WO1993004063A1 - Benzisoxazole compound and use thereof - Google Patents
Benzisoxazole compound and use thereof Download PDFInfo
- Publication number
- WO1993004063A1 WO1993004063A1 PCT/JP1992/001060 JP9201060W WO9304063A1 WO 1993004063 A1 WO1993004063 A1 WO 1993004063A1 JP 9201060 W JP9201060 W JP 9201060W WO 9304063 A1 WO9304063 A1 WO 9304063A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bond
- group
- defined above
- positions
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19920918032 EP0602242A4 (en) | 1991-08-22 | 1992-08-21 | Benzisoxazole compound and use thereof. |
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23739791 | 1991-08-22 | ||
JP3/237397 | 1991-08-22 | ||
JP4/100367 | 1992-03-25 | ||
JP10036792 | 1992-03-25 | ||
JP10176392 | 1992-03-26 | ||
JP4/101707 | 1992-03-26 | ||
JP10170792 | 1992-03-26 | ||
JP4/101763 | 1992-03-26 | ||
JP4/112154 | 1992-04-03 | ||
JP11215492 | 1992-04-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993004063A1 true WO1993004063A1 (en) | 1993-03-04 |
Family
ID=27526005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1992/001060 WO1993004063A1 (en) | 1991-08-22 | 1992-08-21 | Benzisoxazole compound and use thereof |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0602242A4 (ja) |
CA (1) | CA2116117A1 (ja) |
WO (1) | WO1993004063A1 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5750542A (en) * | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
US5916902A (en) * | 1995-09-13 | 1999-06-29 | Pfizer Inc. | Processes and intermediates for preparing 5, 7-dihydro-3- 2-(1-benzylpiperidin-4-yl)ethyl-!6H-pyrrolo- 4, 5-F!-1, 2-benzisoxazol-6-one |
KR20040020457A (ko) * | 2002-08-30 | 2004-03-09 | 주식회사 대웅 | 3-{2-[4-(6-플루오로벤조[d]이속사졸-3-일)피페리디노]에틸}-2-메틸-6,7,8,9-테트라하이드로-4H-피리도[1,2-a]피리미딘-4-온 또는 그 산부가염의 제조방법 |
WO2006090224A1 (en) | 2005-02-25 | 2006-08-31 | Pfizer Japan Inc. | Benzisoxazole derivatives |
WO2007126041A1 (ja) | 2006-04-28 | 2007-11-08 | Eisai R & D Management Co., Ltd. | ベンゾイソオキサゾール化合物 |
EP1891954A2 (en) | 1998-09-30 | 2008-02-27 | Takeda Pharmaceutical Company Limited | Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder |
RU2597766C2 (ru) * | 2011-03-23 | 2016-09-20 | Раквалиа Фарма Инк. | Агонист рецептора 5-нт4 в качестве прокинетического агента |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3327399A (en) | 1998-02-09 | 1999-08-23 | Duphar International Research B.V. | Benzisoxazole derivatives having d4-antagonistic activity |
US7091218B1 (en) | 1999-09-01 | 2006-08-15 | Eisai Co., Ltd. | 4-substituted piperidine compound |
CA2534777A1 (en) * | 2003-08-05 | 2005-02-24 | Samaritan Pharmaceuticals Inc. | Sigma-1 receptor ligand with acetylcholinesterase inhibition properties |
US7538120B2 (en) | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
US7144907B2 (en) * | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61221186A (ja) * | 1985-03-27 | 1986-10-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 新規1,2‐ベンズイソキサゾール‐3‐イル及び1,2‐ベンズイソチアゾール‐3‐イル誘導体 |
EP0449186A2 (en) * | 1990-03-28 | 1991-10-02 | The Du Pont Merck Pharmaceutical Company | N-aralkyl piperidine derivatives as psychotropic drugs |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2654104B1 (fr) * | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
CA2107105C (en) * | 1991-03-28 | 2003-10-07 | Anabella Villalobos | Heterocyclic-cyclic amine derivatives |
-
1992
- 1992-08-21 EP EP19920918032 patent/EP0602242A4/en not_active Withdrawn
- 1992-08-21 CA CA 2116117 patent/CA2116117A1/en not_active Abandoned
- 1992-08-21 WO PCT/JP1992/001060 patent/WO1993004063A1/ja not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61221186A (ja) * | 1985-03-27 | 1986-10-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 新規1,2‐ベンズイソキサゾール‐3‐イル及び1,2‐ベンズイソチアゾール‐3‐イル誘導体 |
EP0449186A2 (en) * | 1990-03-28 | 1991-10-02 | The Du Pont Merck Pharmaceutical Company | N-aralkyl piperidine derivatives as psychotropic drugs |
Non-Patent Citations (1)
Title |
---|
See also references of EP0602242A4 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6498255B2 (en) | 1991-03-28 | 2002-12-24 | Pfizer Inc. | Heterocyclic-cyclic amine derivatives as cholinesterase inhibitors |
US6326382B1 (en) | 1992-03-09 | 2001-12-04 | Eisai Co., Ltd | Heterocyclic-cyclic amine derivatives |
US5750542A (en) * | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
US5916902A (en) * | 1995-09-13 | 1999-06-29 | Pfizer Inc. | Processes and intermediates for preparing 5, 7-dihydro-3- 2-(1-benzylpiperidin-4-yl)ethyl-!6H-pyrrolo- 4, 5-F!-1, 2-benzisoxazol-6-one |
EP1891954A2 (en) | 1998-09-30 | 2008-02-27 | Takeda Pharmaceutical Company Limited | Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder |
KR20040020457A (ko) * | 2002-08-30 | 2004-03-09 | 주식회사 대웅 | 3-{2-[4-(6-플루오로벤조[d]이속사졸-3-일)피페리디노]에틸}-2-메틸-6,7,8,9-테트라하이드로-4H-피리도[1,2-a]피리미딘-4-온 또는 그 산부가염의 제조방법 |
WO2006090224A1 (en) | 2005-02-25 | 2006-08-31 | Pfizer Japan Inc. | Benzisoxazole derivatives |
US8816090B2 (en) | 2005-02-25 | 2014-08-26 | Pfizer Inc. | Benzisoxazole derivatives |
WO2007126041A1 (ja) | 2006-04-28 | 2007-11-08 | Eisai R & D Management Co., Ltd. | ベンゾイソオキサゾール化合物 |
RU2597766C2 (ru) * | 2011-03-23 | 2016-09-20 | Раквалиа Фарма Инк. | Агонист рецептора 5-нт4 в качестве прокинетического агента |
US10137113B2 (en) | 2011-03-23 | 2018-11-27 | Raqualia Pharma Inc. | 5-HT4 receptor agonist as a prokinetic agent |
Also Published As
Publication number | Publication date |
---|---|
EP0602242A1 (en) | 1994-06-22 |
CA2116117A1 (en) | 1993-03-04 |
EP0602242A4 (en) | 1994-06-29 |
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