WO1993000044A1 - Blood sampler - Google Patents

Blood sampler Download PDF

Info

Publication number
WO1993000044A1
WO1993000044A1 PCT/DK1992/000192 DK9200192W WO9300044A1 WO 1993000044 A1 WO1993000044 A1 WO 1993000044A1 DK 9200192 W DK9200192 W DK 9200192W WO 9300044 A1 WO9300044 A1 WO 9300044A1
Authority
WO
WIPO (PCT)
Prior art keywords
needle
bottom
positioning part
part
sampling
Prior art date
Application number
PCT/DK1992/000192
Other languages
French (fr)
Inventor
Troels Keldmann
Peter Klitgaard
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK1208/91 priority Critical
Priority to DK911208A priority patent/DK120891D0/en
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of WO1993000044A1 publication Critical patent/WO1993000044A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/151Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142Devices intended for single use, i.e. disposable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150015Source of blood
    • A61B5/150022Source of blood for capillary blood or interstitial fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150343Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150389Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150503Single-ended needles
    • A61B5/150519Details of construction of hub, i.e. element used to attach the single-ended needle to a piercing device or sampling device
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150633Protective sleeves which are axially extensible, e.g. sleeves connected to, or integrated in, the piercing or driving device; pivotable protective sleeves

Abstract

A blood sampler comprises a cup shaped positioning part having a bottom (1) and a sidewall (2) and a sampling part having a bottom (4) and a sidewall (5). In the bottom (1) of the positioning part there is provided a central opening (9), which at the outer side of the cup is surrounded by a spacing ring (3). The sampling part has a needle (8) centrally through is bottom (4), which needle has at the outside of the sampling part a sharp end and inside the sampling part a sample collector (10). The sampling part fit displaceably into the positioning part with the sharp end of its needle (8) facing the opening (9) in the bottom (1) of this positioning part, but is by a snap lock (6, 7) releasably locked in a position with its bottom (4) near the upper edge of the positioning part. A cup shaped transparent cap (11) fits with its open end into the open end of the sampling part. In use the spacing ring (8) is pressed against the skin (12) by a finger (13) pressing the cap (11) until the snap lock (6, 7) releases and the sampling part passes into the positioning part with its needle (8) projecting through the opening (9) in the bottom (1) of this positioning part into the skin (12).

Description

BLOOD SAMPLER

The invention concerns a blood sampler for taking out small blood samples of the dimension a drop or so.

For many medical purposes it is necessary to take out small blood samples to determine different blood parameters such as glucose content, coagulation time etc. For this purpose the skin of the patient is pierced by a needle or stiletto to provide a small wound from which a single drop of blood is made to bleed out. The blood drop may e.g. be placed on a piece of indicator paper directly as it is often the case when the patient himself frequently makes the necessary determination of one of his blood parameters.

However, such measurement will often be made using electrochemically functioning apparatus having a sensor on which the blood drop must be placed. Such apparatus may be owned by the patient himself, but will usually be clinic equipment used for measuring of blood samples from many different patients. Unless the sensor on which the blood is to be placed is a disposable device which is disposed of each time a patient has placed his droplet of blood thereon the risk of dissimination of infection exists when a patient is directly placing his open wounded finger with the blood drop on a sensor contaminated by blood from a previous patient. This problem may be solved by using a disposable device for carrying the blood from the patient to the sensor. Such a device may be a small sponge into which the blood drop is absorbed and thereafter given off by squeezing the sponge at the sensor. This eliminates the risk as to the patient, but the handling of the free drop of blood on the patient's finger still presents a risk to the members of the clinic staff, especially when they have to help the patients by squeezing a pricked finger to make the blood flow or by wiping off excessive blood from the pricked finger.

The finger pricking may be performed by using a disposable lancet unit in a tool as described in Danish patent application No. 2316/90.

It is the object of the invention to provide a blood sampler by which the finger pricking and the absorption of a blood drop is obtained by using only one disposable article and without using any tool for operating the sampler, and by which the operator of the sampler is protected against coming into contact with the blood.

This is obtained by a sampler as described in claim 1. The sampler is placed with the spacing ring of the positioning part against the skin on the spot where a sample is to be taken. The sampler is pressed against this spot by pressing the bottom of the cover. The pressure on the cover is transferred to the sampling member, and when this pressure is sufficient to overcome the locking force of the pressure releasable lock, the sampling member is pushed downwards until it abuts the base of the positioning part, the needle of the sampling member passing through the opening in the positioning part and through the skin of the patient to a depth where small blood vessels are cut and blood therefrom will pass through the needle and accumulate as a drop at the other end of the needle under the cover.

During the sampling the sampling spot is well confined by the spacing ring which may be provided with an adhesive sealing bonding of the spacing ring to the sampling spot.

According to the invention the inner end of the needle may be provided with a collector with tongues which are bent outwards as petals to form a crown which may hold the blood drop preventing it from trickling down along the needle.

The cover may be made from a transparent material making it possible to inspect when sufficient blood has accumulated at the end of the needle.

Further the cover may be designed so that its opening fits narrowly over the outer side of the spacing ring. When placed fitting over the spacing ring, the cover may be used as a grip when the blood drop is to be transferred to another medium or the cover may serve as a base if the sample is to be stored for a time. At the same time the cover serves as a protection of the sharp needle end which projects from the bottom of the device when used.

In a preferred embodiment the positioning part may have the shape of a cup having the opening in its bottom and the spacing ring on the outer side of its bottom, the sampling member may have the shape of a cup fitting loosely into the positioning part with its open end in the same direction as the open end of this positioning part and may carry the needle in its bottom, and the cover may have the shape of a cup fitting loosely with its open end into the open end of the sampling member.

The pressure releasable lock may appropriately be provided by circumferential ribs on the inner side near the opening of the positioning part and 5 on the outer side near the bottom of the sampling part, respectively, a single rib on one part engaging the space between to neighbouring ribs on the other part.

The positioning part may further have ribs on its inner side near the bottom to lock the sampling member in its position with its bottom abutting the bottom of the positioning part when pressed. Thereby reuse of the device is 0 precluded.

According to the invention the needle may be a sprinkler-needle, which is a needle being pointed without being sharp and having in its side openings communicating with a central bore. Such needles seem to cause less pain and the wounds after the pricking will heal more rapidly as no cut is made in the tissue, s The invention will now be described in further details with reference to the drawing, in which

Figure 1 shows a sectional view of a blood sampler placed on a sampling spot ready for being pressed by a finger, Figure 2 shows the blood sampler of figure 1 with its sampling o member depressed with its needle projecting into the skin, and

Figure 3 the blood sampler of figure 2 made ready for giving of the sample to a measuring station.

The blood sampler in figure 1 comprises a positioning part having the shape 5 of a cup with a bottom 1 and side walls 2, the bottom 1 being provided with a central opening 9 being surrounded by a spacing ring 3 at the outer side of the cup.

A cup shaped sampling member having a bottom 4 and side walls 5 fits loosely into the positioning part with its open end in the same direction as the open end of the o positioning part. The sampling member is held in a position with its bottom placed near the open end of the positioning part, this position being obtained by an internal rib 6 near the opening of the positioning part engaging a circumferential groove 7 in the outer surface of the side wall 5 of the sampling member, which groove 7 here is provided as the space between two neighbouring ribs.

A hypodermic 8 needle is secured centrally through the bottom 4 of the sampling member and has a sharp pointed end directed towards the opening 9, and an end opening into the inner of the cup shaped sampling member. At this last end the needle is extended by a plastic tube, the free end of which by slots is divided into tongues 10, which are bend outwards as petals to form a crown.

The crown is covered by a cup shaped cover 11 fitting with its open end into the open end of the cup shaped sampling member and abutting with the edge of its opening against the inner side of the bottom 4 of the sampling member. The positioning part is placed with its space ring 3 pressed against the skin 12 of the person from whom the blood sample is to be taken. The sample is taken by pressing the bottom of the cover 11 by a finger 13. Thereby the positioning part will initially be pressed against the sampling spot whereby the skin is made ready for piercing, a pillow being formed from the skin inside the spacing ring. This has shown to lessen the sensation of pain. When the pressure has reached a sufficient magnitude the snap lock provided by the rib 6 and the groove 7 is released and the sampling member will pass down into the positioning member until its bottom 4 abuts the bottom 1 of the positioning part. Hereby the pointed end of the needle 8 is passed out through the opening 9 into to the skin 12 of the patient. The pointed end of the needle will cut some capillary blood vessels in the skin and blood will flow through the bore of the needle into the plastic tube and be collected in the crown as a drop 14 as shown in figure 2.

As further shown a circumferential rib 15 is provided on the inner side of the wall 2 near the bottom 1 of the positioning part. This rib 15 will engage the groove 7 when the sampling member is pressed down and this member will be locked in its pressed down position whereby reuse of the sampler is made impossible or at least unattractive.

The cover 11 may now be removed from its position covering the crown with the blood drop and may be fitted on the spacing ring 3. Thereby the needle which is now projecting through the bottom of the positioning part is covered to prevent anybody from being scratched by the pointed end. Further the cover acts as a grip by which the sampler may be handled to transfer the blood drop 14 to a sensor 16 or indicator.

The cover is preferably made from tranparent material to make it possible to inspect that blood is collected in the crown. If the blood does not of itself flow into the crown it may be helpful to sqeeze the skin around the sampling spot, which may be done without risk of coming into contact with the blood as the sampling spot is well confined by the spacing ring 3. This confinement may be made more effective by providing an adhesive on the edge of the spacing ring making it adhere to the skin around the sampling spot.

Claims

1. A blood sampler characterized in, that it comprises a positioning part having a base with an opening surrounded by a spacing ring designed to abut the skin around a sampling spot, a sampling member having a hypodermic needle and being displacably mounted on the positioning part on the side of the base opposite the spacing ring, a pressure releasable lock keeping the displacable sampling member in a position with an outer sharp end of its needle directed towards the opening, a cover covering the other inner end of the needle and upon which a pressure may be exerted to release the snap lock and displace the sampling member towards the positioning part to make the needle protrude through the opening and into the skin at the sampling spot.
2. A blood sampler according to claim 1 , characterized in, that the inner end of the needle is provided with a collector with tongues which are bend outwards as petals to form a crown,
3. A blood sampler according to claim 1 or 2, charac-terized in, that the cover is made from a transparent material.
4. A blood sampler according to any of the preceding claims, characterized in, that the cover is cup shaped having an open end fitting narrowly over the outer side of the space ring.
5. A blood sampler according to any of the preceding claims, characterized in, that the positioning part has the shape of a cup having the opening in its bottom and the space ring on the outer side of its bottom, that the sampling member has the shape of a cup fitting loosely into the positioning part with its open end in the same direction as the open end of this positioning part and carrying the needle in its bottom, and that the cover has the shape of a cup fitting loosely with its open end into the open end of the sampling member.
6. A blood sampler according to claim 5, characterized in, that the pressure releasable lock is provided by circumferential ribs on the inner side near the opening of the positioning part and on the outer side near the bottom of the sampling part, respectively, a single rip on one part engaging the space between two neighbouring ribs on the other part
7. A blood sampler according to claim 6, characterized in, that the positioning part has ribs on its inner side near the bottom to lock the sampling member in its pressed down position.
8. A blood sampler according to any of the preceding claims, characterized in that the needle is a sprinkler-needle.
PCT/DK1992/000192 1991-06-21 1992-06-19 Blood sampler WO1993000044A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DK1208/91 1991-06-21
DK911208A DK120891D0 (en) 1991-06-21 1991-06-21 Blodproevetager

Publications (1)

Publication Number Publication Date
WO1993000044A1 true WO1993000044A1 (en) 1993-01-07

Family

ID=8102190

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1992/000192 WO1993000044A1 (en) 1991-06-21 1992-06-19 Blood sampler

Country Status (3)

Country Link
AU (1) AU2197092A (en)
DK (1) DK120891D0 (en)
WO (1) WO1993000044A1 (en)

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439473A (en) * 1993-12-13 1995-08-08 Modulohm A/S Safety lancet
GB2331935A (en) * 1997-12-04 1999-06-09 Hewlett Packard Co Cartridge for sampling blood
DE19855465B4 (en) * 1997-12-04 2004-11-11 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto An apparatus for blood sampling and analysis
US8197423B2 (en) 2002-04-19 2012-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8690796B2 (en) 2002-04-19 2014-04-08 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8845549B2 (en) 2002-04-19 2014-09-30 Sanofi-Aventis Deutschland Gmbh Method for penetrating tissue
US8845550B2 (en) 2001-06-12 2014-09-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8905945B2 (en) 2002-04-19 2014-12-09 Dominique M. Freeman Method and apparatus for penetrating tissue
US8945910B2 (en) 2003-09-29 2015-02-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9034639B2 (en) 2002-12-30 2015-05-19 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US9089294B2 (en) 2002-04-19 2015-07-28 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US9144401B2 (en) 2003-06-11 2015-09-29 Sanofi-Aventis Deutschland Gmbh Low pain penetrating member
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US9261476B2 (en) 2004-05-20 2016-02-16 Sanofi Sa Printable hydrogel for biosensors
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9561000B2 (en) 2003-12-31 2017-02-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US9560993B2 (en) 2001-11-21 2017-02-07 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9820684B2 (en) 2004-06-03 2017-11-21 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9839386B2 (en) 2002-04-19 2017-12-12 Sanofi-Aventis Deustschland Gmbh Body fluid sampling device with capacitive sensor

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0199484A2 (en) * 1985-04-08 1986-10-29 Audio Bionics Inc Medical system
DE3730469A1 (en) * 1986-09-08 1988-06-16 Wolfgang Dr Med Wagner Device for suction diagnosis or suction injection
US4883068A (en) * 1988-03-14 1989-11-28 Dec In Tech, Inc. Blood sampling device and method
US4889117A (en) * 1989-02-17 1989-12-26 Stevens Peter A Disposable lancet

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0199484A2 (en) * 1985-04-08 1986-10-29 Audio Bionics Inc Medical system
DE3730469A1 (en) * 1986-09-08 1988-06-16 Wolfgang Dr Med Wagner Device for suction diagnosis or suction injection
US4883068A (en) * 1988-03-14 1989-11-28 Dec In Tech, Inc. Blood sampling device and method
US4889117A (en) * 1989-02-17 1989-12-26 Stevens Peter A Disposable lancet

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439473A (en) * 1993-12-13 1995-08-08 Modulohm A/S Safety lancet
GB2331935A (en) * 1997-12-04 1999-06-09 Hewlett Packard Co Cartridge for sampling blood
US6071294A (en) * 1997-12-04 2000-06-06 Agilent Technologies, Inc. Lancet cartridge for sampling blood
DE19855458C2 (en) * 1997-12-04 2002-01-10 Agilent Technologies Inc Lancet cartridge for blood sampling
GB2331935B (en) * 1997-12-04 2002-10-09 Hewlett Packard Co Lancet cartridge for sampling blood
DE19855465B4 (en) * 1997-12-04 2004-11-11 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto An apparatus for blood sampling and analysis
US8845550B2 (en) 2001-06-12 2014-09-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9937298B2 (en) 2001-06-12 2018-04-10 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9802007B2 (en) 2001-06-12 2017-10-31 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9694144B2 (en) 2001-06-12 2017-07-04 Sanofi-Aventis Deutschland Gmbh Sampling module device and method
US9560993B2 (en) 2001-11-21 2017-02-07 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US9498160B2 (en) 2002-04-19 2016-11-22 Sanofi-Aventis Deutschland Gmbh Method for penetrating tissue
US9907502B2 (en) 2002-04-19 2018-03-06 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9839386B2 (en) 2002-04-19 2017-12-12 Sanofi-Aventis Deustschland Gmbh Body fluid sampling device with capacitive sensor
US9072842B2 (en) 2002-04-19 2015-07-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9089294B2 (en) 2002-04-19 2015-07-28 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US9089678B2 (en) 2002-04-19 2015-07-28 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9186468B2 (en) 2002-04-19 2015-11-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US8845549B2 (en) 2002-04-19 2014-09-30 Sanofi-Aventis Deutschland Gmbh Method for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9339612B2 (en) 2002-04-19 2016-05-17 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9724021B2 (en) 2002-04-19 2017-08-08 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8197423B2 (en) 2002-04-19 2012-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8905945B2 (en) 2002-04-19 2014-12-09 Dominique M. Freeman Method and apparatus for penetrating tissue
US8690796B2 (en) 2002-04-19 2014-04-08 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US9034639B2 (en) 2002-12-30 2015-05-19 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US9144401B2 (en) 2003-06-11 2015-09-29 Sanofi-Aventis Deutschland Gmbh Low pain penetrating member
US10034628B2 (en) 2003-06-11 2018-07-31 Sanofi-Aventis Deutschland Gmbh Low pain penetrating member
US8945910B2 (en) 2003-09-29 2015-02-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US9561000B2 (en) 2003-12-31 2017-02-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US9261476B2 (en) 2004-05-20 2016-02-16 Sanofi Sa Printable hydrogel for biosensors
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9820684B2 (en) 2004-06-03 2017-11-21 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation

Also Published As

Publication number Publication date
AU2197092A (en) 1993-01-25
DK120891D0 (en) 1991-06-21

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