WO1993025240A3 - Pretargeting methods and compounds - Google Patents
Pretargeting methods and compounds Download PDFInfo
- Publication number
- WO1993025240A3 WO1993025240A3 PCT/US1993/005406 US9305406W WO9325240A3 WO 1993025240 A3 WO1993025240 A3 WO 1993025240A3 US 9305406 W US9305406 W US 9305406W WO 9325240 A3 WO9325240 A3 WO 9325240A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compounds
- methods
- biotin
- pretargeting methods
- radiohalogenation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
- A61K47/557—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells the modifying agent being biotin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
- A61K47/665—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells the pre-targeting system, clearing therapy or rescue therapy involving biotin-(strept) avidin systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6893—Pre-targeting systems involving an antibody for targeting specific cells clearing therapy or enhanced clearance, i.e. using an antibody clearing agents in addition to T-A and D-M
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
- A61K47/6898—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies using avidin- or biotin-conjugated antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1268—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules host-guest, closed hollow molecules, inclusion complexes, e.g. with cyclodextrins, clathrates, cavitates, fullerenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002134239A CA2134239C (en) | 1992-06-09 | 1993-06-07 | Pretargeting methods and compounds |
JP6501638A JPH07507804A (en) | 1992-06-09 | 1993-06-07 | Pre-targeting methods and compounds |
US08/351,469 US5608060A (en) | 1992-06-09 | 1993-06-07 | Biotinidase-resistant biotin-DOTA conjugates |
EP93915235A EP0646019B9 (en) | 1992-06-09 | 1993-06-07 | Biotin-DOTA conjugates and their use in pretargeting methods |
AT93915235T ATE210464T1 (en) | 1992-06-09 | 1993-06-07 | BIOTIN-DOTA CONJUGATES AND THEIR USE IN PRETARGETING PROCEDURES |
DE69331319T DE69331319T2 (en) | 1992-06-09 | 1993-06-07 | Biotin-DOTA conjugates and their use in "pretargeting" processes |
US08/350,551 US6075010A (en) | 1992-06-09 | 1994-12-07 | Small molecular weight ligand-hexose containing clearing agents |
US08/468,513 US5976535A (en) | 1992-06-09 | 1995-06-06 | Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore |
US08/788,339 US6287536B1 (en) | 1992-06-09 | 1997-01-27 | Two-step pretargeting methods using improved bidtin-active agent conjugates |
US09/316,452 US6358490B2 (en) | 1992-06-09 | 1999-05-21 | Three-step pretargeting methods and compounds |
US09/561,736 US6416738B1 (en) | 1973-12-07 | 2000-04-25 | Pretargeting methods and compounds |
US09/920,454 US6709652B2 (en) | 1992-06-09 | 2001-08-01 | Pretargeting methods and compounds |
US10/076,031 US20030099640A1 (en) | 1992-06-09 | 2002-02-12 | Three-step pretargeting methods and compounds |
US10/125,788 US20030129191A1 (en) | 1992-12-23 | 2002-04-17 | Pretargeting methods and compounds |
US10/775,897 US7078013B2 (en) | 1992-06-09 | 2004-02-10 | Pretargeting methods and compounds |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/895,588 US5283342A (en) | 1992-06-09 | 1992-06-09 | Biotinylated small molecules |
US07/895,588 | 1992-06-09 | ||
US99538192A | 1992-12-23 | 1992-12-23 | |
US99538392A | 1992-12-23 | 1992-12-23 | |
US07/995,381 | 1992-12-23 | ||
US07/995,383 | 1992-12-23 |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US99538192A Continuation-In-Part | 1973-12-07 | 1992-12-23 | |
US99538392A Continuation-In-Part | 1992-06-09 | 1992-12-23 |
Related Child Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16318473A Continuation-In-Part | 1973-12-07 | 1973-12-07 | |
US08/122,979 Continuation US5630996A (en) | 1992-06-09 | 1993-09-16 | Two-step pretargeting methods using improved biotin-active agent conjugates |
US08/156,565 Continuation-In-Part US6022966A (en) | 1992-06-09 | 1993-11-22 | Pretargeting methods and compounds |
US08/156,614 Continuation-In-Part US5578287A (en) | 1992-06-09 | 1993-11-23 | Three-step pretargeting methods using improved biotin-active agent |
US16318893A Continuation-In-Part | 1992-06-09 | 1993-12-07 | |
US16318493A Continuation-In-Part | 1992-06-09 | 1993-12-07 | |
US35100594A Continuation-In-Part | 1992-06-09 | 1994-12-07 | |
US09/316,452 Continuation-In-Part US6358490B2 (en) | 1992-06-09 | 1999-05-21 | Three-step pretargeting methods and compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1993025240A2 WO1993025240A2 (en) | 1993-12-23 |
WO1993025240A3 true WO1993025240A3 (en) | 1994-02-17 |
Family
ID=27420561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1993/005406 WO1993025240A2 (en) | 1973-12-07 | 1993-06-07 | Pretargeting methods and compounds |
Country Status (7)
Country | Link |
---|---|
US (2) | US5608060A (en) |
EP (2) | EP0646019B9 (en) |
JP (1) | JPH07507804A (en) |
AT (1) | ATE210464T1 (en) |
CA (1) | CA2134239C (en) |
DE (1) | DE69331319T2 (en) |
WO (1) | WO1993025240A2 (en) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6416738B1 (en) | 1973-12-07 | 2002-07-09 | Neorx Corporation | Pretargeting methods and compounds |
US6075010A (en) * | 1992-06-09 | 2000-06-13 | Neorx Corporation | Small molecular weight ligand-hexose containing clearing agents |
US5556982A (en) * | 1985-01-14 | 1996-09-17 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
US5525338A (en) * | 1992-08-21 | 1996-06-11 | Immunomedics, Inc. | Detection and therapy of lesions with biotin/avidin conjugates |
US6022966A (en) * | 1993-11-22 | 2000-02-08 | Neorx Corporation | Pretargeting methods and compounds |
US6217869B1 (en) | 1992-06-09 | 2001-04-17 | Neorx Corporation | Pretargeting methods and compounds |
US5578287A (en) * | 1992-06-09 | 1996-11-26 | Neorx Corporation | Three-step pretargeting methods using improved biotin-active agent |
US6358490B2 (en) | 1992-06-09 | 2002-03-19 | Neorx Corporation | Three-step pretargeting methods and compounds |
IL108388A0 (en) * | 1993-01-21 | 1994-04-12 | Harvard College | Amplified direction of effector groups to specific target cells in an animal |
CA2154667A1 (en) * | 1993-02-02 | 1994-08-18 | Linda M. Gustavson | Directed biodistribution of small molecules |
US5482698A (en) * | 1993-04-22 | 1996-01-09 | Immunomedics, Inc. | Detection and therapy of lesions with biotin/avidin polymer conjugates |
US6120768A (en) * | 1993-05-17 | 2000-09-19 | Immunomedics, Inc. | Dota-biotin derivatives |
CA2163107C (en) * | 1993-05-17 | 2001-04-17 | David Milton Goldenberg | Improved detection and therapy of lesions with biotin/avidin-metal chelating protein conjugates |
EP0724601A4 (en) * | 1993-08-17 | 1999-02-03 | Neorx Corp | S 3n chelating compounds for the radiolabeling of ligands, anti-ligands or other proteins |
DE69433343D1 (en) * | 1993-12-07 | 2003-12-24 | Neorx Corp | PRETARGETING METHOD AND MEANS |
JPH09506106A (en) * | 1993-12-07 | 1997-06-17 | ネオルクス コーポレーション | Pregetting method and compound |
US6015897A (en) * | 1993-12-07 | 2000-01-18 | Neorx Corporation | Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota |
IL112372A (en) * | 1994-02-07 | 2001-08-26 | Res Dev Foundation | Non-viral vector for the delivery of genetic information to cells |
US5670347A (en) | 1994-05-11 | 1997-09-23 | Amba Biosciences Llc | Peptide-mediated gene transfer |
CA2192384A1 (en) * | 1994-06-06 | 1995-12-14 | Alan J. Fischman | Biotin compounds for targetting tumors and sites of infection |
US5716594A (en) * | 1994-06-06 | 1998-02-10 | The Jmde Trust | Biotin compounds for targetting tumors and sites of infection |
JPH0889278A (en) * | 1994-09-29 | 1996-04-09 | Ajinomoto Co Inc | Modified protein for introducing gene and its production |
US6908903B1 (en) | 1994-12-07 | 2005-06-21 | Aletheon Pharmaceuticals, Inc. | Cluster clearing agents |
US6172045B1 (en) * | 1994-12-07 | 2001-01-09 | Neorx Corporation | Cluster clearing agents |
US5955605A (en) * | 1995-02-21 | 1999-09-21 | Neorx Corporation | Biotinidase resistant biotin-DOTA conjugates |
US6155266A (en) * | 1995-05-08 | 2000-12-05 | Maxim Pharmaceuticals, Inc. | Method for treatment of cancer and infectious disease |
EP0837696B1 (en) * | 1995-06-07 | 2010-02-24 | Immunomedics, Inc. | Improved delivery of diagnostic and therapeutic agents to a target site |
US5846537A (en) * | 1995-06-07 | 1998-12-08 | University Of Rochester | Modified avidin and streptavidin and methods of use thereof |
US5739313A (en) | 1995-11-13 | 1998-04-14 | Regents Of The University Of Minnesota | Radionuclide labeling of vitamin B12 and coenzymes thereof |
WO1997025069A1 (en) * | 1996-01-11 | 1997-07-17 | Techniclone, Inc. | Antibodies with reduced net positive charge |
US20010023288A1 (en) * | 1999-07-07 | 2001-09-20 | Wilbur D. Scott | Trifunctional reagent for conjugation to a biomolecule |
EP0906015A4 (en) * | 1996-06-06 | 2004-05-12 | Neorx Corp | Liver retention clearing agents |
NZ334803A (en) * | 1996-10-08 | 2000-05-26 | Kreatech Biotechnology Bv | Method for labeling nucleotides by reacting a reactive platinum compound having two reactive moieties, a labeled moiety and another moiety of a spacer with a nucleotide |
CA2283716A1 (en) | 1997-03-14 | 1998-09-17 | Gabriel O. Reznik | Multiflavor streptavidin |
US6376471B1 (en) * | 1997-10-10 | 2002-04-23 | Johns Hopkins University | Gene delivery compositions and methods |
IL125908A (en) | 1998-08-24 | 2005-05-17 | Nst Neurosurvival Technologies | Peptides and pharmaceutical compositions comprising same |
CA2341742A1 (en) * | 1998-08-24 | 2000-03-02 | Maxim Pharmaceuticals, Inc. | Activation and protection of t-cells (cd4+ and cd8+) using an h2 receptor agonist and other t-cell activating agents |
IL131266A0 (en) | 1999-08-05 | 2001-01-28 | N S T Neurosurvival Technologi | Peptides and pharmaceutical compositions comprising same |
US6365379B1 (en) * | 1998-10-06 | 2002-04-02 | Isis Pharmaceuticals, Inc. | Zinc finger peptide cleavage of nucleic acids |
US6498181B1 (en) * | 1999-01-06 | 2002-12-24 | Maxim Pharmaceuticals | Synergistic tumorcidal response induced by histamine |
JP4712975B2 (en) | 1999-01-12 | 2011-06-29 | ケンブリッジ エンタープライズ リミティド | Compositions and methods for inhibiting or enhancing inflammatory responses |
US6602274B1 (en) | 1999-01-15 | 2003-08-05 | Light Sciences Corporation | Targeted transcutaneous cancer therapy |
US6454789B1 (en) * | 1999-01-15 | 2002-09-24 | Light Science Corporation | Patient portable device for photodynamic therapy |
AU2504900A (en) * | 1999-01-15 | 2000-08-01 | Light Sciences Corporation | Therapeutic compositions for metabolic bone disorders or bone metastases |
WO2000041726A2 (en) * | 1999-01-15 | 2000-07-20 | Light Sciences Corporation | Noninvasive vascular therapy |
US6806363B1 (en) * | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
WO2000071171A2 (en) * | 1999-05-21 | 2000-11-30 | Wake Forest University | Sigma-1 ligands for determining carcinoma proliferative status |
US7144991B2 (en) | 1999-06-07 | 2006-12-05 | Aletheon Pharmaceuticals, Inc. | Streptavidin expressed gene fusions and methods of use thereof |
US20030103948A1 (en) * | 1999-06-07 | 2003-06-05 | Neorx Corporation | Streptavidin expressed gene fusions and methods of use thereof |
WO2000075333A1 (en) * | 1999-06-07 | 2000-12-14 | Neorx Corporation | Streptavidin expressed gene fusions and methods of use thereof |
US20030143233A1 (en) * | 1999-06-07 | 2003-07-31 | Neorx Corporation | Streptavidin expressed gene fusions and methods of use thereof |
JP2003501488A (en) * | 1999-06-11 | 2003-01-14 | ネオルックス コーポレイション | High-dose radionuclide complexes for bone marrow suppression |
US7094885B2 (en) * | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
EP1231942A1 (en) * | 1999-10-15 | 2002-08-21 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging agents and as antitumor agents |
US7591995B2 (en) * | 1999-10-15 | 2009-09-22 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
AU785505B2 (en) | 1999-10-15 | 2009-02-26 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
US7067111B1 (en) | 1999-10-25 | 2006-06-27 | Board Of Regents, University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
DE19956029A1 (en) * | 1999-11-22 | 2001-05-23 | Aventis Pharma Gmbh | Active substance carrier system based on coating a substance with enzymatically cleavable side groups, useful for gene therapy especially of cancer and inflammation |
JP2003519670A (en) | 2000-01-12 | 2003-06-24 | ライト サイエンシーズ コーポレイション | New treatments for eye diseases |
NO312708B1 (en) * | 2000-02-21 | 2002-06-24 | Anticancer Therapeutic Inv Sa | Radioactive liposomes for therapy |
BRPI0111220B8 (en) * | 2000-06-02 | 2021-07-27 | Univ Texas | drug conjugates with ethylenedicysteine (ec) |
ATE377048T1 (en) * | 2000-09-06 | 2007-11-15 | Ap Pharma Inc | DEGRADABLE POLYACETAL POLYMERS |
US20020151525A1 (en) * | 2000-10-25 | 2002-10-17 | Collins Douglas A. | Transcobalamin receptor binding conjugates useful for treating abnormal cellular proliferation |
JP2004536034A (en) * | 2001-01-08 | 2004-12-02 | ネオルクス コーポレイション | Therapeutic and diagnostic compounds, compositions and methods |
ITRM20010079A1 (en) * | 2001-02-16 | 2002-08-16 | Sigma Tau Ind Farmaceuti | ADMINODERIVATES OF BIOTIN AND THEM CONJUGATED WITH MACROCYCLIC CHELANTS. |
JP2004528025A (en) * | 2001-02-21 | 2004-09-16 | サーロメッド・インコーポレーテッド | Modified annexin proteins and methods for preventing thrombosis |
US7635676B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaccuticals, Inc. | Modified annexin proteins and methods for their use in organ transplantation |
US20090291086A1 (en) * | 2001-02-21 | 2009-11-26 | Alavita Pharmaceuticals, Inc. | Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia |
US7645739B2 (en) * | 2001-02-21 | 2010-01-12 | Alavita Pharmaceuticals, Inc. | Modified annexin compositions and methods of using same |
US7635680B2 (en) * | 2001-02-21 | 2009-12-22 | Alavita Pharmaceuticals, Inc. | Attenuation of reperfusion injury |
US6441163B1 (en) * | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
AU2002322275A1 (en) * | 2001-06-20 | 2003-01-08 | Mayo Foundation For Medical Education And Research | Adenosyl-cobalamin fortified compositions |
US20060074034A1 (en) * | 2001-09-17 | 2006-04-06 | Collins Douglas A | Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof |
WO2003026674A1 (en) * | 2001-09-28 | 2003-04-03 | Mayo Foundation For Medical Education And Research | Coadministration of transport protein with conjugated cobalamin to deliver agents |
EP1467760A2 (en) * | 2002-01-23 | 2004-10-20 | Light Sciences Corporation | Systems and methods for photodynamic therapy |
US6982154B2 (en) * | 2002-02-21 | 2006-01-03 | Surromed, Inc. | Modified annexin proteins and methods for treating vaso-occlusive sickle-cell disease |
ITRM20020128A1 (en) * | 2002-03-08 | 2003-09-08 | Sigma Tau Ind Farmaceuti | DIMERI OF AVIDINA EFFECTIVE IN INCREASING THE CONCENTRATION OF RADIOACTIVE BIOTIN IN IMMUNOTHERAPY WITH "PRETARGETING". |
AU2003225791A1 (en) * | 2002-03-15 | 2003-09-29 | Department Of Veterans Affairs, Rehabilitation R And D Service | Methods and compositions for directing cells to target organs |
KR100440725B1 (en) * | 2002-06-20 | 2004-07-15 | 주식회사 그린진 바이오텍 | A Method for Increasing an Abiotic-Resistance in Monocot Plants |
US20060171883A1 (en) * | 2002-10-10 | 2006-08-03 | Phillips Catherine A | Detection, localization and staging of tumors using labeled activated lymphocytes directed to a tumor specific epitope |
WO2004074434A2 (en) * | 2003-01-31 | 2004-09-02 | Immunomedics, Inc. | Methods and compositions for administering therapeutic and diagnostic agents |
WO2005051429A2 (en) * | 2003-11-19 | 2005-06-09 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Targeted conjugates with a modified saccharide linker |
US9050378B2 (en) * | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
WO2005114192A1 (en) * | 2004-05-13 | 2005-12-01 | Centre National De La Recherche Scientifique | A device for binding a target entity to a bait entity and detection methods using the same |
US20050271585A1 (en) * | 2004-06-07 | 2005-12-08 | General Electric Company | Extended conjugated polymers |
US20060057062A1 (en) * | 2004-09-10 | 2006-03-16 | Trotter Dinko G | Compositions and methods useful in pretargeted imaging |
CN101068577A (en) * | 2004-10-07 | 2007-11-07 | 皇家飞利浦电子股份有限公司 | Use of the staudinger ligation in imaging and therapy end kits for imaging and therapy |
EP1893038A1 (en) * | 2005-05-17 | 2008-03-05 | Cargill, Incorporated | Granular lecithins, granular lysolecithins, process for their production and compositions containing them |
TWI381852B (en) * | 2005-09-27 | 2013-01-11 | Sigma Tau Ind Farmaceuti | Biotin diaminoderivatives and their conjugates with macrocyclic chelating agents |
US8758723B2 (en) * | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
US10925977B2 (en) * | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
JP5472754B2 (en) | 2009-02-20 | 2014-04-16 | 国立大学法人 東京大学 | Low immunogenic streptavidin and its use |
FI20090100A0 (en) | 2009-03-16 | 2009-03-16 | Wallac Oy | Biotinidaasimääritys |
GB0922369D0 (en) | 2009-12-22 | 2010-02-03 | Hammersmith Imanet Ltd | Labelled biotin conjugates |
MX350974B (en) | 2010-11-18 | 2017-09-27 | Univ Yale | Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus. |
GB201205360D0 (en) | 2012-03-27 | 2012-05-09 | Univ Edinburgh | Biotinidase resistant biotinyl compounds |
JP6178586B2 (en) | 2013-02-20 | 2017-08-09 | サヴィッド・セラピューティックス株式会社 | Biotin variants, streptavidin variants and their use |
EP3068443B1 (en) | 2013-11-12 | 2019-04-10 | Centre for Probe Development and Commercialization | Residualizing linkers and uses thereof |
EP3109252B1 (en) | 2014-02-18 | 2020-12-30 | Savid Therapeutics Inc. | Modified biotin, streptavidin mutant, and usage of them |
EP3316871A4 (en) | 2015-06-30 | 2019-02-20 | The Trustees of Columbia University in the City of New York | Talc-bound compositions and uses thereof |
EP3546470A4 (en) | 2016-11-25 | 2020-08-05 | Savid Therapeutics Inc. | Clearing agent |
WO2018204869A1 (en) | 2017-05-05 | 2018-11-08 | Fusion Pharmaceuticals Inc. | Pharmacokinetic enhancements of bifunctional chelates and uses thereof |
EP3638320A4 (en) | 2017-05-05 | 2021-01-20 | Centre for Probe Development and Commercialization | Igf-1r monoclonal antibodies and uses thereof |
US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
US20210214376A1 (en) | 2018-05-30 | 2021-07-15 | The University Of Tokyo | Halogenated biotin-modified dimer and use thereof |
US10953107B2 (en) * | 2018-06-15 | 2021-03-23 | Trustees Of Boston University | Polypeptide compositions and methods for site-specific targeting of therapeutic agents |
US20220016245A1 (en) | 2018-08-08 | 2022-01-20 | The University Of Tokyo | Conjugate of biotin-modified dimer and phthalocyanine dye |
JP2023511756A (en) | 2020-01-31 | 2023-03-22 | アヴィラー セラピューティクス インコーポレイテッド | ASGPR-binding compounds that degrade extracellular proteins |
JPWO2021210573A1 (en) | 2020-04-14 | 2021-10-21 | ||
WO2021215534A1 (en) | 2020-04-24 | 2021-10-28 | 国立大学法人 東京大学 | Duocarmycin derivative and use thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0251494A2 (en) * | 1986-06-23 | 1988-01-07 | The Board Of Trustees Of The Leland Stanford Junior University | Therapeutic or radiodiagnostic compound |
WO1988008422A1 (en) * | 1987-04-22 | 1988-11-03 | Schering Aktiengesellschaft | Substituted cyclic complex-forming substances, complexes and complex salts, process for manufacturing same, and pharmaceutical agents which contain them |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
NZ211453A (en) * | 1984-03-22 | 1989-01-06 | Biotechnology Research Enterpr | Aryl azides, their preparation and use in the detection, localisation and isolation of polynucleotides |
US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
US4678667A (en) * | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
DE3782169T2 (en) * | 1986-07-03 | 1993-02-25 | Upjohn Co | METHOD FOR PRODUCING ANTIBIOTICA 10381B. |
US5246692A (en) * | 1986-09-05 | 1993-09-21 | The United States Of America As Represented By The Secretary Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
FR2604092B1 (en) * | 1986-09-19 | 1990-04-13 | Immunotech Sa | IMMUNOREACTIVES FOR TARGETING ANIMAL CELLS FOR VISUALIZATION OR DESTRUCTION IN VIVO |
DE3722647A1 (en) * | 1987-07-09 | 1989-01-19 | Gerhard Ohlenschlaeger | GALENIC USE OF A TRIPEPTID AS A MEDICINAL PRODUCT |
DK47389A (en) * | 1988-02-03 | 1989-08-04 | Hybritech Inc | PHARMACOKINETICALLY MODIFIED HAPTEN DERIVATIVES FOR RADIO LABELING ANTIBODIES OR USED AS RADIOTHERAPEUTIC AGENTS |
GB8809616D0 (en) * | 1988-04-22 | 1988-05-25 | Cancer Res Campaign Tech | Further improvements relating to drug delivery systems |
US4923985A (en) * | 1988-05-25 | 1990-05-08 | The United States Of America As Represented By The Department Of Health & Human Services | Process for synthesizing macrocyclic chelates |
US4895955A (en) * | 1988-05-27 | 1990-01-23 | Lifecodes Corporation | Non-radioactive carbodiimide precursor to nucleic acid probes |
AU627477B2 (en) * | 1988-07-05 | 1992-08-27 | Amgen, Inc. | Interleukin ii analogs |
US5364613A (en) * | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
SE465155B (en) * | 1989-12-19 | 1991-08-05 | Exploaterings Ab Tbf | METAL CHELET FORMING HYDROPHIL POLYMER FOR ADSORPTION ETC AND A SAT FOR PREPARATION OF THE POLYMER |
HUT61491A (en) * | 1989-12-27 | 1993-01-28 | Boehringer Ingelheim Int | Process and reagent for diagnosing prothrombic state |
JP2776953B2 (en) * | 1990-04-10 | 1998-07-16 | 日本メジフィジックス株式会社 | Multifunctional metal chelate compounds and their uses |
DE4035760A1 (en) * | 1990-11-08 | 1992-05-14 | Schering Ag | MONO-N-SUBSTITUTED 1,4,7,10-TETRAAZACYCLODODECAN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM |
IT1245748B (en) * | 1990-12-21 | 1994-10-14 | Mini Ricerca Scient Tecnolog | PREPARATION INCLUDING BIOTINYLATE MONOCLONAL ANTIBODIES, AVIDIN AND BIOTIN, FOR DIAGNOSIS OF CANCER DISEASES AND ITS USE |
US5326778A (en) * | 1992-03-03 | 1994-07-05 | Research Corporation Technologies, Inc. | Conjugates of biotin and deferoxamine for radioimmunoimaging and radioimmunotherapy |
CA2154667A1 (en) * | 1993-02-02 | 1994-08-18 | Linda M. Gustavson | Directed biodistribution of small molecules |
-
1993
- 1993-06-07 AT AT93915235T patent/ATE210464T1/en not_active IP Right Cessation
- 1993-06-07 CA CA002134239A patent/CA2134239C/en not_active Expired - Fee Related
- 1993-06-07 EP EP93915235A patent/EP0646019B9/en not_active Expired - Lifetime
- 1993-06-07 EP EP01201994A patent/EP1138334A3/en not_active Withdrawn
- 1993-06-07 WO PCT/US1993/005406 patent/WO1993025240A2/en active IP Right Grant
- 1993-06-07 US US08/351,469 patent/US5608060A/en not_active Expired - Fee Related
- 1993-06-07 JP JP6501638A patent/JPH07507804A/en active Pending
- 1993-06-07 DE DE69331319T patent/DE69331319T2/en not_active Expired - Fee Related
- 1993-09-16 US US08/122,979 patent/US5630996A/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0251494A2 (en) * | 1986-06-23 | 1988-01-07 | The Board Of Trustees Of The Leland Stanford Junior University | Therapeutic or radiodiagnostic compound |
US4863713A (en) * | 1986-06-23 | 1989-09-05 | The Board Of Trustees Of Leland Stanford Jr. Univ. | Method and system for administering therapeutic and diagnostic agents |
WO1988008422A1 (en) * | 1987-04-22 | 1988-11-03 | Schering Aktiengesellschaft | Substituted cyclic complex-forming substances, complexes and complex salts, process for manufacturing same, and pharmaceutical agents which contain them |
Non-Patent Citations (3)
Title |
---|
CHEMICAL ABSTRACTS, vol. 106, no. 8, 23 February 1987, Columbus, Ohio, US; abstract no. 55742f * |
F. VIRZI ET AL.: "NEW INDIUM-111 LABELED BIOTIN DERIVATES FOR IMPROVED IMMUNOTARGETING.", NUCL. MED. BIOL., vol. 18, no. 7, 1991, pages 719 - 726 * |
P. VAN DER SLUIJS ET AL.: "DRUG TARGETING TO THE LIVER WITH LACTOSYLATED ALBUMINS: DOES THE GLYCOPROTEIN TARGET THE DRUG OR IS IT THE DRUG TARGETING THE GLYCOPROTEIN?", HEPATOLOGY, vol. 6, no. 4, 1986, BALTIMORE, pages 723 - 728 * |
Also Published As
Publication number | Publication date |
---|---|
US5630996A (en) | 1997-05-20 |
WO1993025240A2 (en) | 1993-12-23 |
ATE210464T1 (en) | 2001-12-15 |
EP0646019B9 (en) | 2002-12-18 |
DE69331319D1 (en) | 2002-01-24 |
EP1138334A2 (en) | 2001-10-04 |
CA2134239A1 (en) | 1993-12-23 |
EP0646019B1 (en) | 2001-12-12 |
DE69331319T2 (en) | 2002-08-08 |
CA2134239C (en) | 2004-11-23 |
US5608060A (en) | 1997-03-04 |
EP0646019A1 (en) | 1995-04-05 |
JPH07507804A (en) | 1995-08-31 |
EP1138334A3 (en) | 2002-04-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1138334A3 (en) | Pretargeting methods and compounds | |
US5789416B1 (en) | N6 mono heterocyclic substituted adenosine derivatives | |
MY107158A (en) | 3-arylcarbonyl; -1h-indoles useful as therapeutic agents. | |
AU603525B2 (en) | Tetrazole intermediates to antihypertensive compounds | |
BG102425A (en) | (methylsulphonyl)phenyl-2-(5h)-furanons as cyclooxygenase-2-inhibitors | |
IL115790A0 (en) | Pharmaceutical compositions containing boronic ester and acid compounds and methods for the preparation thereof | |
ES2181501T3 (en) | COSMETIC COMPOSITION. | |
DK0775142T3 (en) | Substituted O6 benzyl guanines | |
MX169939B (en) | DETERGENT COMPOSITIONS | |
LU90856I2 (en) | Uprima - apomorphine hydrochloride and its pharmaceutically acceptable derivatives | |
AU1973997A (en) | Pentafluorobenzenesulfonamides and analogs | |
AU8033594A (en) | Aqueous solution inclusion complexes of benzothiophene compounds with water soluble cyclodextrins, and pharmaceutical formulations and methods thereof | |
EP0630260A4 (en) | Polysaccharide-protein conjugates. | |
NZ212768A (en) | 2-substituted-1,3-propylidene diphosphonate derivatives and pharmaceutical compositions | |
IT1235327B (en) | SKI BOOT STRUCTURE. | |
GR3036142T3 (en) | Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents | |
GB9521101D0 (en) | Improvements in or relating to organic compositions | |
ES2159054T3 (en) | DI-TERC-BUTIL-PHENOLIC COMPOUNDS CONTAINING USEFUL SULFUR AS ANTI-INFLAMMATORY AGENTS. | |
UA42722C2 (en) | Sulphides, sulphoxides and sulphones or the pharmaceutically acceptable salts thereof and pharmaceutical composition containing them | |
BR9713176A (en) | Amorphous benzothiophenes, methods of preparation and methods of use | |
EP0436664A4 (en) | Cleavable linkers for the reduction of non-target organ retention of immunoconjugates | |
GR3031118T3 (en) | Novel seco-D steroids active in the cardiovascular system and pharmaceutical compositions containing same | |
AU3300797A (en) | Selenophene anti-tumor agents | |
CA2036507A1 (en) | 2'-deoxy-2'-methylidenecytidine dihydrate, methods for its production and compositions | |
IT1216102B (en) | MECHANISM TO ADJUST THE APPROACH OF A TRAILER TO THE TRAILING VEHICLE, BOTH AS A RESULT OF CHANGES OF DIRECTION AND OF SLOPE CHANGES. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 08122979 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 08133613 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 08156565 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 08156614 Country of ref document: US |
|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): CA JP US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): CA JP US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2134239 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1993915235 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 08351469 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 1993915235 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 1996 753445 Country of ref document: US Date of ref document: 19961125 Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 1997 788339 Country of ref document: US Date of ref document: 19970127 Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 1997 845833 Country of ref document: US Date of ref document: 19970428 Kind code of ref document: A |
|
WWG | Wipo information: grant in national office |
Ref document number: 1993915235 Country of ref document: EP |