WO1994010558A1 - Electrochemical sensor - Google Patents

Electrochemical sensor Download PDF

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Publication number
WO1994010558A1
WO1994010558A1 PCT/GB1993/002241 GB9302241W WO9410558A1 WO 1994010558 A1 WO1994010558 A1 WO 1994010558A1 GB 9302241 W GB9302241 W GB 9302241W WO 9410558 A1 WO9410558 A1 WO 9410558A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
sensor
test station
electrode
magazine
element
Prior art date
Application number
PCT/GB1993/002241
Other languages
French (fr)
Inventor
Uri Friedlander
Irving John Higgins
Eric D'costa
Geoffrey Frank Hall
Nicholas Morris
Original Assignee
Enviromed Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/4875Details of handling test elements, e.g. dispensing or storage, not specific to a particular test method
    • G01N33/48757Test elements dispensed from a stack
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00089Magazines

Abstract

An electrochemical sensor comprises a housing and a polarity of disposable test elements (3) located in the housing and arranged so that the elements are presented sequentially to a test station, wherein the electrodes may be contacted with a specimen containing an analyte, the test station further including electrical contact means adapted to engage said electrode element to produce a signal characteristic of the analyte.

Description

ELECTROCHEMICAL SENSOR

This invention relates to an electrochemical sensor of the kind incorporating a plurality of disposable electrodes contained within a housing. The invention relates particularly but not exclusively to sensors wherein the electrodes incorporate an immobilised enzyme for assay of biological analytes .

Suitable electrodes may be manufactured by absorption or deposition of palladium or platinum onto carbon particles which may subsequently be incorporated in a porous self supporting structure. Alternatively a substrate composed of for example carbon paper or carbon cloth may be employed. The manufacture and properties of such electrodes is disclosed m US-A-4044193, US-A-4166143, US-A-4293396 and US-A-4476696. Alternative constructions of electrodes may be employed. The electrode surface may be plated with a mercury film. A mixture of enzyme, carbon and mediator species may be deposited on the electrode surface to form an enzyme electrode. The electrode may also incorporate a membrane containing mediator according to PCT/GB91 /01444.

According to the present invention an electrochemical sensor comprises a housing and a plurality of disposable electrode elements located in the housing and arranged so that said electrode elements may be presented sequentially in use to a test station wherein the electrodes may be contacted with a specimen containing an analyte, the test station further including electrical contact means adapted to engage said electrode element to produce a signal characteristic of said analyte

The signal may be indicative of the present, absence or concentration of the analyte.

The sensor may include a display adapted to provide a visible, audible or other indication in response to said signal. A liquid crystal display may provide a visible measure of the concentration of the analyte or may indicate whether a particular threshold has been attained. Each electrode preferably comprises a laminar member having a working surface carrying the immobilised reagents and an impermeable substrate. Liquid applied to the working surface is supported thereon for analysis and is prevented from drainage of the electrode to contaminate an adjacent unused electrode element

The test station preferably comprises a receptacle for a liquid specimen. A receptacle may incorporate an aperture communicating with the working surface of the electrode when the latter is engaged with the test station. In preferred embodiments of the invention the receptacle comprises a plate having said aperture for reception of a liquid specimen.

In preferred embodiments of the invention a multiplicity of electrode elements are arranged m stacked relationship in a magazine, the first electrode element engaging said receptacle at the test station to form an impermeable seal preventing a liquid specimen from contacting the second subsequent electrode. The stack of electrodes is preferably biased towards the receptacle for example by means of a spring.

The electrodes may be circular, rectangular, elliptical, polygonal or otherwise shaped. Means is preferably provided to ensure that the electrodes are correctly oriented with respect to the electrical contacts on the test station. This may comprise engagement of surfaces of the electrode element with corresponding formations of the housing.

The magazine is preferably moveable within the housing, being urged in use towards the receptacle to form a liquid- proof seal. In preferred aspects of the invention an ejector is provided to displace spent electrode elements from the test station The ejector may comprise a laminar member slidable between first position wherein an element is located at the test station and a second position wherein the element is ejected from the apparatus. A linearly slidable ejector may be provided. Alternatively a rotatable configuration, in the manner of a daisy wheel may be employed.

The magazine may be closable with a removable top, for example connected to the magazine by means of a screw thread. The ejector is preferably arranged to disengage the top and magazine prior to ejection of the element. In a first preferred embodiment the top may be screwed from the magazine and in a second preferred embodiment the magazine may be unscrewed from the fixed top. An overcentre sprung arrangement may facilitate movement of the ejector between a position wherein the element is disposed in the magazine with the top seals and a second position wherein the element is deployed at the test station. Upon further actuation the ejector returns to the original position and the used element is ejected.

The invention finds particular application in completed analysis of biological fluids, for example blood glucose, alcohol in saliva or urine analysis. The invention also finds use in environmental analysis, for example analysis for ammonia, chlorine, phenols and heavy metals especially lead, copper, zmc, cadmium and mercury, in river water, industrial effluent or other aqueous samples.

The invention is further described by means of example but not in any limitative sense with reference to the accompanying drawings of which:

Figure 1 is an exploded view of the components of a sensor in accordance with the invention;

Figure 2 illustrates the assembled sensor;

Figure 3 is a partially cut away detailed view of the sensor;

Figure 4 is a cross-sectional view illustrating use of the ejector arrangement; and

Figures 5 and 6 are cross-sectional views of alternative arrangements .

The arrangement shown in Figure 1 comprises a plate 1 having a dish-like receptacle 2 communicating with the lower surface of the plate 1 by means of aperture. A plurality of laminar disc-like electrode elements 3 is arranged in overlying stacked relation within a tubular magazine 4. The stack of electrodes 3 is urged upwardly against the lower surface of the plate 1 by means of a first spring 5. A second larger spring - <_ -

6 bears against the tubular magazine 4 and urges the latter into engagement with the plate 1. An outer tube 7 and plug 8 serve to retain the spring loaded arrangement in the correct configuration.

Figure 2 illustrates an example of a sensor in accordance with this invention. A body 10 incorporating an LED display 11 is adapted to conform to a users hand. The receptacle 13 is arranged to receive a liquid specimen and an ejector 12 is arranged when manually actuated to discharge a spent electrode element. Operation of the sensor is described below.

The arrangement shown in Figure 3 includes an upper portion of the inner tube 4 including a sealing ring 15 arranged to prevent ingress of liquid into the stack of unused elements 3. A desiccant disc 16 disposed below the stack of elements 3 serves to maintain the latter in an anhydrous environment. The compression spring 5 bears against the lower surface of the desiccant disc urging the uppermost electrode element into contact with the receptacle at the test station. When circular electrode elements are employed locating means 17 extending lengthwise to the stack of electrodes serves to maintain the stack in the correct orientation with respect to electrical contacts disposed on the lower surface of the plate 1. In alternative embodiments of the invention the electrode elements may be rectangular or otherwise shaped to prevent disorientation of them within the magazine.

Use of the apparatus is described with reference to Figures 4a, b and c. In Figure 4a a stack of electrode elements 30 and desiccant disc 27 are urged upwardly by a spring 25 into engagement with the lower surface of a plate 20 having an aperture 21 to which a liquid specimen 22 may be applied. The upper disc 28 of the stack is sealed at the test station by an 0 ring 29 carried by the magazine 23. The magazine 23 is urged bv comDression spring 26 into engagement with the lower surface of the plate 20. The lower surface of tne plate 20 carries electrical contacts (not shown) adapted to connect to the electrodes on the electrode element 28 at the test station Electrochemical reaction with the analyte specimen 22 produces an electrical signal and provides a visible display in conventional manner.

Figure 4b illustrates the first stage of ejection of a spent electrode 28 from the test station. The magazine 23 is withdrawn against the pressure of the compression spring 26, for example by means of a manual actuator (not shown). An ejector 31 shown in Figure 4c may then be used to displace the element 28 from the test station. Withdrawal of the ejector 31 allows the magazine 23 to return to the position shown in Figure 4a and a fresh electrode element is available for use.

In alternative embodiments of the invention the elements 30 may be disposed in side by side relation rather than in a stack 30. The elements may be mounted on a flexible support member, for example on a strip of release paper. Alternatively the elements 30 may be supplied to the test station by a daisy wheel arrangement.

Figure 5 shows an alternative arrangement wherein the sensor stack 31 is held within a cartridge 32 having a screw top 33 sealed with an 0 ring 34. This provides airtight storage for the sensors when not in use. The sensors are arranged to be delivered from the cartridge by turning the screw top 33. Turning the top 33 raises the top on the thread sufficiently to allow a pusher 35 to push the top electrode sensor from the stack into test position 36. The pusher 35 may be driven by the turning action of the screw top 33 via a pusher gear mechanism 37. The pusher 35 is retracted and the screw top 33 is closed by the action of a coil spring 38. In this arrangement the sensor is dispensed from the sealed cartridge automatically upon the rotation of the cap, and the cap closes, sealing the cartridge when manual pressure is released.

Figure 6 shows a further embodiment wherein the pusher 40 is coupled with a two position spring 41 that allows the pusher to rest in either of two positions in an overcentre manner. The sensor cartridge for magazine 42 carries a stack of sensors 43 and a spring 44 maintains an upward pressure on the stack 43. The first action of the pusher 40 is to lift the cartridge top 45 from the seal 46 to a sufficient distance to allow the uppermost sensor to be pushed into the test position 47. In an alternatively embodiment of the invention the initial action of the pusher causes the body of the cartridge 42 to be lowered a sufficient distance to allow the uppermost sensor to be pushed into the test station 47. In such an arrangement the cartridge top can be fixed and can become a non-disposable component of t - the apparatus, the magazine being /placable when the supply of electrode elements is exhausted.

The electrode elements may incorporate reagents allowing enzyme assay of alcohol, glucose or other metabolites.

Alternatively immunoassay agents may be provided, for example as disclosed in EP 0424586.

Claims

1. An electro-chemical sensor comprising a housing and a polarity of disposable electrode elements located in the housing and arranged so that said electrodes may be presented sequentially in use to a test station wherein the electrodes may be contacted with a specimen containing an analyte, the test station further including electrical contact means adapted to engage said electrode elements to produce a signal characteristic of said analyte.
2. A sensor as claimed in claim 1, wherein the signal is indicative of the presence, absence or concentration of the analyte.
3. A sensor as claimed in any preceding claim, wherein the display is adapted to provide a visible, audible or other indication in response to said signal.
4. A sensor as claimed in any preceding claim wherein said electrode comprises a laminar member having a working surface carrying immobilised reagents and an impermeable substrate.
5. A sensor as claimed in any preceding claim wherein the test station includes a receptacle for a liquid specimen.
6. A sensor as claimed in claim 5, wherein the receptacle comprises an aperture communicating with the working surface of the electrode when the latter is engaged with the test station.
7. A sensor as claimed in any preceding claim, wherein a multiplicity of electrode elements are arranged in stacked relationship in a magazine, the a electrode element being engaged at the test station to cooperate with the receptacle to form an impermeable seal.
8. A sensor as claimed in claim 7, including locator means to ensure that the electrodes are correctly oriented with respect to the test station.
9. A sensor as claimed in claim 7 or 8, wherein the magazine is moveable within the housing, being urged in use towards the receptacle to form an impermeable seal.
10. A sensor as claimed in any preceding claim, including an ejector adapted to displace spent electrode elements from the test station.
11. A sensor as claimed in claim 10, wherein the ejector comprises a laminar member slidable between a first position wherein an element is located at the test station and a second position wherein the element is ejected from the apparatus .
12. A sensor as claimed in claim 11, including a linearly slidable ejector.
13. A sensor as claimed in claim 7 or any claim appendant on claim 7, wherein the magazine includes a sealable top.
14. A sensor as claimed in claim 13 wherein the magazine is sealable with a screw top.
15. A sensor as claimed in claim 13 or 14, wherein actuation of the top causes an electrode element to be presented to the test station.
16. A sensor as claimed in claim 15, wherein the top is arranged to reseal the magazine when manual pressure is released after presentation of the element to the test station.
PCT/GB1993/002241 1992-11-03 1993-11-01 Electrochemical sensor WO1994010558A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB9223016.8 1992-11-03
GB9223016A GB9223016D0 (en) 1992-11-03 1992-11-03 Electrochemical sensor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU5374594A AU5374594A (en) 1992-11-03 1993-11-01 Electrochemical sensor
EP19930924140 EP0667956A1 (en) 1992-11-03 1993-11-01 Electrochemical sensor

Publications (1)

Publication Number Publication Date
WO1994010558A1 true true WO1994010558A1 (en) 1994-05-11

Family

ID=10724459

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/002241 WO1994010558A1 (en) 1992-11-03 1993-11-01 Electrochemical sensor

Country Status (3)

Country Link
EP (1) EP0667956A1 (en)
GB (1) GB9223016D0 (en)
WO (1) WO1994010558A1 (en)

Cited By (48)

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EP0621481A2 (en) * 1993-04-23 1994-10-26 Boehringer Mannheim Gmbh System for analysing the contents of liquid samples
EP0742436A2 (en) * 1995-05-05 1996-11-13 Bayer Corporation Means of handling multiple sensors in a glucose monitoring instrument system
WO1997029847A1 (en) * 1996-02-13 1997-08-21 Selfcare, Inc. Improved glucose monitor and test strip containers for use in same
US5679518A (en) * 1994-10-27 1997-10-21 Merck & Co., Inc. Method for finding transcription activators of the NER steroid hormone receptor
EP0812570A1 (en) * 1996-06-11 1997-12-17 Siemens Elema AB Arrangement for analysing body fluids
EP0826963A2 (en) * 1996-09-02 1998-03-04 Nokia Mobile Phones Ltd. An apparatus for taking and analysing liquid samples, such as blood samples
US5739039A (en) * 1989-12-04 1998-04-14 Ecossensors Limited Microelectrodes and amperometric assays
EP0875754A1 (en) * 1997-04-29 1998-11-04 Eastman Kodak Company Apparatus, magazine and method for electrochemical detection or measurement
EP0885591A2 (en) * 1997-06-19 1998-12-23 Nokia Mobile Phones Ltd. An apparatus for taking samples
WO2002008750A1 (en) * 2000-07-20 2002-01-31 Hypoguard Limited Test member
WO2002008753A2 (en) * 2000-07-20 2002-01-31 Hypoguard Limited Device for measuring analyte concentration in a fluid
WO2002018940A2 (en) * 2000-08-30 2002-03-07 Hypoguard Limited Device for measuring analyte concentration in a fluid
EP1260815A2 (en) * 2001-05-25 2002-11-27 Lifescan, Inc. Methods for automatically monitoring analyte concentration using minimally invasive devices
WO2003042691A1 (en) * 2001-11-14 2003-05-22 Hypoguard Limited Sensor dispensing device
WO2003050534A1 (en) * 2001-12-13 2003-06-19 Hypoguard Limited Test meter calibration
WO2004063747A1 (en) * 2003-01-14 2004-07-29 Hypoguard Limited Sensor dispensing device
EP1480036A1 (en) * 2002-02-28 2004-11-24 ARKRAY, Inc. Measurement instrument, measurement tool storage case and operation mechanism
US6827899B2 (en) 2000-08-30 2004-12-07 Hypoguard Limited Test device
EP1494021A1 (en) * 2002-04-05 2005-01-05 ARKRAY, Inc. Analytical appliance cartridge with retrieval mechanism, and set of the cartridge and analyzer
EP1500925A1 (en) * 2002-04-19 2005-01-26 Matsushita Electric Industrial Co., Ltd. Biosensor cartridge and biosensor dispensing device
EP1347296A3 (en) * 2002-03-18 2005-02-09 Bayer Healthcare, LLC Storage cartridge for biosensors
US6872358B2 (en) * 2002-01-16 2005-03-29 Lifescan, Inc. Test strip dispenser
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WO2006000807A1 (en) * 2004-06-28 2006-01-05 Lifescan Scotland Limited A test strip vial with improved vial cap and method of opening
WO2006009534A1 (en) * 2004-06-18 2006-01-26 Roche Diagnostics Gmbh Dispenser for flattened articles such as diagnostic test strips
US6997343B2 (en) * 2001-11-14 2006-02-14 Hypoguard Limited Sensor dispensing device
WO2006072034A1 (en) * 2004-12-29 2006-07-06 Lifescan Scotland Limited Analyte test meter incorporating an improved display
WO2006116522A1 (en) * 2005-04-25 2006-11-02 Bayer Healthcare Llc Sensor release mechanism for a test meter
US7138089B2 (en) 2000-07-20 2006-11-21 Hypoguard Limited Test device for analyzing blood glucose or other analytes in bodily fluids
US7172728B2 (en) 2002-04-02 2007-02-06 Lifescan, Inc. Test strip containers and methods of using the same
US7364699B2 (en) 2003-06-18 2008-04-29 Bayer Healthcare Llc Containers for reading and handling diagnostic reagents and methods of using the same
US7416699B2 (en) 1998-08-14 2008-08-26 The Board Of Trustees Of The Leland Stanford Junior University Carbon nanotube devices
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US7582262B2 (en) * 2004-06-18 2009-09-01 Roche Diagnostics Operations, Inc. Dispenser for flattened articles
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Cited By (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739039A (en) * 1989-12-04 1998-04-14 Ecossensors Limited Microelectrodes and amperometric assays
EP0621481A3 (en) * 1993-04-23 1995-10-18 Boehringer Mannheim Gmbh System for analysing the contents of liquid samples.
EP0621481A2 (en) * 1993-04-23 1994-10-26 Boehringer Mannheim Gmbh System for analysing the contents of liquid samples
US5757666A (en) * 1993-04-23 1998-05-26 Boehringer Mannheim Gmbh System for analyzing compounds contained liquid samples
US5679518A (en) * 1994-10-27 1997-10-21 Merck & Co., Inc. Method for finding transcription activators of the NER steroid hormone receptor
US5939322A (en) * 1994-10-27 1999-08-17 Merck & Co., Inc. Human steroid receptor
EP0742436A2 (en) * 1995-05-05 1996-11-13 Bayer Corporation Means of handling multiple sensors in a glucose monitoring instrument system
EP0742436A3 (en) * 1995-05-05 1997-03-19 Bayer Ag Means of handling multiple sensors in a glucose monitoring instrument system
EP1607137A3 (en) * 1996-02-13 2007-05-02 Inverness Medical Technology, Inc. Improved glucose monitor and test strip containers for use in same
EP1970123A1 (en) * 1996-02-13 2008-09-17 Diabetes Diagnostics, Inc. Improved glucose monitor and test strip containers for use in same
EP1225448A2 (en) * 1996-02-13 2002-07-24 Inverness Medical Technology, Inc. Improved glucose monitor and test strip containers for use in same
WO1997029847A1 (en) * 1996-02-13 1997-08-21 Selfcare, Inc. Improved glucose monitor and test strip containers for use in same
EP1607137A2 (en) * 1996-02-13 2005-12-21 Inverness Medical Technology, Inc. Improved glucose monitor and test strip containers for use in same
US5989917A (en) * 1996-02-13 1999-11-23 Selfcare, Inc. Glucose monitor and test strip containers for use in same
EP1225448A3 (en) * 1996-02-13 2002-08-28 Inverness Medical Technology, Inc. Improved glucose monitor and test strip containers for use in same
US5902253A (en) * 1996-06-11 1999-05-11 Siemens-Elema Ab Apparatus for analyzing body fluids
EP0812570A1 (en) * 1996-06-11 1997-12-17 Siemens Elema AB Arrangement for analysing body fluids
EP0826963A2 (en) * 1996-09-02 1998-03-04 Nokia Mobile Phones Ltd. An apparatus for taking and analysing liquid samples, such as blood samples
EP0826963A3 (en) * 1996-09-02 1998-10-07 Nokia Mobile Phones Ltd. An apparatus for taking and analysing liquid samples, such as blood samples
EP0875754A1 (en) * 1997-04-29 1998-11-04 Eastman Kodak Company Apparatus, magazine and method for electrochemical detection or measurement
EP0885591A2 (en) * 1997-06-19 1998-12-23 Nokia Mobile Phones Ltd. An apparatus for taking samples
EP0885591A3 (en) * 1997-06-19 1999-12-22 Nokia Mobile Phones Ltd. An apparatus for taking samples
US7416699B2 (en) 1998-08-14 2008-08-26 The Board Of Trustees Of The Leland Stanford Junior University Carbon nanotube devices
WO2002008753A2 (en) * 2000-07-20 2002-01-31 Hypoguard Limited Device for measuring analyte concentration in a fluid
WO2002008753A3 (en) * 2000-07-20 2002-04-18 Hypoguard Ltd Device for measuring analyte concentration in a fluid
US7138089B2 (en) 2000-07-20 2006-11-21 Hypoguard Limited Test device for analyzing blood glucose or other analytes in bodily fluids
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WO2002018940A2 (en) * 2000-08-30 2002-03-07 Hypoguard Limited Device for measuring analyte concentration in a fluid
WO2002018940A3 (en) * 2000-08-30 2002-06-06 Hypoguard Ltd Device for measuring analyte concentration in a fluid
US6827899B2 (en) 2000-08-30 2004-12-07 Hypoguard Limited Test device
EP1260815A2 (en) * 2001-05-25 2002-11-27 Lifescan, Inc. Methods for automatically monitoring analyte concentration using minimally invasive devices
EP1260815A3 (en) * 2001-05-25 2005-03-23 Lifescan, Inc. Methods for automatically monitoring analyte concentration using minimally invasive devices
US7611899B2 (en) 2001-08-13 2009-11-03 Bayer Healthcare Llc Sensor release for a sensor dispensing instrument
US7906336B2 (en) 2001-08-13 2011-03-15 Bayer Healthcare Llc Sensor dispensing instrument
US6997343B2 (en) * 2001-11-14 2006-02-14 Hypoguard Limited Sensor dispensing device
WO2003042691A1 (en) * 2001-11-14 2003-05-22 Hypoguard Limited Sensor dispensing device
WO2003050534A1 (en) * 2001-12-13 2003-06-19 Hypoguard Limited Test meter calibration
US6908008B2 (en) 2001-12-21 2005-06-21 Lifescan, Inc. Test device with means for storing and dispensing diagnostic strips
US6872358B2 (en) * 2002-01-16 2005-03-29 Lifescan, Inc. Test strip dispenser
US7857165B2 (en) 2002-02-28 2010-12-28 Arkray, Inc. Dispensing unit for measuring articles
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EP1347296A3 (en) * 2002-03-18 2005-02-09 Bayer Healthcare, LLC Storage cartridge for biosensors
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US7270247B2 (en) 2002-03-18 2007-09-18 Bayer Healthcare Llc Storage cartridge for biosensors
US8501095B2 (en) 2002-03-18 2013-08-06 Bayer Healthcare Llc Method of dispensing biosensors
US7172728B2 (en) 2002-04-02 2007-02-06 Lifescan, Inc. Test strip containers and methods of using the same
US6881578B2 (en) 2002-04-02 2005-04-19 Lifescan, Inc. Analyte concentration determination meters and methods of using the same
EP1950562A3 (en) * 2002-04-02 2009-06-17 Lifescan Scotland Limited Integrated sample testing meter
EP1494021A1 (en) * 2002-04-05 2005-01-05 ARKRAY, Inc. Analytical appliance cartridge with retrieval mechanism, and set of the cartridge and analyzer
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EP1494021A4 (en) * 2002-04-05 2010-01-13 Arkray Inc Analytical appliance cartridge with retrieval mechanism, and set of the cartridge and analyzer
EP1500925A4 (en) * 2002-04-19 2012-07-11 Panasonic Corp Biosensor cartridge and biosensor dispensing device
EP1500925A1 (en) * 2002-04-19 2005-01-26 Matsushita Electric Industrial Co., Ltd. Biosensor cartridge and biosensor dispensing device
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WO2004063747A1 (en) * 2003-01-14 2004-07-29 Hypoguard Limited Sensor dispensing device
US8178351B2 (en) 2003-06-18 2012-05-15 Bayer Healthcare Llc Containers for reading and handling diagnostic reagents and methods of using the same
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Also Published As

Publication number Publication date Type
EP0667956A1 (en) 1995-08-23 application
GB9223016D0 (en) 1992-12-16 grant

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