WO1994001558A3 - Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor - Google Patents

Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor Download PDF

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Publication number
WO1994001558A3
WO1994001558A3 PCT/US1993/006296 US9306296W WO9401558A3 WO 1994001558 A3 WO1994001558 A3 WO 1994001558A3 US 9306296 W US9306296 W US 9306296W WO 9401558 A3 WO9401558 A3 WO 9401558A3
Authority
WO
WIPO (PCT)
Prior art keywords
steroid
receptors
thyroid superfamily
superfamily
members
Prior art date
Application number
PCT/US1993/006296
Other languages
French (fr)
Other versions
WO1994001558A2 (en
Inventor
Ronald M. Evans
Michael B. Mc Keown
Anthony E. Oro
William A. Segraves
Tso-Pang Yao
Original Assignee
The Salk Institute For Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Salk Institute For Biological Studies filed Critical The Salk Institute For Biological Studies
Priority to EP94904904A priority Critical patent/EP0804568A2/en
Priority to JP6503431A priority patent/JPH08501211A/en
Priority to AU47697/93A priority patent/AU4769793A/en
Publication of WO1994001558A2 publication Critical patent/WO1994001558A2/en
Publication of WO1994001558A3 publication Critical patent/WO1994001558A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.
PCT/US1993/006296 1992-07-02 1993-07-01 Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor WO1994001558A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP94904904A EP0804568A2 (en) 1992-07-02 1993-07-01 Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
JP6503431A JPH08501211A (en) 1992-07-02 1993-07-01 Multispiral Steroid / Thyroid Superfamily Receptor Member with Ultraspiracle Receptor
AU47697/93A AU4769793A (en) 1992-07-02 1993-07-01 Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90790892A 1992-07-02 1992-07-02
US07/907,908 1992-07-02

Publications (2)

Publication Number Publication Date
WO1994001558A2 WO1994001558A2 (en) 1994-01-20
WO1994001558A3 true WO1994001558A3 (en) 1994-05-26

Family

ID=25424841

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/006296 WO1994001558A2 (en) 1992-07-02 1993-07-01 Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor

Country Status (5)

Country Link
EP (1) EP0804568A2 (en)
JP (1) JPH08501211A (en)
AU (1) AU4769793A (en)
CA (1) CA2137462A1 (en)
WO (1) WO1994001558A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996027673A1 (en) * 1995-03-03 1996-09-12 Novartis Ag Control of gene expression in plants by receptor mediated transactivation in the presence of a chemical ligand
EP0859851A1 (en) * 1995-10-10 1998-08-26 Novartis AG Juvenile hormone or one of its agonists as a chemical ligand to control gene expression in plants by receptor mediated transactivation
EP0910652B1 (en) * 1996-04-05 2014-10-08 The Salk Institute For Biological Studies Hormone-mediated methods for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6333318B1 (en) * 1998-05-14 2001-12-25 The Salk Institute For Biological Studies Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto
CA2336207C (en) 1998-09-10 2004-03-23 Pioneer Hi-Bred International, Inc. Ecdysone receptors and methods for their use
US6958236B2 (en) 2000-10-24 2005-10-25 Syngenta Participations Ag Control of gene expression in plants
EP1436394A4 (en) * 2001-09-26 2004-12-29 Rheo Gene Holdings Inc Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
CA2459807C (en) * 2001-09-26 2013-09-03 Jianzhong Zhang Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0244221A1 (en) * 1986-04-30 1987-11-04 Genentech, Inc. Hybrid receptors, nucleic acid encoding them, their preparation, and their use in determination of ligands and their antagonists and agonists
WO1991014695A1 (en) * 1990-03-22 1991-10-03 The Salk Institute For Biological Studies Insect retinoid receptor compositions and methods
WO1991017253A1 (en) * 1990-04-30 1991-11-14 Novo Nordisk A/S Mammalian cells expressing a hybrid receptor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0244221A1 (en) * 1986-04-30 1987-11-04 Genentech, Inc. Hybrid receptors, nucleic acid encoding them, their preparation, and their use in determination of ligands and their antagonists and agonists
WO1991014695A1 (en) * 1990-03-22 1991-10-03 The Salk Institute For Biological Studies Insect retinoid receptor compositions and methods
WO1991017253A1 (en) * 1990-04-30 1991-11-14 Novo Nordisk A/S Mammalian cells expressing a hybrid receptor

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANASTASIA M. KHOURY CHRISTIANSON ET AL.: "DNA binding and heterodimerization of the Drosophila transcription factor chorion factor 1/ultraspiracle", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 89, no. 23, 1 December 1992 (1992-12-01), WASHINGTON US, pages 11503 - 11507 *
ANTHONY E. ORO ET AL.: "Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor", NATURE, vol. 347, 20 September 1990 (1990-09-20), LONDON GB, pages 298 - 301 *
GEOFF RICHARDS: "Switching partners?", CURRENT BIOLOGY, vol. 2, no. 12, 1992, pages 657 - 659 *
HELEN E. THOMAS ET AL.: "Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle", NATURE, vol. 362, 1 April 1993 (1993-04-01), LONDON GB, pages 471 - 475 *
JOURNAL OF CELLULAR BIOCHEMISTRY KEYSTONE SYMPOSIA on Molecular & Cellular Biology Supplement 16F, April 3-16, 1992, page 90 *
MARK LEID ET AL.: "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently", CELL, vol. 68, 24 January 1992 (1992-01-24), CAMBRIDGE, NA US, pages 377 - 395 *
TSO-PANG YAO ET AL.: "Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation", CELL, vol. 71, 2 October 1992 (1992-10-02), CAMBRIDGE, NA US, pages 63 - 72 *

Also Published As

Publication number Publication date
AU4769793A (en) 1994-01-31
CA2137462A1 (en) 1994-01-20
JPH08501211A (en) 1996-02-13
WO1994001558A2 (en) 1994-01-20
EP0804568A2 (en) 1997-11-05

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