WO1993005842A1 - Catheter with spring coil inner lumen - Google Patents

Catheter with spring coil inner lumen

Info

Publication number
WO1993005842A1
WO1993005842A1 PCT/US1992/007948 US9207948W WO1993005842A1 WO 1993005842 A1 WO1993005842 A1 WO 1993005842A1 US 9207948 W US9207948 W US 9207948W WO 1993005842 A1 WO1993005842 A1 WO 1993005842A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
catheter
wire
catheter according
shaft
inner tube
Prior art date
Application number
PCT/US1992/007948
Other languages
French (fr)
Inventor
Don Ik Shin
Leo R. Roucher, Jr.
Original Assignee
Medtronic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • A61M25/005Catheters; Hollow probes characterised by structural features with embedded materials for reinforcement, e.g. wires, coils, braids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/104Balloon catheters used for angioplasty

Abstract

An over-the-wire dilatation catheter with a spring coil inner lumen is disclosed. The wound wire of the spring coil inner lumen is preferably stainless steel flat wire, and the preferred dimensions for the flat wire are 0.0015 inch by 0.006 inch. Usually the inner lumen is jacketed with a biocompatible polymer, preferably polyethylene, and it may be enhanced by a lubricious coating on the interior. The outer shaft is preferably comprised of a stiffer proximal and a more flexible, narrower distal portion.

Description

CATHETER WITH SPRING COIL INNER LUMEN BACKGROUND OF THE INVENTION

Field of the Invention:

This invention relates to catheters for coronary angioplasty, particularly over-the-wire dilatation catheters.

Description of the Prior Art:

Catheters are tube-like members that are inserted into the body for various medical reasons, some diagnostic and others therapeutic. In general, catheters used for coronary angioplasty have an outer tube or shaft with a balloon near the distal tip. The catheter is threaded into the vasculature, with the balloon located within the stenosis. The balloon is then inflated to redistribute the plaque of the stenosis along the artery wall so that it does not block the artery.

In some catheters, an attached stiffening wire extends through the shaft to the tip to aid in the insertion of the catheter into the arteries, which are twisted and tortuous. In some catheters, a separate inner tube, or lumen, extends within the outer tube to hold the guidewire. Where the catheter is a fixed-wire catheter, the guidewire is fixed in place within the inner tube; when the catheter is an over-the-wire catheter, the guidewire is a separate unit which extends through the inner tube and out the open far end.

Among the considerations in designing the catheter is the axial strength of the system. The catheter must be sufficiently strong so that pushing the catheter at the user's end results in forward motion at the distal end. Where the catheter has an inner tube or lumen, it must be strong enough to avoid collapse when the catheter extends around a corner.

SUBSTITUTE SHEET Some catheters use metal in some locations in the catheter. InKraus, et al. , EPO published application 397,055, publishe November 14, 1990, the proximal end of the catheter shaft i formed of stainless steel, and a stainless steel coil form the distal tip of the catheter beyond the balloon. A tip coi is also provided in Mar, U.S. Patent No. 4,771,778, issue September 20, 1988. In Schulte, U.S. Patent No. 3,738,365 issued on June 12, 1973, a small part of what is essentially the outer lumen of a drainage catheter is made extensible by including a metal coil.

In Sheldon, U.S. Patent No. 3,060,972, a flexible tube structure for an endoscopic device is formed of a plurality of end-to-end tubular units. In Bundy, et al., U.S. Patent No. 4,653,496, a helically wound coil having a concentric outer radial cutting cannula is disclosed for the removal of stenotic and occlusive lesions from the vascular system. In Goldberg, et al., U.S. Patent No. 4,351,341, issued September 28, 1982, Samson, et al. , EPO publication 356,748 and Bazell, et al., U.S. Patent No. 4,444,188, issued April 24, 1984, the outer lumen of a balloon catheter includes a coil; the same is the case in Sharrock, U.S. Patent No. 4,368,730, issued January 18, 1983, which discloses a catheter-like introducer.

In Machold, et al. , EPO publication 297,959 published August

31, 1988, the proximal end of the inner tube of a dilatation catheter has a stainless steel liner. In Pinchuk, et al.,

U.S. Patent No. 4,946,466, a balloon is affixed to a metallic, hollow guidewire.

In Dick, EPO published application 388, 486, published

September 26, 1990, a dilatation catheter has a regulating expanding device embodied in a connector having an

"interlumen" made of a tightly wound polymer-coated metal coil.

SUBSTITUTESHEET In Buchbinder, et al., U.S. Patent No. 4,723,936, issued February 9, 1988, and owned by the assignee of the present invention, a catheter, fixed-wire, is disclosed which has an inner tube formed of coiled stainless steel flat wire.

In Hess, U.S Patent No. 4,808,164, issued February 28, 1989, and No. 4,927,413, issued May 22, 1990, a generally fixed-wire catheter is disclosed. The inner lumen is formed of a suitable metal and has an outside diameter of about 0.014 to 0.035 inches. A core is movably and removably mounted inside the lumen. A small "guidewire" extends from the distal tip of the catheter in some embodiments. In others, it extends from the distal tip of the core. Because the Hess catheters are essentially fixed-wire systems, with a core designed particularly to fit the inner lumen, they are not available for use and insertion over a standard guidewire.

This can be a disadvantage of the Hess device. The core designed to go with the catheter must be used in most cases, and the catheter cannot be used in a system in which a small guidewire heeds to be carefully steered through a tortuous pathway ahead of the lesion, and the catheter then moved over the guidewire into place. What is apparently coils of round wire shown in the Hess device and a standard guidewire may easily lockup around corners if used together because the standard wire also has a round coil. Finally, because the device appears to use a round coil, it lacks the axial strength and "pushability" which is needed in an over-the-wire catheter which does not have the added stiffening of a fixed wire.

The above description of art is not intended to constitute an admission that any patent, publication or other information referred to is "prior art" or is enabling with respect to this invention, unless specifically designated as such. In

TITUTE SHEET addition, this section should not be construed to mean that a search has been made or that no other pertinent information as defined in 37 C.F.R. § 1.56(a) exists.

SUMMARY OF THE INVENTION The invention in one aspect is an over-the-wire catheter with a spring coil inner lumen which avoids problems associated with the prior art. It includes an outer shaft, a balloon attached to the outer shaft and adapted for inflation through the outer shaft, and a cylindrical inner tube comprised of a wound wire extending within the inner shaft, the inner tube being open at the distal end to form a lumen for a separate guidewire.

The wound wire is preferably made of stainless steel flat wire, and the preferred dimensions for the flat wire are 0.0015 inches by 0.006 inches. Usually the inner lumen is jacketed with a biocompatible polymer, preferably polyethylene. Sometimes a lubricious coating is applied to the interior of the inner lumen, and the outer shaft may be made of more than one material to enhance both stiffness and flexibility, while maintaining a good-sized inflation lumen.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a plan view of the entire catheter.

Fig. 2 illustrates a transition zone between the proximal and the distal portion of the outer shaft of the catheter.

Fig. 3 is a cross-section of the catheter taken at lines 3-3 of Fig 2.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

SUBSTITUTESHEET The catheter 1 of the present invention is shown generally in Fig. 1. It includes a tubular outer shaft 2, a generally cylindrical inflatable balloon 4, and an inner tube or lumen 6. The balloon is heat shrunk at its proximal end 8 to the outer shaft, and at its distal end 10 to the inner tube, about 2 mm back, from the distal tip 26 of the catheter. The balloon preferably has a 20 cm working length.

The outer shaft and inner tube define a lumen 3.0 therebetween shown on Fig. 3, a cross-section of the catheter. This lumen is used for inflation of the balloon and is open to the interior 12 of the balloon. A Y-shaped manifold 14 of polycarbonate is attached to the outer shaft at the proximal end, via a transition zone of strain relief tubing 26 and 28 formed of polyethylene (preferably Rexene 1017) . It includes one arm 16 accessing the inflation lumen for inflation of the balloon.

The manifold has a second arm 18 which accesses the guidewire lumen 20. Guidewire lumen 20 extends the length of the catheter within the inner tube 6. It is designed so that a guidewire (32 shown in dotted lines in Fig. 3) can be slidingly inserted therethrough. The distal end 26 of the inner tube 6 is open so that the guidewire can be extended through and out the distal end of the catheter.

The inner tube, i.e., the "spring inner lumen" is comprised of a helically wound coil of a biocompatible material. The wire from which the coil is wound is preferably a flat wire, which gives the inner tube advantageous characteristics.. In particular, it provides a smoother surface so that a guidewire (particularly a standard one with round wire) can be easily slid through. Because of the relatively large, mutually-contacting surface of adjacent coils of flat wire, axial strength and stiffness is greater than in the case of

SUBSTITUTESHEET round wire even while a thinner wire is used to minimize the catheter profile.

In the preferred embodiment,, the flat wire is formed of stainless steel (metal is preferred because it does not deform as do most polymers used for tubing) with dimensions of about 0.0015 by 0.006 inches. These dimensions appear to maximize axial strength and flexibility while maintaining desired catheter dimensions. However, other sizes can be used such as those ranging from about 0.001 to 0.003 inches in thickness and about 0.004 to 0.001 inches in width.

The inner lumen has a heat shrunk jacket 34 formed of a low density polyethylene, such as Rexene 1017. A marker band is located at the center of the balloon, is formed of gold, and is heat shrunk into place by the polyethylene jacket. A lubricious material such as Enhance™ silicone coating may be coated on the inner surface to enhance handling of the guidewire. The entire spring coil, before it is wound or jacketed, may be coated with other materials such as Teflon™ to enhance lubricity or provide other advantages. In some embodiments, the spring coil has been plated with gold.

When intended for use with a guidewire up to about 14K (0.014 inches) in size, the inner diameter of the inner tube is about 0.017 to 0.019 inches, and the outer diameter .of the coil itself is about 0.022 inches. The overall diameter of the inner tube with jacket is about 0.024 to about 0.025 inches.

The outer shaft 2 is preferably formed of a biocompatible flexible material such as those known in the art for use in catheters. Particular materials can be polyimides, poly thylenes, and the like. In the preferred embodiment, two materials are used. The proximal portion 22 of the shaft-, usually about 105 cm long, is formed of polyethylene

SUBSTITUTE SHEET terepthalate, preferably Traytuf PET #7200c, and the distal 28 cm or so of the shaft, 24, is formed of polyethylene, preferably Rexene 1017.

The joint.36 between the two portions of the shaft, which is about 5 mm long in the preferred embodiment, is illustrated on Fig. 2; the two portions are overlapped and joined by a biocompatible adhesive such as cyanocrylate. The dual materials are included because PET forms a stiffer shaft than the polyethylene; it provides a stiff proximal end where the catheter is pushed by the user. The polyethylene distal shaft provides more flexibility for a more easily-steerable tip; in addition, the profile of the polyethylene portion is kept smaller for ease of tracking in the coronary vessels. The inner diameter of the PET outer shaft is preferably about 0.034 inches, while the outer diameter is preferably about 0.042 inches. The polyethylene portion, in contrast, has an inner diameter of about 0.031 inches and an outer diameter of about 0.038 inches.

It will be understood that the above description and the illustrations are provided by way of example only, that alternate versions, equivalents, and examples will be apparent to those skilled in the art, and will be within the scope of the invention which is defined by the appended claims;

TITUTE SHEET

Claims

WHAT IS CLAIMED IS:
1. A catheter comprising: an outer tubular shaft; a balloon attached to the outer shaft and adapted for inflation through the outer shaft; a cylindrical inner tube comprised of a wound wire extending within the inner shaft, the inner tube being open at the distal end to form a lumen for a separate guidewire.
2. A catheter according to claim 1 and wherein the wound wire is made of metal.
3. A catheter according to claim 2 and wherein the wound wire is flat wire.
4. A catheter according to 3 and wherein the flat wire is ' stainless steel having dimensions of about 0.0015 inches by 0.006 inches.
5. A catheter according to claim 1 and wherein the wound wire is jacketed with a biocompatible polymer material.
6. A catheter according to claim 5 and wherein the jacket is formed of polyethylene.
7. A catheter according to claim 2 and wherein a lubricious coating is applied to the interior of the inner tube.
8. A catheter according to claim 1 and wherein the outer shaft is formed of polyethylene terepthalate at its proximal portion and polyethylene at its distal end.
SUBSTITUTESHEET
9. A catheter according to claim 1 and wherein about the proximal three-quarters of outer shaft has a greater outer diameter than the distal portion.
SUBSTITUTE SHEET
PCT/US1992/007948 1991-09-26 1992-09-23 Catheter with spring coil inner lumen WO1993005842A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US76584891 true 1991-09-26 1991-09-26
US765,848 1991-09-26

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19920921019 EP0605615A1 (en) 1991-09-26 1992-09-23 Catheter with spring coil inner lumen

Publications (1)

Publication Number Publication Date
WO1993005842A1 true true WO1993005842A1 (en) 1993-04-01

Family

ID=25074669

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/007948 WO1993005842A1 (en) 1991-09-26 1992-09-23 Catheter with spring coil inner lumen

Country Status (2)

Country Link
EP (1) EP0605615A1 (en)
WO (1) WO1993005842A1 (en)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5460608A (en) * 1994-01-25 1995-10-24 Scimed Life Systems, Inc. Kink free catheter
EP0680771A1 (en) * 1994-05-06 1995-11-08 Medtronic, Inc. Insulated extendable/retractable screw-in pacing lead
EP0680816A2 (en) * 1994-05-06 1995-11-08 Medtronic, Inc. Plasma process for reducing friction within the lumen of polymeric tubing
US5483951A (en) * 1994-02-25 1996-01-16 Vision-Sciences, Inc. Working channels for a disposable sheath for an endoscope
EP0715863A2 (en) 1994-11-10 1996-06-12 Target Therapeutics, Inc. Catheter
NL1000081C2 (en) * 1995-04-06 1996-10-08 Cordis Europ Small diameter and wall thickness catheter
US5695499A (en) * 1994-10-27 1997-12-09 Schneider (Usa) Inc. Medical device supported by spirally wound wire
US5702373A (en) * 1995-08-31 1997-12-30 Target Therapeutics, Inc. Composite super-elastic alloy braid reinforced catheter
US5891112A (en) * 1995-04-28 1999-04-06 Target Therapeutics, Inc. High performance superelastic alloy braid reinforced catheter
US5891114A (en) * 1997-09-30 1999-04-06 Target Therapeutics, Inc. Soft-tip high performance braided catheter
US5951539A (en) * 1997-06-10 1999-09-14 Target Therpeutics, Inc. Optimized high performance multiple coil spiral-wound vascular catheter
US5971975A (en) * 1996-10-09 1999-10-26 Target Therapeutics, Inc. Guide catheter with enhanced guidewire tracking
US6143013A (en) * 1995-04-28 2000-11-07 Target Therapeutics, Inc. High performance braided catheter
US6152912A (en) * 1997-06-10 2000-11-28 Target Therapeutics, Inc. Optimized high performance spiral-wound vascular catheter
US6159187A (en) * 1996-12-06 2000-12-12 Target Therapeutics, Inc. Reinforced catheter with a formable distal tip
US6217566B1 (en) 1997-10-02 2001-04-17 Target Therapeutics, Inc. Peripheral vascular delivery catheter
EP1120128A1 (en) * 2000-01-28 2001-08-01 Cook Incorporated A catheter system
US6348041B1 (en) 1999-03-29 2002-02-19 Cook Incorporated Guidewire
US6383146B1 (en) 1999-03-29 2002-05-07 Cook Incorporated Guidewire
US6589227B2 (en) 2000-01-28 2003-07-08 William Cook Europe Aps Endovascular medical device with plurality of wires
US6689120B1 (en) 1999-08-06 2004-02-10 Boston Scientific Scimed, Inc. Reduced profile delivery system
EP1660151A2 (en) * 2003-09-02 2006-05-31 St. Jude Medical, Cardiology Division, Inc. Devices and methods for crossing a chronic total occlusion
US7815625B2 (en) 1998-10-23 2010-10-19 Boston Scientific Scimed, Inc. Catheter having improved bonding region
US7815599B2 (en) 2004-12-10 2010-10-19 Boston Scientific Scimed, Inc. Catheter having an ultra soft tip and methods for making the same
US7942849B2 (en) 1993-10-27 2011-05-17 Schneider Gmbh Catheter with multilayer tube
US8066666B2 (en) 1993-10-27 2011-11-29 Schneider (Europe) A.G. Multilayer interventional catheter
US8216498B2 (en) 2008-09-10 2012-07-10 Boston Scientific Scimed, Inc. Catheter having a coextruded fluoropolymer layer

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1495702A1 (en) 2003-07-10 2005-01-12 Nestec S.A. Device for the extraction of a cartridge

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982000592A1 (en) * 1980-08-15 1982-03-04 Co Uresil Balloon catheter
WO1989001800A1 (en) * 1987-08-24 1989-03-09 Progressive Angioplasty Systems, Inc. Catheter for balloon angioplasty
EP0358117A2 (en) * 1988-09-06 1990-03-14 Advanced Cardiovascular Systems, Inc. Composite vascular catheter
US4917666A (en) * 1988-11-14 1990-04-17 Medtronic Versaflex, Inc. Steerable thru-lumen catheter
EP0397459A1 (en) * 1989-05-08 1990-11-14 Medtronic, Inc. Catheter
WO1991013649A1 (en) * 1990-03-16 1991-09-19 Medtronic, Inc. Dilatation catheter

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982000592A1 (en) * 1980-08-15 1982-03-04 Co Uresil Balloon catheter
WO1989001800A1 (en) * 1987-08-24 1989-03-09 Progressive Angioplasty Systems, Inc. Catheter for balloon angioplasty
EP0358117A2 (en) * 1988-09-06 1990-03-14 Advanced Cardiovascular Systems, Inc. Composite vascular catheter
US4917666A (en) * 1988-11-14 1990-04-17 Medtronic Versaflex, Inc. Steerable thru-lumen catheter
EP0397459A1 (en) * 1989-05-08 1990-11-14 Medtronic, Inc. Catheter
WO1991013649A1 (en) * 1990-03-16 1991-09-19 Medtronic, Inc. Dilatation catheter

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8066666B2 (en) 1993-10-27 2011-11-29 Schneider (Europe) A.G. Multilayer interventional catheter
US7942849B2 (en) 1993-10-27 2011-05-17 Schneider Gmbh Catheter with multilayer tube
US5460608A (en) * 1994-01-25 1995-10-24 Scimed Life Systems, Inc. Kink free catheter
US5483951A (en) * 1994-02-25 1996-01-16 Vision-Sciences, Inc. Working channels for a disposable sheath for an endoscope
EP0680771A1 (en) * 1994-05-06 1995-11-08 Medtronic, Inc. Insulated extendable/retractable screw-in pacing lead
EP0680816A3 (en) * 1994-05-06 1996-07-31 Medtronic Inc Plasma process for reducing friction within the lumen of polymeric tubing.
US5593550A (en) * 1994-05-06 1997-01-14 Medtronic, Inc. Plasma process for reducing friction within the lumen of polymeric tubing
EP0680816A2 (en) * 1994-05-06 1995-11-08 Medtronic, Inc. Plasma process for reducing friction within the lumen of polymeric tubing
US5695499A (en) * 1994-10-27 1997-12-09 Schneider (Usa) Inc. Medical device supported by spirally wound wire
US5658264A (en) * 1994-11-10 1997-08-19 Target Therapeutics, Inc. High performance spiral-wound catheter
EP0715863A2 (en) 1994-11-10 1996-06-12 Target Therapeutics, Inc. Catheter
US5795341A (en) * 1994-11-10 1998-08-18 Target Therapeutics, Inc. High performance spiral-wound catheter
US5853400A (en) * 1994-11-10 1998-12-29 Target Therapeutics, Inc. High performance spiral-wound catheter
NL1000081C2 (en) * 1995-04-06 1996-10-08 Cordis Europ Small diameter and wall thickness catheter
US5891112A (en) * 1995-04-28 1999-04-06 Target Therapeutics, Inc. High performance superelastic alloy braid reinforced catheter
US6143013A (en) * 1995-04-28 2000-11-07 Target Therapeutics, Inc. High performance braided catheter
US5702373A (en) * 1995-08-31 1997-12-30 Target Therapeutics, Inc. Composite super-elastic alloy braid reinforced catheter
US5971975A (en) * 1996-10-09 1999-10-26 Target Therapeutics, Inc. Guide catheter with enhanced guidewire tracking
US6159187A (en) * 1996-12-06 2000-12-12 Target Therapeutics, Inc. Reinforced catheter with a formable distal tip
US5951539A (en) * 1997-06-10 1999-09-14 Target Therpeutics, Inc. Optimized high performance multiple coil spiral-wound vascular catheter
US6152912A (en) * 1997-06-10 2000-11-28 Target Therapeutics, Inc. Optimized high performance spiral-wound vascular catheter
US5891114A (en) * 1997-09-30 1999-04-06 Target Therapeutics, Inc. Soft-tip high performance braided catheter
US6165163A (en) * 1997-09-30 2000-12-26 Target Therapeutics, Inc. Soft-tip performance braided catheter
US6217566B1 (en) 1997-10-02 2001-04-17 Target Therapeutics, Inc. Peripheral vascular delivery catheter
US8636717B2 (en) 1998-10-23 2014-01-28 Boston Scientific Scimed, Inc. Catheter having improved bonding region
US8292874B2 (en) 1998-10-23 2012-10-23 Boston Scientific Scimed, Inc. Catheter having improved bonding region
US7815625B2 (en) 1998-10-23 2010-10-19 Boston Scientific Scimed, Inc. Catheter having improved bonding region
US6348041B1 (en) 1999-03-29 2002-02-19 Cook Incorporated Guidewire
US6383146B1 (en) 1999-03-29 2002-05-07 Cook Incorporated Guidewire
US6689120B1 (en) 1999-08-06 2004-02-10 Boston Scientific Scimed, Inc. Reduced profile delivery system
US7025758B2 (en) 2000-01-28 2006-04-11 William Cook Europe Aps Endovascular medical device with plurality of wires
US6589227B2 (en) 2000-01-28 2003-07-08 William Cook Europe Aps Endovascular medical device with plurality of wires
EP1120128A1 (en) * 2000-01-28 2001-08-01 Cook Incorporated A catheter system
EP1660151A2 (en) * 2003-09-02 2006-05-31 St. Jude Medical, Cardiology Division, Inc. Devices and methods for crossing a chronic total occlusion
US7815599B2 (en) 2004-12-10 2010-10-19 Boston Scientific Scimed, Inc. Catheter having an ultra soft tip and methods for making the same
US8973239B2 (en) 2004-12-10 2015-03-10 Boston Scientific Scimed, Inc. Catheter having an ultra soft tip and methods for making the same
US8216498B2 (en) 2008-09-10 2012-07-10 Boston Scientific Scimed, Inc. Catheter having a coextruded fluoropolymer layer

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