WO1995023799A1 - Process for the preparation of an indazole-3-carboxamide derivative - Google Patents
Process for the preparation of an indazole-3-carboxamide derivative Download PDFInfo
- Publication number
- WO1995023799A1 WO1995023799A1 PCT/EP1995/000764 EP9500764W WO9523799A1 WO 1995023799 A1 WO1995023799 A1 WO 1995023799A1 EP 9500764 W EP9500764 W EP 9500764W WO 9523799 A1 WO9523799 A1 WO 9523799A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- benzyl
- methyl
- endo
- compound
- azabicyclo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Definitions
- EP-A-0200444 (Beecham Group pic) describes certain 5-HT (5- hydroxytryptamine) antagonists which are described as possessing a number of therapeutic utilities, inter alia the prevention of vomiting following the administration of cytotoxic agents.
- the compound described in Example 6 is endo-N-(9-methyl-9- azabicyclo[3.3.1]non-3-yl)-l-methylindazole-3-carboxamide, and this compound has been assigned the INN granisetron.
- EP-A-0200444 discloses that granisetron can be prepared by reacting l-methylindazole-3-carboxylic acid chloride with endo-3- amino-9-methyl-9-azabicyclo[3.3.1 ]nonane.
- the present invention provides a process for preparing granisetron (1) or a pharmaceutically acceptable salt thereof:
- R is a nitrogen-protecting group which does not significantly reduce the nucleophilicity of a secondary amino group, and optionally forming a pharmaceutically acceptable salt.
- R is benzyl, substituted benzyl, t-butyl, allyl, or a silyl group such as t-butyldimethylsilyl.
- substituted benzyl include benzyl substituted with one or more chloro, alkyl or alkoxy groups, preferably methyl or methoxy groups.
- p-Methoxybenzyl and p-chlorobenzyl are two specific examples.
- the reaction is carried out under conditions appropriate to remove the protecting group.
- R is benzyl or substituted benzyl the reaction may be carried out by treatment under strongly acidic non-aqueous conditions, e.g. methanesulphonic acid, trifluoroacetic acid, or hydrogen chloride or hydrogen bromide in acetic acid.
- R is t-butyl the reaction may be carried out under non- aqueous acidic conditions, for example by treatment with trifluoroacetic acid.
- R is allyl the reaction may be carried using tetrakis(triphenyiphosphine)-palladium(0).
- Silyl groups such as t-butyldimethylsilyl can generally be removed by treatment under acidic conditions, for example by treatment with hydrogen chloride in ethanol or trifluoroacetic acid, or by treatment with fluoride ion, for example potassium fluoride or tetrabutylammonium fluoride in a lower alkanol such as methanol.
- fluoride ion for example potassium fluoride or tetrabutylammonium fluoride in a lower alkanol such as methanol.
- Compounds of Structure (2) can be prepared by reacting an amine of Structure (4), in which R is defined as above, with a compound of Structure (3) in which Q is a leaving group displaceable by a secondary amine.
- leaving groups displaceable by a secondary amine include halogen, such as chloro and bromo, C ⁇ _6 alkoxy such as methoxy or ethoxy, and N-imidazolyl.
- the reaction is carried out carried out carried out at ambient or elevated temperature in an organic solvent such as toluene or dichloromethane.
- This process is advantageous because of its overall selectivity and in particular it does not give rise to bis-acylated products, compared to the process described in EP-A-0200444.
- the compounds of Structure (4) in which R is benzyl or substituted benzyl can be prepared by reducing an imine of Structure (5) (or a tautomeric enamine thereof); suitably the reduction is carried out using sodium borohydride, sodium cyanoborohydride or lithium aluminium hydride, or by selective catalytic hydrogenation, for example using hydrogen and a palladium catalyst.
- the imines of Structure (5) can be prepared by condensing a ketone of Structure (6) with benzylamine or a substituted benzylamine, or by reacting the amine of Structure (7) with benzaldehyde or a substituted benzaldehyde.
- this reaction will be carried out with an acid catalyst under conditions suitable for dehydration e.g. by heating in toluene, or by treatment with titanium tetrachloride or molecular sieve 3A or similar.
- the compounds of Structure (4) in which R is benzyl, substituted benzyl or allyl can be prepared by reacting the amine of Structure (7) with a benzyl or allyl halide, for example benzyl chloride or allyl bromide.
- N-Benzyl-N-(endo-9-methyl-9-azabicyclo-[3,3,l]-non-3-yl)-l-methylindazole-3- carboxamide monohydrochloride (1.00 g) and methane sulphonic acid (5.0 ml) were heated at 70°C with stirring for 1.5 hours. TLC showed a strong spot corresponding to granisetron and confirmed that no starting material remained.
- the solution was cooled to room temperature, poured into ice cold water (200 ml), made alkaline using sodium hydroxide and extracted with dichloromethane (100 ml).
- the dichloromethane extract was washed twice with water (50 ml), dried over magnesium sulphate and evaporated to a foam. This was treated with toluene (50 ml) and concentrated hydrochloric acid (0.25 g) and again evaporated to dryness.
- the residue was treated with isopropanol (50 ml) and allowed to crystallise in the cold.
- the white solid was collected by filtration, washed with a little isopropanol and dried in the oven at 75°C.
- N-4-Methoxybenzyl-N-(endo-9-methyl-9-azabicyclo-[3,3,l]-non-3-yl)-l- methylindazole-3-carboxamide monohydrochloride (1.00 g) and methane sulphonic acid (5.0 ml) were heated at 70°C with stirring for 20 minutes. TLC showed a strong spot corresponding to granisetron and confirmed that no starting material remained. The cooled mixture was poured into ice cold water, and the product isolated following the method of Example 1(d). Yield 0.57 g (76.6%) IR and NMR spectroscopy confirmed that the product was granisetron.
- N-4-Methoxybenzyl-N-(endo-9-methyl-9-azabicyclo-[3,3,l]-non-3-yl)-l- methylindazole-3-carboxamide monohydrochloride (1.00 g) was stirred in • trifluoroacetic acid (4.0 ml) at room temperature. After an initial vigorous reaction, the mixture was warmed briefly to 70°C and examined by TLC, which confirmed that the reaction was complete. The mixture was poured into ice cold water (100 ml) and filtered. The filtrate was made alkaline and extracted with dichloromethane (100 ml). The product was isolated from this extract following the method of Example 1(d). Yield 0.41 g (55.0%). IR and NMR spectroscopy confirmed that the product was granisetron.
- 9-Methyl-9-azabicyclo[3.3.1]nonan-3-one (Ref: Org. Synth Coll Vol. 4. 816) is heated under reflux in toluene with benzylamine with p-toluene sulphonic acid catalysis to give 3-benzimino-9-methyl-9-azabicyclo[3.3.1]nonane. This is reduced with sodium cyanoborohydride in tetrahydrofuran to give 3-benzylamino-9-methyl-9- azabicyclo[3.3.1]nonane.
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Catalysts (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69510186T DE69510186D1 (en) | 1994-03-03 | 1995-02-28 | METHOD FOR PRODUCING INDAZOL-3-CARBONAMIDE DERIVATES |
EP95912187A EP0748321B1 (en) | 1994-03-03 | 1995-02-28 | Process for the preparation of an indazole-3-carboxamide derivative |
MX9603818A MX9603818A (en) | 1994-03-03 | 1995-02-28 | Process for the preparation of an indazole-3-carboxamide derivative. |
JP52270295A JP4034339B2 (en) | 1994-03-03 | 1995-02-28 | Method for producing indazole-3-carboxamide derivative |
GR990402203T GR3031121T3 (en) | 1994-03-03 | 1999-08-31 | Process for the preparation of an indazole-3-carboxamide derivative |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9404055.7 | 1994-03-03 | ||
GB9404055A GB9404055D0 (en) | 1994-03-03 | 1994-03-03 | Novel process |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995023799A1 true WO1995023799A1 (en) | 1995-09-08 |
Family
ID=10751194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1995/000764 WO1995023799A1 (en) | 1994-03-03 | 1995-02-28 | Process for the preparation of an indazole-3-carboxamide derivative |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0748321B1 (en) |
JP (1) | JP4034339B2 (en) |
AT (1) | ATE181073T1 (en) |
DE (1) | DE69510186D1 (en) |
ES (1) | ES2132650T3 (en) |
GB (1) | GB9404055D0 (en) |
GR (1) | GR3031121T3 (en) |
MX (1) | MX9603818A (en) |
WO (1) | WO1995023799A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2124163A1 (en) * | 1995-03-01 | 1999-01-16 | Smithkline Beecham Plc | New process for obtaining pharmaceutically active compounds |
ES2125162A1 (en) * | 1995-03-25 | 1999-02-16 | Smithkline Beecham Plc | Process for preparing a pharmaceutically active compound |
ES2129349A1 (en) * | 1996-02-13 | 1999-06-01 | Smithkline Beecham Plc | Process for the preparation of granisetron |
AT406051B (en) * | 1995-02-10 | 2000-02-25 | Smithkline Beecham Plc | NEW PROCEDURE |
AT406770B (en) * | 1995-03-01 | 2000-08-25 | Smithkline Beecham Plc | Novel process for the preparation of granisetron |
WO2003080606A1 (en) * | 2002-03-26 | 2003-10-02 | Laboratorios Vita, S.A. | Process for preparing a pharmaceutically active compound (granisetron) |
WO2007088557A1 (en) * | 2006-02-01 | 2007-08-09 | Natco Pharma Limited | Process for highly pure crystalline granisetron base |
EP2323654A1 (en) * | 2008-08-19 | 2011-05-25 | ScinoPharm Taiwan, Ltd. | Polymorphic form of granisetron hydrochloride and methods of making the same |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0081054A2 (en) * | 1978-12-30 | 1983-06-15 | Beecham Group Plc | Azabicyclo alkyl derivatives |
EP0200444A2 (en) * | 1985-04-27 | 1986-11-05 | Beecham Group Plc | Azabicyclononyl-indazole-carboxamide having 5-HT antagonist activity |
-
1994
- 1994-03-03 GB GB9404055A patent/GB9404055D0/en active Pending
-
1995
- 1995-02-28 WO PCT/EP1995/000764 patent/WO1995023799A1/en active IP Right Grant
- 1995-02-28 EP EP95912187A patent/EP0748321B1/en not_active Expired - Lifetime
- 1995-02-28 ES ES95912187T patent/ES2132650T3/en not_active Expired - Lifetime
- 1995-02-28 DE DE69510186T patent/DE69510186D1/en not_active Expired - Lifetime
- 1995-02-28 MX MX9603818A patent/MX9603818A/en unknown
- 1995-02-28 AT AT95912187T patent/ATE181073T1/en active
- 1995-02-28 JP JP52270295A patent/JP4034339B2/en not_active Expired - Lifetime
-
1999
- 1999-08-31 GR GR990402203T patent/GR3031121T3/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0081054A2 (en) * | 1978-12-30 | 1983-06-15 | Beecham Group Plc | Azabicyclo alkyl derivatives |
EP0200444A2 (en) * | 1985-04-27 | 1986-11-05 | Beecham Group Plc | Azabicyclononyl-indazole-carboxamide having 5-HT antagonist activity |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT406051B (en) * | 1995-02-10 | 2000-02-25 | Smithkline Beecham Plc | NEW PROCEDURE |
ES2124163A1 (en) * | 1995-03-01 | 1999-01-16 | Smithkline Beecham Plc | New process for obtaining pharmaceutically active compounds |
AT406770B (en) * | 1995-03-01 | 2000-08-25 | Smithkline Beecham Plc | Novel process for the preparation of granisetron |
AT407637B (en) * | 1995-03-01 | 2001-05-25 | Smithkline Beecham Plc | NEW METHOD FOR PRODUCING GRANISETRON |
ES2125162A1 (en) * | 1995-03-25 | 1999-02-16 | Smithkline Beecham Plc | Process for preparing a pharmaceutically active compound |
AT406678B (en) * | 1995-03-25 | 2000-07-25 | Smithkline Beecham Plc | METHOD FOR PRODUCING GRANISETRON OR A PHAMRAZEUTICALLY ACCEPTABLE SALT THEREOF |
ES2129349A1 (en) * | 1996-02-13 | 1999-06-01 | Smithkline Beecham Plc | Process for the preparation of granisetron |
WO2003080606A1 (en) * | 2002-03-26 | 2003-10-02 | Laboratorios Vita, S.A. | Process for preparing a pharmaceutically active compound (granisetron) |
US7071209B2 (en) | 2002-03-26 | 2006-07-04 | Laboratorios Vita, S.A. | Process for preparing a pharmaceutically active compound (granisetron) |
WO2007088557A1 (en) * | 2006-02-01 | 2007-08-09 | Natco Pharma Limited | Process for highly pure crystalline granisetron base |
EP2323654A1 (en) * | 2008-08-19 | 2011-05-25 | ScinoPharm Taiwan, Ltd. | Polymorphic form of granisetron hydrochloride and methods of making the same |
EP2323654A4 (en) * | 2008-08-19 | 2012-10-24 | Scinopharm Taiwan Ltd | Polymorphic form of granisetron hydrochloride and methods of making the same |
Also Published As
Publication number | Publication date |
---|---|
GR3031121T3 (en) | 1999-12-31 |
ATE181073T1 (en) | 1999-06-15 |
EP0748321B1 (en) | 1999-06-09 |
MX9603818A (en) | 1997-03-29 |
ES2132650T3 (en) | 1999-08-16 |
GB9404055D0 (en) | 1994-04-20 |
EP0748321A1 (en) | 1996-12-18 |
JP4034339B2 (en) | 2008-01-16 |
JPH09509673A (en) | 1997-09-30 |
DE69510186D1 (en) | 1999-07-15 |
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