WO1994020105A1 - Interleukin-1 inhibitor - Google Patents
Interleukin-1 inhibitor Download PDFInfo
- Publication number
- WO1994020105A1 WO1994020105A1 PCT/JP1994/000266 JP9400266W WO9420105A1 WO 1994020105 A1 WO1994020105 A1 WO 1994020105A1 JP 9400266 W JP9400266 W JP 9400266W WO 9420105 A1 WO9420105 A1 WO 9420105A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diseases
- interleukin
- methyl
- dihydro
- alkyl group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU60461/94A AU676267B2 (en) | 1993-03-10 | 1994-02-22 | Interleukin-1 inhibitor |
DK94907087T DK0688218T3 (en) | 1993-03-10 | 1994-02-22 | Interleukin-1 inhibitor |
EP94907087A EP0688218B1 (en) | 1993-03-10 | 1994-02-22 | Interleukin-1 inhibitor |
KR1019950703767A KR100191943B1 (en) | 1993-03-10 | 1994-02-22 | Interleukin-1 inhibitor |
DE69421694T DE69421694T2 (en) | 1993-03-10 | 1994-02-22 | INTERLEUKIN-1 INHIBITOR |
US08/523,810 US6034100A (en) | 1993-03-10 | 1995-09-05 | Method for inhibiting cytokine secretion |
GR20000400186T GR3032492T3 (en) | 1993-03-10 | 2000-01-27 | Interleukin-1 inhibitor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5/48501 | 1993-03-10 | ||
JP4850193 | 1993-03-10 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/523,810 Continuation-In-Part US6034100A (en) | 1993-03-10 | 1995-09-05 | Method for inhibiting cytokine secretion |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994020105A1 true WO1994020105A1 (en) | 1994-09-15 |
Family
ID=12805138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1994/000266 WO1994020105A1 (en) | 1993-03-10 | 1994-02-22 | Interleukin-1 inhibitor |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0688218B1 (en) |
KR (1) | KR100191943B1 (en) |
CN (1) | CN1088586C (en) |
AT (1) | ATE186642T1 (en) |
AU (1) | AU676267B2 (en) |
DE (1) | DE69421694T2 (en) |
DK (1) | DK0688218T3 (en) |
ES (1) | ES2140531T3 (en) |
GR (1) | GR3032492T3 (en) |
TW (1) | TW244336B (en) |
WO (1) | WO1994020105A1 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002013830A1 (en) * | 2000-08-14 | 2002-02-21 | Senju Pharmaceutical Co., Ltd. | Cytokine production inhibitors |
US6514986B2 (en) | 2000-11-22 | 2003-02-04 | Wockhardt Limited | Chiral fluoroquinolone arginine salt forms |
US6608078B2 (en) | 2000-05-08 | 2003-08-19 | Wockhardt Limited | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
US6664267B1 (en) | 2002-05-28 | 2003-12-16 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
US6750224B1 (en) | 1999-05-07 | 2004-06-15 | Wockhardt Limited | Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment |
US6878713B2 (en) | 2001-04-25 | 2005-04-12 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US6964966B2 (en) | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US7098219B2 (en) | 2000-08-01 | 2006-08-29 | Wockhart Limited | Inhibitors of cellular efflux pumps of microbes |
US7164023B2 (en) | 2003-09-04 | 2007-01-16 | Wockhardt Limited | Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399134A (en) * | 1980-11-10 | 1983-08-16 | Otsuka Pharmaceutical Co., Ltd. | Pyrroloquinoline and benzoquinolizine compounds and antimicrobial compositions |
JPS5995220A (en) * | 1982-11-22 | 1984-06-01 | Ajinomoto Co Inc | Immunotherapeutic agent |
EP0287951A2 (en) * | 1987-04-16 | 1988-10-26 | Otsuka Pharmaceutical Co., Ltd. | 7-Piperazinyl- or 7-Morpholino-4-oxo-quinoline-3-carboxylic acid derivatives, their preparation and their use as antimicrobial agents |
US4894374A (en) * | 1988-08-17 | 1990-01-16 | American Home Products Corporation | Substituted 1,2-dihydro-4h-3,1-benzoxazin-4-one derivatives inhibitors of interleukin 1 |
WO1991007401A1 (en) * | 1989-11-13 | 1991-05-30 | Schering Corporation | 3-substituted-1-(aryl or arylalkyl)-2(1h)-quinolinones |
-
1994
- 1994-02-22 AT AT94907087T patent/ATE186642T1/en active
- 1994-02-22 KR KR1019950703767A patent/KR100191943B1/en not_active IP Right Cessation
- 1994-02-22 DE DE69421694T patent/DE69421694T2/en not_active Expired - Lifetime
- 1994-02-22 WO PCT/JP1994/000266 patent/WO1994020105A1/en active IP Right Grant
- 1994-02-22 ES ES94907087T patent/ES2140531T3/en not_active Expired - Lifetime
- 1994-02-22 EP EP94907087A patent/EP0688218B1/en not_active Expired - Lifetime
- 1994-02-22 DK DK94907087T patent/DK0688218T3/en active
- 1994-02-22 CN CN94191407A patent/CN1088586C/en not_active Expired - Lifetime
- 1994-02-22 AU AU60461/94A patent/AU676267B2/en not_active Expired
- 1994-02-23 TW TW083101544A patent/TW244336B/zh not_active IP Right Cessation
-
2000
- 2000-01-27 GR GR20000400186T patent/GR3032492T3/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399134A (en) * | 1980-11-10 | 1983-08-16 | Otsuka Pharmaceutical Co., Ltd. | Pyrroloquinoline and benzoquinolizine compounds and antimicrobial compositions |
JPS5995220A (en) * | 1982-11-22 | 1984-06-01 | Ajinomoto Co Inc | Immunotherapeutic agent |
EP0287951A2 (en) * | 1987-04-16 | 1988-10-26 | Otsuka Pharmaceutical Co., Ltd. | 7-Piperazinyl- or 7-Morpholino-4-oxo-quinoline-3-carboxylic acid derivatives, their preparation and their use as antimicrobial agents |
US4894374A (en) * | 1988-08-17 | 1990-01-16 | American Home Products Corporation | Substituted 1,2-dihydro-4h-3,1-benzoxazin-4-one derivatives inhibitors of interleukin 1 |
WO1991007401A1 (en) * | 1989-11-13 | 1991-05-30 | Schering Corporation | 3-substituted-1-(aryl or arylalkyl)-2(1h)-quinolinones |
Non-Patent Citations (1)
Title |
---|
DATABASE WPI Derwent World Patents Index; AN 84-173727 * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6750224B1 (en) | 1999-05-07 | 2004-06-15 | Wockhardt Limited | Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment |
US6753333B2 (en) | 1999-12-14 | 2004-06-22 | Wockhardt Limited | Chiral fluoroquinolone arginine salt forms |
US6608078B2 (en) | 2000-05-08 | 2003-08-19 | Wockhardt Limited | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
US7098219B2 (en) | 2000-08-01 | 2006-08-29 | Wockhart Limited | Inhibitors of cellular efflux pumps of microbes |
WO2002013830A1 (en) * | 2000-08-14 | 2002-02-21 | Senju Pharmaceutical Co., Ltd. | Cytokine production inhibitors |
US6514986B2 (en) | 2000-11-22 | 2003-02-04 | Wockhardt Limited | Chiral fluoroquinolone arginine salt forms |
US7393957B2 (en) | 2001-04-25 | 2008-07-01 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US6878713B2 (en) | 2001-04-25 | 2005-04-12 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US6964966B2 (en) | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US7626032B2 (en) | 2001-04-25 | 2009-12-01 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US6664267B1 (en) | 2002-05-28 | 2003-12-16 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
US7132541B2 (en) | 2002-05-28 | 2006-11-07 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
US7164023B2 (en) | 2003-09-04 | 2007-01-16 | Wockhardt Limited | Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate |
Also Published As
Publication number | Publication date |
---|---|
EP0688218A1 (en) | 1995-12-27 |
DK0688218T3 (en) | 2000-03-13 |
CN1088586C (en) | 2002-08-07 |
ATE186642T1 (en) | 1999-12-15 |
EP0688218B1 (en) | 1999-11-17 |
DE69421694D1 (en) | 1999-12-23 |
AU6046194A (en) | 1994-09-26 |
DE69421694T2 (en) | 2000-05-25 |
TW244336B (en) | 1995-04-01 |
GR3032492T3 (en) | 2000-05-31 |
AU676267B2 (en) | 1997-03-06 |
KR100191943B1 (en) | 1999-06-15 |
ES2140531T3 (en) | 2000-03-01 |
CN1118991A (en) | 1996-03-20 |
KR960700720A (en) | 1996-02-24 |
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