WO1994025091A1 - A device for metering and administering a liquid preparation - Google Patents
A device for metering and administering a liquid preparation Download PDFInfo
- Publication number
- WO1994025091A1 WO1994025091A1 PCT/SE1994/000360 SE9400360W WO9425091A1 WO 1994025091 A1 WO1994025091 A1 WO 1994025091A1 SE 9400360 W SE9400360 W SE 9400360W WO 9425091 A1 WO9425091 A1 WO 9425091A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- piston rod
- cartridge
- coupling
- injection
- couplings
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31536—Blocking means to immobilize a selected dose, e.g. to administer equal doses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
Definitions
- the concentra ⁇ tion of the liquid preparation such that the portion 1/N will give the desired dose of the pharmaceutically active agent.
- a device for the repeated dosing of a liquid preparation from a multi-dose con- tainer comprises a holder device for a multi-dose container having a defined volume and con ⁇ taining a preparation having a defined composition, and the multi-dose container is provided with a fixed front wall, through which may be arranged an outlet for the preparation, and a movable rear wall, which may act as a piston for expelling the preparation through said outlet, and a piston rod, by which the rear movable wall may be urged forwards.
- the piston rod is provided with releasable blocking means by which the forward movement of it is limited to a predetermined length, which corresponds to a forward movement of the rear movable wall corresponding to 1/N of the multi-dose container, N being an integer having a value of 2 or higher.
- front and forward refer to the direction in which the liquid preparation is made to flow when it is administered. Conversely, the opposite direction is denoted as “rear” and “rearward”, respectively.
- the device comprises a barrel for holding at its front end part an injection cartridge and a piston rod for actuating said injection cartridge to expel a set amount of the liquid preparation from the cartridge.
- the releasable blocking means comprise a fixed chuck and a movable chuck which clamp around the piston rod through the action of a spring force, said clamping action being releasable by reducing said spring force.
- the front chuck is fixed in relation to the barrel and the cartridge, and its clamping action around the piston rod may be actuated to lock it securely to the chuck, or may be released to allow the piston rod to move in relation to the chuck.
- the rear chuck is movable in relation to the barrel and the cartridge, and can be moved along the piston rod, when its clamping action is released, or may follow the piston rod in its movement, when the clamping action is actuated.
- the rear chuck When a measured dose of the liquid preparation is to be administered, the rear chuck is moved rearwards against a spring force by.means of a yoke arrangement, which at the same time releases the clamping action of the chuck such that it can move along the piston rod at the same time as said piston rod is locked in place by means of the clamping action of the front chuck.
- the rearward movement of the rear chuck is limited by stopping means, and the clamping action of this chuck is actuated again in this rear position, so that the chuck is locked in place in said rear position.
- the distance that the rear chuck is moved rearward is predetermined and set in the device, and determines the magnitude of the dose of the liquid preparation.
- the important feature of the device described above is that the dose set can be infinitely varied. This is necessary for administering in accordance with the method described, where no residue should be left after administering a determined number of doses.
- This method and device should not be confused with the prior art methods and devices for administering liquid prepara ⁇ tions.
- the prior art devices for repeated administra- tion from a multi-dose cartridge usually consist of an injection device which comprises a mechanism for a stepwise forward movement of the rear movable wall of the injection cartridge, such as a screw or ratchet mechanism. The steps which are possible with this type of mechanism are fixed and a dose can only be deter ⁇ mined by a given number of steps.
- the prior art mechanism may be adapted to the injection cartridge in such a manner that an advancement of the mechanism by one step will give a dosed amount of, for example, 1/8 of the volume of the cartridge.
- the mechanism cannot then be easily adapted to give a dose of, for example, 1/7, 1/9 or 1/10 of the volume of the car ⁇ tridge. This means that only a limited number of dose amounts are possible without giving a residue.
- N is an integer.
- the value of N may be set on the device before a series of administrations is started, and it should not then be easy to change unintentionally.
- This range of doses may then be presented in a table, from a computer memory, or in a nomograph, for easy reference by the physician.
- an injection device for an infinitely variable metering and administering of a liquid preparation, and comprising a holder device for a multi-dose injection cartridge which comprises a fixed front wall through which may be arranged a liquid connection for discharging the pre ⁇ paration, and a rear, movable wall which may be moved forward by means of a piston rod to expel the prepara ⁇ tion from the cartridge, the movement of said piston rod being governed by two couplings arranged along the length of said piston rod, each of said couplings being capable of releasably gripping and retaining said piston rod by means of locking means.
- the forward coupling is fixed in relation to the holder device and the injection cartridge, and the rear coupling may be moved rearwards along the piston rod against a spring pressure and again grip said piston rod in a rear posi ⁇ tion, after which the forward coupling may be released to free the piston rod such that said spring pressure will move the piston rod and the rear coupling locked thereto forward for a predetermined distance and there ⁇ by also move the rear movable wall of the injection cartridge forward to expel a predetermined amount of the liquid preparation from the cartridge.
- each of the coup ⁇ lings consists of a clamping shoe having a wedge-shaped groove, the cross-section of which is adapted to that of the piston rod, and lever means arranged in each clamping shoe, by means of which the piston rod and the clamping shoe may be clamped together to lock the piston rod in the groove of said clamping shoe, or the clamping shoe may be released from the piston rod to release said coupling.
- the holder device is provid ⁇ ed with stopping means at its rear part, which re ⁇ strict the rearward movement of said rear coupling, and said stopping means are adjustable in the longitudinal direction such that said rearward movement and thereby also the forward movement of the piston rod at the administering, may be set at a predetermined value.
- a yoke is provided for the rearward movement of the rear coupling, said yoke being connected to the rear coupling and its lever means in such a way that said coupling is released from the piston rod as it is moved rearwards and is again locked to the piston rod when said movement is termin ⁇ ated.
- the lever means of the two couplings are spring loaded in such a manner that they strive to lock each of the couplings to the piston rod.
- the lever means comprise eccentric disks, which by being rotated may lock the couplings to the piston rod or release said couplings.
- figure 1 shows the arrangement of the device before it has been readied for an administering.
- Figure 2 shows the device after it has been readied for an administering.
- Figure 3 shows the device after an administering has been made, and also an arrangement for exchanging an emptied injection cartridge for a fresh one.
- Figure 4 is a partly sectional view along IV-IV in figure 1. In all figures, like parts have the same reference numbers.
- figures 1 to 3 only show those parts of the injection device which characterize it in accordance with the present invention. Therefore, these drawing figures do not show the holder device for the injection cartridge or the injection cartridge as such, for example. The arrangement of these parts is conven ⁇ tional and apparent to a person skilled in the art.
- the front coupling 2 is stationary in relation to the holder device and the injection cartridge of the device.
- the piston rod 1 may be forced into the groove of the clamping shoe 4 by means of an eccentric disk 7, which may be rotated around the axis 9.
- This axis 9 also serves as the fulcrum for lever means comprising an outer arm 8 and an inner arm 10, which both are solidly connected to the eccentric disk 7 and its axis 9.
- the eccentric disk 7 will turn about the axis 9 in such a way that the piston rod 1 is urged into the groove of the clamping shoe 4 to lock the piston rod 1 and the front coupling 2 securely together.
- the rear coupling 3 is arranged movable in the longitu- dinal direction along the piston rod 1. It comprises a clamping shoe 5 of a design similar to the front clamping shoe 4, having a wedge-shaped groove 6 with a cross-section adapted to that of the piston rod 1.
- An eccentric disk 12 can be rotated around the axis 13 by means of the outer lever arm 14 or the inner lever arm 15. When the outer lever arm 14 is moved outward, or the inner lever arm 15 is moved forward, the eccentric disk 12 will rotate in such a way that the piston rod 1 is forced into the groove 6 of the rear clamping shoe 5, to lock the rear coupling 3 to the piston rod. When the outer lever arm 14 is moved inward and the inner lever arm 15 is moved rearward, the eccentric disk 12 will rotate around the axis 13 in such a way that the piston rod 1 is released from the rear coupling 3.
- the stopping means 25 are connected to the holder device (not shown) in such a way that they can be fixed in a predetermined position in relation to said holder device. This setting of the position of the stopping means 25 determines the distance A between the rear end flange 20 of the sleeve 19 and the stopping means 25, and by this also the distance that the piston rod 1 travels forward when a dose is administered.
- FIG 2 shows the device of the invention where the rear coupling 3 has been moved rearward such that the sleeve 19 at its rear face abuts the stopping means 25.
- the rear coupling 3 has been locked to the piston rod 1 by means of the compression spring 21 which urges the ring 18 forward against the pins 17, which in turn move the inner lever arm 15 forward to rotate the eccentric disk 12 such that the clamping shoe 5 is locked to the piston rod 1.
- the rear coupling 3 is now situated at a longitudinal distance A from the front coupling 2 which is the same as the distance A shown in figure 1 between the sleeve 19 and the stopping means 25, and the injection spring 24 has been cocked.
- the device is now ready for the admin ⁇ istering of an injection.
- FIG. 3 shows schematically the device of the inven- tion after an injection has been administered and an emptied injection cartridge is to be replaced with a fresh one.
- the rear coupling 3 and the piston rod 1 have moved forward such that the rear coupling 3 rests against the stationary front coupling 2.
- the forward part of the piston rod 1 extends into the injection cartridge 28.
- the rear end of this injec ⁇ tion cartridge is in contact with a sensor arm 29, which is urged against said rear end by means of a compression spring 32.
- the sensor arm 29 is also con ⁇ nected to an actuating slide 31, which is provided with two inclined surfaces 34 and 35. These two surfaces 34 and 35 may be brought into contact with the outer lever arms 8 and 14 by means of the spring 32, but as long as the sensor arm 29 is held back by the rear end of the injection cartridge 28, they are not in contact with said lever arms 8 and 14.
- the device is shown before it has been readied for an injection. This may be the first injec ⁇ tion from a fresh injection cartridge, or a number of injections may already have been administered.
- the movable rear coupling 3 rests against the stationary front coupling 2 and the piston rod 1 is firmly locked to both couplings 2 and 3.
- the spring 11 pulls the inner lever arm forwards, and this movement will rotate the eccentric disk 7 such that the piston rod 1 is urged into the groove 6 of the clamping shoe 4.
- the spring 21 in the sleeve 19 will push the ring 18 forward to act on the pins 17 and in this way turn the inner lever arm 5 in the forward direction. This will make the eccentric disk 12 rotate around the axis 13 to urge the piston rod 1 into the groove 6 of the clamping shoe 5.
- the rear end 20 of the sleeve 19 on the rear coupling 3 is situated at a predetermined distance, A from the stopping device 25.
- This distance A may be set to a predetermined value by moving the stopping device 25 in the longitudinal direction, and it determines the stroke of the piston in the injection cartridge at the administering. This setting should therefore not be easy to change unintentionally.
- the user pulls the yoke 23 rearwards.
- the ring 22 connected with the yoke 23 will then move rearwards and will then also act on the pins 17 on the inner lever arms 15 and 16 against the pressure of the spring 21 on the ring 18 inside the sleeve 19. This will make the inner lever arm 15 turn in the rearward direction such that the eccentric disk 12 will also rotate around the axis 13 to release the clamping shoe 5 from the piston rod 1.
- the rear coup ⁇ ling 3 will then be free to follow the ring 22 and the yoke 23 in their movement rearwards against the pres ⁇ sure of the injection spring 24.
- the administration is carried out by means of the injection spring 24 only, and the user will not have to make any special effort to expel the injectable preparation from the cartridge.
- the device of the invention has certain auto-injecting properties, which is a valuable advantage of the invention. The user will only have to insert the injection needle at the site of the injec ⁇ tion, and the injection itself will be effected by simply releasing the lock between the piston rod 1 and the front coupling 2.
- the release of the piston rod 1 from the front coupling 2 by the movement of the outer lever arm 8 may be effected by a trigger mechanism of a suitable design.
- trigger mechanisms are well-known to those skilled in the art, and need not have to described here in detail.
- the device After the injection has been administered, the device is again in the state shown in figure 1. To prepare the device for a subsequent injection, the user will only have move the rear coupling 3 rearwards by means of the ring 22 and the yoke 23, as has been described in the foregoing. This process may be repeated as many times as desired, until the injection cartridge 28 has been emptied. In the preferred system for administering injections, there will be no residue left in the car ⁇ tridge, as the doses have been set to this effect. This has been described in the introductory part of this specification.
- FIG 3 shows the device of the invention when an injection cartridge is to be replaced. It is seen that the rear end of the cartridge 28 rests against a sensor arm 29, which is spring loaded in the forward direction by means of the spring 32.
- the cartridge 28 may be removed, for instance by removing the front part of the holder device, such as by unscrewing it, from a rear part of said holder device. The cartridge can then be pulled out in the forward direction.
- the sensor arm 29 When the cartridge 28 is pulled out in the forward direction, the sensor arm 29 will also be moved forward by the action of the spring 24.
- the sensor arm 29 is connected to a releasing slide 31, which has two in ⁇ clined surfaces 34 and 35 which will get into contact with the outer lever arms 8 and 14, respectively, such that these lever arms are moved inwards in the radial direction. This inward movement will also make the eccentric disks 7 and 12, respectively, rotate around the axes 9 and 13, respectively, such that the two couplings 2 and 3 are released from the piston rod 1.
- the piston rod 1 will then be freed and can be taken out from the device.
- the cartridge When a fresh injection cartridge is to be inserted into the device of the invention, the cartridge is first combined with the piston rod in such a way that said piston rod rests against the rear face of the rear movable wall or piston of the injection cartridge.
- the assembly of piston rod and cartridge is then inserted into the holder device in such a way that the piston rod 1 is inserted through the two couplings 2 and 3 and the cartridge is introduced until its rear end abuts the sensor arm 29 and has moved this arm rearward to a predetermined position.
- the inclined surfaces 34 and 35 of the slide 31 will no longer be in contact with the outer lever arms 8 and 14, respective- ly, and these lever arms will then be free to move outwards through the influence of the springs 11 and 21, respectively.
- the couplings 2 and 3 will now lock to the piston rod 1, and the device can now be readied for further injections.
- the device of the invention may be used for single- chamber or dual-chamber injection cartridges.
- the device With a single-chamber cartridge, the device is ready for ad- ministering injections immediately after a fresh car ⁇ tridge has been inserted.
- the components in the two chambers With a dual-chamber car ⁇ tridge, the components in the two chambers will first have to mixed before an injection can be administered. This can easily be carried out by making a suitable number of "dry-run" administerings to advance the rear piston in the dual-chamber cartridge to force the liquid component in the rear chamber over into the front chamber and advance the rear piston to its posi ⁇ tion for administering the mixed preparation.
- liquid injectable preparation in the present specification and claims is intended to encompass injectable solutions as well as injectable emulsions, suspensions and other dispersions suitable for parenteral injection.
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU95105589A RU2143929C1 (en) | 1993-04-30 | 1994-04-22 | Injection device for unlimited varied dosing and introduction of liquid preparation |
CA002138295A CA2138295C (en) | 1993-04-30 | 1994-04-22 | A device for metering and administering a liquid preparation |
JP52415494A JP3503827B2 (en) | 1993-04-30 | 1994-04-22 | Device for metering and dispensing liquid preparations |
KR1019940704834A KR100309360B1 (en) | 1993-04-30 | 1994-04-22 | Devices for weighing and processing liquid preparations |
US08/362,481 US5735824A (en) | 1993-04-30 | 1994-04-22 | Device for metering and administering a liquid preparation |
UA95018077A UA27918C2 (en) | 1993-04-30 | 1994-04-22 | Injection device for metering and administering a liquid preparation |
DE69405672T DE69405672T2 (en) | 1993-04-30 | 1994-04-22 | DEVICE FOR MEASURING AND ADMINISTERING A LIQUID PREPARATION |
EP94914660A EP0648135B1 (en) | 1993-04-30 | 1994-04-22 | A device for metering and administering a liquid preparation |
AU66935/94A AU672703B2 (en) | 1993-04-30 | 1994-04-22 | A device for metering and administering a liquid preparation |
NO945076A NO308777B1 (en) | 1993-04-30 | 1994-12-29 | Injection device for infinitely variable measurement and assignment of a liquid preparation |
FI946151A FI113345B (en) | 1993-04-30 | 1994-12-29 | Apparatus for dispensing and administering a liquid preparation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9301495-9 | 1993-04-30 | ||
SE19939301495A SE9301495D0 (en) | 1993-04-30 | 1993-04-30 | A DEVICE FOR MEASURING AND ADMINISTRATING A LIQUID PREPARATION |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994025091A1 true WO1994025091A1 (en) | 1994-11-10 |
Family
ID=20389795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1994/000360 WO1994025091A1 (en) | 1993-04-30 | 1994-04-22 | A device for metering and administering a liquid preparation |
Country Status (16)
Country | Link |
---|---|
US (1) | US5735824A (en) |
EP (1) | EP0648135B1 (en) |
JP (1) | JP3503827B2 (en) |
KR (1) | KR100309360B1 (en) |
AT (1) | ATE158188T1 (en) |
AU (1) | AU672703B2 (en) |
CA (1) | CA2138295C (en) |
DE (1) | DE69405672T2 (en) |
DK (1) | DK0648135T3 (en) |
EE (1) | EE03018B1 (en) |
FI (1) | FI113345B (en) |
NO (1) | NO308777B1 (en) |
RU (1) | RU2143929C1 (en) |
SE (1) | SE9301495D0 (en) |
UA (1) | UA27918C2 (en) |
WO (1) | WO1994025091A1 (en) |
Families Citing this family (7)
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US7799521B2 (en) * | 1998-06-24 | 2010-09-21 | Chen & Chen, Llc | Thermal cycling |
JP4321738B2 (en) * | 1998-06-24 | 2009-08-26 | チェン アンド チェン エルエルシー | Liquid sample test system |
US6780617B2 (en) | 2000-12-29 | 2004-08-24 | Chen & Chen, Llc | Sample processing device and method |
AU2002341644B2 (en) | 2001-09-11 | 2008-02-28 | Iquum, Inc. | Sample vessels |
ES2604352T3 (en) * | 2003-02-05 | 2017-03-06 | Iquum, Inc. | Sample Processing |
DE102014107718B3 (en) * | 2014-06-02 | 2015-04-02 | Seca Ag | Receiving device for electrical impedance analysis |
CN112546333B (en) * | 2021-01-15 | 2022-12-20 | 泉州烜燊工程管理有限公司 | Paediatrics infusion support with high stability ability |
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WO1993008854A1 (en) * | 1991-11-04 | 1993-05-13 | Kabi Pharmacia Ab | A method and device for dosing a liquid preparation |
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CH607620A5 (en) * | 1977-03-07 | 1978-09-29 | Contraves Ag | |
US4254767A (en) * | 1979-07-30 | 1981-03-10 | Mixon Jr James L | Laboratory device for small animals |
US4368732A (en) * | 1980-06-16 | 1983-01-18 | Bertrand Cassou | Artificial insemination device for aviculture |
US4589870A (en) * | 1984-02-21 | 1986-05-20 | Indicon, Inc. | Incremental actuator for syringe |
NZ212899A (en) * | 1984-07-31 | 1987-10-30 | Phillips Pty Ltd N J | Piston operated adjustable volume dose injector for animals |
AU573369B2 (en) * | 1984-07-31 | 1988-06-02 | N.J. Phillips Pty. Limited | A rumen injector |
US4737151A (en) * | 1986-07-25 | 1988-04-12 | Clement John G | Syringe injector |
US5176646A (en) * | 1991-02-19 | 1993-01-05 | Takayuki Kuroda | Motorized syringe pump |
US5228883A (en) * | 1991-05-02 | 1993-07-20 | Eli Lilly And Company | Portable drug delivery system |
-
1993
- 1993-04-30 SE SE19939301495A patent/SE9301495D0/en unknown
-
1994
- 1994-04-22 AT AT94914660T patent/ATE158188T1/en not_active IP Right Cessation
- 1994-04-22 DE DE69405672T patent/DE69405672T2/en not_active Expired - Fee Related
- 1994-04-22 JP JP52415494A patent/JP3503827B2/en not_active Expired - Fee Related
- 1994-04-22 US US08/362,481 patent/US5735824A/en not_active Expired - Fee Related
- 1994-04-22 WO PCT/SE1994/000360 patent/WO1994025091A1/en active IP Right Grant
- 1994-04-22 AU AU66935/94A patent/AU672703B2/en not_active Ceased
- 1994-04-22 KR KR1019940704834A patent/KR100309360B1/en not_active IP Right Cessation
- 1994-04-22 UA UA95018077A patent/UA27918C2/en unknown
- 1994-04-22 DK DK94914660.9T patent/DK0648135T3/en active
- 1994-04-22 EP EP94914660A patent/EP0648135B1/en not_active Expired - Lifetime
- 1994-04-22 RU RU95105589A patent/RU2143929C1/en not_active IP Right Cessation
- 1994-04-22 CA CA002138295A patent/CA2138295C/en not_active Expired - Fee Related
- 1994-11-15 EE EE9400140A patent/EE03018B1/en not_active IP Right Cessation
- 1994-12-29 FI FI946151A patent/FI113345B/en active
- 1994-12-29 NO NO945076A patent/NO308777B1/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993008854A1 (en) * | 1991-11-04 | 1993-05-13 | Kabi Pharmacia Ab | A method and device for dosing a liquid preparation |
Also Published As
Publication number | Publication date |
---|---|
SE9301495D0 (en) | 1993-04-30 |
US5735824A (en) | 1998-04-07 |
RU2143929C1 (en) | 2000-01-10 |
ATE158188T1 (en) | 1997-10-15 |
AU672703B2 (en) | 1996-10-10 |
KR950702128A (en) | 1995-06-19 |
DE69405672T2 (en) | 1998-03-19 |
CA2138295A1 (en) | 1994-11-10 |
FI946151A (en) | 1994-12-29 |
CA2138295C (en) | 2005-10-18 |
DE69405672D1 (en) | 1997-10-23 |
JP3503827B2 (en) | 2004-03-08 |
KR100309360B1 (en) | 2001-12-15 |
UA27918C2 (en) | 2000-10-16 |
EP0648135B1 (en) | 1997-09-17 |
RU95105589A (en) | 1996-11-10 |
AU6693594A (en) | 1994-11-21 |
NO945076L (en) | 1995-02-16 |
FI946151A0 (en) | 1994-12-29 |
EE03018B1 (en) | 1997-08-15 |
DK0648135T3 (en) | 1998-04-14 |
JPH07508914A (en) | 1995-10-05 |
FI113345B (en) | 2004-04-15 |
NO945076D0 (en) | 1994-12-29 |
NO308777B1 (en) | 2000-10-30 |
EP0648135A1 (en) | 1995-04-19 |
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