WO1994006382A1 - Improvements in skin plasters - Google Patents

Improvements in skin plasters Download PDF

Info

Publication number
WO1994006382A1
WO1994006382A1 PCT/IE1993/000050 IE9300050W WO9406382A1 WO 1994006382 A1 WO1994006382 A1 WO 1994006382A1 IE 9300050 W IE9300050 W IE 9300050W WO 9406382 A1 WO9406382 A1 WO 9406382A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
skin
plaster
swab
flap
dressing
Prior art date
Application number
PCT/IE1993/000050
Other languages
French (fr)
Inventor
Gerard Patrick Duffy
Original Assignee
Gerard Patrick Duffy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/02Adhesive plasters or dressings
    • A61F13/0203Adhesive plasters or dressings having a fluid handling member
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00365Plasters use
    • A61F2013/00412Plasters use for use with needles, tubes or catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00544Plasters form or structure
    • A61F2013/00553Plasters form or structure with detachable parts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00544Plasters form or structure
    • A61F2013/0057Plasters form or structure with openable cover
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00795Plasters special helping devices
    • A61F2013/008Plasters special helping devices easy removing of the protection sheet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00795Plasters special helping devices
    • A61F2013/00817Plasters special helping devices handles or handling tabs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00795Plasters special helping devices
    • A61F2013/00825Plasters special helping devices protection of wound surround
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00855Plasters pervious to air or vapours
    • A61F2013/00859Plasters pervious to air or vapours with macroscopic openings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00897Plasters package for individual plaster
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/84Accessories, not otherwise provided for, for absorbent pads
    • A61F2013/8476Accessories, not otherwise provided for, for absorbent pads with various devices or method

Abstract

A plaster (10) for topical application comprises a strip (11) securable to the skin by adhesive (13, 13'), a first flap (18) which when pulled exposes to the skin surface a first swab (20) which wipes the skin and a second flap (18') which when pulled exposes in succession to the skin surface a second swab (20') which wipes the skin and then a dressing (14) which remains in contact with the skin. At least one of the swabs (20, 20') can be impregnated with an antiseptic agent so that the action of pulling a flap (18, 18') can result in the skin being cleansed and sterilized prior to the dressing (14) coming into contact therewith. The flaps (18, 18') are each detachable from a central portion (12) at weakened lines (19, 19'), respectively. The surface of the plaster (10) overlying the dressing (14) is provided with an openable aperture (15, 16) for accessing the skin.

Description

Description

Improvements in Skin Plasters

Technical Field

This invention relates to skin plasters of the type comprising various types of fabric or synthetic materials and an adhesive substance for local application to cuts and abrasions and puncture sites resulting from needles, cannulas and the like, hereinafter referred to collectively as plasters.

Background Art

In general, in procedures where a plaster is applied to the skin, the skin is first swabbed with an antiseptic, such as surgical spirit and optionally dried with a further swab before the plaster is actually affixed to the skin. Thus, one must have such swabs and antiseptic agent to hand.

A plaster which obviated the need for swabs and a skin antiseptic would be of considerable benefit to medical personnel applying such plasters but also in the home, schools, leisure areas and the workplace, where all of these separate items may not readily be to hand.

A further problem is that once a plaster is in place, if access is required to the site of application, the plaster must be removed. The removal of a plaster can cause pain because the adhesive adheres to the site of application. Thus, a plaster which permitted access to the site of application without removing the plaster would have advantages in the situations hereinbefore mentioned. Disclosure of Invention

The invention provides a plaster for topical application, which comprises a folded strip securable to the skin by adhesive and a flap which when pulled exposes in succession to the skin surface a swab which wipes the skin and then a dressing which remains in contact with the skin.

The plaster according to the invention can be provided with a further flap which when pulled exposes to the skin surface a further swab which wipes the skin.

According to a preferred embodiment of the invention, the plaster comprises a first flap which when pulled exposes to the skin surface a first swab which wipes the skin and a second flap which when pulled exposes in succession to the skin surface a second swab which wipes the skin and then the dressing which remains in contact with the skin.

Preferably, the first swab is impregnated with an antiseptic agent.

Thus, the plaster according to the invention obviates the need for a separate wiping of the skin with an antiseptic agent to which a plaster is to be applied prior to application of said plaster, because this operation can be inherent in the application of the plaster as hereinbefore described by virtue of the structure and mode of application thereof.

The second swab, when such is present, can be impregnated with an active agent.

For example, the active agent can be a rubefacient, such as camphor or menthol or other locally acting peripheral vasodilator. Other active agents that might be used to impregnate a swab forming part of the plaster according to the invention include an antimicrobial agent, an antioxidant, a pH-controlling agent, a plasticizer, a surfactant, a humectant or a penetration enhancer.

The swab might also be impregnated with a local anaesthetic to suppress irritation and pain at the site of application of the plaster, depending on the medical procedure to be carried out on the patient.

In a further preferred embodiment once the plaster is secured in situ and the or each flap has been pulled to expose and bring the dressing into contact with the skin, means are provided for readily detaching the flaps and associated swab carrying portions of the plaster. Suitably said means comprise a weakened line from which the flaps and associated swab carrying portions can be detached by a tearing action, such as a tear-away strip.

The dressing itself can also be impregnated with an active agent.

For example, the dressing can be impregnated with a haemostatic agent, such as thrombin. However, the active agent can also be an antimicrobial agent, including an antibiotic or, indeed, any of the active agents hereinabove specified for impregnation of a swab forming part of the plaster according to the invention.

The dressing can also contain an active agent in a form suitable for percutaneous or transdermal administration.

It will be appreciated that when the or each swab and or the dressing are impregnated with an active agent, the plaster must be composed of such materials or be of such a construction that mixing or leakage of the active agent(s), as appropriate, is prevented. For example, the or each swab can be provided with a foil backing which prevents leakage or transfer of the active agent into the overlying layers of the plaster in the folded condition. Following detachment of the flaps they are generally discarded. However, a swab on the or each flap can be used to take a specimen of body fluid or discharge from broken skin for analysis by biochemical, histological or other pathological procedure.

According to a still further preferred embodiment according to the invention the surface of the plaster overlying the dressing is provided with an openable aperture for accessing the skin once the plaster is affixed to the skin.

This embodiment of the invention allows access for injection, transfusion, the insertion of a cannula and many other medical procedures. By using materials conventionally used to form plasters, one can simply form such an openable aperture by a punching operation which generates a flap, which can be opened to access the skin but which remains attached to or hinged to the plaster and which can be closed again by simply pushing the flap back into position.

It will also be appreciated that the plaster according to the invention would be particularly suited for use in blood banks on blood or plasma donors. Thus, the plaster with one or two flaps could be applied to the site from which blood or plasma is to be withdrawn and successively wiped with antiseptic and optionally dried, the needle by means of which the blood is to be withdrawn is then passed through the aperture following opening thereof. Once the donation has been taken, the needle will be withdrawn and the aperture closed, optionally following introduction of an effective amount of a haemostatic agent through the aperture. Of course, it will be appreciated that the dressing as such could be impregnated with a haemostatic agent in the ready-to- use state of the plaster.

As indic ted above, the plaster according to the invention is manufactured υm materials conventionally used in plaster manufacture. The swabs can be formed of any suitable material such as lint, gauze and various types of mesh, as required. By selecting appropriate materials, one can achieve a plaster that is porous to air or, alternatively, occlusive, as required, depending on the particular application of the plaster. The outer surface of the plaster, in use, can be comprised of a waterproof material, if required.

Likewise, the adhesive material will be conventional adhesive material or material having inherent tackiness secundem artem.

The invention also provides a plaster for topical application comprising an openable aperture for accessing the skin once the plaster has been affixed to the skin.

The invention will be further illustrated by the following description of an embodiment thereof, given by way of example only with reference to the accompanying Drawings:

Brief description of the Drawings

Fig. 1 is a schematic representation of a plaster according to the invention in the folded state, details of underlying layers thereof being shown in dotted outline;

Fig. 2 is a schematic representation of the plaster of Fig. 1 in the unfolded state; and

Fig. 3 is an end elevation in section of the plaster of Fig. 1.

Best mode for carrying out the Invention

Referring to the Drawings and, in particular, Fig. 2 thereof, there is indicated, generally at 10, a plaster consisting of a strip 11 cut to the desired dimensions and which can be folded into the configuration shown in each of Figs. 1 and 3.

The plaster 10 has a central portion 12 of a slightly greater width than the remainder of the strip 11 , so as to accommodate a strip of adhesive (not shown) along the longitudinal edges 13, 13' thereof. A dressing 14 is shown in dotted outline affixed on the under surface of said central portion 12 and an aperture 15 closeable by a flap 16 is cut from the central portion 12 but remains attached or hinged along a portion 17 of the edge of the aperture 15.

On either side of the central portion 12 there is a flap 18, 18' each of which is attached to the central portion 12 by a weakened line 19, 19', respectively. Each of the flaps 18, 18' carries a swab 20, 20' shown in dotted outline on the under surface thereof. Each of the flaps 18, 18' has a tapered end portion 21, 21' which, together with a portion of the flap 18, 18', projects beyond the central portion 12 when the plaster is in the folded condition and by means of which the swabs 20, 20' and the dressing 14 are successively brought into contact with the skin following application of the plaster 10 thereto. First the tapered end portion 21 and then the tapered end portion 21' is pulled so as to unfold the plaster 10 from the configuration shown in each of Figs. 1 and 3 to the fully opened configuration depicted in Fig. 2.

Once the flap 18 has been pulled into the fully extended position as shown in Fig. 2, it can simply be detached from the central portion 12 at the weakened line 19. Likewise, once the flap 18' has been pulled into the fully extended position as shown in Fig. 2, it too can simply be detached at weakened line 19'.

The flap 16 can be opened and closed, as required, for example, for the insertion and subsequent removal of a needle.

Claims

Claims
1. A plaster for topical application, which comprises a folded strip securable to the skin by adhesive and a flap which when pulled exposes in succession to the skin surface a swab which wipes the skin and then a dressing which remains in contact with the skin.
2. A plaster according to Claim 1, which is provided with a further flap which when pulled exposes to the skin surface a further swab which wipes the skin.
3. A plaster according to Claim 2, which comprises a first flap which when pulled exposes to the skin surface a first swab which wipes the skin and a second flap which when pulled exposes in succession to the skin surface a second swab which wipes the skin and then the dressing which remains in contact with the skin.
4. A plaster according to Claim 3, wherein the first swab is impregnated with an antiseptic agent.
5. A plaster according to Claim 3 or 4, wherein the second swab is impregnated with an active agent.
6. A plaster according to any preceding claim, wherein once the plaster is secured in situ and the or each flap has been pulled to expose and bring the dressing into contact with the skin, means are provided for readily detaching the flaps and associated swab carrying portions of the plaster.
7. A plaster according to Claim 6, wherein the means comprise a weakened line from which the flaps and associated swab carrying portions can be detached by a tearing action.
8. A plaster according to any preceding claim, wherein the surface of the plaster overlying the dressing is provided with an openable aperture for accessing the skin once the plaster is affixed to the skin.
9. A plaster according to any preceding claim, wherein the plaster in the folded condition is provided with one or a pair of peel- off strip(s).
10. A plaster for topical application comprising an openable aperture for accessing the skin once the plaster has been affixed to the skin.
AMENDED CLAIMS
[received by the International Bureau on 29 December 1993 (29.12.93) ; original claim 10 cancel led ; other claims unchanged ( 1 page) ]
openable aperture for accessing the skin once the plaster is affixed to the skin.
9. A plaster according to any preceding claim, wherein the plaster in the folded condition is provided with one or a pair of peel- off strip(s).
PCT/IE1993/000050 1992-09-22 1993-09-22 Improvements in skin plasters WO1994006382A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IE922676 1992-09-22
IE922676 1992-09-22

Publications (1)

Publication Number Publication Date
WO1994006382A1 true true WO1994006382A1 (en) 1994-03-31

Family

ID=11039762

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IE1993/000050 WO1994006382A1 (en) 1992-09-22 1993-09-22 Improvements in skin plasters

Country Status (1)

Country Link
WO (1) WO1994006382A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5603946A (en) * 1993-10-08 1997-02-18 Bristol-Myers Squibb Company Wound dressing
ES2141021A1 (en) * 1997-09-23 2000-03-01 Moreno Miguel Angel Rodriguez Antiseptic-disinfectant sticking plaster.
US6992232B1 (en) * 2005-06-02 2006-01-31 Kemeny Emanuel S Adhesive bandage and packaging for one-handed placement
US8591447B2 (en) 2010-06-29 2013-11-26 Jennifer DiGrazia Wound and bandage protection system and method

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3018881A (en) * 1960-06-02 1962-01-30 Minnesota Mining & Mfg Adhesive bandage package unit
US4176664A (en) * 1978-03-13 1979-12-04 Stanley Kalish Impregnated bandage
US4738678A (en) * 1987-03-11 1988-04-19 Paulis Robert A Diaper/wipe combination
USRE33353E (en) * 1985-01-24 1990-09-25 Minnesota Mining And Manufacturing Company Thin film surgical dressing with delivery system
US5086763A (en) * 1990-08-06 1992-02-11 Hathman Johnnie L Protective reclosable wound dressing

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3018881A (en) * 1960-06-02 1962-01-30 Minnesota Mining & Mfg Adhesive bandage package unit
US4176664A (en) * 1978-03-13 1979-12-04 Stanley Kalish Impregnated bandage
USRE33353E (en) * 1985-01-24 1990-09-25 Minnesota Mining And Manufacturing Company Thin film surgical dressing with delivery system
US4738678A (en) * 1987-03-11 1988-04-19 Paulis Robert A Diaper/wipe combination
US5086763A (en) * 1990-08-06 1992-02-11 Hathman Johnnie L Protective reclosable wound dressing

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5603946A (en) * 1993-10-08 1997-02-18 Bristol-Myers Squibb Company Wound dressing
ES2141021A1 (en) * 1997-09-23 2000-03-01 Moreno Miguel Angel Rodriguez Antiseptic-disinfectant sticking plaster.
US6992232B1 (en) * 2005-06-02 2006-01-31 Kemeny Emanuel S Adhesive bandage and packaging for one-handed placement
US8591447B2 (en) 2010-06-29 2013-11-26 Jennifer DiGrazia Wound and bandage protection system and method

Similar Documents

Publication Publication Date Title
US3342183A (en) Absorbent adhesive patch impregnated with a vasoconstrictor
US3236370A (en) Sterile surgical drape
US3111943A (en) Aseptic surgical wound protector
C.‐W. YU et al. Hidradenitis suppurativa: a disease of follicular epithelium, rather than apocrine glands
US4917112A (en) Universal bandage with transparent dressing
US5115801A (en) Hydrogel burn dressing product
US4915694A (en) Antimicrobial wound dressing and skin fixator for percutaneous conduits
US5384174A (en) Adhesive sheet
US5780048A (en) First aid bandage dressing system and method of application thereof
US6043408A (en) Wound dressing having a movable flap for alternately viewing and covering a wound
US5236421A (en) Fixing system for fastening catheters, cannulas or the like to the skin surface and process for the sterile fastening thereof
US4976726A (en) Skin closure devices
US5962011A (en) Device for delivery of dermatological ingredients
US5383891A (en) Nose bleed kid
US5074316A (en) Brachial angiography surgical drape
EP0051935A2 (en) Medical device for covering a portion of the anatomical surfaces of a living being
US4490141A (en) Catheter stabilizer and method of securing same to a patient
US5106362A (en) Vented absorbent dressing
US4334530A (en) Indicia-bearing adhesive bandages
US5497788A (en) Wound closure device for viewing a wound and method
EP0161865A2 (en) Adhesive wound dressing
US5106629A (en) Transparent hydrogel wound dressing
US5417668A (en) Removable protective cover for use with a body catheter
US20050215953A1 (en) Intravenous catheter and I.V. medical line securement dressing and stabilizer for human and veterinary medicine
EP0284219A2 (en) Adhesive dressings, their preparation and use

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU BR CA CZ FI HU JP KR NO NZ PL RU US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
NENP Non-entry into the national phase in:

Ref country code: CA

122 Ep: pct application non-entry in european phase