WO1992016211A1 - New use of diphenylbutyl-piperazinecarboxamides in the treatment of substance disorders - Google Patents
New use of diphenylbutyl-piperazinecarboxamides in the treatment of substance disorders Download PDFInfo
- Publication number
- WO1992016211A1 WO1992016211A1 PCT/SE1992/000182 SE9200182W WO9216211A1 WO 1992016211 A1 WO1992016211 A1 WO 1992016211A1 SE 9200182 W SE9200182 W SE 9200182W WO 9216211 A1 WO9216211 A1 WO 9216211A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carbon atoms
- hydrogen
- groups
- halogen
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Abstract
Description
Claims
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT92907159T ATE199057T1 (en) | 1991-03-22 | 1992-03-23 | NEW USE OF DIPHENYLBUTYL-PIPERAZINE CARBOXAMIDE FOR THE TREATMENT OF DISORDERS RELATED TO THE USE OF TOXIC SUBSTANCES |
RO92-01457A RO109702B1 (en) | 1991-03-22 | 1992-03-23 | Treatment method for the illnesses which are resulting from substances abuse |
CS923449A CZ282222B6 (en) | 1991-03-22 | 1992-03-23 | The use of 4-£4,4-bis(4-fluorophenyl)butyl|-n-ethyl-1-piperazinecarboxamide amperozide for the preparation of a medicament |
KR1019920702939A KR100196674B1 (en) | 1991-03-22 | 1992-03-23 | Use of diphenylbutyl-piperazinecarboxamides in the treatment of substance disorders and pharmaceutical compositions containing them |
BR9204969A BR9204969A (en) | 1991-03-22 | 1992-03-23 | NEW JOBS OF DIPHENYLBUTYL-PIPERAZINECARBOXAM IDES IN THE TREATMENT OF DISTURBANCES CAUSED BY SUBSTANCES |
US07/949,869 US5434156A (en) | 1991-03-22 | 1992-03-23 | Use of diphenylbutyl-piperazinecarboxamides in the treatment of substance disorders |
CA002083505A CA2083505C (en) | 1991-03-22 | 1992-03-23 | New use of diphenylbutyl-piperazinecarboxamides in the treatment of substance disorders |
SK3449-92A SK279237B6 (en) | 1991-03-22 | 1992-03-23 | Use of amperozide, 4-[4,4-bis(4-fluorophenyl)butyl]-n-ethyl-1- -piperazinecarboxamide |
DE69231680T DE69231680T2 (en) | 1991-03-22 | 1992-03-23 | NEW USE OF DIPHENYLBUTYL-PIPERAZINE CARBOXAMIDES FOR THE TREATMENT OF INTERFERENCES RELATING TO THE USE OF TOXIC SUBSTANCES |
AU14280/92A AU653797B2 (en) | 1991-03-22 | 1992-03-23 | New use of diphenylbutyl-piperazinecarboxamides in the treatment of substance disorders |
EP92907159A EP0538422B1 (en) | 1991-03-22 | 1992-03-23 | New use of diphenylbutylpiperazinecarboxamides in the treatment of substance disorders |
RU9292016400A RU2095062C1 (en) | 1991-03-22 | 1992-03-23 | Blocking agent of withdrawal syndrome that is a result of drug habituation to over intaking drugs and substances causing habituation, pharmacological composition based on thereof and a method of relief or prevention of withdrawal syndrome |
DK92907159T DK0538422T3 (en) | 1991-03-22 | 1992-03-23 | New use of diphenylbutyl-piperazine carboxamides for the treatment of substance abuse disorders |
BG97108A BG61829B1 (en) | 1991-03-22 | 1992-11-20 | Use of diphenylbutyl-piperazinecarboxamides in the treatment of substance abuce disorders |
NO924502A NO301311B1 (en) | 1991-03-22 | 1992-11-23 | New use of diphenylbutyl-piperazine carboxamides in the treatment of substance abuse disorders |
GR20010400653T GR3035805T3 (en) | 1991-03-22 | 2001-04-27 | New use of diphenylbutylpiperazinecarboxamides in the treatment of substance disorders. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9100860-7 | 1991-03-22 | ||
SE9100860A SE9100860D0 (en) | 1991-03-22 | 1991-03-22 | NEW USE |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992016211A1 true WO1992016211A1 (en) | 1992-10-01 |
Family
ID=20382242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1992/000182 WO1992016211A1 (en) | 1991-03-22 | 1992-03-23 | New use of diphenylbutyl-piperazinecarboxamides in the treatment of substance disorders |
Country Status (24)
Country | Link |
---|---|
US (2) | US5434156A (en) |
EP (1) | EP0538422B1 (en) |
JP (1) | JP3221611B2 (en) |
KR (1) | KR100196674B1 (en) |
AT (1) | ATE199057T1 (en) |
AU (1) | AU653797B2 (en) |
BG (1) | BG61829B1 (en) |
BR (1) | BR9204969A (en) |
CA (1) | CA2083505C (en) |
CZ (1) | CZ282222B6 (en) |
DE (1) | DE69231680T2 (en) |
DK (1) | DK0538422T3 (en) |
EE (1) | EE02973B1 (en) |
ES (1) | ES2154261T3 (en) |
GR (1) | GR3035805T3 (en) |
HU (2) | HU9203632D0 (en) |
IE (1) | IE920920A1 (en) |
NO (1) | NO301311B1 (en) |
PT (1) | PT100279B (en) |
RO (1) | RO109702B1 (en) |
RU (1) | RU2095062C1 (en) |
SE (1) | SE9100860D0 (en) |
SK (1) | SK279237B6 (en) |
WO (1) | WO1992016211A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993020821A1 (en) * | 1992-04-21 | 1993-10-28 | Kabi Pharmacia Ab | Agents for treating substance abuse disorders |
EP0755680A2 (en) * | 1995-07-11 | 1997-01-29 | Pola Chemical Industries Inc | Use of piperazine compounds as narcotic antagonists |
US6951861B1 (en) | 1999-10-07 | 2005-10-04 | Smithkline Beechan Corporation | Chemical compounds |
US7060702B2 (en) | 2000-10-17 | 2006-06-13 | Smithkline Beecham Corporation | Chemical compounds |
US7276509B2 (en) | 2002-02-08 | 2007-10-02 | Glaxo Group Limited | Piperidine derivatives and their use as antagonists of tachykinins |
USRE39921E1 (en) | 1999-10-07 | 2007-11-13 | Smithkline Beecham Corporation | Chemical compounds |
US7482365B2 (en) | 2002-02-08 | 2009-01-27 | Glaxo Group Limited | Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases |
US7652012B2 (en) | 2002-02-08 | 2010-01-26 | Glaxo Group Limited | 2-(R)-(4-fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide maleate and pharmaceutical compositions thereof |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9100860D0 (en) * | 1991-03-22 | 1991-03-22 | Kabi Pharmacia Ab | NEW USE |
US6265393B1 (en) | 1998-08-07 | 2001-07-24 | Heinrichs William Leroy | Prevention of endometriosis signs or symptons |
US6090780A (en) * | 1999-04-07 | 2000-07-18 | Chandon Prasad | Histidyl-proline diketopiperazine and method of use |
US20050192271A1 (en) * | 2003-07-15 | 2005-09-01 | Hythiam, Inc. | Use of selective chloride channel modulators to treat alcohol and/or stimulant substance abuse |
JP2004519461A (en) * | 2001-01-17 | 2004-07-02 | ハイチアム,インコーポレイテッド | Use of flumazenil in the manufacture of a medicament for the treatment of alcoholism |
US7183410B2 (en) * | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
US20030060475A1 (en) * | 2001-08-10 | 2003-03-27 | Boehringer Ingelheim Pharma Kg | Method of using flibanserin for neuroprotection |
US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
WO2005102342A1 (en) * | 2004-04-22 | 2005-11-03 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions for the treatment of sexual disorders ii |
US20050239798A1 (en) * | 2004-04-22 | 2005-10-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the treatment of premenstrual and other female sexual disorders |
US20060025420A1 (en) * | 2004-07-30 | 2006-02-02 | Boehringer Ingelheimn International GmbH | Pharmaceutical compositions for the treatment of female sexual disorders |
JP2008511569A (en) * | 2004-09-03 | 2008-04-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | How to treat attention-deficit hyperactivity disorder |
WO2006096439A2 (en) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases |
JP2008538741A (en) * | 2005-03-04 | 2008-11-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Pharmaceutical composition for the treatment and / or prevention of depression |
CA2599937A1 (en) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders |
JP2008540356A (en) * | 2005-05-06 | 2008-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Drug abuse treatment methods |
EP1888071A1 (en) * | 2005-05-19 | 2008-02-20 | Boehringer Ingelheim International GmbH | Method for the treatment of drug-induced sexual dysfunction |
WO2006125041A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of sexual dysfunctions due to medical conditions |
JP2009503020A (en) | 2005-08-03 | 2009-01-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Use of flibanserin in the treatment of obesity |
JP2009513604A (en) * | 2005-10-29 | 2009-04-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Benzimidazolone derivatives for the treatment of premenstrual disorders and other female sexual disorders |
US20070123540A1 (en) * | 2005-10-29 | 2007-05-31 | Angelo Ceci | Sexual desire enhancing medicaments comprising benzimidazolone derivatives |
US20070105869A1 (en) * | 2005-11-08 | 2007-05-10 | Stephane Pollentier | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders |
PE20080090A1 (en) * | 2006-05-09 | 2008-03-14 | Boehringer Ingelheim Int | FLIBANSERIN FOR THE TREATMENT OF POST-MENOPAUSAL DISORDERS OF SEXUAL DESIRE |
DE602007004615D1 (en) | 2006-06-30 | 2010-03-18 | Boehringer Ingelheim Pharma | FLIBANSERIN FOR THE TREATMENT OF HARNINE INCONTINENCE AND ASSOCIATED DISEASES |
US20090318469A1 (en) * | 2006-07-14 | 2009-12-24 | Boehringer Ingelheim International Gmbh | Use of Flibanserin for the Treatment of Sexual Disorders in Females |
KR20090042967A (en) | 2006-08-14 | 2009-05-04 | 베링거 인겔하임 인터내셔날 게엠베하 | Formulations of flibanserin and method for manufacturing the same |
CL2007002214A1 (en) * | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | PHARMACEUTICAL COMPOSITION IN THE FORM OF COMPRESSED, WHERE AT LEAST THE LENGTH OF THE COMPRESSED IN THE PREVIOUS STATE OF THE APPLICATION IS AT LEAST 7/12 OF THE PILOR DIAMETER OF THE PATIENT AND AFTER INGERING IT IN THE FOOD STATE, THE LENGTH OF THE COMP |
AU2007287639A1 (en) * | 2006-08-25 | 2008-02-28 | Boehringer Ingelheim International Gmbh | Controlled release system and method for manufacturing the same |
PE20091188A1 (en) * | 2007-09-12 | 2009-08-31 | Boehringer Ingelheim Int | COMPOUND 1- [2- (4- (3-TRIFLUOROMETIL-PHENYL) PIPERAZIN-1-IL) ETHYL] -2,3-DIHYDRO-1H-BENZIMIDAZOL-2-ONA (FLIBANSERIN), ITS ADDITION SALTS AND PHARMACEUTICAL COMPOSITIONS THAT THEY CONTAIN |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4308387A (en) * | 1978-10-20 | 1981-12-29 | Ab Ferrosan | Diphenylbutyl-piperzinecarboxamides |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9100860D0 (en) * | 1991-03-22 | 1991-03-22 | Kabi Pharmacia Ab | NEW USE |
-
1991
- 1991-03-22 SE SE9100860A patent/SE9100860D0/en unknown
-
1992
- 1992-03-23 DE DE69231680T patent/DE69231680T2/en not_active Expired - Fee Related
- 1992-03-23 BR BR9204969A patent/BR9204969A/en not_active Application Discontinuation
- 1992-03-23 EP EP92907159A patent/EP0538422B1/en not_active Expired - Lifetime
- 1992-03-23 HU HU9203632A patent/HU9203632D0/en unknown
- 1992-03-23 IE IE092092A patent/IE920920A1/en not_active IP Right Cessation
- 1992-03-23 ES ES92907159T patent/ES2154261T3/en not_active Expired - Lifetime
- 1992-03-23 PT PT100279A patent/PT100279B/en not_active IP Right Cessation
- 1992-03-23 KR KR1019920702939A patent/KR100196674B1/en not_active IP Right Cessation
- 1992-03-23 US US07/949,869 patent/US5434156A/en not_active Expired - Fee Related
- 1992-03-23 HU HU9203632A patent/HU217833B/en not_active IP Right Cessation
- 1992-03-23 JP JP50658392A patent/JP3221611B2/en not_active Expired - Fee Related
- 1992-03-23 RO RO92-01457A patent/RO109702B1/en unknown
- 1992-03-23 SK SK3449-92A patent/SK279237B6/en unknown
- 1992-03-23 RU RU9292016400A patent/RU2095062C1/en not_active IP Right Cessation
- 1992-03-23 AU AU14280/92A patent/AU653797B2/en not_active Ceased
- 1992-03-23 CA CA002083505A patent/CA2083505C/en not_active Expired - Fee Related
- 1992-03-23 WO PCT/SE1992/000182 patent/WO1992016211A1/en active IP Right Grant
- 1992-03-23 DK DK92907159T patent/DK0538422T3/en active
- 1992-03-23 AT AT92907159T patent/ATE199057T1/en not_active IP Right Cessation
- 1992-03-23 CZ CS923449A patent/CZ282222B6/en not_active IP Right Cessation
- 1992-11-20 BG BG97108A patent/BG61829B1/en unknown
- 1992-11-23 NO NO924502A patent/NO301311B1/en unknown
-
1994
- 1994-11-17 EE EE9400358A patent/EE02973B1/en not_active IP Right Cessation
-
1995
- 1995-04-25 US US08/428,899 patent/US5618817A/en not_active Expired - Fee Related
-
2001
- 2001-04-27 GR GR20010400653T patent/GR3035805T3/en not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4308387A (en) * | 1978-10-20 | 1981-12-29 | Ab Ferrosan | Diphenylbutyl-piperzinecarboxamides |
US4447433A (en) * | 1978-10-20 | 1984-05-08 | Ab Ferrosan | Diphenylbutyl-piperazinecarboxamides to treat pain |
Non-Patent Citations (2)
Title |
---|
Life Sciences, Vol. 47, 1990 EVA ERIKSSON: "Amperozide, a putative anti-psychotic drug: uptake inhibition and release of dopamine in vitro in the rat brain", pp 2111-2117, see especially page 2116. * |
Pharmacology & Toxicology Supplement, Vol. 1, 1990 J. SVARTENGREN et al: "Receptor binding properties of amperozide", pp 8-11. * |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993020821A1 (en) * | 1992-04-21 | 1993-10-28 | Kabi Pharmacia Ab | Agents for treating substance abuse disorders |
US5565455A (en) * | 1992-04-21 | 1996-10-15 | Pharmacia Ab | Method for treating substance abuse disorders |
EP0755680A2 (en) * | 1995-07-11 | 1997-01-29 | Pola Chemical Industries Inc | Use of piperazine compounds as narcotic antagonists |
EP0755680A3 (en) * | 1995-07-11 | 1998-01-14 | Pola Chemical Industries Inc | Use of piperazine compounds as narcotic antagonists |
US6100280A (en) * | 1995-07-11 | 2000-08-08 | Pola Chemical Industries, Inc. | Narcotic antagonist |
US7345041B2 (en) | 1999-10-07 | 2008-03-18 | Smithkline Beecham Corporation | Chemical compounds |
US7071196B2 (en) | 1999-10-07 | 2006-07-04 | Smithkline Beecham Croporation | Chemical compounds |
USRE39921E1 (en) | 1999-10-07 | 2007-11-13 | Smithkline Beecham Corporation | Chemical compounds |
US6951861B1 (en) | 1999-10-07 | 2005-10-04 | Smithkline Beechan Corporation | Chemical compounds |
US7625904B2 (en) | 1999-10-07 | 2009-12-01 | Smithkline Beecham Corporation | Methods for the treatment of sleep disorders |
US7060702B2 (en) | 2000-10-17 | 2006-06-13 | Smithkline Beecham Corporation | Chemical compounds |
US7119092B2 (en) | 2000-10-17 | 2006-10-10 | Smithkline Beecham Corporation | Chemical compounds |
US7294630B2 (en) | 2000-10-17 | 2007-11-13 | Smithkline Beecham Corporation | Piperazinyl piperidine tachykinin antagonists |
US7648990B2 (en) | 2000-10-17 | 2010-01-19 | Glaxosmithkline Llc | Chemical compounds |
US7276509B2 (en) | 2002-02-08 | 2007-10-02 | Glaxo Group Limited | Piperidine derivatives and their use as antagonists of tachykinins |
US7482365B2 (en) | 2002-02-08 | 2009-01-27 | Glaxo Group Limited | Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases |
US7652012B2 (en) | 2002-02-08 | 2010-01-26 | Glaxo Group Limited | 2-(R)-(4-fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide maleate and pharmaceutical compositions thereof |
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