WO1991019475A1 - Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene d¿4? - Google Patents

Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene d¿4?

Info

Publication number
WO1991019475A1
WO1991019475A1 PCT/US1991/003674 US9103674W WO9119475A1 WO 1991019475 A1 WO1991019475 A1 WO 1991019475A1 US 9103674 W US9103674 W US 9103674W WO 9119475 A1 WO9119475 A1 WO 9119475A1
Authority
WO
WIPO (PCT)
Prior art keywords
benzoheterobicyclic
quinolinyl
leukotriene
antagonists
derivatives
Prior art date
Application number
PCT/US1991/003674
Other languages
French (fr)
Other versions
WO1991019475A2 (en
Inventor
Fu-Chih Huang
Keith Steward Learn
Ashvin V Gavai
Original Assignee
Rorer Int Holdings
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rorer Int Holdings filed Critical Rorer Int Holdings
Priority to JP3514411A priority Critical patent/JPH07121941B2/en
Priority to CA002083822A priority patent/CA2083822A1/en
Publication of WO1991019475A2 publication Critical patent/WO1991019475A2/en
Publication of WO1991019475A1 publication Critical patent/WO1991019475A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

This invention relates to certain quinolinyl-benzoheterobicyclic compounds and their use as valuable pharmaceutical agents, particularly as lipoxygenase inhibitors and/or leukotriene antagonists and/or as mediator release inhibitors useful as anti-inflammatory and anti-allergic agents.
PCT/US1991/003674 1990-05-30 1991-05-24 Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene d¿4? WO1991019475A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP3514411A JPH07121941B2 (en) 1990-05-30 1991-05-24 Leukotriene D (4) Quinolinyl-benzoheterobicyclic derivatives as antagonists
CA002083822A CA2083822A1 (en) 1990-05-30 1991-05-24 Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene d4

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/532,464 US5041453A (en) 1990-05-30 1990-05-30 Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4
US532,464 1990-05-30

Publications (2)

Publication Number Publication Date
WO1991019475A2 WO1991019475A2 (en) 1991-12-26
WO1991019475A1 true WO1991019475A1 (en) 1991-12-26

Family

ID=24121928

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/003674 WO1991019475A1 (en) 1990-05-30 1991-05-24 Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene d¿4?

Country Status (6)

Country Link
US (1) US5041453A (en)
EP (1) EP0532705A4 (en)
JP (1) JPH07121941B2 (en)
AU (1) AU8429991A (en)
CA (1) CA2083822A1 (en)
WO (1) WO1991019475A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0799826A1 (en) * 1996-04-02 1997-10-08 Kowa Co. Ltd. Heteroaryl substituted phenylene derivatives, their preparation and their use as leukotriene receptor antagonists
EP0905134A1 (en) * 1997-09-25 1999-03-31 Kowa Company, Ltd. Piperidine derivatives as LTD4 and H1 antagonists
DE102008018675A1 (en) 2008-04-14 2009-10-15 Bayer Schering Pharma Aktiengesellschaft Oxo-heterocyclic substituted carboxylic acid derivatives and their use

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157040A (en) * 1991-04-05 1992-10-20 Merck & Co., Inc. Substituted quinolines as angiotensin ii antagonists
DE4129742A1 (en) * 1991-09-06 1993-03-11 Bayer Ag HETEROCYCLICALLY SUBSTITUTED CHINOLYLMETHOXY-PHENYLACETAMIDE
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicyclic compounds and pharmaceutical compositions containing them
US5731324A (en) * 1993-07-22 1998-03-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
US6137002A (en) 1993-07-22 2000-10-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
US6448269B1 (en) 1993-07-22 2002-09-10 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
KR20020081424A (en) * 2000-03-09 2002-10-26 아벤티스 파마 도이칠란트 게엠베하 Therapeutic uses of PPAR mediators
PE20070335A1 (en) * 2005-08-30 2007-04-21 Novartis Ag SUBSTITUTE BENZIMIDAZOLES AND METHODS FOR THEIR PREPARATION
US20070065898A1 (en) * 2005-09-21 2007-03-22 Wyeth Fluorescence polarization assays for binding of caspase inhibitors and probes therefor
DE102009012314A1 (en) 2009-03-09 2010-09-16 Bayer Schering Pharma Aktiengesellschaft Oxo-heterocyclic substituted alkylcarboxylic acids and their use
DE102009046115A1 (en) 2009-10-28 2011-09-08 Bayer Schering Pharma Aktiengesellschaft Substituted 3-phenylpropanoic acids and their use
EP2569301A1 (en) 2010-05-12 2013-03-20 Abbvie Inc. Indazole inhibitors of kinase
BR112013013663A2 (en) 2010-12-07 2016-09-06 Bayer Ip Gmbh substituted 1-benzylcycloalkylcarboxylic acids and their use
DE102011007272A1 (en) 2011-04-13 2012-10-18 Bayer Pharma Aktiengesellschaft Branched 3-phenylpropionic acid derivatives and their use
DE102012208530A1 (en) 2012-05-22 2013-11-28 Bayer Pharma AG Substituted piperidinoacetamides and their use
FR3019819B1 (en) * 2014-04-09 2018-03-23 Centre National De La Recherche Scientifique (Cnrs) CYTOTOXIC COMPOUNDS INHIBITING TUBULIN POLYMERIZATION
US10479802B2 (en) * 2014-08-29 2019-11-19 Chdi Foundation, Inc. Probes for imaging huntingtin protein
US10905667B2 (en) 2018-07-24 2021-02-02 Bayer Pharma Aktiengesellschaft Orally administrable modified-release pharmaceutical dosage form
AU2022292554A1 (en) 2021-06-14 2024-01-04 Scorpion Therapeutics, Inc. Urea derivatives which can be used to treat cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186201A (en) * 1977-02-07 1980-01-29 Riker Laboratories, Inc. Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds
US4851409A (en) * 1986-02-14 1989-07-25 Merck Frosst Canada Inc. 2-substituted quinoline dioic acids and pharmaceutical compositions
WO1989012628A1 (en) * 1988-06-21 1989-12-28 Rorer International (Overseas) Inc. Quinoline derivatives as antagonists of leukotriene d4
US4946855A (en) * 1987-12-14 1990-08-07 Sawai Pharmaceutical Co., Ltd. Carboxamide derivatives having tetrazole and thiazole rings and their use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3908298A1 (en) * 1989-03-14 1990-09-20 Bayer Ag SUBSTITUTED (CHINOLIN-2-YL-METHOXY) PHENYL-N, N'-SULFONYL HARVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186201A (en) * 1977-02-07 1980-01-29 Riker Laboratories, Inc. Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds
US4851409A (en) * 1986-02-14 1989-07-25 Merck Frosst Canada Inc. 2-substituted quinoline dioic acids and pharmaceutical compositions
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4946855A (en) * 1987-12-14 1990-08-07 Sawai Pharmaceutical Co., Ltd. Carboxamide derivatives having tetrazole and thiazole rings and their use
WO1989012628A1 (en) * 1988-06-21 1989-12-28 Rorer International (Overseas) Inc. Quinoline derivatives as antagonists of leukotriene d4

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0799826A1 (en) * 1996-04-02 1997-10-08 Kowa Co. Ltd. Heteroaryl substituted phenylene derivatives, their preparation and their use as leukotriene receptor antagonists
US5885987A (en) * 1996-04-02 1999-03-23 Kowa Co., Ltd. Phenylene derivatives
US6011033A (en) * 1996-04-02 2000-01-04 Kowa Co., Ltd. Phenylene derivatives
EP0905134A1 (en) * 1997-09-25 1999-03-31 Kowa Company, Ltd. Piperidine derivatives as LTD4 and H1 antagonists
US6107308A (en) * 1997-09-25 2000-08-22 Kowa Co., Ltd. Piperidine derivatives
DE102008018675A1 (en) 2008-04-14 2009-10-15 Bayer Schering Pharma Aktiengesellschaft Oxo-heterocyclic substituted carboxylic acid derivatives and their use

Also Published As

Publication number Publication date
JPH05506455A (en) 1993-09-22
JPH07121941B2 (en) 1995-12-25
EP0532705A4 (en) 1993-05-05
EP0532705A1 (en) 1993-03-24
CA2083822A1 (en) 1991-12-01
AU8429991A (en) 1992-01-07
US5041453A (en) 1991-08-20

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