WO1994009785A2 - Methods and compositions of (+) doxazosin for the treatment of benign prostatic hyperplasia and atherosclerosis - Google Patents
Methods and compositions of (+) doxazosin for the treatment of benign prostatic hyperplasia and atherosclerosis Download PDFInfo
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- WO1994009785A2 WO1994009785A2 PCT/US1993/010503 US9310503W WO9409785A2 WO 1994009785 A2 WO1994009785 A2 WO 1994009785A2 US 9310503 W US9310503 W US 9310503W WO 9409785 A2 WO9409785 A2 WO 9409785A2
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- doxazosin
- amount
- pharmaceutically acceptable
- composition according
- acceptable salt
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Definitions
- This invention relates to novel compositions of matter containing optically pure (+) doxazosin. These compositions are of utility in the treatment of patients with benign prostatic hyperplasia (BPH) or in the treatment of patients with elevated serum low density lipoprotein (LDL) levels. Pure (+) doxazosin exhibits little of the hypotensive activity associated with the (-) enantiomer and is therefore superior to racemic doxazosin for these indications. Also disclosed are methods for treating BPH and elevated LDL in a human while avoiding the hypotensive effects that are associated with the racemic mixture of doxazosin by administering the (+) isomer of doxazosin to said human.
- BPH benign prostatic hyperplasia
- LDL serum low density lipoprotein
- the active compound of these compositions and methods is an optical isomer of doxazosin, which is described by Young and Brogden in Drugs 35. 525-541 (1988) and United States Patent No. 4,188,390. Chemically, the active compound is the (+) isomer of 4-amino-2-[4-(1 ,4-benzodioxan-2-carbonyl)piperazin-1- yl]-6,7-dimethoxyquinazoline also known as l-(4- amino-6,7-dimethoxy-2-quinazolinyl)-4-[ (2,3-dihydro- l,4-benzodioxan-2-yl)carbonyl]piperazine hereinafter referred to as doxazosin.
- (+) Doxazosin which is the subject of the present invention, is available commercially only as the 1:1 racemic mixture. That is, (+) doxazosin is available only as a mixture of optical isomers, called enantiomers.
- the racemic mixture of doxazosin is commercially available for administration as a ethanesulfonate ( esylate) salt, but extensive pharmacology has been published on the hydrochloride salt as well.
- D-lactic acid is the same as (-) lactic acid
- L-lactic acid is (+)
- stereoisomer are identical except that they are mirror images of one another.
- a specific stereoisomer may also be referred to as an enantiomer, and a mixture of such isomers is often called an enantiomeric or racemic mixture.
- Doxazosin (I) is a representative of a group of drugs that block - adrenoceptors.
- ⁇ - Receptors are innervated by postganglionic sympathetic neuronal fibers and are located in many body systems, including the cardiovascular system and the urinary tract.
- Evidence is now beginning to accumulate that there are subtypes of ⁇ - receptors, making ⁇ , adrenergic receptors a family of recognition units rather than a monolithic element.
- Bylund fFASEB J. 6, 832-839 (1992) ] has presented evidence that there are at least three presently differentiable _ receptor subtypes.
- Prazosin (II) an achiral analog of doxazosin, is reported to have similar affinities for each of these subtypes.
- Doxazosin has a single chiral center located on the carbon adjacent to the carboxyl group (shown in formula I) . This gives rise to a pair of enantiomers which have been resolved by Ley et al. [Recent Advances in Chiral Separations, Steven and Wilson
- racemic doxazosin The racemic mixture of doxazosin is presently used primarily as an antihypertensive agent. Doxazosin's oral bioavailability is good and the plasma half life in man is approximately 10 hours following both oral and intravenous administration. There are reports that the administration of racemic doxazosin leads to modestly decreased total cholesterol and LDL levels. [Young & Brogden Drugs 35, 525-541 (1988) and references therein.] There is also a report of the use of prazosin (II) to treat BPH [Hedlund et al., J. Urology 130. 275-278 (1983)]. However, neither of the drugs has enjoyed widespread use for either BPH or improvement of serum lipid profiles because of the cardiovascular effects that are the primary result of their administration.
- a troublesome cardiovascular problem related to the use of previously known ct_ receptor antagonists for the treatment of BPH and the improvement of serum lipid profiles is their hypotensive activity, which is particularly reflected in the problem of orthostatic hypotension.
- Symptomatic orthostatic hypotension is most likely to occur with high initial doses of earlier ⁇ - antagonists or may occur when the dose is increased rapidly.
- Reflex tachycardia is also occasionally observed.
- the optically pure (+) isomer of doxazosin is an effective agent for the treatment of BPH that avoids the hypotensive effects of racemic doxazosin. It is also an effective agent for the improvement of serum lipid profiles that avoids the adverse effects associated with the administration of the racemic mixture.
- the present invention also includes methods for treating BPH and for treating or preventing atherosclerosis in a human while avoiding the cardiovascular effects that are associated with the racemic mixture of doxazosin, by administering the optically pure (+) isomer of doxazosin to said human.
- the present invention encompasses a method of eliciting an increase in urine flow in a human, while avoiding the concomitant liability of hypotensive effects associated with the administration of racemic doxazosin, which comprises administering to a human an amount of (+) doxazosin, or a pharmaceutically acceptable salt thereof, substantially free of its (-) stereoisomer, said amount being sufficient to increase urine flow, but insufficient to cause the hypotensive effects associated with the racemic mixture of doxazosin.
- the present invention also encompasses a composition for increasing urine flow in a human, which comprises an amount of (+) doxazosin, or a pharmaceutically acceptable salt thereof, substantially free of its (-) stereoisomer, said amount being sufficient to increase urine flow but insufficient to cause the hypotensive effects associated with racemic doxazosin.
- the present invention also encompasses a method of lowering plasma cholesterol and low density lipoprotein levels in a human while avoiding the concomitant liability of adverse effects associated with racemic doxazosin, which comprises administering to a human an amount of (+) doxazosin, or a pharmaceutically acceptable salt thereof, substantially free of its (-) stereoisomer, said amount being sufficient to lower the cholesterol and LDL levels but insufficient to cause the adverse effects associated with racemic doxazosin.
- the present invention also encompasses a composition for lowering serum cholesterol and low density lipoprotein in humans, which comprises an amount of (+) doxazosin or a pharmaceutically acceptable salt thereof, substantially free of its (-) stereoisomer, said amount being sufficient to lower serum low density lipoproteins, but insufficient to cause adverse effects associated with the administration of racemic doxazosin.
- racemic doxazosin i.e. a 1:1 racemic mixture of the two enantiomers
- racemic doxazosin has been shown to improve the profile of serum lipoproteins in humans.
- Epidemiological studies have indicated that high concentrations of high density lipoprotein (HDL) cholesterol are a negative risk factor for coronary artery disease, while high concentrations of low density lipoprotein (LDL) cholesterol are a positive risk factor.
- HDL high density lipoprotein
- LDL low density lipoprotein
- prazosin exerts an ⁇ -adrenoceptor blocking effect on both human prostatic adenoma tissue and prostatic capsule tissue in vitro.
- ⁇ -adrenoceptors contributes to the obstruction of benign prostatic hyperplasia, their blockade ought to be effective therapeutically, and, in fact, prazosin has been shown to improve urinary flow and bladder evacuation in patients suffering from benign prostatic hyperplasia.
- doxazosin There are no reports of the use of doxazosin for this indication.
- the use of substantially pure (+) doxazosin makes possible the improvement in urinary flow and bladder evacuation without the concomitant cardiovascular activity of classical ⁇ , antagonists and racemic doxazosin. It is therefore, more desirable to administer the (+) isomer of doxazosin than racemic doxazosin.
- doxazosin includes, but is not limited to hypotension, postural hypotension, nausea, lethargy, fatigue and dizziness.
- Side effects that have been reported with doxazosin include headache, blurred vision, edema, chest discomfort, constipation, dry mouth, sexual dysfunction, anxiety or nervousness, insomnia, palpitations, tachycardia, rash, paresthesia, muscle cramps, increased sweating, conjunctivitis, diarrhea, flatulence, dyspnea, leukopenia, neutropenia, rhinitis and increased frequency of micturition.
- compositions contain a greater proportion of the (+) isomer of doxazosin in relation to the (-) isomer.
- the term “substantially free of its (-) isomer” as used herein means that the composition is at least 90% by weight of (+) doxazosin and 10% by weight or less of (-) doxazosin.
- the term “substantially free of the (-) stereoisomer” means that the composition contains at least 99% by weight of (+) doxazosin, and 1% or less of (-) doxazosin.
- the term "substantially free of its (-) stereoisomer” as used herein means that the composition contains greater than 99% by weight of (+) doxazosin. These percentages are based upon the total amount of doxazosin in the composition.
- the terms “substantially optically pure (+) isomer of doxazosin or “substantially optically pure (+) doxazosin” and “optically pure (+) isomer of doxazosin and “optically pure (+) doxazosin” are also encompassed by the above-described amounts.
- the chemical synthesis of the racemic mixture of doxazosin can be performed by the method described in U.S. Patent 4,188,390.
- the individual enantiomers of doxazosin may be obtained by resolution of the racemic mixture of enantiomers using conventional means.
- Doxazosin may be resolved with an optically active acid such as tartaric acid at the N-(l,4- benzodioxan-2-carbonyl)piperazine stage or at the final product.
- the benzodioxan- carboxylic acid intermediate can be resolved with an optically active base such as brucine or ⁇ -- phenethyla ine.
- the optically pure (+) isomer can be prepared from the racemic mixture by enzymatic biocatalytic resolution. See for example, U.S. Patent Nos. 5,057,427 and 5,077,217, the disclosures of which are incorporated herein by reference.
- a prophylactic or therapeutic dose of (+) doxazosin in the acute or chronic management of disease will vary with the severity of the condition to be treated, and the route of administration.
- the dose, and perhaps the dose frequency, will also vary according to the age, body weight, and response of the individual patient.
- the total daily dose range, for (+) doxazosin, for the conditions described herein is from about 0.1 mg to about 20 mg, in single or divided doses.
- a daily dose range should be between about 0.5 mg to about 10 mg, in single or divided doses, while most preferably, a daily dose range should be between about 0.5 mg to about
- the therapy should be initiated at a lower dose, perhaps about 0.5 mg to about 1 mg, and increased up to about 10 mg or higher depending on the patient's global response. It is further recommended that children, and patients over 65 years, and those with impaired renal, or hepatic function, initially receive low doses, and that they be titrated based on individual response(s) and blood level(s). It may be necessary to use dosages outside these ranges in some cases, as will be apparent to those skilled in the art. Further, it is noted that the clinician or treating physician will know how and when to interrupt, adjust, or terminate therapy in conjunction with individual patient response. The terms "an amount sufficient to increase urine flow but insufficient to cause said hypotensive effects" and "an amount sufficient to lower cholesterol and
- Any suitable route of administration may be employed for providing the patient with an effective dosage of (+) doxazosin.
- oral, rectal, parenteral (subcutaneous, intramuscular, intravenous), transdermal, and like forms of administration may be employed.
- Dosage forms include tablets, troches, dispersions, suspensions, solutions, capsules, patches, and the like.
- compositions of the present invention comprise (+) doxazosin as the active ingredient, or a pharmaceutically acceptable salt thereof, and may also contain a pharmaceutically acceptable carrier, and optionally, other therapeutic ingredients.
- salts or “a pharmaceutically acceptable salt thereof” refer to salts prepared from pharmaceutically acceptable non- toxic acids or bases including inorganic acids and bases and organic acids and bases. Since the compound of the present invention is basic, salts may be prepared from pharmaceutically acceptable non- toxic acids including-inorganic and organic acids.
- Suitable pharmaceutically acceptable acid addition salts for the compound of the present invention include acetic, benzenesulfonic (besylate) , benzoic, camphorsulfonic, citric, ethenesulfonic, fumaric, gluconic, glutamic, hydrobromic, hydrochloric, isethionic, lactic, maleic, malic, mandelic, methanesulfonic (mesylate) , mucic, nitric, pamoic, pantothenic, phosphoric, succinic, sulf ric, tartaric, p-toluenesulfonic, and the like.
- compositions of the present invention include compositions such as suspensions, solutions, elixirs, aerosols, and solid dosage forms.
- Carriers such as starches, sugars, microcrystalline cellulose, diluents, granulating agents, lubricants, binders, disintegrating agents, and the like, are commonly used in the case of oral solid preparations (such as powders, capsules, and tablets) , with the oral solid preparations being preferred over the oral liquid preparations.
- the most preferred oral solid preparation is tablets.
- tablets and capsules represent the most advantageous oral dosage unit form, in which case solid pharmaceutical carriers are employed. If desired, tablets may be coated by standard aqueous or nonaqueous techniques.
- the compounds of the present invention may also be administered by controlled release means and/or delivery devices such as those described in U.S.Patent Nos. : 3,845,770; 3,916,899; 3,536,809; 3,598,123; and 4,008,719; the disclosures of which are hereby incorporated by reference.
- compositions of the present invention suitable for oral administration may be presented as discrete units such as capsules, cachets, or tablets, or aerosol sprays, each containing a predetermined amount of the active ingredient, as a powder or granules, or as a solution or a suspension in an aqueous liquid, a non-aqueous liquid, an oil-in-water emulsion, or a water-in-oil liquid emulsion.
- Such compositions may be prepared by any of the methods of pharmacy, but all methods include the step of bringing into association the active ingredient with the carrier which constitutes one or more necessary ingredients.
- the compositions are prepared by uniformly and intimately admixing the active ingredient with liquid carriers or finely divided solid carriers or both, and then, if necessary, shaping the product into the desired presentation.
- a tablet may be prepared by compression or molding, optionally, with one or more accessory ingredients.
- Compressed tablets may be prepared by compressing in a suitable machine the active ingredient in a free-flowing form such as powder or granules, optionally mixed with a binder, lubricant, inert diluent, surface active or dispersing agent.
- Molded tablets may be made by molding in a suitable machine, a mixture of the powdered compound moistened with an inert liquid diluent.
- each tablet contains from about 0.5 mg to about 10 mg of the active ingredient.
- the tablet, cachet or capsule contains either one of three dosages, about 0.5 mg, about 2 mg or about 8 mg of the active ingredient.
- a test for activity in lowering serum LDL and cholesterol is carried out according to the method of Havel et al. [Arteriosclerosis 2 . 467-474 (1982)].
- WHHL Homozygous Watanabe-heritable hyperlipidemic
- Blood is collected from the ear veins of unanesthetized rabbits or from the abdominal aorta of anesthetized rabbits and placed on ice. Lipoproteins are separated from plasma by sequential ultracentrifugation. For analysis of lipoprotein composition and for separation of protein components, samples are recentrifuged at their upper density limits. Total cholesterol and triglycerides are estimated in plasma, and lipoprotein fractions by the automated technique of Rush et al. [Rush RL, Leon L, Turrell J. "Automated simultaneous cholesterol and triglyceride determination on the autoanalyzer II instrument.” In: Advances in Automated Analysis- Technicon International Congress-1970/Clinical Analysis. Mt. Kisco: Futura, 1970; 1:503-507] For measurements of lipoprotein composition, one can also estimate free and esterified cholesterol, phospholipids, and protein.
- a test for vascular dilatation is carried out as follows: New Zealand White rabbits, weighing 2.0 to 2.5 kg, are sacrificed by cervical dislocation and the thoracic aortas excised immediately. The aortas are then immersed in warm, oxygenated Krebs- bicarbonate solution and cut in transverse or spiral strips, 1 to 3 mm in width. The strips are suspended vertically in tissue baths containing an isotonic bicarbonate buffer.
- composition of this buffer may be as follows (amount in millimoles per liter) : NaCl, 119.0; KC1, 4.7; CaCl 2 , 2.5; MgS0 4 , 1.5; KH 2 P0 4 , 1.2; NaHC0 3 , 25.0; and dextrose, 11.0.
- the bathing medium is aerated with 95% 0 2 and 5% C0 2 and maintained at 37.O ⁇ 0.5° C and pH 7.4.
- the lower end of each strip is secured to a tissue holder and the upper end attached via a string or a fine chain to a force-displacement transducer; responses are displayed on recorders.
- Tissues are placed under an initial tension of 0.1 to 2.0 g and permitted to stretch and equilibrate before testing.
- the tension on the strips is readjusted intermittently to the initial tension during the equilibration period.
- Drugs are introduced into the tissue baths with syringes or pipettes and removed by drainage and replacement of the bathing medium from preheated, oxygenated reservoirs. Responses are expressed as gram changes in tension above base-line.
- the response of the tissue to l ⁇ g/mL phenylephrine is measured.
- the tissue is incubated with varying concentrations of the test substances and the response to phenylephrine re-evaluated.
- the tissues are precontracted with an ⁇ -receptor stimulator such as phenylephrine and relaxed by gradual additions of a test substance to the bath fluid.
- a test for insulin resistance is carried out as an indication of favorable changes in serum lipid levels.
- Castelli, American Heart Journal. 112: 432- 40 (1986) and McKeigne et al, British Heart Journal. 60: 390-96 (1988) have shown that insulin resistance and hyperinsulinemia lead to decreases in plasma HDL cholesterol concentrations and increases in plasma triglyceride levels.
- the beneficial effects of doxazosin on plasma lipids are therefore consistent with previous findings of a decreased insulin resistance in man after dosing with doxazosin, and a test protocol which measures insulin resistance correlates with an expectation of similar responses in serum lipids jn vivo.
- Insulin is a hormone that activates various biochemical processes in the body, the most well known being facilitation of glucose transport over cell membranes and activation of cell growth.
- the development of insulin resistance is common both in diabetics and nondiabetics, but it is only the glucose transport system that develops resistance to insulin.
- the normal body produces more insulin and the diabetic patient has to inject higher doses of insulin.
- insulin also is a growth hormone, the increased insulin concentration induces an accelerated growth of atherosclerotic lesions and increased risk for cardiovascular morbidity and mortality.
- SHRs spontaneously hypertensive rats
- Racemic doxazosin, (-) doxazosin, and (+) doxazosin are studied for their effects on glucose transport, insulin plasma concentration and arterial blood pressure.
- systolic blood pressure measured via tail cuff occlusion
- fasting levels of plasma insulin and triglycerides are made: (1) systolic blood pressure (measured via tail cuff occlusion) ; (2) fasting levels of plasma insulin and triglycerides; and (3) glucose tolerance.
- the SHRs receive vehicle or test compound via oral gavage once or twice daily for two or four weeks. Measurements of blood pressure, circulating insulin and triglycerides, and glucose clearance are made following two (and four) weeks of drug administration. Any changes in insulin resistance resulting from the drug treatment are evident as changes in the ratio of plasma glucose/plasma insulin levels and from the glucose tolerance tests.
- a test for orthostatic hypotension and reflex tachycardia is carried out in dogs. Groups of dogs are tested with suitable doses of racemic doxazosin, (-) doxazosin, and (+) doxazosin and the effects on blood pressure (orthostatic hypotension) and heart rate (reflex tachycardia) are monitored and recorded at predetermined time intervals. Conscious normotensive dogs with surgically implanted arterial catheters are used to study the effects of the drugs on orthostatic hypotension and heart rate. The animals may also be equipped with cutaneous electrodes connected to suitable equipment for recording electrocardiograms. The tip of the indwelling catheter is positioned at the junction between the aorta and the left carotid artery.
- Blood pressure is measured by means of a pressure transducer and heart rate is computed from the systolic peaks in blood pressure or from the R-waves of the EKG.
- Doses of the test compounds are given orally or parenterally and the effects on the cardiovascular parameters are initially recorded with the animals in normal standing position. The animals are then held by their front paws and lifted into an upright position, standing on their hind paws. Drugs causing orthostatic hypotension will cause a sudden fall in recorded arterial blood pressure, sometimes accompanied by a reflex tachycardia.
- the active ingredient, (+) doxazosin is sieved and blended with the excipient.
- the mixture is filled into suitably sized two-piece hard gelatin capsules using suitable machinery.
- Other doses may be prepared by altering the fill weight and if necessary, changing the capsule size to suit.
- the active ingredient is blended with the lactose until a uniform blend is formed.
- the smaller quantity of cornstarch is blended with the water to form the resulting cornstarch paste. This is then mixed with the uniform blend until a uniform wet mass is formed and the remaining cornstarch is added and mixed until uniform granules are obtained.
- the granules are screened through a suitable milling machine using a 1/4" stainless steel screen. The milled granules are dried in a suitable drying oven and milled through a suitable milling machine again. The magnesium stearate is then blended and the resulting mixture is compressed into tablets of desired shape, thickness, hardness and disintegration.
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Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9501286A HU219482B (en) | 1992-11-04 | 1993-11-02 | Use of (+) doxazosin for producing pharmaceutical compositions eliciting an increase in urine flow |
EP94900492A EP0667775A1 (en) | 1992-11-04 | 1993-11-02 | Methods and compositions of (+) doxazosin for the treatment of benign prostatic hyperplasia and atherosclerosis |
AU55461/94A AU5546194A (en) | 1992-11-04 | 1993-11-02 | Methods and compositions of (+) doxazosin for the treatment of benign prostatic hyperplasia and atherosclerosis |
KR1019950701804A KR950703961A (en) | 1992-11-04 | 1993-11-02 | Benign prostate thickening and arteriosclerosis treatment method and composition for (+) doxazosin |
JP6511387A JPH08502977A (en) | 1992-11-04 | 1993-11-02 | Method for treating benign prostatic hyperplasia and atherosclerosis and (+) doxazosin composition |
RU95113499A RU2139053C1 (en) | 1992-11-04 | 1993-11-02 | Method of enhancing urination in humans |
NO951718A NO308196B1 (en) | 1992-11-04 | 1995-05-03 | Use of (+) doxazosin for the manufacture of a drug for the treatment of benign prostatic hyperplasia to increase urinary flow |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97068592A | 1992-11-04 | 1992-11-04 | |
US07/970,685 | 1992-11-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1994009785A2 true WO1994009785A2 (en) | 1994-05-11 |
WO1994009785A3 WO1994009785A3 (en) | 1994-08-04 |
Family
ID=25517324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1993/010503 WO1994009785A2 (en) | 1992-11-04 | 1993-11-02 | Methods and compositions of (+) doxazosin for the treatment of benign prostatic hyperplasia and atherosclerosis |
Country Status (11)
Country | Link |
---|---|
US (1) | US5508279A (en) |
EP (1) | EP0667775A1 (en) |
JP (1) | JPH08502977A (en) |
KR (1) | KR950703961A (en) |
AU (1) | AU5546194A (en) |
CA (1) | CA2147866A1 (en) |
HU (1) | HU219482B (en) |
NO (1) | NO308196B1 (en) |
NZ (1) | NZ257993A (en) |
RU (1) | RU2139053C1 (en) |
WO (1) | WO1994009785A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1123705A1 (en) * | 2000-02-09 | 2001-08-16 | Pfizer Products Inc. | Pharmaceutical combinations for treating lower urinary tract disfunctions |
CN1769285B (en) * | 2004-11-05 | 2010-05-05 | 华北制药集团新药研究开发有限责任公司 | Doxazosin salt with optical activity |
CN102260250A (en) * | 2005-11-11 | 2011-11-30 | 华北制药集团新药研究开发有限责任公司 | (-) doxazosin mesylate type IV crystal as well as preparation method and application thereof |
CN107951852A (en) * | 2017-12-31 | 2018-04-24 | 威海贯标信息科技有限公司 | A kind of Doxazosin tablet composition |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL120302A0 (en) * | 1996-03-27 | 1997-06-10 | Pfizer | Use of alpha1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia |
US6177430B1 (en) | 1997-03-27 | 2001-01-23 | Pfizer Inc | Use of α1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia |
US6200573B1 (en) | 1999-12-03 | 2001-03-13 | Starcor Pharmaceuticals, Inc. | Method of medical management for lower urinary tract symptoms and benign prostatic hyperplasia |
US6596686B2 (en) | 2001-03-12 | 2003-07-22 | International Flavors & Fragrances Inc. | Use of dihydropyrans as fragrance Material |
SI1443917T1 (en) * | 2001-11-07 | 2006-06-30 | Synthon Bv | Tamsulosin tablets |
US7175127B2 (en) * | 2002-09-27 | 2007-02-13 | C.G. Bretting Manufacturing Company, Inc. | Rewinder apparatus and method |
KR20050092519A (en) * | 2004-03-16 | 2005-09-22 | 화이자 인코포레이티드 | COMBINATIONS OF ATORVASTATIN AND α1 ADRENERGIC RECEPTOR ANTAGONISTS |
KR100635301B1 (en) * | 2004-09-15 | 2006-10-17 | 지엘팜텍 주식회사 | A sustained-release tablet containing doxazosin mesylate |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4188390A (en) * | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
WO1992016213A1 (en) * | 1991-03-20 | 1992-10-01 | Merck & Co., Inc. | Pharmaceutical combination for the treatment of prostatic hyperplasia, containing a 5 alpha-reductase inhibitor and an antiandrogen |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5212176A (en) * | 1990-06-29 | 1993-05-18 | Abbott Laboratories | R(+)-terazosin |
-
1993
- 1993-11-02 CA CA002147866A patent/CA2147866A1/en not_active Abandoned
- 1993-11-02 KR KR1019950701804A patent/KR950703961A/en not_active Application Discontinuation
- 1993-11-02 EP EP94900492A patent/EP0667775A1/en not_active Withdrawn
- 1993-11-02 RU RU95113499A patent/RU2139053C1/en active
- 1993-11-02 HU HU9501286A patent/HU219482B/en not_active IP Right Cessation
- 1993-11-02 NZ NZ257993A patent/NZ257993A/en unknown
- 1993-11-02 WO PCT/US1993/010503 patent/WO1994009785A2/en not_active Application Discontinuation
- 1993-11-02 AU AU55461/94A patent/AU5546194A/en not_active Abandoned
- 1993-11-02 JP JP6511387A patent/JPH08502977A/en active Pending
-
1994
- 1994-03-07 US US08/206,764 patent/US5508279A/en not_active Expired - Fee Related
-
1995
- 1995-05-03 NO NO951718A patent/NO308196B1/en not_active IP Right Cessation
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EP1123705A1 (en) * | 2000-02-09 | 2001-08-16 | Pfizer Products Inc. | Pharmaceutical combinations for treating lower urinary tract disfunctions |
US7138405B2 (en) | 2000-02-09 | 2006-11-21 | Novartis International Pharmaceutical Ltd | Pharmaceutical combinations |
EP2266571A1 (en) * | 2000-02-09 | 2010-12-29 | Novartis International Pharmaceutical Ltd. | Pharmaceutical combinations for treating lower urinary tract disfunctions |
AU2009227918B2 (en) * | 2000-02-09 | 2011-09-22 | Aspen Global Incorporated | Pharmaceutical combinations |
CN1769285B (en) * | 2004-11-05 | 2010-05-05 | 华北制药集团新药研究开发有限责任公司 | Doxazosin salt with optical activity |
CN102260249A (en) * | 2005-11-11 | 2011-11-30 | 华北制药集团新药研究开发有限责任公司 | (-) doxazosin mesylate type II crystal as well as preparation method and application thereof |
CN102260250A (en) * | 2005-11-11 | 2011-11-30 | 华北制药集团新药研究开发有限责任公司 | (-) doxazosin mesylate type IV crystal as well as preparation method and application thereof |
CN102321079A (en) * | 2005-11-11 | 2012-01-18 | 华北制药集团新药研究开发有限责任公司 | (-) doxazosin mesylate crystal VI as well as preparation method and application thereof |
CN102321079B (en) * | 2005-11-11 | 2013-08-28 | 华北制药集团新药研究开发有限责任公司 | (-) doxazosin mesylate crystal VI as well as preparation method and application thereof |
CN102321078B (en) * | 2005-11-11 | 2013-08-28 | 华北制药集团新药研究开发有限责任公司 | Doxazosin mesylate III form crystal, and preparation method and usage thereof |
CN102321080B (en) * | 2005-11-11 | 2013-09-25 | 华北制药集团新药研究开发有限责任公司 | Doxazosin mesylate V form crystal, and preparation method and usage thereof |
CN102260250B (en) * | 2005-11-11 | 2013-09-25 | 华北制药集团新药研究开发有限责任公司 | (-) doxazosin mesylate type IV crystal as well as preparation method and application thereof |
CN102260249B (en) * | 2005-11-11 | 2013-11-13 | 华北制药集团新药研究开发有限责任公司 | (-) doxazosin mesylate type II crystal as well as preparation method and application thereof |
CN107951852A (en) * | 2017-12-31 | 2018-04-24 | 威海贯标信息科技有限公司 | A kind of Doxazosin tablet composition |
Also Published As
Publication number | Publication date |
---|---|
NO951718D0 (en) | 1995-05-03 |
RU2139053C1 (en) | 1999-10-10 |
NZ257993A (en) | 1997-05-26 |
HUT73678A (en) | 1996-09-30 |
CA2147866A1 (en) | 1994-05-11 |
WO1994009785A3 (en) | 1994-08-04 |
HU9501286D0 (en) | 1995-06-28 |
NO308196B1 (en) | 2000-08-14 |
KR950703961A (en) | 1995-11-17 |
NO951718L (en) | 1995-05-03 |
HU219482B (en) | 2001-04-28 |
JPH08502977A (en) | 1996-04-02 |
US5508279A (en) | 1996-04-16 |
EP0667775A1 (en) | 1995-08-23 |
AU5546194A (en) | 1994-05-24 |
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