WO1994029456A3 - Herpes simplex virus type-2 protease - Google Patents

Herpes simplex virus type-2 protease Download PDF

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Publication number
WO1994029456A3
WO1994029456A3 PCT/US1994/005920 US9405920W WO9429456A3 WO 1994029456 A3 WO1994029456 A3 WO 1994029456A3 US 9405920 W US9405920 W US 9405920W WO 9429456 A3 WO9429456 A3 WO 9429456A3
Authority
WO
WIPO (PCT)
Prior art keywords
protease
herpes simplex
simplex virus
virus type
hsv
Prior art date
Application number
PCT/US1994/005920
Other languages
French (fr)
Other versions
WO1994029456A2 (en
Inventor
Kevin R Steffy
Warren M Kati
Leonard Katz
Thomas P Mcgonigal
Aparna V Sarthy
Sharon E Schoen
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to EP94920039A priority Critical patent/EP0708833A1/en
Priority to CA002164601A priority patent/CA2164601A1/en
Priority to JP7501849A priority patent/JPH08510918A/en
Publication of WO1994029456A2 publication Critical patent/WO1994029456A2/en
Publication of WO1994029456A3 publication Critical patent/WO1994029456A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
    • C07K16/087—Herpes simplex virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Protease activity associated with herpes simplex virus (HSV) type 2 was identified. The complete nucleotide and amino acid sequence of the protease was determined. The HSV-2 nucleic acid segment encoding the protease substrate ICP35 was also sequenced. Recombinant vectors and host cells for expressing the protease are also described.
PCT/US1994/005920 1993-06-08 1994-05-25 Herpes simplex virus type-2 protease WO1994029456A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP94920039A EP0708833A1 (en) 1993-06-08 1994-05-25 Herpes simplex virus type-2 protease
CA002164601A CA2164601A1 (en) 1993-06-08 1994-05-25 Herpes simplex virus type-2 protease
JP7501849A JPH08510918A (en) 1993-06-08 1994-05-25 Herpes simplex virus type 2 protease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7381993A 1993-06-08 1993-06-08
US08/073,819 1993-06-08
US24539094A 1994-05-23 1994-05-23
US08/245,390 1994-05-23

Publications (2)

Publication Number Publication Date
WO1994029456A2 WO1994029456A2 (en) 1994-12-22
WO1994029456A3 true WO1994029456A3 (en) 1995-03-02

Family

ID=26754923

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/005920 WO1994029456A2 (en) 1993-06-08 1994-05-25 Herpes simplex virus type-2 protease

Country Status (4)

Country Link
EP (1) EP0708833A1 (en)
JP (1) JPH08510918A (en)
CA (1) CA2164601A1 (en)
WO (1) WO1994029456A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7568294A (en) * 1993-08-20 1995-03-21 Smithkline Beecham Corporation Hsv-2 ul26 gene, capsid proteins, immunoassays and protease inhibitors
WO2010135747A1 (en) 2009-05-22 2010-11-25 Genocea Biosciences Inc. Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response
EP2643014A4 (en) 2010-11-24 2015-11-11 Genocea Biosciences Inc Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response
CA2885693C (en) 2011-11-23 2020-07-28 Genocea Biosciences, Inc. Nucleic acid vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response
WO2018064232A1 (en) 2016-09-28 2018-04-05 Genocea Biosciences, Inc. Methods and compositions for treating herpes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514830A2 (en) * 1991-05-24 1992-11-25 Arch Development Corporation Methods and compositions of a preparation and use of a herpes protease
WO1993001291A1 (en) * 1991-07-05 1993-01-21 The Johns Hopkins University Herpes virus proteinase and method of assaying

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514830A2 (en) * 1991-05-24 1992-11-25 Arch Development Corporation Methods and compositions of a preparation and use of a herpes protease
WO1993001291A1 (en) * 1991-07-05 1993-01-21 The Johns Hopkins University Herpes virus proteinase and method of assaying

Also Published As

Publication number Publication date
JPH08510918A (en) 1996-11-19
EP0708833A1 (en) 1996-05-01
CA2164601A1 (en) 1994-12-22
WO1994029456A2 (en) 1994-12-22

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