WO1994018860A1 - Method and apparatus for controlling the supply of energy to a heating load in a smoking article - Google Patents

Method and apparatus for controlling the supply of energy to a heating load in a smoking article Download PDF

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Publication number
WO1994018860A1
WO1994018860A1 PCT/US1994/002256 US9402256W WO9418860A1 WO 1994018860 A1 WO1994018860 A1 WO 1994018860A1 US 9402256 W US9402256 W US 9402256W WO 9418860 A1 WO9418860 A1 WO 9418860A1
Authority
WO
WIPO (PCT)
Prior art keywords
energy
heating load
microcontroller
puff
smoking article
Prior art date
Application number
PCT/US1994/002256
Other languages
French (fr)
Other versions
WO1994018860B1 (en
Inventor
Hugh J. Mccafferty
Charles T. Higgins
William L. Lucas, Sr.
Original Assignee
Philip Morris Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philip Morris Products Inc. filed Critical Philip Morris Products Inc.
Priority to EP94910213A priority Critical patent/EP0637212B1/en
Priority to DE69420344T priority patent/DE69420344T2/en
Priority to KR1019940703692A priority patent/KR100286488B1/en
Priority to JP51934894A priority patent/JP3696619B2/en
Priority to AU62750/94A priority patent/AU677642B2/en
Priority to CA002134122A priority patent/CA2134122C/en
Publication of WO1994018860A1 publication Critical patent/WO1994018860A1/en
Priority to NO944048A priority patent/NO944048L/en
Publication of WO1994018860B1 publication Critical patent/WO1994018860B1/en

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Classifications

    • AHUMAN NECESSITIES
    • A24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24FSMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/50Control or monitoring
    • A24F40/53Monitoring, e.g. fault detection
    • AHUMAN NECESSITIES
    • A24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24FSMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/50Control or monitoring
    • A24F40/51Arrangement of sensors
    • AHUMAN NECESSITIES
    • A24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24FSMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/60Devices with integrated user interfaces
    • AHUMAN NECESSITIES
    • A24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24FSMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/20Devices using solid inhalable precursors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/13General characteristics of the apparatus with means for the detection of operative contact with patient, e.g. lip sensor

Definitions

  • a smoking article is a device in which a flavor generating material, such as tobacco or a tobacco-derived substance, is heated in order to release flavorants.
  • a flavor generating material such as tobacco or a tobacco-derived substance
  • One type of smoking article is described in commonly assigned United States Patent No. 5,060,671, which is hereby incorporated by reference in its entirety. That patent describes an electrically heated smoking article that uses a disposable array of electrical heating elements. Each heating element has an individual charge of tobacco flavor generating material deposited thereon. The disposable array is easily mated to the "permanent" portion of the smoking article, which contains a power supply, such as a battery, and control circuitry.
  • a power supply such as a battery
  • control circuitry should be provided for selecting which of the heating elements in the array will be energized for a particular puff. If the smoker is required to manually select the particular element to be heated, the enjoyment associated with using a smoking article may be diminished. Further ⁇ more, the control circuitry should be capable of preventing repeated actuation of any one heating element, to avoid re-heating of a charge of tobacco flavor generating material and consequent generation of undesirable compounds which may have an adverse impact on flavor.
  • the control circuitry in a smoking article should also be capable of regulating the power deliv ⁇ ered to each heating element to ensure that a suffi ⁇ cient amount of energy is transferred to the tobacco flavor generating material, so that a consistent aerosol or vapor is generated for each puff.
  • the power source of such smoking articles typically a battery or a series of batteries
  • Smoking articles are typically small, hand ⁇ held devices that are carried by the smoker, and the power supply in such devices (i.e., the batteries) have limited storage capacity.
  • the control circuitry for an electrically powered smoking article should not excessively consume the limited power resources.
  • the control circuitry should be capable of informing the smoker when the power supply is no longer able to deliver enough energy fast enough during a puff to provide an acceptable aerosol or vapor.
  • an apparatus for controlling delivery of energy from a power supply to a heating load array in a smoking article.
  • the apparatus includes a puff sensor for sensing when a smoker draws a puff from the smoking article and a switch for coupling a selected heating element in the load array to the power supply.
  • the apparatus further includes means for measuring the amount of energy delivered to the selected heating element, and a microcontroller for closing the switch associated with the selected heating element to connect the selected heating element to the power supply when the puff sensor senses a puff.
  • the microcontroller opens the switch associated with the selected heating element to disconnect the selected heating element from the power supply when a predetermined amount of energy has been delivered to the selected heating element.
  • FIG. 1 is a schematic block diagram of a control circuit for an electrically heated smoking article in accordance with the principles of the present inven ⁇ tion;
  • FIGS. 2a-2d show a flowchart for a program for the microcontroller of the control circuit shown in FIG. 1.
  • control apparatus 100 for an electrically powered smoking article in accordance with the principles of the present invention is described.
  • Apparatus 100 serves several functions with respect to the smoking article it is intended to control. First, apparatus
  • apparatus 100 applies current to the selected heating element 101 in load array 102 for a period of time that is long enough to produce an acceptable aerosol or vapor for an average puff.
  • apparatus 100 provides the smoker with information regarding the status of the smoking article. Such information may include the number of puffs remaining, whether the power source has discharged to an unacceptable level, and whether load array 102 is present in the article.
  • Apparatus 100 comprises microcontroller 106, switch array 108 and puff sensor 110. Broadly, appa ⁇ ratus 100 remains in a power saving mode until a smoker inhales through the mouthpiece of the smoking article. Puff sensor 110 senses the inhalation, and informs microcontroller 106 that a puff is in progress. Microcontroller 106, after performing various tests described below, closes an element of switch array 108 to apply power to a selected one of heating elements 101 of load array 102 from power supply 112. As the selected one of heating elements 101 of load array 102 heats, the tobacco flavor generating material deposited thereon generates a flavored vapor or aerosol for the smoker to inhale.
  • Microcontroller 106 monitors the power delivered to the selected one of heating elements 101 (which has a known nominal resistance and known resistance-temperature coefficient) by receiving a signal on A/D input line 114, representative of the voltage of power supply 112, into analog-to-digital converter input 116. When a predetermined amount of energy has been delivered to the selected one of heating elements 101 of load array 102, microcontroller 106 ceases power delivery.
  • load array 102 has eight heating elements 101, although other load configurations may be used in accordance with the principles of the present invention.
  • each heating element 101 of load array 102 is used only once.
  • microcontroller 106 repeats the above-described process of causing a predetermined amount of energy to be supplied to the next sequential one of heating elements 101 (as programmatically defined) in load array 102, until all eight heating elements 101 have been used.
  • the smoker discards the spent load array 102 and may install a new load array 102, whereupon the se ⁇ quence may be repeated.
  • microcontroller 106 is preferably one such as a 68HC805B6 microcontroller available commercially from Motorola Incorporated of Phoenix, Arizona, which can be programmed to operate in a fast, slow or stop mode. In slow mode, microcontroller 106 operates approximately l/16th as fast and consumes approximately l/16th the power of fast mode. In stop mode, it consumes even less power.
  • microcon ⁇ troller 106 stops it can be restarted by an external interrupt via interrupt line 118 or by a power-on reset. When microcontroller 106 restarts, it auto ⁇ matically enters fast mode. Accordingly, after any restart, software (described below) immediately returns microcontroller 106 to slow mode.
  • Power consumption is further minimized in appa- ratus 100 by deriving the power for auxiliary circuits, such as puff sensor 110 and voltage reference 122, from output ports of microcontroller 106.
  • auxiliary circuits such as puff sensor 110 and voltage reference 122
  • puff sensor enable line 124 drives puff sensor 110
  • Voltage reference enable line 126 drives voltage reference 122.
  • apparatus 100 is constructed to operate in one of two modes, smoking mode and dormant mode.
  • apparatus 100 enters dormant mode if there is no load array 102 present in the smoking article, if load array 102 has been expended, if the smoking session has extended beyond a predetermined period of time (e.g., fifteen minutes) , or if power supply 112 has discharged to an unacceptable level.
  • a predetermined period of time e.g., fifteen minutes
  • power supply 112 has discharged to an unacceptable level.
  • dormant mode puff sensor 110, oscillator 120 and voltage reference 122 are disabled, wake-up logic 130 is enabled via wake-up logic enable line 132 and microcontroller 106 is in stop mode.
  • apparatus 100 draws a minimum amount of current from power supply 112.
  • the dormant mode of apparatus 100 can only be interrupted by the insertion of load array 102.
  • load array 102 When load array 102 is inserted, a voltage appears between resistors 134 and 136, which serves as a logic signal to enable wake-up logic 130, which in turn generates an interrupt on interrupt line 118.
  • This interrupt causes apparatus 100 to "awaken” and enter smoking mode for fifteen minutes, unless eight puffs occur sooner.
  • microcontroller 106 remains in stop mode as often as possible during smoking mode, and the auxiliary circuits are activated on an as-needed basis.
  • wake-up logic 130 is disabled, and oscillator 120 (which has a period of approximately 10 ms) is started. Every 10 ms, oscilla ⁇ tor 120 sends an interrupt to microcontroller 106 via interrupt line 118, which causes microcontroller 106 to enter fast mode, which is immediately stepped down to slow mode.
  • microcontroller 106 While operating in slow mode, microcontroller 106 periodically checks for the presence of load array 102, in order to ensure that the smoker has not removed it after apparatus 100 has entered smoking mode.
  • This check is performed by measuring the voltage between resistors 136 and 142, the resistances of which are selected so that the maximum voltage that appears between them when load array 102 is inserted is within the range allowed by voltage reference 122. This voltage is supplied to another analog-to-digital converter input 138 of microcontroller 106 via A/D input line 140. If no load array 102 is present, microcontroller 106 enters the dormant mode.
  • puff sensor 110 is enabled if load array 102 is present in the article.
  • puff sensor 110 may include a lip pressure sensor that senses the pressure of the lips of the smoker on the mouthpiece of the smoking article.
  • puff sensor 110 may include an air flow sensor that senses airflow through the smoking article.
  • puff sensor 110 includes an air pressure sensor that senses a drop in air pressure caused by the flow of air through the smoking article.
  • puff sensor 110 preferably includes a piezoresistive pressure transducer, such as the type NPH-5-002.5G NOVA sensor available from Lucas- Nova of Freemont, California, or a type QLT004D sensor, available from SenSym Incorporated of Sunnyvale, California.
  • a piezoresistive pressure transducer such as the type NPH-5-002.5G NOVA sensor available from Lucas- Nova of Freemont, California, or a type QLT004D sensor, available from SenSym Incorporated of Sunnyvale, California.
  • Puff sensor 110 identifies when the smoker draws a puff from the smoking article by sending a signal to microcontroller 106.
  • Microcontroller 106 debounces the puff sensor signal by requiring the signal to be present for five consecutive readings in each of three consecutive 10 ms windows to be deemed a true puff. If no true puff is detected, microcontroller 106 switches off puff sensor 110 and enters stop mode, subject to the next interrupt from oscillator 120.
  • microcontroller 106 remains in slow mode oscillator 120 and puff sensor 110 are disabled, and voltage reference 122 is enabled. Voltage reference 122 defines the resolution of the analog-to-digital converter built into microcontroller 106.
  • a timer internal to microcontroller 106 replaces oscillator 120 as the timing source.
  • the internal clock is generally consid- ered more accurate, and is also set for 10 ms.
  • microcon ⁇ troller 106 In response to a detected true puff, microcon ⁇ troller 106 enables a selected switch of switch array 108, so that power is supplied from power supply 112 to the corresponding heating element 101 in load array 102. A predetermined fraction of the voltage that is applied to the selected heating element 101, which appears between resistors 144 and 146, is supplied to analog-to-digital input 116 via A/D input line 114. The resistance values of resistors 144 and 146 are selected so that the maximum voltage that appears between them is within the range allowed by voltage reference 122. Thus, microcontroller 106 receives a signal indicative of the voltage supplied to the selected heating element 101.
  • Microcontroller 106 causes power supply 112 to supply a predetermined amount of energy to the load over a predetermined time, to heat the load to a predetermined temperature in order to generate an acceptable aerosol which may be inhaled by the smoker.
  • Energy delivered to the selected one of heating elements 101 in load array 102 is calculated by moni ⁇ toring the power delivered over a period of time.
  • power is supplied to the load continuously from the beginning of a puff and the energy delivered to the load is measured until a predetermined total has been delivered.
  • the estimated puff time (e.g., one second) is divided into a number of intervals, for example ten.
  • Power is supplied and energy measured during each interval until the correct proportional amount of energy has been delivered for that interval - - e.g., one tenth of the total. Power is turned off after the appropriate amount of energy has been deliv ⁇ ered during an interval, until the start of the next interval.
  • the energy measurement method of the present invention provides a means for monitoring changes in the amount of energy stored in power supply 112. If power supply 112 cannot deliver the required amount of energy within the predetermined period of time, the batteries are no longer useful and must be recharged or replaced. When this condition arises, apparatus 100 enters dormant mode.
  • microcontroller 106 After the appropriate amount energy for a puff has been delivered, microcontroller 106 disables voltage reference 122 and enters stop mode. After all heating elements 101 of load array 102 have been energized, apparatus 100 enters dormant mode. When a spent load array 102 is disconnected, microcontroller 106 will be susceptible to noise which may be interpreted by microcontroller 106 as an interrupt from wake-up logic 130 to enter smoking mode. However, when A/D input line 140 is checked for the presence of load array 102 and it is not found, microcontroller 106 will immedi- ately reenter dormant mode until load array 102 is connected.
  • Apparatus 100 preferably includes display 104 coupled to microcontroller 106.
  • display 104 is a liquid crystal display that may be used to display information relating to the state of load array 102, or other information that may be useful in the operation of the smoking article.
  • display 104 may be used to inform the consumer of the number of puffs remaining, the presence or absence of load array 102, or that power supply 112 has discharged to an unacceptable level.
  • FIGS. 2a-2d a flowchart illus ⁇ trating preferred software for microcontroller 106 is described, as it may be implemented in suitable microcode or any higher level computing language.
  • the main program begins at start 200, which is followed by step 202 at which oscillator 120 is start ⁇ ed.
  • microcontroller 106 enters stop mode, where it waits subject to an interrupt from oscillator 120.
  • interrupt service routine 300 described in connection with FIG. 2b, is executed.
  • interrupt service routine 300 services interrupts generated either by oscillator 120 or wake-up logic 130.
  • microcontroller 106 steps down from fast mode (which it automatically enters after being awakened from stop mode) and enters slow mode.
  • the program checks to see if wake-up logic 130 was enabled. If wake-up logic 130 was enabled, it indicates that interrupt service routine 300 is servicing an interrupt generated by wake-up logic 130, which means that apparatus 100 was in dormant mode.
  • wake- up logic 130 is disabled, and the program returns to dormant subroutine 400 (described below) . If wake-up logic 130 was not enabled at test 304, puff sensor 110 is enabled at step 308.
  • a determination is made as to whether a true puff was sensed by puff sensor 110.
  • Debouncing criteria require that puff sensor 110 detect a pressure drop for five consecutive readings in each of three consecutive executions of interrupt service routine 300. If a true puff is detected, a "puff sensed" flag is set at step 312. At step 314, puff sensor 110 is disabled, and control is then returned to the main program.
  • test 206 is performed after control is returned to the main program.
  • the program checks to see if load array 102 is connected to the article, if less than the maximum number of puffs have been taken (e.g., eight puffs), and if apparatus 100 has been in smoking mode for less than the maximum smoking mode duration (e.g., fifteen minutes) .
  • microcontroller 106 enables voltage reference 122, checks if the voltage between resistors 134 and 142 exceeds a threshold, and then disables voltage refer ⁇ ence 122.
  • dormant subroutine 400 is called at step 208 to cause apparatus 100 to enter dormant mode.
  • oscillator 120 is disabled at step 402, and then wake- up logic 130 is enabled at step 404.
  • microcontroller 106 enters stop mode, and waits subject to an interrupt, which under these conditions, is the result of insertion of load array 102.
  • interrupt service routine 300 executes steps 302, 304 and 306, described above, and then returns control to dormant subroutine 400, which in turn returns control to the main program.
  • step 208 the program loops back to step 202, which indicates the start of smoking mode caused by the insertion of load array 102. If all of the conditions of test 206 are met, test 210 is performed to determine if the "puff sensed" flag was set in interrupt service routine 300. If the flag was not set, the program loops back to step 204, to cause microcontroller 106 to enter stop mode until the next interrupt from oscillator 120 is re- ceived. Otherwise, oscillator 120 is disabled at step 212, then voltage reference 122 is enabled at step 214, and then at step 216, microcontroller 106 increments a variable that tracks the number of puffs taken. At step 218, power subroutine 500, described in connection with FIG. 2d, is called to control the supply of power to one of heating elements 101 in load array 102.
  • test 502 is performed to determine if energy has been supplied in all intervals of the current puff.
  • the puff length is estimated (e.g., one second), and the estimated puff length is divided into a number of intervals (e.g., ten inter- vals, each of 100 ms) .
  • the amount of energy required to generate an acceptable aerosol or vapor is propor ⁇ tioned among the intervals in substantially equal fractional amounts.
  • test 502 determines if all of the intervals have elapsed.
  • test 506 is performed to determine if the correct fractional amount of energy has been supplied to the selected heating element 101 during the current interval. If test 506 determines that an insufficient amount of energy has been delivered thus far during the current interval, test 514 is performed to determine if the current interval has elapsed before the appropriate amount of energy was supplied. If the current interval has not elapsed, the program loops back to test 506.
  • test 506 causes power subroutine 500 to branch to step 508, at which the appropriate switch of switch array 108 is disabled.
  • step 510 the program waits until the current interval has elapsed, in the likely event that the correct fractional amount of energy was supplied before the interval elapsed.
  • step 512 the current interval in incremented, and the program loops back to test 502 to begin power delivery during the next interval.
  • test 514 is executed many times within the test 506/514 loop to determine if the current interval has elapsed before the correct frac- tional amount of energy has been delivered.
  • an error condition is defined in step 516, to indicate that power supply 112 no longer has sufficient stored energy to be useful. After the error condition is defined, the program returns to the main menu.
  • the program returns from power subroutine 500 to step 220, at which the number of puffs remaining is displayed on display 104.
  • step 222 voltage reference 122 is disabled, and then test 224 is performed to determine if control was returned from power subroutine 500 with an error condition defined. If an error condition was not defined, the program loops back to step 202, to prepare for the next puff. Otherwise, an error symbol is displayed on display 104 at step 226, and the program loops back to step 208 to call dormant subroutine 400.
  • dormant mode the consumer may replace power supply 112, which will cause a power-on reset and execution of the main program beginning at start 200.

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  • Engineering & Computer Science (AREA)
  • Human Computer Interaction (AREA)
  • Control Of Resistance Heating (AREA)
  • Manufacturing Of Cigar And Cigarette Tobacco (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Catching Or Destruction (AREA)

Abstract

A method and an apparatus for controlling energy flow into a heating load array of a smoking article are provided. In response to a pressure drop in the mouthpiece of the smoking article, a selected load in the heating load array is switchably connected to a power supply. Energy delivered to the load is measured and the load is disconnected when a predetermined amount of energy has been delivered.

Description

METHOD AND APPARATUS FOR CONTROLLING
THE SUPPLY OF ENERGY TO A HEATING
LOAD IN A SMOKING ARTICLE
Background of the Invention
This invention relates to electrically powered smoking articles, and particularly to methods and apparatus for controlling the supply of energy to electrically powered smoking articles. A smoking article is a device in which a flavor generating material, such as tobacco or a tobacco-derived substance, is heated in order to release flavorants. One type of smoking article is described in commonly assigned United States Patent No. 5,060,671, which is hereby incorporated by reference in its entirety. That patent describes an electrically heated smoking article that uses a disposable array of electrical heating elements. Each heating element has an individual charge of tobacco flavor generating material deposited thereon. The disposable array is easily mated to the "permanent" portion of the smoking article, which contains a power supply, such as a battery, and control circuitry. In such a device, an aerosol or vapor containing flavorants is generated as a result of a transfer of thermal energy from at least one, but less than all of the heating elements to the tobacco flavor generating material deposited thereon for each puff taken by the smoker.
In smoking articles which use an array of heating elements, control circuitry should be provided for selecting which of the heating elements in the array will be energized for a particular puff. If the smoker is required to manually select the particular element to be heated, the enjoyment associated with using a smoking article may be diminished. Further¬ more, the control circuitry should be capable of preventing repeated actuation of any one heating element, to avoid re-heating of a charge of tobacco flavor generating material and consequent generation of undesirable compounds which may have an adverse impact on flavor.
The control circuitry in a smoking article should also be capable of regulating the power deliv¬ ered to each heating element to ensure that a suffi¬ cient amount of energy is transferred to the tobacco flavor generating material, so that a consistent aerosol or vapor is generated for each puff. The power source of such smoking articles (typically a battery or a series of batteries) loses charge over time; there¬ fore, it may be necessary to energize the heating elements longer as the power supply ages, in order to deliver the same amount of energy as when the power supply was new, so as to achieve an acceptable aerosol or vapor.
Smoking articles are typically small, hand¬ held devices that are carried by the smoker, and the power supply in such devices (i.e., the batteries) have limited storage capacity. Thus, the control circuitry for an electrically powered smoking article should not excessively consume the limited power resources. Furthermore, the control circuitry should be capable of informing the smoker when the power supply is no longer able to deliver enough energy fast enough during a puff to provide an acceptable aerosol or vapor.
In view of the foregoing, it would be desirable to provide a method and an apparatus for controlling the delivery of energy to a heater array in a smoking article so that a predetermined amount of energy is delivered to individual heating elements in the heater array on demand.
It would also be desirable to provide a method and an apparatus for controlling the delivery of energy to a heater array in a smoking article which minimize the amount of energy required to control the heater array.
It would further be desirable to provide a method and an apparatus for controlling a heater array in a smoking article so that energy is automatically and sequentially delivered to unused heating elements on demand until all of the heating elements in the heater array have been powered.
It would still further be desirable to provide a method and an apparatus for controlling a heater array which automatically detect the presence of the heater array.
It would yet further be desirable to provide a method and an apparatus for controlling a heater array which notify the smoker when the power supply has discharged to an unacceptable level.
Summary of the Invention
It is an object of this invention to provide a method and an apparatus for controlling the delivery of energy to a heater array in a smoking article so that a predetermined amount of energy is delivered to individual heating elements in the heater array on demand.
It is also an object of this invention to provide a method and an apparatus for controlling the delivery of energy to a heater array in a smoking article which minimize the amount of energy required to control the heater array.
It is a further object of this invention to provide a method and an apparatus for controlling a heater array in a smoking article so that energy is automatically and sequentially delivered to unused heating elements on demand until all of the heating elements in the heater array have been powered. It is still a further object of this invention to provide a method and an apparatus for controlling a heater array which automatically detect the presence of the heater array. It is yet a further object of this invention to provide a method and an apparatus for controlling a heater array which notify the smoker when the power supply has discharged to an unacceptable level.
In accordance with this invention, there is pro- vided an apparatus for controlling delivery of energy from a power supply to a heating load array in a smoking article. The apparatus includes a puff sensor for sensing when a smoker draws a puff from the smoking article and a switch for coupling a selected heating element in the load array to the power supply. The apparatus further includes means for measuring the amount of energy delivered to the selected heating element, and a microcontroller for closing the switch associated with the selected heating element to connect the selected heating element to the power supply when the puff sensor senses a puff. The microcontroller opens the switch associated with the selected heating element to disconnect the selected heating element from the power supply when a predetermined amount of energy has been delivered to the selected heating element.
Brief Description of the Drawings
The above and other objects and advantages of this invention will be apparent upon consideration of the following detailed description, taken in conjunction with the accompanying drawings, in which like reference characters refer to like parts throughout and in which:
FIG. 1 is a schematic block diagram of a control circuit for an electrically heated smoking article in accordance with the principles of the present inven¬ tion; and
FIGS. 2a-2d show a flowchart for a program for the microcontroller of the control circuit shown in FIG. 1.
Detailed Description of the Invention
Referring to FIG. 1, an illustrative embodiment of control apparatus 100 for an electrically powered smoking article in accordance with the principles of the present invention is described. Apparatus 100 serves several functions with respect to the smoking article it is intended to control. First, apparatus
100 sequentially selects at least one heating element
101 in a load array 102 to energize each time the smoker draws a puff from the smoking article. Second, apparatus 100 applies current to the selected heating element 101 in load array 102 for a period of time that is long enough to produce an acceptable aerosol or vapor for an average puff. Third, apparatus 100 provides the smoker with information regarding the status of the smoking article. Such information may include the number of puffs remaining, whether the power source has discharged to an unacceptable level, and whether load array 102 is present in the article.
Apparatus 100 comprises microcontroller 106, switch array 108 and puff sensor 110. Broadly, appa¬ ratus 100 remains in a power saving mode until a smoker inhales through the mouthpiece of the smoking article. Puff sensor 110 senses the inhalation, and informs microcontroller 106 that a puff is in progress. Microcontroller 106, after performing various tests described below, closes an element of switch array 108 to apply power to a selected one of heating elements 101 of load array 102 from power supply 112. As the selected one of heating elements 101 of load array 102 heats, the tobacco flavor generating material deposited thereon generates a flavored vapor or aerosol for the smoker to inhale. Microcontroller 106 monitors the power delivered to the selected one of heating elements 101 (which has a known nominal resistance and known resistance-temperature coefficient) by receiving a signal on A/D input line 114, representative of the voltage of power supply 112, into analog-to-digital converter input 116. When a predetermined amount of energy has been delivered to the selected one of heating elements 101 of load array 102, microcontroller 106 ceases power delivery.
Typically, load array 102 has eight heating elements 101, although other load configurations may be used in accordance with the principles of the present invention. Preferably, each heating element 101 of load array 102 is used only once. With each puff, microcontroller 106 repeats the above-described process of causing a predetermined amount of energy to be supplied to the next sequential one of heating elements 101 (as programmatically defined) in load array 102, until all eight heating elements 101 have been used. After all heating elements 101 have been used, the smoker discards the spent load array 102 and may install a new load array 102, whereupon the se¬ quence may be repeated.
Because apparatus 100 is typically battery oper¬ ated, it should preferably use a minimum amount of energy. To accommodate the low power consumption requirement, microcontroller 106 is preferably one such as a 68HC805B6 microcontroller available commercially from Motorola Incorporated of Phoenix, Arizona, which can be programmed to operate in a fast, slow or stop mode. In slow mode, microcontroller 106 operates approximately l/16th as fast and consumes approximately l/16th the power of fast mode. In stop mode, it consumes even less power. Once microcon¬ troller 106 stops, it can be restarted by an external interrupt via interrupt line 118 or by a power-on reset. When microcontroller 106 restarts, it auto¬ matically enters fast mode. Accordingly, after any restart, software (described below) immediately returns microcontroller 106 to slow mode.
Power consumption is further minimized in appa- ratus 100 by deriving the power for auxiliary circuits, such as puff sensor 110 and voltage reference 122, from output ports of microcontroller 106. In a preferred embodiment, puff sensor enable line 124 drives puff sensor 110 and Voltage reference enable line 126 drives voltage reference 122.
To further minimize power consumption, apparatus 100 is constructed to operate in one of two modes, smoking mode and dormant mode. Preferably, apparatus 100 enters dormant mode if there is no load array 102 present in the smoking article, if load array 102 has been expended, if the smoking session has extended beyond a predetermined period of time (e.g., fifteen minutes) , or if power supply 112 has discharged to an unacceptable level. In dormant mode, puff sensor 110, oscillator 120 and voltage reference 122 are disabled, wake-up logic 130 is enabled via wake-up logic enable line 132 and microcontroller 106 is in stop mode. Thus, in dormant mode, apparatus 100 draws a minimum amount of current from power supply 112. Preferably, the dormant mode of apparatus 100 can only be interrupted by the insertion of load array 102. When load array 102 is inserted, a voltage appears between resistors 134 and 136, which serves as a logic signal to enable wake-up logic 130, which in turn generates an interrupt on interrupt line 118. This interrupt causes apparatus 100 to "awaken" and enter smoking mode for fifteen minutes, unless eight puffs occur sooner.
To further conserve energy, microcontroller 106 remains in stop mode as often as possible during smoking mode, and the auxiliary circuits are activated on an as-needed basis. Before microcontroller 106 is stopped after entering smoking mode, wake-up logic 130 is disabled, and oscillator 120 (which has a period of approximately 10 ms) is started. Every 10 ms, oscilla¬ tor 120 sends an interrupt to microcontroller 106 via interrupt line 118, which causes microcontroller 106 to enter fast mode, which is immediately stepped down to slow mode. While operating in slow mode, microcontroller 106 periodically checks for the presence of load array 102, in order to ensure that the smoker has not removed it after apparatus 100 has entered smoking mode. This check is performed by measuring the voltage between resistors 136 and 142, the resistances of which are selected so that the maximum voltage that appears between them when load array 102 is inserted is within the range allowed by voltage reference 122. This voltage is supplied to another analog-to-digital converter input 138 of microcontroller 106 via A/D input line 140. If no load array 102 is present, microcontroller 106 enters the dormant mode.
On every interrupt generated by oscillator 120, puff sensor 110 is enabled if load array 102 is present in the article. A variety of different implementations of puff sensor 110 are possible for sensing an occur¬ rence of a puff on the smoking article. For example, puff sensor 110 may include a lip pressure sensor that senses the pressure of the lips of the smoker on the mouthpiece of the smoking article. Alternatively, puff sensor 110 may include an air flow sensor that senses airflow through the smoking article. In a preferred embodiment, puff sensor 110 includes an air pressure sensor that senses a drop in air pressure caused by the flow of air through the smoking article. In this preferred embodiment, puff sensor 110 preferably includes a piezoresistive pressure transducer, such as the type NPH-5-002.5G NOVA sensor available from Lucas- Nova of Freemont, California, or a type QLT004D sensor, available from SenSym Incorporated of Sunnyvale, California.
Puff sensor 110 identifies when the smoker draws a puff from the smoking article by sending a signal to microcontroller 106. Microcontroller 106 debounces the puff sensor signal by requiring the signal to be present for five consecutive readings in each of three consecutive 10 ms windows to be deemed a true puff. If no true puff is detected, microcontroller 106 switches off puff sensor 110 and enters stop mode, subject to the next interrupt from oscillator 120.
If a true puff is detected, microcontroller 106 remains in slow mode oscillator 120 and puff sensor 110 are disabled, and voltage reference 122 is enabled. Voltage reference 122 defines the resolution of the analog-to-digital converter built into microcontroller 106. During application of power to one of heating elements 101 in load array 102, a timer internal to microcontroller 106 replaces oscillator 120 as the timing source. The internal clock is generally consid- ered more accurate, and is also set for 10 ms.
In response to a detected true puff, microcon¬ troller 106 enables a selected switch of switch array 108, so that power is supplied from power supply 112 to the corresponding heating element 101 in load array 102. A predetermined fraction of the voltage that is applied to the selected heating element 101, which appears between resistors 144 and 146, is supplied to analog-to-digital input 116 via A/D input line 114. The resistance values of resistors 144 and 146 are selected so that the maximum voltage that appears between them is within the range allowed by voltage reference 122. Thus, microcontroller 106 receives a signal indicative of the voltage supplied to the selected heating element 101. Microcontroller 106 causes power supply 112 to supply a predetermined amount of energy to the load over a predetermined time, to heat the load to a predetermined temperature in order to generate an acceptable aerosol which may be inhaled by the smoker. Energy delivered to the selected one of heating elements 101 in load array 102 is calculated by moni¬ toring the power delivered over a period of time. In a first preferred embodiment, power is supplied to the load continuously from the beginning of a puff and the energy delivered to the load is measured until a predetermined total has been delivered. In a second preferred embodiment, the estimated puff time (e.g., one second) is divided into a number of intervals, for example ten. Power is supplied and energy measured during each interval until the correct proportional amount of energy has been delivered for that interval - - e.g., one tenth of the total. Power is turned off after the appropriate amount of energy has been deliv¬ ered during an interval, until the start of the next interval.
The energy measurement method of the present invention provides a means for monitoring changes in the amount of energy stored in power supply 112. If power supply 112 cannot deliver the required amount of energy within the predetermined period of time, the batteries are no longer useful and must be recharged or replaced. When this condition arises, apparatus 100 enters dormant mode.
After the appropriate amount energy for a puff has been delivered, microcontroller 106 disables voltage reference 122 and enters stop mode. After all heating elements 101 of load array 102 have been energized, apparatus 100 enters dormant mode. When a spent load array 102 is disconnected, microcontroller 106 will be susceptible to noise which may be interpreted by microcontroller 106 as an interrupt from wake-up logic 130 to enter smoking mode. However, when A/D input line 140 is checked for the presence of load array 102 and it is not found, microcontroller 106 will immedi- ately reenter dormant mode until load array 102 is connected.
Apparatus 100 preferably includes display 104 coupled to microcontroller 106. Preferably, display 104 is a liquid crystal display that may be used to display information relating to the state of load array 102, or other information that may be useful in the operation of the smoking article. For example, display 104 may be used to inform the consumer of the number of puffs remaining, the presence or absence of load array 102, or that power supply 112 has discharged to an unacceptable level.
Referring now to FIGS. 2a-2d, a flowchart illus¬ trating preferred software for microcontroller 106 is described, as it may be implemented in suitable microcode or any higher level computing language. In FIG. 2a, the main program begins at start 200, which is followed by step 202 at which oscillator 120 is start¬ ed. At step 204, microcontroller 106 enters stop mode, where it waits subject to an interrupt from oscillator 120. When an interrupt is received, interrupt service routine 300, described in connection with FIG. 2b, is executed. Referring now to FIG. 2b, interrupt service routine 300 services interrupts generated either by oscillator 120 or wake-up logic 130. At step 302, microcontroller 106 steps down from fast mode (which it automatically enters after being awakened from stop mode) and enters slow mode. At test 304, the program checks to see if wake-up logic 130 was enabled. If wake-up logic 130 was enabled, it indicates that interrupt service routine 300 is servicing an interrupt generated by wake-up logic 130, which means that apparatus 100 was in dormant mode. At step 306, wake- up logic 130 is disabled, and the program returns to dormant subroutine 400 (described below) . If wake-up logic 130 was not enabled at test 304, puff sensor 110 is enabled at step 308. At test 310, a determination is made as to whether a true puff was sensed by puff sensor 110. Debouncing criteria require that puff sensor 110 detect a pressure drop for five consecutive readings in each of three consecutive executions of interrupt service routine 300. If a true puff is detected, a "puff sensed" flag is set at step 312. At step 314, puff sensor 110 is disabled, and control is then returned to the main program.
Referring again to FIG. 2a, test 206 is performed after control is returned to the main program. At test 206, the program checks to see if load array 102 is connected to the article, if less than the maximum number of puffs have been taken (e.g., eight puffs), and if apparatus 100 has been in smoking mode for less than the maximum smoking mode duration (e.g., fifteen minutes) . To check for the presence of load array 102, microcontroller 106 enables voltage reference 122, checks if the voltage between resistors 134 and 142 exceeds a threshold, and then disables voltage refer¬ ence 122.
If any of the conditions of test 206 are not met, dormant subroutine 400, described in connection with FIG. 2c, is called at step 208 to cause apparatus 100 to enter dormant mode. Referring now to FIG. 2c, oscillator 120 is disabled at step 402, and then wake- up logic 130 is enabled at step 404. At step 406, microcontroller 106 enters stop mode, and waits subject to an interrupt, which under these conditions, is the result of insertion of load array 102. When the interrupt is generated, interrupt service routine 300 executes steps 302, 304 and 306, described above, and then returns control to dormant subroutine 400, which in turn returns control to the main program.
Referring again to FIG. 2a, from step 208, the program loops back to step 202, which indicates the start of smoking mode caused by the insertion of load array 102. If all of the conditions of test 206 are met, test 210 is performed to determine if the "puff sensed" flag was set in interrupt service routine 300. If the flag was not set, the program loops back to step 204, to cause microcontroller 106 to enter stop mode until the next interrupt from oscillator 120 is re- ceived. Otherwise, oscillator 120 is disabled at step 212, then voltage reference 122 is enabled at step 214, and then at step 216, microcontroller 106 increments a variable that tracks the number of puffs taken. At step 218, power subroutine 500, described in connection with FIG. 2d, is called to control the supply of power to one of heating elements 101 in load array 102.
Referring now to FIG. 2d, power subroutine 500 is described. First, test 502 is performed to determine if energy has been supplied in all intervals of the current puff. As described above, in a preferred embodiment for delivering energy to a heating element 101 in load array 102, the puff length is estimated (e.g., one second), and the estimated puff length is divided into a number of intervals (e.g., ten inter- vals, each of 100 ms) . The amount of energy required to generate an acceptable aerosol or vapor is propor¬ tioned among the intervals in substantially equal fractional amounts. Thus, test 502 determines if all of the intervals have elapsed. If all of the intervals have elapsed, control is returned to the main program; otherwise, the heating element 101 of load array 102 associated with the current puff is energized at step 504 by enabling the corresponding switch in switch array 108. Immediately after the selected heating element 101 is energized, test 506 is performed to determine if the correct fractional amount of energy has been supplied to the selected heating element 101 during the current interval. If test 506 determines that an insufficient amount of energy has been delivered thus far during the current interval, test 514 is performed to determine if the current interval has elapsed before the appropriate amount of energy was supplied. If the current interval has not elapsed, the program loops back to test 506. Thus, during each interval, a loop consisting of tests 506 and 514 is repeated many times as energy is being supplied to the selected heating element 101. This loop permits microcontroller 106 to effectively monitor the amount of energy supplied to the selected heating element 101 in a continuous manner. Once the correct fractional amount of energy has been delivered to the selected heating element 101, test 506 causes power subroutine 500 to branch to step 508, at which the appropriate switch of switch array 108 is disabled. Then at step 510, the program waits until the current interval has elapsed, in the likely event that the correct fractional amount of energy was supplied before the interval elapsed. Then at step 512, the current interval in incremented, and the program loops back to test 502 to begin power delivery during the next interval.
As previously described, test 514 is executed many times within the test 506/514 loop to determine if the current interval has elapsed before the correct frac- tional amount of energy has been delivered. When the current interval elapses before the correct fractional amount of energy has been supplied to the selected heating element 101, an error condition is defined in step 516, to indicate that power supply 112 no longer has sufficient stored energy to be useful. After the error condition is defined, the program returns to the main menu.
Referring again to FIG. 2a, the program returns from power subroutine 500 to step 220, at which the number of puffs remaining is displayed on display 104. At step 222, voltage reference 122 is disabled, and then test 224 is performed to determine if control was returned from power subroutine 500 with an error condition defined. If an error condition was not defined, the program loops back to step 202, to prepare for the next puff. Otherwise, an error symbol is displayed on display 104 at step 226, and the program loops back to step 208 to call dormant subroutine 400. In dormant mode, the consumer may replace power supply 112, which will cause a power-on reset and execution of the main program beginning at start 200.
Thus it is seen that a method and an apparatus for controlling the delivery of energy to a heater array in a smoking article so that a predetermined amount of energy is delivered to individual heating elements in the heater array on demand is provided. One skilled in the art will appreciate that the present invention can be practiced by other than the described embodiments, which are presented for purposes of illustration and not of limitation, and the present invention is limited only by the claims which follow.

Claims

1. An apparatus for controlling delivery of energy from a power supply to a heating load (101) in a smoking article, comprising: » puff sensor means (110) for sensing when a smoker draws a puff from said smoking article; switching means (108) for coupling said heating lead to said power supply; energy measurement means (106, 116), coupled to said heating load, for measuring an amount of energy delivered to said heating load; and control means (106) , coupled to said puff sensor means, said switching means and said energy measurement means, for enabling said switching means to connect said heating load to said power supply when said puff sensor means senses a puff and for disabling said switching means to disconnect said heating load from said power supply when a predetermined amount of energy as measured by said energy measurement means has been delivered to said heating load.
2. An apparatus for controlling delivery of energy from a power supply to a plurality of heating loads (101) in a smoking article, comprising: puff sensor means (110) for sensing when a smoker draws a puff from said smoking article; switching means (108) for selectively coupling at least one of said plurality of heating loads to said power supply; energy measurement means (106, 116), coupled to said power source, for measuring an amount of energy delivered to said at least one heating load; and control means (106) , coupled to said puff sensor means, said switching means and said energy measurement means, for enabling said switching means to connect said at least one heating load to said power supply when said puff sensor means senses a puff and for disabling said switching means to disconnect said at least one heating load from said power supply when a predetermined amount of energy as measured by said energy measurement means has been delivered to said at least one heating load.
3. Apparatus according to Claim 2, wherein said control means further comprises means for enabling said switching means to select at least one unused heating load each time said puff sensor means senses a puff, until all of said plurality of heating loads have been used.
4. Apparatus according to Claim 3, further comprising display means (104) , coupled to said control means, for displaying a symbol indicative of a number of unused heating loads remaining.
5. Apparatus according to any of Claims 1 to 4, wherein the control means (106) comprises means for enabling the switching means so that the prede¬ termined amount of energy is delivered from the power supply to the heating load or the at least one heating load within a predetermined period of time.
6. Apparatus according to Claim 5, wherein the control means (106) further comprises: means for dividing the predetermined period of time into a plurality of intervals, each of the in¬ tervals being a duration substantially equal to a predetermined fraction of the period of time; and means for enabling the switching means so that a corresponding fraction of the predetermined amount of energy is delivered from the power supply to the heating load or the at least one heating load during each of the plurality of intervals.
7. Apparatus according to any preceding claim, comprising oscillator means (120) , coupled to the control means, for generating interrupt signals at a predetermined rate.
8. Apparatus according to Claim 7, wherein the control means (106) comprises a microcontroller.
9. Apparatus according to Claim 8, wherein the microcontroller (106) comprises: means for maintaining the microcontroller in a stop mode; means for entering a run mode upon receipt of an interrupt from the oscillator means; and means for returning to the stop mode after entering the run mode when the puff sensor means has not sensed a puff.
10. Apparatus according to Claim 6, wherein the microcontroller further comprises means for re¬ turning to the stop mode after entering the run mode when the puff sensor means senses a puff and the predetermined amount of energy has been delivered from the power supply to the heating load or the at least one heating mode.
11. Apparatus according to Claim 6, wherein the microcontroller further comprises: means for disabling the puff sensor means when the microcontroller enters the stop mode; and means for enabling the puff sensor means when the microcontroller receives an interrupt signal form the oscillator.
12. Apparatus according to any of Claims 8 to 11, further comprising load sensor means (130, 134, 136) , coupled to the microcontroller and the heating load, for sensing when the heating load is coupled to the apparatus.
13. Apparatus according to Claim 12, wherein the microcontroller comprises means, responsive to the load sensor means, for enabling the apparatus to enter a dormant mode when the heating load or the at least one heating load is not coupled to the apparatus.
14. Apparatus according to Claim 13, wherein the means for enabling the apparatus to enter a dormant mode comprises: means for disabling the oscillator; and means for causing the microcontroller to enter a stop mode.
15. Apparatus of Claim 14, further com¬ prising wake-up logic means (130) , coupled to the microcontroller, for generating an interrupt signal when the, or the at least one, heating load (101) is coupled to the apparatus.
16. Apparatus according to Claim 15, wherein the microcontroller further comprises: means for receiving the interrupt signal from the wake-up logic means; means for enabling the microcontroller to enter a run mode upon receipt of the interrupt signal from the wake-up logic means; and means for enabling the oscillator means upon receipt of the interrupt signal from the wake-up logic means.
17. Apparatus according to Claim 5, wherein the control means comprises means for determining that the power supply has sufficient stored energy to deliver the predetermined amount of energy to the heating load within the predetermined period of time.
18. Apparatus according to Claim 17, further comprising display means (104) for displaying an error symbol when the power source has insufficient stored energy to deliver the predetermined amount of energy to the heating load (101) or the at least one heating load (101) within the predetermined period of time.
19. Apparatus according to any of Claims 8 to 16, wherein: the energy measurement means comprises an analog-to-digital converter (116) to measure a voltage that is applied to the heating load and to provide a digital representation of the measured voltage; and the microcontroller comprises means for monitoring the digital representation of the measured voltage, for determining a duration that the measured voltage is applied to the heating load (101) or the at least one heating load (101) , and for calculating energy delivered to the heating load while the measured voltage is applied to the heating load (101) or at least one heating load (101) from the measured voltage, the determined duration and a predetermined resistance of the heating load or the at least one heating load.
20. Apparatus of Claim 19, wherein the analog-to-digital converter (116) is provided by the microcontroller.
21. Apparatus according to any preceding claim, wherein the puff sensor means (110) comprises a pressure transducer that senses a pressure drop in a mouthpiece of the smoking article.
22. A method for controlling energy flow in a smoking article, comprising: sensing the presence of a heating load in the smoking article; sensing when a puff is drawn on the smoking article; and delivering a predetermined amount of energy to the heating load in response to a sensed puff.
23. The method of Claim 22, wherein the step of delivering the predetermined amount of energy com¬ prises delivering the predetermined amount of energy to the heating load within a predetermined period of time.
24. A method for determining when a battery in a smoking article has insufficient stored energy, cαrtprising: measuring an amount of energy delivered to a heating load of the smoking article within a prede¬ termined period of time; and comparing the measured amount of energy to an expected amount of energy to determine if the measured amount of energy is less than the expected amount of energy, which indicates that the battery has insuffi¬ cient stored energy.
25. A smoking article including apparatus for controlling delivery of energy from a power supply to one or more heating loads according to any of Claims 1 to 31.
PCT/US1994/002256 1993-02-24 1994-02-24 Method and apparatus for controlling the supply of energy to a heating load in a smoking article WO1994018860A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP94910213A EP0637212B1 (en) 1993-02-24 1994-02-24 Method and apparatus for controlling the supply of energy to a heating load in a smoking article
DE69420344T DE69420344T2 (en) 1993-02-24 1994-02-24 METHOD AND DEVICE FOR CONTROLLING THE ENERGY DELIVERY OF A HEATING DEVICE IN A SMOKING ITEM
KR1019940703692A KR100286488B1 (en) 1993-02-24 1994-02-24 Method and apparatus for controlling energy supply to heating rod in smoking apparatus
JP51934894A JP3696619B2 (en) 1993-02-24 1994-02-24 Method and apparatus for controlling energy supply to a heating load of a smoking article
AU62750/94A AU677642B2 (en) 1993-02-24 1994-02-24 Method and apparatus for controlling the supply of energy to a heating load in a smoking article
CA002134122A CA2134122C (en) 1993-02-24 1994-02-24 Method and apparatus for controlling the supply of energy to a heating load in a smoking article
NO944048A NO944048L (en) 1993-02-24 1994-10-24 A method and apparatus for controlling the energy supply of a heat load in a smoking article

Applications Claiming Priority (2)

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US08/021,965 1993-02-24

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EP (1) EP0637212B1 (en)
JP (1) JP3696619B2 (en)
KR (1) KR100286488B1 (en)
AT (1) ATE183894T1 (en)
AU (1) AU677642B2 (en)
CA (1) CA2134122C (en)
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GEP20002172B (en) 2000-07-25
CA2134122C (en) 2005-04-19
KR950700692A (en) 1995-02-20
DE69420344T2 (en) 2000-03-30
DE69420344D1 (en) 1999-10-07
EP0637212A1 (en) 1995-02-08
ATE183894T1 (en) 1999-09-15
KR100286488B1 (en) 2001-04-16
CA2134122A1 (en) 1994-08-25
AU6275094A (en) 1994-09-14
US5372148A (en) 1994-12-13
JP3696619B2 (en) 2005-09-21
EP0637212B1 (en) 1999-09-01
JPH07506008A (en) 1995-07-06
AU677642B2 (en) 1997-05-01

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