cluster of residues required for receptor binding", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 28, 5 October 1991 (1991-10-05), pages 18989 - 18994, XP002018437 *
SCHMID J.: "Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes", THE JOURNAL OF IMMUNOLOGY, vol. 139, no. 1, 1 July 1987 (1987-07-01), pages 250 - 256, XP002018164 *
TAKEDA J., UNBUBLISHED *
WERNETTE HAMMOND M.E.: "Receptor recognition and specificity of interleukin-8 is determined by residues that cluster near a surface-accessible hydrophobic pocket", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 14, 5 April 1996 (1996-04-05), pages 8228 - 8235, XP002018166 *

Also Published As

Publication number Publication date
WO1997000601A2 (en) 1997-01-09
AU6283996A (en) 1997-01-22

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