WO1994029274A1 - New active compounds - Google Patents
New active compounds Download PDFInfo
- Publication number
- WO1994029274A1 WO1994029274A1 PCT/SE1994/000552 SE9400552W WO9429274A1 WO 1994029274 A1 WO1994029274 A1 WO 1994029274A1 SE 9400552 W SE9400552 W SE 9400552W WO 9429274 A1 WO9429274 A1 WO 9429274A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- quinoline
- mmol
- methylene chloride
- butyryl
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
Definitions
- the present invention relates to novel compounds, and therapeutically acceptable salts thereof, which inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be used in the prevention and treatment of gastrointestinal inflammatory diseases.
- the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a therapeutically acceptable salt thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above.
- the invention thus relates to compounds of the general formula I:
- R 3 is C 1 -C 6 alkyl
- n is an integer 2 or 3;
- n is an integer 0, 1 or 2.
- C 1 -C 6 alkyl denotes a straight or branched alkyl group having from 1 to 6 carbon atoms.
- Examples of said lower alkyl include methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl, t-butyl and straight- and branched-chain pentyl and hexyl.
- cycloalkyl denotes a cyclic alkyl group having a ring size from C 3 to C 6 , optionally additionally substituted by lower alkyl.
- examples of said cycloalkyl include
- C 1 -C 6 alkoxy denotes a straight or branched alkoxy group having from 1 to 6 carbon atoms.
- Examples of said lower alkoxy include methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, sec-butoxy, t-butoxy and straight- and branched-chain pentoxy and hexoxy.
- halogen shall mean fluorine, chlorine, bromine or iodine.
- the end products of the formula I are obtained either in neutral or salt form. Both the free base and the salts of these end products are within the scope of the invention.
- Add addition salts of the new compounds may in a manner known per se be transformed into the free base using basic agents such as alkali or by ion exchange.
- the free base obtained may also form salts with organic or inorganic adds.
- adds are used which form suitably therapeutically acceptable salts.
- examples of such adds are hydrohalogen acids, sulfonic adds, phosphoric add, nitric add, aliphatic, alicydic, aromatic or heterocyclic carboxyl or sulfonic adds, such as formic add, acetic add, propionic acid, succinic add, glycolic add, lactic add, malic add, tartaric add, dtric acid, ascorbic add, maleic add, hydroxymaleic add, pyruvic add, p-hydroxybensoic add, embonic add, methanesulfonic add, ethanesulfonic add, hydroxyethanesulfonic acid, halogenbensenesulfonic add, toluenesulfonic add or naphthalenesulfonic add.
- Preferred compounds of the formula I are those wherein
- R 1 is CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , CH(CH 3 ) 2 , cyclopropyl or
- R 2 is CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , CH(CH 3 ) 2 , CH(CH 3 )CH 2 CH 3 , OCH 3 , OCH 2 CH 3 , or halogen;
- R 3 is CH 3 , CH 2 CH 3 , CH(CH 3 ) 2 or CH 2 CH 2 CH 3 ;
- R 4 is H, CH 3 , CH 2 CH 3 , halogen or OH.
- R 1 is CH 2 CH 3 or CH 2 CH 2 CH 3 ;
- R 2 is CH 3 , CH 2 CH 3 , CH(CH 3 ) 2 , OCH 3 , or Cl;
- R 3 is CH 3 , CH 2 CH 3 or CH 2 CH 2 CH 3 ;
- R 4 is H, CH 3 , F, Cl or OH.
- the most preferred compound of the invention is that wherein R ,1 is CH 2 CH 2 CH 3 ; R 2 and R 3 is CH 3 ; R 4 is H; m is 2; and n is 1; i.e. the compound 3-butyryl-4-(2-methylphenylamino)-8-(2-methylsulfinylethoxy)quinoline.
- the invention relates to compounds of the formula I for use in therapy.
- the present invention also provides processes for the manufacture of the compounds with the general formula I. Such compounds are prepared in the following way:
- R 1 , R 3 , m and n are as defined above and X is a leaving group, such as a halide, tosyloxy or mesyloxy.
- This reaction is conducted with or without a solvent.
- a solvent is preferably a solvent such as acetonitrile, tetrahydrofuran, toluene or dimethyl formamide.
- the reaction temperature usually ranges from about 20°C to about the boiling point of the solvent used, more preferably from about 20°C to about 110°C.
- the reaction time usually ranges from about 1 hour to about 24 hours.
- reaction temperature usually ranges from about 30°C to about 170°C
- reaction time usually ranges from 15 minutes to about 2 hours.
- Compounds of the formula I wherein R 1 , R 2 , R 3 , R 4 and m are as defined above under (A) and n is 1 or 2 can be prepared by oxidizing a compound of formula I wherein R 1 , R 2 , R 3 , R 4 and m are as defined above under (A) and n is 0. This oxidation may be carried out by using an oxidizing agent such as sodium hypochlorite, nitric add, hydrogen peroxide, (optionally in presence of vanadium compounds), peradds, peresters, ozone,
- oxidation may also be carried out enzymatically by using an oxidizing enzyme or microbiotically by using a suitable microorganism.
- the invention relates to the use of a compound as defined above for the manufacture of a medicament for the inhibition of gastric add secretion, or for the treatment of gastrointestinal inflammatory diseases.
- the compounds of the invention may be used for prevention and treatment of gastrointestinal inflammatory diseases, and gastric add-related diseases in mammals induding man, such as gastritis, gastric ulcer, duodenal ulcer, reflux esophagitis and Zollinger-Ellison syndrom.
- the compounds may be used for treatment of other gastrointestinal disorders where gastric antisecretory effect is desirable, e.g. in patients with gastrinomas, and in patients with acute upper
- gastrointestinal bleeding may also be used in patients in intensive care situations, and pre-and postoperatively to prevent add aspiration and stress ulceration.
- the invention relates to pharmaceutical
- compositions containing at least one compound of the invention, or a therapeutically acceptable salt thereof, as active ingredient containing at least one compound of the invention, or a therapeutically acceptable salt thereof, as active ingredient.
- the compounds of the invention can also be used in formulations together with other active ingredients, e.g. for the treatment or prophylaxis of conditions involving infection by Helicobacter pylori of human gastric mucosa.
- Such other active ingredients may be antimicrobial agents, especially:
- ⁇ -lactam antibiotics such as amoxidllin, ampicillin, cephalothin, cefador or cefixime; or
- erythromydn or darithromydn
- tetracyclines such as tetracycline or doxycydine
- aminoglycosides such as gentamycin, kanamycin or amikacin; or quinolones such as norfloxadn, dprofloxadn or enoxadn; or others such as metronidazole, nitrofurantoin or chloramphenicol; or preparations containing bismuth salts such as bismuth subdtrate, bismuth subsalicylate, bismuth subcarbonate, bismuth subnitrate or bismuth subgallate.
- the compounds of the invention are formulated into pharmaceutical formulations for oral, rectal, parenteral or other mode of administration.
- the pharmaceutical formulation contains a compound of the invention in combination with one or more pharmaceutically acceptable ingredients.
- the carrier may be in the form of a solid, semi-solid or liquid diluent, or a capsule.
- These pharmaceutical preparations are a further object of the invention.
- the amount of active compounds is between 0.1-95% by weight of the preparation, preferably between 0.2-20% by weight in preparations for parenteral use and preferably between 1 and 50% by weight in preparations for oral administration.
- the compound selected may be mixed with solid, powdered ingredients, such as lactose, saccharose, sorbitol, mannitol, starch, amylopectin, cellulose derivatives, gelatin, or another suitable ingredient, as well as with disintegrating agents and lubricating agents such as magnesium stearate, calrium stearate, sodium steryl fumarate and polyethylene glycol waxes.
- solid, powdered ingredients such as lactose, saccharose, sorbitol, mannitol, starch, amylopectin, cellulose derivatives, gelatin, or another suitable ingredient, as well as with disintegrating agents and lubricating agents such as magnesium stearate, calrium stearate, sodium steryl fumarate and polyethylene glycol waxes.
- disintegrating agents and lubricating agents such as magnesium stearate, calrium stearate, sodium steryl fumarate and polyethylene glycol waxes.
- Soft gelatine capsules may be prepared with capsules containing a mixture of the active compound or compounds of the invention, vegetable oil, fat, or other suitable vehide for soft gelatine capsules.
- Hard gelatine capsules may contain granules of the active compound.
- Hard gelatine capsules may also contain the active compound in combination with solid powdered ingredients such as lactose, saccharose, sorbitol, mannitol, potato starch, corn starch, amylopectin, cellulose derivatives or gelatine.
- Dosage units for rectal administration may be prepared (i) in the form of suppositories which contain the active substance mixed with a neutral fat base; (ii) in the form of a gelatine rectal capsule which contains the active substance in a mixture with a vegetable oil, paraffin oil or other suitable vehide for gelatine rectal capsules; (iii) in the form of a ready-made micro enema; or (iv) in the form of a dry micro enema formulation to be reconstituted in a suitable solvent just prior to administration.
- Liquid preparations for oral administration may be prepared in the form of syrups or suspensions, e.g. solutions or suspensions containing from 0.2% to 20% by weight of the active ingredient and the remainder consisting of sugar or sugar alcohols and a mixture of ethanol, water, glycerol, propylene glycol and polyethylene glycol. If desired, such liquid
- Liquid preparations may contain colouring agents, flavouring agents, saccharine and carboxymethyl cellulose or other thickening agent.
- Liquid preparations for oral administration may also be prepared in the form of a dry powder to be reconstituted with a suitable solvent prior to use.
- Solutions for parenteral administration may be prepared as a solution of a compound of the invention in a pharmaceutically acceptable solvent, preferably in a concentration from 0.1% to 10% by weight. These solutions may also contain stabilizing ingredients and/or buffering ingredients and are dispensed into unit doses in the form of ampoules or vials. Solutions for parenteral administration may also be prepared as a dry preparation to by reconstituted with a suitable solvent extemporaneously before use.
- the typical daily dose of the active substance varies within a wide range and will depend on various factors such as for example the individual requirement of each patient, the route of administration and the disease. In general, oral and parenteral dosages will be in the range of 5 to 1000 mg per day of active substance.
- Example 11 ( 1 H-NMR, 300 MHz, CDCl 3 ): 1.25 (m,6H), 2.73-2.81 (m,5H), 3.15 (q, 2H), 3.22 (m, 1H), 3.41-3.49 (m,1H), 4.62 (m,2H), 6.84 (d,1H), 6.93-7.19 (m,5H), 7.31 (d,1H), 9.19 (s,1H), 11.88 (s,1H).
- Example 12 ( 1 H-NMR, 300 MHz, CDCl 3 ): 1.29 (m,6H), 2.77 (q,2H), 3.16 (q,2H), 3.37 (s,3H), 3.61 (t,2H), 4.60 (t,2H), 6.85 (d,1H), 6.94-7.20 (m,5H), 7.31 (d,1H), 9.14 (s,1H), 11.90 (s,1H).
- Example 14 ( 1 H-NMR, 300 MHz, CDCl 3 ) 0.95 (t, 3H), 1.75 (m, 2H), 2.20 (s, 3H), 2.70 (s, 3H), 3.00 (t, 2H), 3.10 (m, 1H), 3.30-3.40 (m, 1H), 4.50 (m, 2H), 6.70 (m, 1H), 6.75 (m, 1H), 6.85-6.95 (m, 3H), 7.00 (m, 1H), 9.10 (s, 1H), 11.85 (s,1H).
- Example 15 ( 1 H-NMR, 300 MHz, CDCl 3 ) : 1.05 (t, 3H), 1.80 (m, 2H), 2.30 (s, 3H), 3.10 (t, 2H), 3.40 (s, 3H), 3.60 (t, 2H), 4.60 (t, 2H), 6.75-6.80 (m, 1H), 6.85-6.90 (m, 1H), 6.95-7.05 (m, 4H), 9.15 (s, 1H), 11.85 (s,1H).
- Example 16 ( 1 H-NMR, 300 MHz, CDCl 3 ) : 1.05 (t, 3H), 1.80 (m, 2H), 2.30 (s, 3H), 3.10 (t, 2H), 3.40 (s, 3H), 3.60 (t, 2H), 4.60 (t, 2H), 6.75-6.80 (m, 1H), 6.85-6.90 (m, 1H), 6.95-7.05 (m, 4H), 9.15 (s, 1H), 11.85 (s,1H).
- Example 18 ( 1 H-NMR, 300 MHz, CDCl 3 ) : 1.05 (t, 3H), 1.30 (t, 3H), 1.85 (m, 2H), 2.75 (m, 2H), 2.85 (s, 3H), 3.05 (t, 2H), 3.20-3.30 (m, 1H), 3.40-3.50 (m, 1H), 4.65 (m, 2H), 6.85 (m, 1H), 6.90-7.00 (m, 1H), 7.05-7.10 (m, 3H), 7.15 (t, 1H), 7.30 (m, 1H), 9.20 (s, 1H), 11.95 (s,1H).
- Example 19 ( 1 H-NMR, 300 MHz, CDCl 3 ) : 1.05 (t, 3H), 1.30 (t, 3H), 1.85 (m, 2H), 2.75 (m, 2H), 3.10 (t, 2H), 3.40 (s, 3H), 3.65 (m, 2H), 4.60 (m, 2H), 6.85 (d, 1H), 6.95-7.10 (m, 4H), 7.20 (t, 1H), 7.30 (m, 1H), 9.10 (s, 1H).
- Example 27 ( 1 H-NMR, 300 MHz, CDCl 3 ) 1.05 (t, 3H), 1.80 (m, 2H), 2.20 (s, 3H), 2.75 (s, 3H), 3.05 (m, 2H), 3.10-3.20 (m, 1H), 3.40-3.50 (m, 1H), 4.55 (m, 2H), 6.55-6.60 (m, 1H), 6.75-6.80 (m, 2H), 6.90-6.95 (m, 1H), 7.00-7.10 (m, 2H), 9.15 (s, 1H).
- Example 28 ( 1 H-NMR, 300 MHz, CDCl 3 ) 1.05 (t, 3H), 1.80 (m, 2H), 2.25 (s, 3H), 3.05 (t, 2H), 3.35 (s, 3H), 3.60 (m, 2H), 4.55 (m, 2H), 6.55-6.60 (m, 1H), 6.75 (m, 1H), 6.80-6.85 (m, 1H), 6.95-7.05 (m, 2H), 7.10 (m, 1H), 9.10 (s, 1H).
- Example 29 ( 1 H-NMR, 300 MHz, CDCl 3 ) 1.05 (t, 3H), 1.80 (m, 2H), 2.25 (s, 3H), 3.05 (t, 2H), 3.35 (s, 3H), 3.60 (m, 2H), 4.55 (m, 2H), 6.55-6.60 (m, 1H), 6.75 (m, 1H), 6.80-6.85 (m, 1H), 6.95-7.05 (m, 2H), 7.10 (m
- Example 45 ( 1 H-NMR, 300 MHz, CDCl 3 ) 1.3 (t, 3H), 2.38 (s, 3H), 2.44-2.55 (m, 2H), 2.65 (s, 3H), 2.9-3.02 (m, 1H), 3.08-3.23 (m, 3H), 4.28-4.4 (m, 2H), 6.85-6.92 (m, 1H), 6.95-7.18 (m, 5H), 7.25-7.34 (m, 1H), 9.25 (s, 1H), 11.8 (s, 1H)
- Example 46 ( 1 H-NMR, 300 MHz, CDCl 3 ) 1.28 (t,3H), 2.35 (s, 3H), 2.45-2.58 (m, 2H), 2.95 (s, 3H), 3.18 (q, 2H), 3.4 (t, 2H), 4.35 (t, 2H), 6.85-6.92 (m, 1H), 6.95-7.15 (m, 5H), 7.22-7.33 (m, 1H), 9.23 (s, 1H), 11.83 (s, 1H)
- 3-butyryl-4-(2-cWorophenylamino)-8-(3-memyltWopropoxy)quinoline (0.31 g, 0.72 mmol) was dissolved in methylene chloride (10ml), 5 ml water was added and then a solution of 1.5 ml (1.09 mmol) of 5% NaOCl in 10 ml methylene chloride was added. The mixture was stirred for 4 h at room temperature. The organic phase was separated and evaporated.
- 3-butyryl-4-(2-methylphenylamino)-8(3-methylsulfinylpropoxy)quinoline 3-butyryl-4-(2-memylphenylamino)-8-(3-methylthiopropoxy)quinoline (0.33 g, 0.8 mmol) was dissolved in methylene chloride (15 ml), 5 ml water was added and then a solution of 1.5 ml (1.09 mmol) of 5% NaOCl in 10 ml methylene chloride was added. The mixture was stirred for 4 h at room temperature. The organic phase was separated and evaporated.
- 3-butyryl-4-(2-methoxyphenylamino)-8-(3-methylthiopropoxy)quinoline (0.30 g, 0.70 mmol) was dissolved in methylene chloride (10 ml), 5 ml water was added and then a solution of 1.5 ml (1.09 mmol) of 5% NaOCl in 10 ml methylene chloride was added. The mixture was stirred for 4 h at room temperature. The organic phase was separated and evaporated.
- Example 56 The filtrate from the first crystallization in Example 56 was evaporated.
- the salt was neutralized with a saturated sodium bicarbonate solution in methylene chloride and water.
- the organic layer was dried over sodium sulfate and the solvent was evaporated.
- the solid residue (4.6 g, 0.011 mole) and L-(+)-tartaric add (1.68 g, 0.011 mole) were dissolved in warm methanol (110 ml). The solution was allowed to cool to room temperature and stirred for 72 h.
- the predpitate was filtered off and washed with a total amount of 11 ml methanol giving 1.5 g of the tartaric salt.
- n-hexane 2-propanol: acetonitrile: diethyl amine (82: 18: 2: 0.1);
- a syrup containing 1% (weight per volume) of active substance is prepared from the following ingredients:
- Sugar and saccharine are dissolved in 60 g of warm water. After cooling the acid addition salt is dissolved in the sugar solution and glycerol and a solution of flavouring agents dissolved in ethanol are added. The mixture is diluted with water to a final volume of 100 ml.
- a tablet containing 50 mg of active compound is prepared from the following ingredients: I Compound according to Example 2 500 g
- Compound according to Example 2 powder, is mixed with lactose and granulated with a water solution of methyl cellulose and sodium carbonate. The wet is forced through a sieve and the granulate dried in an oven. After drying, the granulate is mixed with polyvinylpyrrolidone and magnesium stearate. The dry mixture is pressed into tablet cores (10,000 tablets), each tablet containing 50 mg of active substance, in a tabletting machine using 7 mm diameter punches.
- a solution of hydroxypropyl methylcellulose and polyethylene glycol in purified water is prepared. After dispersion of titanium dioxide the solution is sprayed onto the tablets I in an Accela Cota ® , Manesty coating equipment. A final tablet weight of 130 mg is obtained.
- a parenteral formulation for intravenous use containing 4 mg of active compound per ml, is prepared from the following ingredients: Compound according to Example 2 4 g
- Compound according to Example 2 is dissolved in polyethylene glycol 400 and 550 ml of water is added. pH of the solution is brought to pH 7.4 by adding a water solution of disodium hydrogen phosphate and water is added to a final volume of 1000 ml. The solution is filtered through a 0.22 um filter and immediately dispensed into 10 ml sterile ampoules. The ampoules are sealed.
- BIOLOGICAL TESTS A. Inhibiting effect on acid secretion in vitro in isolated rabbit gastric glands was measured as described by Berglindh et al. (1976) Acta Physiol. Scand. 97, 401-414.
- the compounds according to Examples 1-12 had an IC 50 value in the range of 0.5 to 6.0 uM.
- the compounds according to Examples 13-57 had an IC 50 value in the range of 0.75 to 14 ⁇ M
- mice of the Sprague-Dawly strain were used. They were equipped with cannulated fistulae in the stomach (lumen) and the upper part of the duodenum, for collection of gastric secretions and administration of test substances, respectively. A fourteen days recovery period after surgery was allowed before testing commenced. Before secretory tests, the animals were deprived of food but not water for 20 h. The stomach was repeatedly washed through the gastric cannula with tap water (37°C), and 6 ml of Ringer-Glucose given subcutaneously.
- the compounds 1-12 in Table 1 had an ED 50 value in the range of 1.0-12 ⁇ mole/kg. The results are based on gastric add secretion during the second hour after drug/vehide administration.
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- Organic Chemistry (AREA)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU96100758A RU2142454C1 (en) | 1993-06-11 | 1994-06-08 | 4-amino-3-acylquinoline derivatives, method of preparation thereof, pharmaceutical agent based thereof, method of preparation of pharmaceutical agent, and intermediate compound |
AU70121/94A AU680516B2 (en) | 1993-06-11 | 1994-06-08 | New active compounds |
DE69425823T DE69425823T2 (en) | 1993-06-11 | 1994-06-08 | SUBSTITUTED CHINOLINE DERIVATIVES, AND THEIR USE AS INHIBITORS OF THE GAS secretion |
EP94919046A EP0702672B1 (en) | 1993-06-11 | 1994-06-08 | Substituted quinoline derivatives and their use as inhibitors of gastric acid secretion |
AT94919046T ATE196134T1 (en) | 1993-06-11 | 1994-06-08 | SUBSTITUTED QUINOLINE DERIVATIVES AND THEIR USE AS GASTRIC SECRETION INHIBITORS |
BR9406772A BR9406772A (en) | 1993-06-11 | 1994-06-08 | Compound pharmaceutical composition use of the compound processes for preparing the compound for inhibiting gastric acid secretion for the treatment of inflammatory gastrointestinal diseases for the treatment or prophylaxis of conditions Helicobacter pylori infection of human gastric mucosa and pharmaceutical formulation |
US08/270,167 US5889021A (en) | 1993-06-11 | 1994-06-08 | Active Compounds |
PL94311957A PL177766B1 (en) | 1993-06-11 | 1994-06-08 | Novel active compounds |
JP50167595A JP3623794B2 (en) | 1993-06-11 | 1994-06-08 | New active compounds |
SK1549-95A SK154995A3 (en) | 1993-06-11 | 1994-06-08 | Novel efective compositions |
NO954928A NO305799B1 (en) | 1993-06-11 | 1995-12-05 | New quinoline derivatives, pharmaceutical preparations containing such derivatives, their use and intermediates |
FI955896A FI955896A (en) | 1993-06-11 | 1995-12-08 | New active compounds |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9302005A SE9302005D0 (en) | 1993-06-11 | 1993-06-11 | NEW ACTIVE COMPOUNDS |
SE9302005-5 | 1993-06-11 | ||
SE9303970-9 | 1993-11-30 | ||
SE9303970A SE9303970D0 (en) | 1993-11-30 | 1993-11-30 | New active compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994029274A1 true WO1994029274A1 (en) | 1994-12-22 |
Family
ID=26661770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1994/000552 WO1994029274A1 (en) | 1993-06-11 | 1994-06-08 | New active compounds |
Country Status (25)
Country | Link |
---|---|
US (1) | US5889021A (en) |
EP (1) | EP0702672B1 (en) |
JP (1) | JP3623794B2 (en) |
CN (1) | CN1045955C (en) |
AT (1) | ATE196134T1 (en) |
AU (1) | AU680516B2 (en) |
BR (1) | BR9406772A (en) |
CA (1) | CA2164875A1 (en) |
CZ (1) | CZ326095A3 (en) |
DE (1) | DE69425823T2 (en) |
EE (1) | EE03123B1 (en) |
EG (1) | EG20435A (en) |
ES (1) | ES2150494T3 (en) |
FI (1) | FI955896A (en) |
HU (1) | HUT75122A (en) |
IL (1) | IL109685A (en) |
IS (1) | IS4164A (en) |
NO (1) | NO305799B1 (en) |
NZ (1) | NZ267740A (en) |
PL (1) | PL177766B1 (en) |
RU (1) | RU2142454C1 (en) |
SG (1) | SG47820A1 (en) |
SK (1) | SK154995A3 (en) |
TW (1) | TW261613B (en) |
WO (1) | WO1994029274A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996017830A1 (en) * | 1994-12-08 | 1996-06-13 | Astra Aktiebolag | Compounds for inhibition of gastric acid secretion |
US7619091B2 (en) | 2002-07-16 | 2009-11-17 | Prana Biotechnology Limited | 8-hydroxy quinoline derivatives |
CN106928233A (en) * | 2015-12-31 | 2017-07-07 | 上海医药集团股份有限公司 | The salt of quinolines, its crystal formation, preparation method, composition and application |
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US6077850A (en) * | 1997-04-21 | 2000-06-20 | G.D. Searle & Co. | Substituted benzopyran analogs for the treatment of inflammation |
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996017830A1 (en) * | 1994-12-08 | 1996-06-13 | Astra Aktiebolag | Compounds for inhibition of gastric acid secretion |
AU697006B2 (en) * | 1994-12-08 | 1998-09-24 | Astra Aktiebolag | Compounds for inhibition of gastric acid secretion |
US7619091B2 (en) | 2002-07-16 | 2009-11-17 | Prana Biotechnology Limited | 8-hydroxy quinoline derivatives |
US8975278B2 (en) | 2002-07-16 | 2015-03-10 | Prana Biotechnology Limited | 8-hydroxy quinoline derivatives |
US9169211B2 (en) | 2002-07-16 | 2015-10-27 | Prana Biotechnology Limited | 8-hydroxy quinoline derivatives |
US9302993B2 (en) | 2002-07-16 | 2016-04-05 | Prana Biotechnology Limited | 8-hydroxy quinoline derivatives |
CN106928233A (en) * | 2015-12-31 | 2017-07-07 | 上海医药集团股份有限公司 | The salt of quinolines, its crystal formation, preparation method, composition and application |
CN106928233B (en) * | 2015-12-31 | 2021-02-12 | 上海医药集团股份有限公司 | Salt of quinoline compound, crystal form, preparation method, composition and application thereof |
Also Published As
Publication number | Publication date |
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AU680516B2 (en) | 1997-07-31 |
NO954928L (en) | 1995-12-05 |
US5889021A (en) | 1999-03-30 |
EP0702672A1 (en) | 1996-03-27 |
SK154995A3 (en) | 1996-09-04 |
IL109685A (en) | 1999-03-12 |
HUT75122A (en) | 1997-04-28 |
IS4164A (en) | 1994-12-12 |
DE69425823T2 (en) | 2001-01-18 |
DE69425823D1 (en) | 2000-10-12 |
NO954928D0 (en) | 1995-12-05 |
IL109685A0 (en) | 1994-11-28 |
JPH09510951A (en) | 1997-11-04 |
RU2142454C1 (en) | 1999-12-10 |
NO305799B1 (en) | 1999-07-26 |
JP3623794B2 (en) | 2005-02-23 |
PL177766B1 (en) | 2000-01-31 |
PL311957A1 (en) | 1996-03-18 |
CA2164875A1 (en) | 1994-12-22 |
EG20435A (en) | 1999-04-29 |
HU9503529D0 (en) | 1996-02-28 |
BR9406772A (en) | 1996-02-21 |
EP0702672B1 (en) | 2000-09-06 |
SG47820A1 (en) | 1998-04-17 |
ES2150494T3 (en) | 2000-12-01 |
NZ267740A (en) | 1997-05-26 |
FI955896A0 (en) | 1995-12-08 |
AU7012194A (en) | 1995-01-03 |
ATE196134T1 (en) | 2000-09-15 |
EE03123B1 (en) | 1998-10-15 |
CN1125438A (en) | 1996-06-26 |
FI955896A (en) | 1995-12-08 |
CN1045955C (en) | 1999-10-27 |
CZ326095A3 (en) | 1996-05-15 |
TW261613B (en) | 1995-11-01 |
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