WO1996029108A1 - Improved nebulizer and inhalation device containing same - Google Patents
Improved nebulizer and inhalation device containing same Download PDFInfo
- Publication number
- WO1996029108A1 WO1996029108A1 PCT/US1996/003795 US9603795W WO9629108A1 WO 1996029108 A1 WO1996029108 A1 WO 1996029108A1 US 9603795 W US9603795 W US 9603795W WO 9629108 A1 WO9629108 A1 WO 9629108A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aerosol
- gas
- inhalation device
- nebulizer
- liquid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
Definitions
- This invention relates to methods of producing aerosols for patients, and in particular, to apparatus for improving the delivery of aerosol therapeutics and diagnostics.
- Aerosol inhalation equipment is often used in medical facilities for generating aerosol mists for diagnostic and therapeutic procedures. Such devices are especially useful in pulmonary therapy for pneumonia and for introducing radioactive vapors for diagnosing diseases.
- the engine of most aerosol-generating equipment is the nebulizer, a device which mixes pressurized air or oxygen with diagnostic or therapeutic fluids to create an aerosol mist.
- the liquid to be aerosolized is placed in a liquid reservoir in the nebulizer. Air under pressure enters the system and acts to draw the liquid up a delivery tube to an aerosol exit orifice, similar to a jet pump. At the aerosol exit orifice, the fluid is atomized into a fine mist.
- a typical nebulizer is disclosed in Bordoni et al . , U.S. Patent No. 4,823,784.
- nebulizer The overall effectiveness of a nebulizer depends largely upon the distribution and size of the droplets produced. Droplets larger than 3.5 micrometers generally do not leave the nebulizer and run back into the bowl to be atomized again. Droplets between about 1.5 and 3.5 micrometers often collect on the walls of the delivery system and frequently settle onto the lips, mouth, or bronchial tubes of the patient without ever reaching the alveolar, often referred to as the "deep lung" .
- This invention provides a nebulizer for use in an aerosol inhalation device for supplying an aerosol mist to a patient.
- the nebulizer includes a liquid inlet for receiving a liquid and a gas inlet for receiving a pressurized gas. The gas and liquid are combined to provide an aerosol mist through an aerosol outlet in the nebulizer.
- the nebulizer of this invention includes means for redirecting the pressurized gas to create a swirling action and shear force so that greater atomization of therapeutic or diagnostic liquids can be accomplished without a loss in liquid delivery efficiency.
- the swirling motion produced by the nebulizers of this invention produces a shear force on the liquid that is greater than that developed when the air flows straight through the orifice.
- the amount of medicine delivered to the patient for a given treatment time is improved and an aerosol consisting of smaller drops is produced.
- the devices of this invention can increase the rate of delivery of the droplets within the desired size range of .5 - 1.5 micrometers, while reducing the number of larger drops, e.g. above about 3 micrometers, that impact on the baffle and fall back into the reservoir.
- This invention also provides a nebulizer having a liquid reservoir for storing a prescribed liquid and a gas inlet for receiving a pressurized gas .
- a venturi tube Connected to the gas inlet of this embodiment is a venturi tube for providing an axial jet velocity to the pressurized gas.
- the venturi tube has a conical cross-section with a larger opening at one end of the tube and a smaller opening at the other end.
- a gas deflection member Located within the venturi tube is a gas deflection member for providing a tangential velocity to the pressurized gas.
- This nebulizer also includes a fluid conduit providing passage of a portion of the prescribed liquid from the liquid reservoir to a point located distally from the venturi outlet opening upon the production of a vacuum by the venturi tube.
- a baffle is also included distally from the venturi tube outlet opening for contacting the aerosol mist and reducing the amount of droplets in the mist which exceed about 3 micrometers .
- the aerosol mist exits an aerosol outlet, which can be connected to a conduit of an aerosol inhalation device.
- the nebulizer of this embodiment provides an aerosol mist having an obscuration rating of at least about 10% and a median droplet size of less than 1 micrometer.
- FIG. 1 is a side elevation view of a preferred aerosol inhalation device of this invention, illustrating some of the more important connections and features in phantom, and the substance recovery media in cross-section;
- FIG. 2 is a top planar view of the aerosol inhalation device of FIG. 1;
- FIG. 3 is a side elevation, exploded view of the proximal end of the aerosol inhalation apparatus of FIG. 1;
- FIG. 4 is a side elevation, cross-sectional view of a preferred nebulizer design for use in connection with the preferred aerosol inhalation apparatus of FIG. 1.
- Improved nebulizers for creating aerosol mists and aerosol inhalation devices containing these nebulizers are provided by this invention. These devices employ improved nebulization techniques for providing increased sheer action during atomization of therapeutic and diagnostic fluids so that a greater delivery rate of smaller liquid droplets are provided to the deep lung of patients.
- This device 100 contains some basic elements which represent groups of constituent parts that are labeled together for convenience. These elements include a nebulizer 10 for producing an aerosol and an exhaust port 70 for exit gases, a form of substance recovery media 20, and a rain-off chamber 30 which helps to contain humidity and recycle expensive therapeutic and diagnostic fluids back into the nebulizer 10.
- a nebulizer 10 for producing an aerosol and an exhaust port 70 for exit gases
- a form of substance recovery media 20 for exit gases
- a rain-off chamber 30 which helps to contain humidity and recycle expensive therapeutic and diagnostic fluids back into the nebulizer 10.
- one-way valve 51 closes, one-way valve 41 opens, and exhaust gases are channeled through exhaust conduit 40 into the rain-off chamber 30 where aerosol, water vapor, liquid and gases are separated. Liquid constituents are returned to the nebulizer by gravitational force, exhaust gases are discharged, and any left-over aerosol is temporarily stored in the chamber 30.
- the left-over aerosol is returned back to the patient through one-way valve 51.
- compressed air or oxygen is typically received through the gas inlet 13 at the proximal end of the nebulizer 10.
- a compressor can be attached to the nipple of the gas inlet 13 to generate a source of compressed air at a pressure of about 35-50 psi and a flow rate of less than about 10 liters per minute, and preferably about 6 liters per minute.
- a gas flow control device which in the preferred embodiment, provides both an axial jet velocity and a tangential velocity to the gas.
- This can be accomplished by a combination of a swirler 14 and gas channel wall 26, shown more clearly in FIG. 4.
- the swirler 14 preferably consists of a spiral air passage, although there are many other ways to produce a swirling action, such as by employing vanes, a propeller-device, or inner helical grooves mounted within the gas channel wall 26.
- the gas channel wall 26 preferably is in the shape of a venturi tube so as to provide an axial jetting velocity to the compressed gas.
- a high delivery rate aerosol can be produced because the normal breakup of liquid caused by the axial jetting action is enhanced by the swirling air flow, and more shearing forces are created, providing more efficient atomization. The result is that more smaller drop sizes are produced at the same overall liquid delivery flow rates as provided by existing nebulizers.
- the nebulizer 10 also includes a bowl housing 11 for containing a liquid reservoir 12.
- the liquid reservoir is charged to a liquid level 19 located below the deflector dome 16.
- the swirling gases then exit at the gas channel exit orifice 27 and create a venturi vacuum.
- This vacuum draws liquid from the liquid reservoir 12 through liquid channel 17 formed between liquid channel insert 15 and gas channel wall 26, which mixes with the swirling gas jet at the liquid channel orifice 18 to form an aerosol.
- the aerosol contacts the lower surface of the deflector dome 16, which collects droplets larger than about 3 - 3.5 micrometers and returns them back into the liquid reservoir 12 along the wall of the bowl housing 11, so that they can be atomized later. Particles between about 1.5 and 3.5 micrometers can also collect along the bowl housing 11 and be returned in similar fashion.
- the aerosol thus produced, exits the aerosol outlet 28 and is channeled through the one-way valve 51 into the aerosol conduit 50 and to the patient. Injections of additional liquid, or an additional substance, can be delivered into the liquid reservoir through injection port 35.
- the aerosol produced by the nebulizer 10 of this invention preferably has an increased delivery rate of liquid drops within the size range of about 0.5-1.5 micrometers.
- One way of measuring the delivery rate is to pass a laser light beam, infrared radiation or an equivalent radiation source through a cloud produced by the aerosol and measure the amount of light that passes through the mist with a light detector.
- the reading for the amount of light that is obscured by the mist is called the "obscuration rating" of the aerosol and is directly related to the aerosol's delivery rate.
- the aerosols of this invention have a preferred obscuration rating of at least 10% even though they can simultaneously produce a median droplet size of less than one micrometer.
- This invention provides a substance recovery media 20 located in the proximal end of the aerosol inhalation device 100, preferably between the rain-off chamber 30 and exhaust port 70.
- the substance recovery media 20 should be able to achieve high moisture output with low resistance to exhaust gases. It is also desirable that it be salt- and toxic-free.
- the preferred the substance recovery media 20 contains a fibrous material having a plurality of air channels formed therein for attracting liquid onto the fibers, while permitting gas to flow through. Such material should be able to recover moisture, including therapeutic and diagnostic liquids, as well as water vapor exhausted by the patient.
- Acceptable substance recovery materials include polymer- or natural fiber-based moisture exchange media, such as H E media produced by 3M.
- HME media can achieve an extremely high moisture return rate with low resistance to exiting gases. It is salt-free, so it does not leech out salts that can corrode the equipment or be recycled back into the nebulizer. It comes in thicknesses of about 18-24 mm, has a moisture output of greater than 28 mg/1 at 500 ml tidal volume, and exhibits a resistance to flow of up to 2.8 cm H 2 0 at 60 1/m.
- the preferred substance recovery media 20 is disposed below a recovery media cap 24 and is sandwiched between filter 21 and snap ring 22, although it is envisioned that the filter 21 could be located more distally or proximally in the inhalation device.
- the preferred filter 21 consists of thermoplastic strands of woven or non-woven material which are layered to acquire a desired filtration density of about 200g/cm 3 .
- the thermoplastic preferably is polypropylene or polyethylene, although many other polymers would be suitable.
- the filter 21 can be die cut into a desired shape to fit the substance recovery form, recovery media cap 24, or both.
- the filter 21 should be of sufficient size and density to prevent the penetration of vapors, toxins, viruses etc., from exiting exhaust port 70. It can be electrostatically charged or treated to be hydrophilic or hydrophobic depending on the end use for the material.
- One preferred filtration media is a product manufactured by 3M under the trademark FILTRETE.
- a seal of less than about .25 inch in width is provided around the filter's outer periphery.
- the filter 21 can be sealed by such methods as heat sealing, ultrasonic sealing, or by applying pressure to melt the thermoplastic strands along the edge of the filter 21 to form a relatively solid mass.
- the filter 21 can also be sealed to fit within holding frames, filter shelves or other mechanisms to give it strength and shape to satisfy a particular filtration requirement.
- Other methods of sealing the periphery of the die cut edge of the filter can include using adhesive sealing materials such as wax, varnish, epoxy, or glue that would solidify the die cut edge and create a water and vapor seal.
- holding frames and shelves are designed with edge clamps which mechanically retain a filter in place, but allow vapor and other contaminants to pass around the die cut limits of the filter. By providing a positive adhesive or melted seal around the filter, such vapor leaks are substantially eliminated.
- the sealed edge filter of the preferred embodiment has application outside of the nebulizer field, and can be useful in many applications where particle capture is critical and space is at a premium.
- Such applications include ventilation systems, air purifiers, air conditioners, computers, vacuum cleaners, copying machines, laser printers and other equipment.
- applications include breathing circuits, spirometers, incubator filters, radioaerosol moisture trapping devices and similar apparatus.
- the rain-off chamber 30, described above, can be fabricated within the body 23 of the aerosol inhalation device 100. As shown in FIG. 3, the body 23 is preferably located between the nebulizer 10 and the substance recovery media 20.
- the rain-off chamber 30 is desirably positioned proximally from one-way valve 41, and one-way valve 51.
- aerosol enters in the lower half of the rain-off chamber 30 from the nebulizer 10 and is directed through one-way valve 51 into the aerosol conduit 50 for patient use.
- exhaust gases and leftover aerosol vapor travel down exhaust conduit 40, through one-way valve 41, and back into the upper portion of the rain-off chamber 30.
- the gases, with their entrained vapors contact the inner surfaces of the rain-off chamber 30, and the larger droplets accumulate immediately upon exhaust deflector 32. Since nearly 66% of the total amount of aerosol inhaled by the patient is returned through the exhaust conduit 40, the rain-off chamber 30 can be important in order to recycle and conserve expensive diagnostic and therapeutic liquids.
- these vapors come in contact with the inner surfaces of the rain-off chamber, they condense or bead up onto the surfaces and are fed by gravitational forces downward through the rain-off return 34 and back into the liquid reservoir 12 of the nebulizer 10.
- a significant portion of the interior surfaces of this chamber 30 are hydrophobic, in that the liquid contact angle of droplets on these surfaces is less than about 90 degrees.
- the rain- off surfaces preferably have a critical surface tension of less than about 40 dyres/cm, and more preferably less than about 32 dyres/cm.
- Hydrophobic polymers, ceramics, cellulosic and metallic materials or other materials which have been coated to be hydrophobic can be used. Suitable materials include polyethylene, polypropylene, fluorocarbons, silicones and the like.
- One commercial resin that has proved to be acceptable is Exxon's Exact Resin No. 4024. Silicone rubber and polyethylene, however, appear to show the greatest promise in recycling aerosol products.
- this invention provides improved nebulizers and aerosol inhalation apparatus that contain them. These nebulizers can increase the rate of delivery of efficacious aerosol mists to the deep lung of patients by using improved nebulization techniques. Additionally, improved rain-off techniques are used to recirculate valuable therapeutic and diagnostic fluids for reatomization, and more effective substance recovery and filtration designs are disclosed for protecting the hospital environment and returning liquid and liquid vapor back to the nebulizer or patient.
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69628835T DE69628835D1 (en) | 1995-03-22 | 1996-03-20 | IMPROVED NEGLAVER AND THIS INHALING DEVICE |
EP96908872A EP0830164B1 (en) | 1995-03-22 | 1996-03-20 | Improved nebulizer and inhalation device containing same |
AU52571/96A AU713481B2 (en) | 1995-03-22 | 1996-03-20 | Improved nebulizer and inhalation device containing same |
BR9607944-4A BR9607944A (en) | 1995-03-22 | 1996-03-20 | Aerosol inhalation device |
AT96908872T ATE243541T1 (en) | 1995-03-22 | 1996-03-20 | IMPROVED NEBULISER AND INHALER DEVICE CONTAINING SAME |
JP8528592A JPH11502440A (en) | 1995-03-22 | 1996-03-20 | Improved nebulizer and inhaler incorporating the nebulizer |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/409,190 | 1995-03-22 | ||
US08/409,360 US5630409A (en) | 1995-03-22 | 1995-03-22 | Nebulizer and inhalation device containing same |
US08/409,360 | 1995-03-22 | ||
US08/409,259 US5611332A (en) | 1995-03-22 | 1995-03-22 | Aerosol inhalation device containing a rain-off chamber |
US08/409,259 | 1995-03-22 | ||
US08/409,190 US5603314A (en) | 1995-03-22 | 1995-03-22 | Aerosol filtration device and inhalation apparatus containing same |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996029108A1 true WO1996029108A1 (en) | 1996-09-26 |
Family
ID=27410791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/003795 WO1996029108A1 (en) | 1995-03-22 | 1996-03-20 | Improved nebulizer and inhalation device containing same |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0830164B1 (en) |
JP (1) | JPH11502440A (en) |
AT (1) | ATE243541T1 (en) |
AU (1) | AU713481B2 (en) |
BR (1) | BR9607944A (en) |
CA (1) | CA2216103A1 (en) |
DE (1) | DE69628835D1 (en) |
WO (1) | WO1996029108A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8656909B2 (en) | 2005-07-28 | 2014-02-25 | Glaxo Group Limited | Nozzle for a nasal inhaler |
WO2014099556A1 (en) * | 2012-12-19 | 2014-06-26 | Carefusion 303, Inc. | Nebulizer mouthpiece for reducing drug loss |
CN104353163A (en) * | 2014-03-31 | 2015-02-18 | 中国医学科学院生物医学工程研究所 | Multi-functional lung-heat clearing and beauty instrument, and application method thereof |
US10874810B2 (en) | 2009-08-11 | 2020-12-29 | Resmed Motor Technologies Inc. | Single stage, axial symmetric blower and portable ventilator |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009079078A1 (en) | 2007-12-14 | 2009-06-25 | Labogroup S.A.S. | Delivering aerosolizable food products |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4268460A (en) * | 1977-12-12 | 1981-05-19 | Warner-Lambert Company | Nebulizer |
US4462397A (en) * | 1981-04-03 | 1984-07-31 | Terumo Corporation | Breathing circuit |
US5036840A (en) * | 1990-06-20 | 1991-08-06 | Intertech Resources Inc. | Nebulizer system |
US5044361A (en) * | 1987-04-14 | 1991-09-03 | Zenova Aktiebolag | Method and apparatus for reuse of anesthetics |
US5309900A (en) * | 1991-03-21 | 1994-05-10 | Paul Ritzau Pari-Werk Gmbh | Atomizer particularly for use in devices for inhalation therapy |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3592191A (en) * | 1969-01-17 | 1971-07-13 | Richard R Jackson | Recovery of anesthetic agents |
US3874379A (en) * | 1973-08-15 | 1975-04-01 | Becton Dickinson Co | Manifold nebulizer system |
FR2478074A1 (en) * | 1980-03-17 | 1981-09-18 | Rhone Poulenc Ind | PROCESS FOR THE PREPARATION OF TRIFLUOROMETHYLBENZENES FROM THE CORRESPONDING TRICHLORO- OR TRIBROMO-METHYLBENZENES |
US4767576A (en) * | 1984-10-15 | 1988-08-30 | Cimco | Nebulizer with auxiliary gas input |
US5020530A (en) * | 1990-05-07 | 1991-06-04 | Miller Warren C | Inhalation therapy device |
-
1996
- 1996-03-20 CA CA002216103A patent/CA2216103A1/en not_active Abandoned
- 1996-03-20 AT AT96908872T patent/ATE243541T1/en not_active IP Right Cessation
- 1996-03-20 AU AU52571/96A patent/AU713481B2/en not_active Ceased
- 1996-03-20 DE DE69628835T patent/DE69628835D1/en not_active Expired - Lifetime
- 1996-03-20 EP EP96908872A patent/EP0830164B1/en not_active Expired - Lifetime
- 1996-03-20 WO PCT/US1996/003795 patent/WO1996029108A1/en active IP Right Grant
- 1996-03-20 JP JP8528592A patent/JPH11502440A/en not_active Ceased
- 1996-03-20 BR BR9607944-4A patent/BR9607944A/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4268460A (en) * | 1977-12-12 | 1981-05-19 | Warner-Lambert Company | Nebulizer |
US4462397A (en) * | 1981-04-03 | 1984-07-31 | Terumo Corporation | Breathing circuit |
US5044361A (en) * | 1987-04-14 | 1991-09-03 | Zenova Aktiebolag | Method and apparatus for reuse of anesthetics |
US5036840A (en) * | 1990-06-20 | 1991-08-06 | Intertech Resources Inc. | Nebulizer system |
US5309900A (en) * | 1991-03-21 | 1994-05-10 | Paul Ritzau Pari-Werk Gmbh | Atomizer particularly for use in devices for inhalation therapy |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8656909B2 (en) | 2005-07-28 | 2014-02-25 | Glaxo Group Limited | Nozzle for a nasal inhaler |
US10874810B2 (en) | 2009-08-11 | 2020-12-29 | Resmed Motor Technologies Inc. | Single stage, axial symmetric blower and portable ventilator |
WO2014099556A1 (en) * | 2012-12-19 | 2014-06-26 | Carefusion 303, Inc. | Nebulizer mouthpiece for reducing drug loss |
US9248252B2 (en) | 2012-12-19 | 2016-02-02 | Carefusion 303, Inc. | Nebulizer mouthpiece for reducing drug loss |
EP3144024A1 (en) * | 2012-12-19 | 2017-03-22 | Carefusion 303 Inc. | Nebulizer mouthpiece for reducing drug loss |
AU2013363364B2 (en) * | 2012-12-19 | 2017-11-30 | Sunmed Group Holdings, Llc | Nebulizer mouthpiece for reducing drug loss |
US10130786B2 (en) | 2012-12-19 | 2018-11-20 | Vyaire Medical Consumables, LLC | Nebulizer mouthpiece for reducing drug loss |
EP4035713A1 (en) * | 2012-12-19 | 2022-08-03 | Carefusion 303 Inc. | Nebulizer mouthpiece for reducing drug loss |
CN104353163A (en) * | 2014-03-31 | 2015-02-18 | 中国医学科学院生物医学工程研究所 | Multi-functional lung-heat clearing and beauty instrument, and application method thereof |
Also Published As
Publication number | Publication date |
---|---|
CA2216103A1 (en) | 1996-09-26 |
DE69628835D1 (en) | 2003-07-31 |
EP0830164A1 (en) | 1998-03-25 |
AU5257196A (en) | 1996-10-08 |
EP0830164B1 (en) | 2003-06-25 |
ATE243541T1 (en) | 2003-07-15 |
AU713481B2 (en) | 1999-12-02 |
BR9607944A (en) | 1999-11-30 |
EP0830164A4 (en) | 1998-11-18 |
JPH11502440A (en) | 1999-03-02 |
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