WO1996015821A1 - Medical glass container suitable for use in needleless injectors - Google Patents

Medical glass container suitable for use in needleless injectors Download PDF

Info

Publication number
WO1996015821A1
WO1996015821A1 PCT/GB1995/002649 GB9502649W WO9615821A1 WO 1996015821 A1 WO1996015821 A1 WO 1996015821A1 GB 9502649 W GB9502649 W GB 9502649W WO 9615821 A1 WO9615821 A1 WO 9615821A1
Authority
WO
WIPO (PCT)
Prior art keywords
container according
container
plastics material
glass container
hollow glass
Prior art date
Application number
PCT/GB1995/002649
Other languages
French (fr)
Inventor
Terence Edward Weston
Anthony Philip Licence
Original Assignee
Weston Medical Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Weston Medical Limited filed Critical Weston Medical Limited
Priority to DK95936667T priority Critical patent/DK0792174T3/en
Priority to EP95936667A priority patent/EP0792174B1/en
Priority to BR9509791A priority patent/BR9509791A/en
Priority to DE69508104T priority patent/DE69508104T2/en
Priority to JP51664396A priority patent/JP3399962B2/en
Priority to RU97110272A priority patent/RU2145885C1/en
Priority to AU38517/95A priority patent/AU3851795A/en
Publication of WO1996015821A1 publication Critical patent/WO1996015821A1/en
Priority to NO972265A priority patent/NO972265L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic

Definitions

  • the invention relates to glass containers, particularly those subjected to high pressures.
  • the invention employs the principle that glass is able to withstand higher forces if the surfaces are maintained in a state of compressive stress.
  • the accepted theories on glass fracture propose that breakage occurs through the rapid growth of icrocracks on the glass surface when the glass is stressed, in addition to fractures originating from gross surface defects. By holding the surfaces in compressive stress, this stress must be overcome before crack growth can occur.
  • a container adapted to withstand a high internal pressure, comprising a hollow glass body and compression means for exerting a compressive force on the hollow glass body.
  • the compression means is a tight fitting sleeve assembled onto the capsule body so as to exert a compressive force on a preferably cylindrical wall thereof.
  • a borosilicate glass cylinder having a bore of 5mm diameter and a wall thickness of 2.19mm will sometimes break when subjected to internal pressures of 80 bars and transient pressures of 4000 bars. Furthermore, the cylinders are unable to withstand more than two applications of such pressures.
  • a polycarbonate sleeve having a nominal interference fit of 0.05mm enables the cylinders to withstand at least 20 applications of such pressures without damage.
  • Figure 1 shows a glass needleless injection capsule 1 having a main body portion defined by a wall which is cylindrical both internally and externally, a flange 2 at one end thereof, and a tapered portion at the other end terminating in a discharge orifice 3.
  • the capsule l contains injectate 4 and a free, slidable piston 5.
  • a sleeve 6 is an interference fit onto the cylindrical wall of the capsule 1.
  • a thread 7 on the sleeve 6 enables the assembly to be screwed into and retained by an injector actuator (not shown) .
  • injector actuator not shown
  • There are many alternative methods of securing the assembly to the actuator such as snap fitting, or ultrasonic welding, adhesives, or metal clips, to name a few examples.
  • the discharge orifice 3 is placed on the subject's skin, and the free piston 5 is struck by the ram of the actuator. This blow is transferred to the injectate 4 causing a rapid rise in pressure. This causes a corresponding tensile stress in the walls of the capsule 1, tending to burst it. This is prevented by the compressive stress induced by the tight-fitting sleeve 6 which partly or fully resists the tensile stress resulting from the hydraulic impact.
  • the invention prevents the breakage of glass capsules when subjected to high pressure. It also protects the glass surface from damage during storage.
  • the sleeve 6 is preferably made from a transparent plastic, such as a polycarbonate, polyethertetrapthalate, polystyrene, or cellulose ester (e.g. cellulose acetate- propionate) , which enables the contents to be examined.
  • a transparent plastic such as a polycarbonate, polyethertetrapthalate, polystyrene, or cellulose ester (e.g. cellulose acetate- propionate) , which enables the contents to be examined.
  • the strength of the glass may be further improved by ion stuffing, thermal pre-stressing, or etching, and the present specification allows for all combinations of materials and processes which will achieve the object of the invention.

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Table Devices Or Equipment (AREA)
  • Glass Compositions (AREA)

Abstract

A cylindrical medical glass container (1) suitable for use in needleless injectors contains a liquid (4) and a piston (5) in contact with the liquid. By acting on the piston (5) with a ram, liquid (4) is highly pressurised and dispensed rapidly through a hole (3) in a container (1). To prevent the glass container from breaking during pressurisation, a comprehensive sleeve (6) is fitted to the outside of the container (1).

Description

MEDICAL GLASS CONTAINER SUITABLE FOR USE IN NEEDLELESS INJECTORS
The invention relates to glass containers, particularly those subjected to high pressures.
International Specification WO 95/03844 discloses a needleless injector for delivering a liquid medicament into the skin. During the injection, very high pressures of short duration are generated. A preferred embodiment of that invention requires a liquid medicament to be stored in the dispenser in a glass container, preferably a cylindrical glass container, which also serves as the pressure vessel. In order to withstand these high pressures, the container may be provided with thick walls. However, these make it more difficult and costly to make. These size and cost disadvantages partly offset the potential benefits of needleless injectors compared with conventional hypodermic syringes. It is an object of a preferred embodiment of the present invention to provide a glass container which can be used in such a needleless injector, without it having to be provided with such thick walls.
The invention employs the principle that glass is able to withstand higher forces if the surfaces are maintained in a state of compressive stress. The accepted theories on glass fracture propose that breakage occurs through the rapid growth of icrocracks on the glass surface when the glass is stressed, in addition to fractures originating from gross surface defects. By holding the surfaces in compressive stress, this stress must be overcome before crack growth can occur.
According to the present invention there is provided a container adapted to withstand a high internal pressure, comprising a hollow glass body and compression means for exerting a compressive force on the hollow glass body.
In one embodiment thereof the compression means is a tight fitting sleeve assembled onto the capsule body so as to exert a compressive force on a preferably cylindrical wall thereof.
It has been found that a borosilicate glass cylinder having a bore of 5mm diameter and a wall thickness of 2.19mm will sometimes break when subjected to internal pressures of 80 bars and transient pressures of 4000 bars. Furthermore, the cylinders are unable to withstand more than two applications of such pressures. A polycarbonate sleeve having a nominal interference fit of 0.05mm enables the cylinders to withstand at least 20 applications of such pressures without damage.
An embodiment of the invention is shown in the single figure of drawing, which is a diagrammatic longitudinal section.
Figure 1 shows a glass needleless injection capsule 1 having a main body portion defined by a wall which is cylindrical both internally and externally, a flange 2 at one end thereof, and a tapered portion at the other end terminating in a discharge orifice 3. The capsule l contains injectate 4 and a free, slidable piston 5. A sleeve 6 is an interference fit onto the cylindrical wall of the capsule 1. A thread 7 on the sleeve 6 enables the assembly to be screwed into and retained by an injector actuator (not shown) . There are many alternative methods of securing the assembly to the actuator, such as snap fitting, or ultrasonic welding, adhesives, or metal clips, to name a few examples.
In use, the discharge orifice 3 is placed on the subject's skin, and the free piston 5 is struck by the ram of the actuator. This blow is transferred to the injectate 4 causing a rapid rise in pressure. This causes a corresponding tensile stress in the walls of the capsule 1, tending to burst it. This is prevented by the compressive stress induced by the tight-fitting sleeve 6 which partly or fully resists the tensile stress resulting from the hydraulic impact.
Thus it may be seen that the invention prevents the breakage of glass capsules when subjected to high pressure. It also protects the glass surface from damage during storage.
The sleeve 6 is preferably made from a transparent plastic, such as a polycarbonate, polyethertetrapthalate, polystyrene, or cellulose ester (e.g. cellulose acetate- propionate) , which enables the contents to be examined. The strength of the glass may be further improved by ion stuffing, thermal pre-stressing, or etching, and the present specification allows for all combinations of materials and processes which will achieve the object of the invention.

Claims

CLAIMS :
1. A glass container adapted to withstand a high internal pressure, comprising a hollow glass body and compression means for exerting a compressive force on the hollow glass body.
2. A container according to claim l, wherein the hollow glass body is generally cylindrical over at least a portion thereof.
3. A container according to claim 1, adapted for use as a capsule in a needleless injector, comprising a main body portion defined by an internally cylindrical wall, has a flange at one end thereof, and a tapered portion at the other end terminating in a discharge orifice.
4. A container according to clarm 3, wherein the wall of the main body portion is also externally cylindrical.
5. A glass container according to any preceding claim, wherein the compression means is a sleeve which fits tightly around the hollow glass body.
6. A container according to claim 5, wherein the sleeve is of a plastics material.
7. A container according to claim 6, wherein the plastics material is transparent.
8. A container according to claim 7, wherein the plastics material is selected from the group consisting of polycarbonates, polyethertetraphthalates, polystyrenes and cellulose esters.
9. A container according to claim 8, wherein the plastics material is cellulose acetate-propionate.
PCT/GB1995/002649 1994-11-19 1995-11-13 Medical glass container suitable for use in needleless injectors WO1996015821A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DK95936667T DK0792174T3 (en) 1994-11-19 1995-11-13 Medical glass container suitable for use in needle-free injection devices
EP95936667A EP0792174B1 (en) 1994-11-19 1995-11-13 Medical glass container suitable for use in needleless injectors
BR9509791A BR9509791A (en) 1994-11-19 1995-11-13 Glass container adapted to withstand high internal pressure
DE69508104T DE69508104T2 (en) 1994-11-19 1995-11-13 MEDICAL GLASS CONTAINER SUITABLE FOR USE IN NEEDLESS SYRINGE DEVICES
JP51664396A JP3399962B2 (en) 1994-11-19 1995-11-13 Medical glass container suitable for use in needleless syringes
RU97110272A RU2145885C1 (en) 1994-11-19 1995-11-13 Medical glass container for needless injectors
AU38517/95A AU3851795A (en) 1994-11-19 1995-11-13 Medical glass container suitable for use in needleless injectors
NO972265A NO972265L (en) 1994-11-19 1997-05-16 Medical glass container adapted for use in needle-free injectors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9423505A GB9423505D0 (en) 1994-11-19 1994-11-19 Reinforced glass container
GB9423505.8 1994-11-19

Publications (1)

Publication Number Publication Date
WO1996015821A1 true WO1996015821A1 (en) 1996-05-30

Family

ID=10764754

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1995/002649 WO1996015821A1 (en) 1994-11-19 1995-11-13 Medical glass container suitable for use in needleless injectors

Country Status (15)

Country Link
EP (1) EP0792174B1 (en)
JP (1) JP3399962B2 (en)
KR (1) KR970706860A (en)
AT (1) ATE177014T1 (en)
AU (1) AU3851795A (en)
BR (1) BR9509791A (en)
CA (1) CA2205464A1 (en)
DE (1) DE69508104T2 (en)
DK (1) DK0792174T3 (en)
ES (1) ES2128096T3 (en)
GB (1) GB9423505D0 (en)
NO (1) NO972265L (en)
RU (1) RU2145885C1 (en)
WO (1) WO1996015821A1 (en)
ZA (1) ZA959741B (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997013536A1 (en) * 1995-10-09 1997-04-17 Alain Moreau Defarges Needleless jet injection device comprising a moulded-on cartridge
WO2000015281A1 (en) * 1998-09-15 2000-03-23 Weston Medical Limited Needleless injector cartridge
US6174304B1 (en) 1994-12-20 2001-01-16 Weston Medical Limited Filling device for a needless injector cartridge
US6251091B1 (en) 1995-12-16 2001-06-26 Weston Medical Limited Needleless injector drug capsule and filling method
US6280410B1 (en) 1996-04-02 2001-08-28 Weston Medical Limited Method of filling a drug capsule and article produced thereby
WO2001091835A1 (en) * 2000-05-30 2001-12-06 Crossject Needleless syringe with membrane isolating a multiple duct injector
WO2003045479A1 (en) 2001-11-21 2003-06-05 Aradigm Corporation A needleless injector drug capsule and a method for filling thereof
US6681810B2 (en) 1994-12-20 2004-01-27 Aradigm Corporation Filling device for a needleless injector cartridge
WO2007065544A1 (en) * 2005-12-07 2007-06-14 Painless Tech Gmbh Injection device for the needle-free injection of a medium
EP2092947A1 (en) * 1999-02-18 2009-08-26 Bioject, Inc. Single-use needle-less injection apparatus
US9533098B2 (en) 2007-11-19 2017-01-03 Painless Tech Gmbh Injection device for the needle-free injection of a medium

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2812202B1 (en) 2000-07-28 2002-09-13 Poudres & Explosifs Ste Nale NEEDLELESS SYRINGE OPERATING BY COMPRESSION OF THE TANK CONTAINING THE LIQUID ACTIVE INGREDIENT
DE102005058655A1 (en) * 2005-12-07 2007-06-14 Painless Tech Gmbh Device for needle-free injection, useful e.g. for subcutaneous or intramuscular administration, comprises injection and ampoule units, the latter having a base component and jacket that exerts a compressive force
DE102005058656A1 (en) * 2005-12-07 2007-06-14 Painless Tech Gmbh Device for needle-free injection, useful e.g. for subcutaneous or intramuscular administration, includes injection unit having a spring element that activates a propelling element to deliver medium
FR3058718B1 (en) * 2016-11-15 2020-11-06 Crossject AIR TEMPERING PROCESS OF AN ELONGATED HOLLOW GLASS BODY INCLUDING AN AXIAL DRILLING
CN115768504A (en) 2020-06-05 2023-03-07 株式会社大赛璐 Needleless injector

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3650084A (en) * 1968-01-15 1972-03-21 Scherer Corp R P Method for filling and sealing plastic ampoules
US3688765A (en) * 1969-10-03 1972-09-05 Jack S Gasaway Hypodermic injection device
US3782380A (en) * 1973-01-04 1974-01-01 Gaast H V D Medicament injecting device
EP0584531A2 (en) * 1992-08-17 1994-03-02 Medrad Inc. Front-loading medical injector and syringe for use therewith

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3650084A (en) * 1968-01-15 1972-03-21 Scherer Corp R P Method for filling and sealing plastic ampoules
US3688765A (en) * 1969-10-03 1972-09-05 Jack S Gasaway Hypodermic injection device
US3782380A (en) * 1973-01-04 1974-01-01 Gaast H V D Medicament injecting device
EP0584531A2 (en) * 1992-08-17 1994-03-02 Medrad Inc. Front-loading medical injector and syringe for use therewith

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6681810B2 (en) 1994-12-20 2004-01-27 Aradigm Corporation Filling device for a needleless injector cartridge
US6174304B1 (en) 1994-12-20 2001-01-16 Weston Medical Limited Filling device for a needless injector cartridge
WO1997013536A1 (en) * 1995-10-09 1997-04-17 Alain Moreau Defarges Needleless jet injection device comprising a moulded-on cartridge
US6251091B1 (en) 1995-12-16 2001-06-26 Weston Medical Limited Needleless injector drug capsule and filling method
US6554818B2 (en) 1996-04-02 2003-04-29 Weston Medical Limited Method of filling a drug capsule and article produced thereby
US6280410B1 (en) 1996-04-02 2001-08-28 Weston Medical Limited Method of filling a drug capsule and article produced thereby
US6673038B2 (en) 1998-09-15 2004-01-06 Aradigm Corporation Needleless injector cartridge
WO2000015281A1 (en) * 1998-09-15 2000-03-23 Weston Medical Limited Needleless injector cartridge
EP2092947A1 (en) * 1999-02-18 2009-08-26 Bioject, Inc. Single-use needle-less injection apparatus
FR2809626A1 (en) * 2000-05-30 2001-12-07 Poudres & Explosifs Ste Nale NEEDLELESS SYRINGE WITH INSULATION MEMBRANE OF A MULTICONDED EJECTOR
WO2001091835A1 (en) * 2000-05-30 2001-12-06 Crossject Needleless syringe with membrane isolating a multiple duct injector
US7513885B2 (en) 2000-05-30 2009-04-07 Crossject Needleless syringe with membrane isolating a multiple duct injector
US6979310B2 (en) 2000-05-30 2005-12-27 Crossject Needleless syringe with membrane isolating a multiple duct injector
US7156822B2 (en) 2000-05-30 2007-01-02 Crossject Needleless syringe with membrane isolating a multiple duct injector
US8241243B2 (en) * 2001-11-21 2012-08-14 Zogenix, Inc. Needleless injector drug capsule and a method for filling thereof
WO2003045479A1 (en) 2001-11-21 2003-06-05 Aradigm Corporation A needleless injector drug capsule and a method for filling thereof
US8663158B2 (en) 2001-11-21 2014-03-04 Zogenix, Inc. Needleless injector drug capsule and a method for filling thereof
US8491524B2 (en) * 2001-11-21 2013-07-23 Zogenix, Inc. Needleless injector drug capsule and a method for filling thereof
US20120253273A1 (en) * 2001-11-21 2012-10-04 William Henry Needleless injector drug capsule and a method for filling thereof
US8241244B2 (en) 2001-11-21 2012-08-14 Zogenix, Inc. Needleless injector drug capsule and a method for filling thereof
US8118771B2 (en) 2001-11-21 2012-02-21 Zogenix, Inc. Needleless injector drug capsule and a method for filling thereof
EP2103319A2 (en) * 2005-12-07 2009-09-23 Painless Tech GmbH Injection device and ampoule unit for an injection device for injecting a medium without use of a needle
EP2103319A3 (en) * 2005-12-07 2009-10-28 Painless Tech GmbH Injection device and ampoule unit for an injection device for injecting a medium without use of a needle
WO2007065542A1 (en) * 2005-12-07 2007-06-14 Painless Tech Gmbh Injection device and ampoule unit
US8480617B2 (en) 2005-12-07 2013-07-09 Painless Tech Gmbh Injection device and ampoule unit
WO2007065544A1 (en) * 2005-12-07 2007-06-14 Painless Tech Gmbh Injection device for the needle-free injection of a medium
US20090157039A1 (en) * 2005-12-07 2009-06-18 Painless Tech Gmbh Injection device and ampoule unit
US9533098B2 (en) 2007-11-19 2017-01-03 Painless Tech Gmbh Injection device for the needle-free injection of a medium

Also Published As

Publication number Publication date
NO972265D0 (en) 1997-05-16
EP0792174B1 (en) 1999-03-03
DK0792174T3 (en) 1999-09-27
EP0792174A1 (en) 1997-09-03
CA2205464A1 (en) 1996-05-30
GB9423505D0 (en) 1995-01-11
MX9703591A (en) 1998-07-31
KR970706860A (en) 1997-12-01
NO972265L (en) 1997-05-16
BR9509791A (en) 1997-12-30
DE69508104T2 (en) 1999-07-15
RU2145885C1 (en) 2000-02-27
JP3399962B2 (en) 2003-04-28
AU3851795A (en) 1996-06-17
JPH10509613A (en) 1998-09-22
ATE177014T1 (en) 1999-03-15
DE69508104D1 (en) 1999-04-08
ZA959741B (en) 1996-06-12
ES2128096T3 (en) 1999-05-01

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