Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/0012—Galenical forms characterised by the site of application
  • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
  • A61K47/02—Inorganic compounds
• • C—CHEMISTRY; METALLURGY
  • C01—INORGANIC CHEMISTRY
  • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
  • C01B33/00—Silicon; Compounds thereof
  • C01B33/20—Silicates
  • C01B33/22—Magnesium silicates
• • C—CHEMISTRY; METALLURGY
  • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
  • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
  • C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
  • C09C1/28—Compounds of silicon
• • C—CHEMISTRY; METALLURGY
  • C01—INORGANIC CHEMISTRY
  • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
  • C01P2006/00—Physical properties of inorganic compounds
  • C01P2006/60—Optical properties, e.g. expressed in CIELAB-values

Definitions

• Talc belongs among very important technical raw materials and it is utilizable in various indu ⁇ stries, as for instance for production of electro- technical ceramics products, heat-resistant vessels, stoves, in cosmetics, etc. It is a very important entering raw material at the production of medica ⁇ ments where it fulfills the function of a sliding substance .
• the invention concerns talc,as an entering raw material for production of medicaments, at which it tackles the the procedure of its treatment with the aim to obtain an outlet product of a less valuable raw material.
• the sediment In the reaction mixture there is afterwards separated the sediment and following the adjustment of its acidity to the value pH 5 up to 8 it is mixed with water and sulphuric acid in the ratio 10 up to 20 volume * of sediment, 74 up to 89 volume % of water and 1 up to 6 volume % of sulphu ⁇ ric acid in accordance with the laboratory tempera ⁇ ture, and at constant stirring is the reaction mix ⁇ ture heated during 0.5 hour up to 6 hours to the temperature 75°C up to 125°C and it is kept at this temperature until the time when there is reached a quasi unchangeable value of iron content in the reaction mixture,and then the sediment is separated, its acidity is adjusted to the pH value 5 up to 8 and subsequently it is dried and sterilized at the temperature 160°C up to 250°C during two up to four hours.
• the technological procedure which is an object of protection, is outstanding especially because of its contribution consisting in the ability to treat talc in an economically advantageous way for the purposes of medicaments production, starting para ⁇ meters of which reach besides the standard level also a lower and even very bad level.
• the resulting product produced by the proposed procedure reaches the same and in some properties even better parame ⁇ ters than are ones reached by the technologies of talc treatment at which the entering product has higher quality parameters.
• Talc treated in the way in accordance with the invention reaches the value of loss by annealing less than 5% , content of sub ⁇ stances soluble in water at the temperature 105°C is less than 0.155K,content of substances soluble in acidic environment is less than 1.6*, content of iron in percentual expression is less than 0 .4% and in weight expression it is less than 69 mg/kg, whiteness is at least 67.0%.
• the substance does not develop carbonates and its alkaline components are of blue colour and acidic components are of green colour.
• the sediment was diluted with water in the quantity 4 liters and into the solution there was gradually added 0.2 liter of 96% sulphuric acid with the den ⁇ sity 1.83, then the reaction mixture was heated and at constant stirring kept at the temperature 90°C up to 95°C during 285 minutes,when there was reached the quasi stable value of the iron content.
• the solid com ⁇ ponents were separated,the sediment was washed with water four times with the quantity of water 10 li ⁇ ters, by which there was reached the acidity value of the sediment of pH 7. fterwards the sediment was dried and sterilized at the temperature 160°C du ⁇ ring 240 minutes.
• the result of the mentioned pro ⁇ cedure was the talc which had following parameters: loss by annealing 4.82%, content of substances so ⁇ luble in warm water at 105°C 0.11%, content of sub ⁇ stances soluble in the acidic environment 1.56%, content of iron in the percentual expression 0.023%, carbonates were not being developed, alkaline sub ⁇ stances were of blue colour and acidic substances were of green colour.There was reached the whiteness of the product of 67.8%.
• the sediment was diluted with ten liters of water and into the resulting wa ⁇ ter solution there was gradually added 0.4 1 of 96% sulphuric acid with the density 1.83, the reaction solution was at constant stirring heated and maintained at the temperature 100°C for two hours, when there was reached a quasi stable value of iron content in the solution. Afterwards the solid com ⁇ ponents were separated by sedimentation and the se ⁇ diment was washed four times always with the quan ⁇ tity of water 10 liters, by which there was reached the acidity value of the sediment of pH 7. Then the sediment was dried and sterilized at the temperatu ⁇ re 160°C.
• the result of the mentioned process was the product characterized with following parameters: loss by annealing 3.99%, content of substances so ⁇ luble in warm water at 105°C 0.11%, content of sub ⁇ stances soluble in the acidic environment 0.66%, content of iron in the percentual expression 0.011%, carbonates were not being developed, alka ⁇ line substances were of blue colour and acidic substances were of green colour. There was reached the whiteness of the product of 68.1%.
• the invention is utilizable in the chemical industry and the result of the procedure, which is subject to the protection, forms an important ente ⁇ ring raw material for pharmaceutical industry at the production of tabletted medicaments and oint ⁇ ment bases.

Landscapes

• Health & Medical Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Pharmacology & Pharmacy (AREA)
• Medicinal Chemistry (AREA)
• Inorganic Chemistry (AREA)
• Epidemiology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Dermatology (AREA)
• Silicates, Zeolites, And Molecular Sieves (AREA)
• Cosmetics (AREA)

Priority Applications (1)

Applications Claiming Priority (2)

Publications (1)

Family

ID=20433172

Family Applications (1)

Country Status (4)

Cited By (1)

Citations (2)

• 1994
  • 1994-01-28 SK SK10394A patent/SK278312B6/sk not_active IP Right Cessation
• 1995
  • 1995-01-27 WO PCT/SK1995/000001 patent/WO1995020542A1/en not_active Ceased
  • 1995-01-27 CZ CZ952811A patent/CZ284979B6/cs not_active IP Right Cessation
  • 1995-01-27 AU AU18296/95A patent/AU1829695A/en not_active Abandoned

Patent Citations (2)

Non-Patent Citations (5)

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