WO1994024121A1 - Novel 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents - Google Patents
Novel 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents Download PDFInfo
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- WO1994024121A1 WO1994024121A1 PCT/US1994/004240 US9404240W WO9424121A1 WO 1994024121 A1 WO1994024121 A1 WO 1994024121A1 US 9404240 W US9404240 W US 9404240W WO 9424121 A1 WO9424121 A1 WO 9424121A1
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- compound
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- alkyl
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- lower alkyl
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- 0 C*1(C)OC(C=C(C(*)*)C(*)C2)=C2O1 Chemical compound C*1(C)OC(C=C(C(*)*)C(*)C2)=C2O1 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/54—Radicals substituted by oxygen atoms
Definitions
- the present invention relates to novel 1,2-benzodioxole and 1,2-dialkoxybenzene derivatives which are active as ocular hypotensive agents.
- the present invention also relates to methods of administering a pharmaceutical composition containing one or more of said 1,2-benzodioxole and 1,2-dialkoxybenzene
- Ocular hypotensive agents are useful in the treatment of a number of various ocular hypertensive conditions, such as post-surgical and post-laser trabeculectomy ocular hypertensive episodes, glaucoma, and as presurgical adjuncts.
- Glaucoma is a disease of the eye characterized by increased intraocular pressure. On the basis of its etiology, glaucoma has been classified as primary or secondary. For example, primary glaucoma in adults (congenital glaucoma) may be either open-angle or acute or chronic angle-closure. Secondary glaucoma results from pre-existing ocular diseases such as uveitis, intraocular tumor or an enlarged cataract.
- the underlying causes of primary glaucoma are not yet known.
- the increased intraocular tension is due to the obstruction of aqueous humor outflow.
- chronic open-angle glaucoma the anterior chamber and its anatomic structures appear normal, but drainage of the aqueous humor is impeded.
- acute or chronic angle-closure glaucoma the anterior chamber is shallow, the filtration angle is narrowed, and the iris may obstruct the trabecular meshwork at the entrance of the canal of Schlemm. Dilation of the pupil may push the root of the iris forward against the angle, and may produce pupillary block and thus precipitate an acute attack. Eyes with narrow anterior chamber angles are
- Secondary glaucoma is caused by any interference with the flow of aqueous humor from the posterior chamber into the anterior chamber and subsequently, into the canal of Schlemm.
- Inflammatory disease of the anterior segment may prevent aqueous escape by causing complete posterior synechia in iris bombe and may plug the drainage channel with exudates.
- Other common causes are intraocular tumors, enlarged
- cataracts central retinal vein occlusion, trauma to the eye, operative procedures and intraocular
- glaucoma occurs in about 2% of all persons over the age of 40 and may be asymptotic for years before progressing to rapid loss of vision.
- topical B-adrenoreceptor antagonists have traditionally been the drugs of choice for treating glaucoma.
- Prostagladins were earlier regarded as potent ocular hypertensives; however, evidence accumulated in the last two decades shows that some prostaglandins are highly effective ocular hypotensive agents and are suitable for the long-term medical management of glaucoma. (See, for example, M. S. Starr, Exp. Eye
- hypotensive agents include: sodium metabisulfate, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite, sodium metabisulfite
- hypotensive agents particularly for agents which are more effective, have lesser side-effects or act through a different biological mechanism than presently known ocular hypotensives.
- W is (CH 2 ) n where n is 1 or 2, or n is 0 and W represents lower alkyl groups attached to each oxygen; m is an integer between 1 and 8;
- R 1 is COOH or a pharmaceutically acceptable salt thereof, COOR 4 , CONR 5 R 6 , CONR 5 SO 2 R 7 , CH 2 OH, CH 2 OR 7 , CH 2 O-COR 7 , CH 2 O-CONR 5 ,R 7 , CH 2 OCOOR 7 , CH 2 NH 2 , CH 2 NR 5 R 6 , CH 2 NR 5 COR 7 , CHO, CH(OR 8 ) 2 , CHOR 9 O, -COR 10 , CR 10 (OR 8 ) 2 , or CR 10 OR 9 O, where R 4 is an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R 4 is phenyl or lower alkyl phenyl, R 5 and R 6
- R 7 is alkyl of 1 to 10 carbons, phenyl or lower alkylphenyl
- R 8 is lower alkyl
- R 9 is divalent alkyl radical of 2 - 5 carbons
- R 10 is an alkyl OR cycloalkyl containing 1 to 5 carbons
- R 2 is H, COR 7 , R 7 , CO-OR 7 , CO-NR 5 ,R 7 , PO(OH)OR 7 , PO(OR 7 ) 2 , POR 7 OH, or POR 7 (OR 7 );
- R 3 is lower alkyl, phenyl, lower alkyl or halogen substituted phenyl, phenyl substituted lower alkyl, or heteroaryl substituted lower alkyl.
- the present invention relates to pharmaceutical compositions containing as active ingredient one or more compounds of the present invention (or their pharmaceutically acceptable salts).
- the present invention relates to methods of administering to a mammal a pharmaceutical composition having as its active
- ingredient one or more compounds of Formula 1 for the purpose of lowering intraocular pressure in the eye of the mammal.
- the present invention relates to novel compounds of Formula 1, and to their use in pharmaceutical compositions and methods for the purpose of lowering intraocular pressure in the eye of a mammal.
- alkyl refers to and covers any and all groups which are known as normal alkyl, branch-chain alkyl and cycloalkyl.
- Lower alkyl means the above-defined broad definition of alkyl groups having 1 to 6 carbons, and as applicable, 3 to 6 carbons for branch chained and cyclo-alkyl groups.
- ester refers to and covers any compound falling within the definition of that term classically used in organic chemistry. Where the ester is derived from a carboxylic acid corresponding to Formula 1, the term covers the products derived from the treatment of this function with alcohols,
- ester is derived from alcohols corresponding to Formula 1, the term covers compounds of the formula -CH 2 OCOR 7 where R 7 is defined as in connection with Formula 1.
- Amide has the meaning classically accorded that term in organic chemistry. In this instance it includes but is not limited to unsubstituted amides and aliphatic mono-and di-substituted amides.
- a pharmaceutically acceptable salt may be prepared for any compound used in the method of treatment of this invention, if the compound has a functionality capable of forming such salt, for example an acid functionality.
- a pharmaceutically acceptable salt may be any salt which retains the activity of the parent compound and does not impart any deleterious or untoward effect on the subject to which it is administered and in the context in which it is administered.
- Such a salt may be derived from any organic or inorganic acid or base.
- the salt may be a mono or polyvalent ion.
- the inorganic ions sodium, potassium, calcium, and magnesium.
- Organic amine salts may be made with amines, particularly ammonium salts such as mono-, di- and trialkyl amines or ethanol amines. Salts may also be formed with caffeine, tromethanine and similar molecules. Where there is a nitrogen sufficiently basic as to be capable of forming acid addition salts, such may be formed with any inorganic or organic acids or alkylating agent such as methyl iodide.
- Preferred salts are those formed with inorganic acids such as hydrochloric acid, sulfuric acid or phosphoric acid. Any of a number of simple organic acids such as mono-, di- or tri-acid may also be used.
- the compounds of the present invention contain one or more chiral centers and therefore exist in
- W represents normal-lower alkyl groups attached to each oxygen of the benzene ring, or where W represents (CH 2 ) n and n is 1.
- n is between 3 to 5, and even more preferred where m is 4.
- R 1 is COOH, CH 2 OH or COOR 4 where R 4 is lower alkyl, particularly methyl.
- R 2 is H, or COR 7 where R 7 is lower alkyl
- R 3 is lower alkyl, or phenyl
- R 3 is Ph-CH 2 -CH 2 , or n-pentyl.
- compositions may be prepared by combining a therapeutically effective amount of at least one compound according to the present invention, or a pharmaceutically acceptable salt thereof, as an active ingredient, with conventional ophthalmically acceptable pharmaceutical excipients, and by
- the therapeutically efficient amount typically is between about 0.0001 and about 5% (w/v), preferably about 0.001 to about 1.0% (w/v) in liquid formulations.
- solutions are prepared using a physiological saline solution as a major vehicle.
- the pH of such ophthalmic solutions should preferably be maintained between 4.5 and 8.0 with an appropriate buffer system, a neutral pH being preferred but not essential.
- the formulations may also contain conventional, pharmaceutically acceptable preservatives, stabilizers and surfactants.
- Preferred preservatives that may be used in the pharmaceutical compositions of the present invention include, but are not limited to, benzalkonium chloride, chlorobutanol, thimerosal, phenylmercuric acetate and phenylmercuric nitrate.
- a preferred surfactant is, for example, Tween 80.
- vehicles may be used in the ophthalmic preparations of the present invention. These vehicles include, but are not limited to, polyvinyl alcohol, povidone,
- Tonicity adjustors may be added as needed or convenient. They include, but are not limited to, salts, particularly sodium chloride, potassium
- buffers include acetate buffers, citrate buffers, phosphate buffers and borate buffers. Acids or bases may be used to adjust the pH of these formulations as needed.
- an ophthalmically acceptable antioxidant for use in the present invention includes, but is not limited to, sodium metabisulfite, sodium thiosulfate, acetylcysteine, butylated hydroxyanisol and butylated hydroxytoluene.
- excipient components which may be included in the ophthalmic preparations are chelating agents.
- the preferred chelating agent is edentate disodium, although other chelating agents may also be used in place or in conjunction with it.
- ingredients are usually used in the following amounts: Ingredient Amount (% w/v)
- pH adjustor q.s. pH 4.5-7.5
- the actual dose of the active compounds of the present invention depends on the specific compound, and on the condition to be treated; the selection of the appropriate dose is well within the knowledge of the skilled artisan.
- Containers suitable for dropwise application are usually made of suitable inert, non-toxic plastic material, and generally contain between about 0.5 and about 15 ml solution.
- One package may contain one or more unit doses.
- Especially preservative-free solutions are often formulated in non-resealable containers containing up to about ten, preferably up to about five units doses, where a typical unit dose is from one to about 8 drops, preferably one to about 3 drops.
- the volume of one drop is about 20-35 ⁇ l.
- compounds of the invention were also found to inhibit DNA synthesis as observed in an assay where the incorporation of tritium labeled thymidine into Swiss 3T3 cells is measured.
- the assay is
- Swiss mouse 3T3 cells were maintained in Dulbec ⁇ o's modified Eagle's medium (DMEM) low glucose and supplemented with 10% fetal bovine serum FBS), 2 mM 1-glutamine and 1% antibiotic-antimycotic 100 X. The cultures were incubated in 5% CO 2 in air at 37 °C.
- DMEM Dulbec ⁇ o's modified Eagle's medium
- test compounds concentrations of the test compounds. All compounds were dissolved in absolute ethanol, diluted with sterile filtered normal saline and added to the medium so that the final ethanol control cultures were
- Pulse-labeling of the cultures consisted of collecting the conditioned, drug-treated or control containing media, then adding 1 ⁇ Ci/ml [ 3 H]-TdR and incubating the cultures in the [ 3 H]- TdR containing medium for 5 hours. The cells were then washed with phosphate buffered saline and fixed with 6%
- TCA trichloroacetic acid
- the cells were scraped from the culture wells and transferred to tubes. Each well was rinsed with 6% TCA and the rinse was added to the appropriate tubes. After centrifugation at 2800 RPM for 20 minutes at room temperature, an aliquot of the supernatant containing unincorporated [ 3 H]-TdR (SI) was transferred to scintillation tubes. Radioactivity was measured by liquid-scintillation counting using Beckman HP cocktail. The remainder SI supernatant was decanted and 3% perchloric acid (PCA) was added to the cell pellet. The DNA was denatured by placing the tubes in heating blocks at 95°C for 20 minutes,
- Table 2 shows the observed CPM (counts per minute) obtained in the assay with the vehicle (control) and with several concentrations of Compound 5. Table 2 also shows the percentage of labeled thymidine incorporation (as measured by CPM) in the samples containing the test compound, as compared to the
- the compounds of the invention can be made by a number of different synthetic chemical pathways. To illustrate the invention, the following detailed
- the aldehyde function of Compound 10 is protected as an acetal by reaction with ethyleneglycol in the presence of acid.
- the resulting acetal (Compound 11) is reacted with an aldehyde of the formula R 3 -CHO in the presence of strong base (such as tertiary butyl lithium), and the resulting secondary alcohol is acetylated to provide a compound of Formula 4.
- the R 3 - group of the aldehyde reagent R 3 -CHO is defined as in connection with Formula 1.
- the acetal blocking group is removed, by treatment with acid, from the 5 carboxaldehyde function of the compound of Formula 4, to yield a compound of Formula 5.
- the compound of Formula 5 has a free aldehyde group which is reacted with a Wittig reagent of Formula 6.
- m' of Formula 6 is defined as an integer having the values of 1 to 7, and for this reason compounds of Formula 1 where m is between 2 to 8 can be prepared in accordance with the procedure shown in Reaction Scheme 1.
- the Wittig reagent of Formula 6 can be prepared in accordance with synthetic procedures known in the art, for example from the brominated carboxylic acid ester, of the formula Br(CH 2 ) m ,COOEt.
- the Wittig reagent of Formula 6 where m' is 3, can be prepared substantially in accordance with the procedure described by Wernic at al. in Journal of Org. Chem., 1989, Volume 54, 4224 - 4228 at page 4226.
- the olephinic product of the Wittig reaction between compounds of Formula 5 and Formula 6 is thereafter hydrogenated to yield a compound of Formula 7.
- Formula 7 depicts compounds of Formula 1, where the R 2 group is acetyl (COCH 3 ) and R 1 is ethyl carboxylate (CO 2 Et).
- the compounds of Formula 7 can be converted to further compounds of Formula 1, such as into the compounds of Formula 8 where R 2 is H and R 1 is CO 2 H, obtainable by saponification, compounds of Formula 9 where R 2 is H and R 1 is CH 2 OH, obtainable by reduction with lithium borohydride, and compounds of Formula 10 where R 2 is H and R 1 is methyl (or other alkyl), obtainable by saponification and trans-esterification.
- ester functionality of the compounds of Formula 7 can be converted to the amide, sulfonamide, aldehyde, ketone, acetal, ketal, and amino functionalities set forth in connection with Formula l by reactions which are per se well known to the
- the aldehyde group of Compound 30 is protected by reaction with ethylene glycol to obtain the acetal (1,3-dioxolane) derivative Compound 31 .
- Compound 31 is reacted with an aldehyde of the formula R 3 -CHO in the presence of strong base such as tertiary butyl lithium.
- the secondary hydroxyl group which is obtained as a result of reaction with the aldehyde is protected by a suitable base-stable protective group, such as the tertiary butyl-diphenylsilyl group, to yield the compound of Formula 11.
- olephinic compound is hydrogenated and the t-butyl-diphenylsilyl blocking group is removed for example by treatment with tetrabutylammonium fluoride in tetrahydrofuran, to yield compounds of Formula 12.
- compounds of Formula 12 are such compounds of Formula 1 where the R 1 group is
- 1,3-Benzodioxole-6-bromo-5-carboxaldehyde (Compound 10) To a solution of 1,3-benzodioxole-5-carboxaldehyde (piperonal, Aldrich, 30 g., 0.20 mol) in glacial acetic acid (60 mL) was added a solution of bromine (12.0 mL, 0.23 mol) in HOAc (37.5 mL). The resultant solution was stirred for 16 hours and poured into H 2 O (1500 mL). The precipitate was removed by vacuum filtration and washed with 0.2N aqueous sodium thiosulfate followed by ice-cold Et 2 O. The white solid was dissolved in MeOH with heating and upon allowing to cool to 23°C white needles crystallized. The crystals were collected by vacuum filtration to give 22.4 g (49%) of the title compound.
- the crude olephinic product (200 mg, 0.512 mmol) was hydrogenated in EtOAc in the presence of 10 % palladium on carbon catalyst substantially in
- Lithium hydroxide (0.48 mL of a 0.5N aqueous solution, 0.240 mmol) was added to a solution of ( ⁇ )-ethyl 5-[2-(1-hydroxy)hexyl-4,5-dimethoxyphenyl]-1-pentanoate (Compound 34, 44 mg, 0.120 mmol) in THF (0.96 mL) at 23°C. After 16 hours the reaction was acidified with 10% citric acid and extracted with
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Abstract
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Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69427228T DE69427228T2 (en) | 1993-04-21 | 1994-04-18 | NEW 1,3-BENZODIOXOL AND 1,2-DIALKOXYBENZOL DERIVATIVES AS EYE PRESSURING AGENTS |
EP94915817A EP0695300B1 (en) | 1993-04-21 | 1994-04-18 | Novel 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
AU67700/94A AU679749B2 (en) | 1993-04-21 | 1994-04-18 | Novel 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
AT94915817T ATE201205T1 (en) | 1993-04-21 | 1994-04-18 | NEW 1,3-BENZODIOXOLE AND 1,2-DIALKOXYBENZENE DERIVATIVES AS EYE PRESSURE-LOWERING AGENTS |
JP52351894A JP3989950B2 (en) | 1993-04-21 | 1994-04-18 | Novel 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as intraocular pressure-lowering agents |
CA002160712A CA2160712C (en) | 1993-04-21 | 1994-04-18 | Novel 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/051,104 | 1993-04-21 | ||
US08/051,104 US5369127A (en) | 1993-04-21 | 1993-04-21 | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
Publications (1)
Publication Number | Publication Date |
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WO1994024121A1 true WO1994024121A1 (en) | 1994-10-27 |
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ID=21969369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/US1994/004240 WO1994024121A1 (en) | 1993-04-21 | 1994-04-18 | Novel 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
Country Status (10)
Country | Link |
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US (6) | US5369127A (en) |
EP (1) | EP0695300B1 (en) |
JP (1) | JP3989950B2 (en) |
AT (1) | ATE201205T1 (en) |
AU (2) | AU679749B2 (en) |
CA (1) | CA2160712C (en) |
DE (1) | DE69427228T2 (en) |
ES (1) | ES2156151T3 (en) |
HU (1) | HUT73416A (en) |
WO (1) | WO1994024121A1 (en) |
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WO2001005388A2 (en) * | 1999-07-14 | 2001-01-25 | Sucampo, A.G. | Use of a fatty derivative for the treatment of external secretiondisorders |
WO2006062839A1 (en) * | 2004-12-08 | 2006-06-15 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
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US5710288A (en) * | 1993-04-21 | 1998-01-20 | Allergan | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
US5369127A (en) * | 1993-04-21 | 1994-11-29 | Allergan, Inc. | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
US5633218A (en) * | 1995-05-24 | 1997-05-27 | E. I. Du Pont De Nemours And Company | Herbicidal benzodioxoles and benzodioxanes |
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AR029001A1 (en) * | 1999-08-23 | 2003-06-04 | Smithkline Beecham Corp | DERIVATIVES OF BENCIL-3,4-METHYLENDIOXYCHINAMIC AND THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT |
AU6925500A (en) * | 1999-08-23 | 2001-03-19 | Smithkline Beecham Corporation | Fatty acid synthase inhibitors |
WO2001034552A2 (en) | 1999-11-09 | 2001-05-17 | Alcon Universal Ltd. | Benzenoid derivatives of 15-hydroxyeicosatetraenoic acid and methods of their use in treating dry eye disorders |
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US5151440A (en) * | 1990-02-28 | 1992-09-29 | Allergan, Inc. | Method for reducing or maintaining intraocular pressure in the mammalian eye by administering pharmaceutical compositions containing 2-(2-alkylphenylamino)-oxazolines, 2-(2-alkylphenyl-amino)-thiazolines and 2-(2-alkylphenylamino)-imidazolines |
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US5530028A (en) * | 1992-11-23 | 1996-06-25 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-diacylhydrazines |
WO1994002474A1 (en) * | 1992-07-17 | 1994-02-03 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
US5369127A (en) * | 1993-04-21 | 1994-11-29 | Allergan, Inc. | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
-
1993
- 1993-04-21 US US08/051,104 patent/US5369127A/en not_active Expired - Fee Related
-
1994
- 1994-04-18 WO PCT/US1994/004240 patent/WO1994024121A1/en active IP Right Grant
- 1994-04-18 HU HU9502004A patent/HUT73416A/en unknown
- 1994-04-18 EP EP94915817A patent/EP0695300B1/en not_active Expired - Lifetime
- 1994-04-18 AT AT94915817T patent/ATE201205T1/en not_active IP Right Cessation
- 1994-04-18 DE DE69427228T patent/DE69427228T2/en not_active Expired - Fee Related
- 1994-04-18 CA CA002160712A patent/CA2160712C/en not_active Expired - Fee Related
- 1994-04-18 JP JP52351894A patent/JP3989950B2/en not_active Expired - Fee Related
- 1994-04-18 ES ES94915817T patent/ES2156151T3/en not_active Expired - Lifetime
- 1994-04-18 AU AU67700/94A patent/AU679749B2/en not_active Ceased
- 1994-11-28 US US08/345,176 patent/US5523296A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/485,521 patent/US5654329A/en not_active Expired - Fee Related
-
1996
- 1996-02-27 US US08/607,736 patent/US5714621A/en not_active Expired - Lifetime
-
1997
- 1997-05-01 AU AU19986/97A patent/AU695059B2/en not_active Ceased
- 1997-11-21 US US08/975,812 patent/US5814657A/en not_active Expired - Lifetime
-
1998
- 1998-06-09 US US09/094,269 patent/US5874460A/en not_active Expired - Lifetime
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DE3218048A1 (en) * | 1981-05-13 | 1983-01-05 | Ferrer Internacional S.A., Barcelona | Cyclic alpha -amino derivatives of 1-(3',4'-methylenedioxyphenyl)-ethanol, a process for their preparation and medicaments containing them |
EP0292230A2 (en) * | 1987-05-18 | 1988-11-23 | Ajinomoto Co., Inc. | Phenylacetic acid derivatives and their use in the preparation of cephalosporin antibiotics |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001005388A2 (en) * | 1999-07-14 | 2001-01-25 | Sucampo, A.G. | Use of a fatty derivative for the treatment of external secretiondisorders |
WO2001005388A3 (en) * | 1999-07-14 | 2002-05-10 | Sucampo Ag | Use of a fatty derivative for the treatment of external secretiondisorders |
US6566398B1 (en) | 1999-07-14 | 2003-05-20 | R-Tech Ueno, Ltd. | Method for treatment of external secretion disorders |
US7396946B2 (en) | 1999-07-14 | 2008-07-08 | Sucampo Ag | Compound for treatment of external secretion disorders |
WO2006062839A1 (en) * | 2004-12-08 | 2006-06-15 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
US7425572B2 (en) | 2004-12-08 | 2008-09-16 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
Also Published As
Publication number | Publication date |
---|---|
JPH08509225A (en) | 1996-10-01 |
US5814657A (en) | 1998-09-29 |
ATE201205T1 (en) | 2001-06-15 |
DE69427228D1 (en) | 2001-06-21 |
ES2156151T3 (en) | 2001-06-16 |
US5714621A (en) | 1998-02-03 |
AU695059B2 (en) | 1998-08-06 |
US5654329A (en) | 1997-08-05 |
AU679749B2 (en) | 1997-07-10 |
EP0695300A1 (en) | 1996-02-07 |
AU1998697A (en) | 1997-07-31 |
CA2160712C (en) | 2005-12-27 |
HUT73416A (en) | 1996-07-29 |
EP0695300B1 (en) | 2001-05-16 |
AU6770094A (en) | 1994-11-08 |
HU9502004D0 (en) | 1995-09-28 |
CA2160712A1 (en) | 1994-10-27 |
US5523296A (en) | 1996-06-04 |
DE69427228T2 (en) | 2001-08-30 |
US5369127A (en) | 1994-11-29 |
JP3989950B2 (en) | 2007-10-10 |
US5874460A (en) | 1999-02-23 |
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