WO1993017665A1 - Methods and apparatus for drug delivery using supercritical solutions - Google Patents

Methods and apparatus for drug delivery using supercritical solutions Download PDF

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Publication number
WO1993017665A1
WO1993017665A1 PCT/US1993/001501 US9301501W WO9317665A1 WO 1993017665 A1 WO1993017665 A1 WO 1993017665A1 US 9301501 W US9301501 W US 9301501W WO 9317665 A1 WO9317665 A1 WO 9317665A1
Authority
WO
WIPO (PCT)
Prior art keywords
methods
supercritical fluid
physiologically active
drug delivery
animal
Prior art date
Application number
PCT/US1993/001501
Other languages
French (fr)
Inventor
Robert E. Sievers
Brooks M. Hybertson
Brian N. Hansen
Original Assignee
Sievers Robert E
Hyberston Brooks M
Hansen Brian N
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sievers Robert E, Hyberston Brooks M, Hansen Brian N filed Critical Sievers Robert E
Priority to AU37261/93A priority Critical patent/AU3726193A/en
Priority to DE69314326T priority patent/DE69314326T2/en
Priority to EP93906094A priority patent/EP0627910B1/en
Priority to CA002131393A priority patent/CA2131393C/en
Publication of WO1993017665A1 publication Critical patent/WO1993017665A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/30—Mixing gases with solids
    • B01F23/39—Mixing systems, i.e. flow charts or diagrams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/04—Specific aggregation state of one or more of the phases to be mixed
    • B01F23/043—Mixing fluids or with fluids in a supercritical state, in supercritical conditions or variable density fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/09—Mixing systems, i.e. flow charts or diagrams for components having more than two different of undetermined agglomeration states, e.g. supercritical states
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/30—Mixing gases with solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/30—Mixing gases with solids
    • B01F23/32—Mixing gases with solids by introducing solids in gas volumes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/28—Jet mixers, i.e. mixers using high-speed fluid streams characterised by the specific design of the jet injector
    • B01F25/281—Jet mixers, i.e. mixers using high-speed fluid streams characterised by the specific design of the jet injector the jet injector being of the explosive rapid expansion of supercritical solutions [RESS] or fluid injection of molecular spray [FIMS] type, i.e. the liquid is jetted in an environment (gas or liquid) by nozzles, in conditions of significant pressure drop, with the possible generation of shock waves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/008—Processes carried out under supercritical conditions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/24—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
    • B05B7/26—Apparatus in which liquids or other fluent materials from different sources are brought together before entering the discharge device
    • B05B7/28—Apparatus in which liquids or other fluent materials from different sources are brought together before entering the discharge device in which one liquid or other fluent material is fed or drawn through an orifice into a stream of a carrying fluid
    • B05B7/32—Apparatus in which liquids or other fluent materials from different sources are brought together before entering the discharge device in which one liquid or other fluent material is fed or drawn through an orifice into a stream of a carrying fluid the fed liquid or other fluent material being under pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00—Processes for applying liquids or other fluent materials
    • B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
    • B05D1/025—Processes for applying liquids or other fluent materials performed by spraying using gas close to its critical state
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D2401/00—Form of the coating product, e.g. solution, water dispersion, powders or the like
    • B05D2401/90—Form of the coating product, e.g. solution, water dispersion, powders or the like at least one component of the composition being in supercritical state or close to supercritical state
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Abstract

Methods and apparatus for delivering physiologically active compounds to a target human or animal employ a supercritical fluid solution comprising a supercritical fluid solvent and a physiologically active solute. The supercritical fluid solution is passed into a subcritical region to evaporate the solvent and form a gas-borne dispersion of solute particles. The gas-borne dispersion of solute particles is administered directly to the target human or animal. The apparatus for delivering the physiologically active compound are of the hand-held type.
PCT/US1993/001501 1992-03-06 1993-02-19 Methods and apparatus for drug delivery using supercritical solutions WO1993017665A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU37261/93A AU3726193A (en) 1992-03-06 1993-02-19 Methods and apparatus for drug delivery using supercritical solutions
DE69314326T DE69314326T2 (en) 1992-03-06 1993-02-19 METHOD AND DEVICE FOR RELEASING ACTIVE SUBSTANCE BY SUPER-CRITICAL SOLUTIONS
EP93906094A EP0627910B1 (en) 1992-03-06 1993-02-19 Methods and apparatus for drug delivery using supercritical solutions
CA002131393A CA2131393C (en) 1992-03-06 1993-02-19 Method and apparatus for drug delivery using supercritical solutions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US846,331 1992-03-06
US07/846,331 US5301664A (en) 1992-03-06 1992-03-06 Methods and apparatus for drug delivery using supercritical solutions

Publications (1)

Publication Number Publication Date
WO1993017665A1 true WO1993017665A1 (en) 1993-09-16

Family

ID=25297595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/001501 WO1993017665A1 (en) 1992-03-06 1993-02-19 Methods and apparatus for drug delivery using supercritical solutions

Country Status (7)

Country Link
US (1) US5301664A (en)
EP (1) EP0627910B1 (en)
AT (1) ATE158716T1 (en)
CA (1) CA2131393C (en)
DE (1) DE69314326T2 (en)
MX (1) MX9301246A (en)
WO (1) WO1993017665A1 (en)

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WO1995031964A1 (en) * 1994-05-21 1995-11-30 Glaxo Wellcome Australia Limited Fluticasone propionate formulations
EP0718035A3 (en) * 1994-12-19 1997-04-09 Basf Ag Method and apparatus for preparing dispersions containing active substances
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
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Cited By (32)

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Publication number Priority date Publication date Assignee Title
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
WO1995024892A1 (en) * 1994-03-14 1995-09-21 Abbott Laboratories Aerosol drug formulations containing vitamin e
EP1160018A3 (en) * 1994-04-08 2002-01-09 Robert E. Sievers Method and apparatus for fine particle formation
EP1160018A2 (en) * 1994-04-08 2001-12-05 Sievers, Robert, E. Method and apparatus for fine particle formation
US5993781A (en) * 1994-05-21 1999-11-30 Glaxo Wellcome Australia Ltd. Fluticasone propionate nebulizable formulations
CN1098680C (en) * 1994-05-21 2003-01-15 葛兰素惠尔康澳大利亚有限公司 Medicine
WO1995031964A1 (en) * 1994-05-21 1995-11-30 Glaxo Wellcome Australia Limited Fluticasone propionate formulations
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CA2131393A1 (en) 1993-09-16
EP0627910B1 (en) 1997-10-01
EP0627910A1 (en) 1994-12-14
MX9301246A (en) 1993-09-01
ATE158716T1 (en) 1997-10-15
DE69314326T2 (en) 1998-04-09
CA2131393C (en) 2002-05-28
DE69314326D1 (en) 1997-11-06
US5301664A (en) 1994-04-12

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