WO1991009958A3 - Method of delivering molecules into eukaryotic cells - Google Patents
Method of delivering molecules into eukaryotic cells Download PDFInfo
- Publication number
- WO1991009958A3 WO1991009958A3 PCT/US1990/007607 US9007607W WO9109958A3 WO 1991009958 A3 WO1991009958 A3 WO 1991009958A3 US 9007607 W US9007607 W US 9007607W WO 9109958 A3 WO9109958 A3 WO 9109958A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- eukaryotic cells
- delivering molecules
- delivering
- interest
- molecule
- Prior art date
Links
- 210000003527 eukaryotic cell Anatomy 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000003855 cell nucleus Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002071214A CA2071214C (en) | 1989-12-21 | 1990-12-21 | Method of delivering molecules into eukaryotic cells |
DE69028412T DE69028412T2 (en) | 1989-12-21 | 1990-12-21 | METHOD FOR TRANSPORTING MOLECULES IN EUKARYOT CELLS |
JP91503306A JPH05505102A (en) | 1989-12-21 | 1990-12-21 | How to deliver molecules into eukaryotic cells |
EP91903111A EP0506884B1 (en) | 1989-12-21 | 1990-12-21 | Method of delivering molecules into eukaryotic cells |
AU71829/91A AU658818B2 (en) | 1989-12-21 | 1990-12-21 | Method of delivering molecules into eukaryotic cells using tat protein conjugate |
GR960402831T GR3021474T3 (en) | 1989-12-21 | 1996-10-24 | Method of delivering molecules into eukaryotic cells |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45445089A | 1989-12-21 | 1989-12-21 | |
US454,450 | 1989-12-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1991009958A2 WO1991009958A2 (en) | 1991-07-11 |
WO1991009958A3 true WO1991009958A3 (en) | 1991-08-08 |
Family
ID=23804657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1990/007607 WO1991009958A2 (en) | 1989-12-21 | 1990-12-21 | Method of delivering molecules into eukaryotic cells |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0506884B1 (en) |
JP (1) | JPH05505102A (en) |
AT (1) | ATE142266T1 (en) |
AU (1) | AU658818B2 (en) |
CA (1) | CA2071214C (en) |
DE (1) | DE69028412T2 (en) |
DK (1) | DK0506884T3 (en) |
ES (1) | ES2091916T3 (en) |
GR (1) | GR3021474T3 (en) |
WO (1) | WO1991009958A2 (en) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5804604A (en) * | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
US6316003B1 (en) | 1989-12-21 | 2001-11-13 | Whitehead Institute For Biomedical Research | Tat-derived transport polypeptides |
US5652122A (en) * | 1989-12-21 | 1997-07-29 | Frankel; Alan | Nucleic acids encoding and methods of making tat-derived transport polypeptides |
NZ239893A (en) * | 1990-09-25 | 1993-11-25 | Hoechst Japan | A method for introducing a foreign dna into a cell |
US5633230A (en) * | 1990-10-24 | 1997-05-27 | Allelix Biopharmaceuticals, Inc. | Treatment of cytomegalovirus infection |
WO1993012230A1 (en) * | 1991-12-13 | 1993-06-24 | Sri International | Triple-helix formation at (punpyn).(punpyn) tracts |
DK0656950T3 (en) * | 1992-08-21 | 1999-07-19 | Biogen Inc | TAT-derived transport polypeptides |
IL106760A (en) * | 1992-08-25 | 1999-12-31 | Miles Inc | Protein-nucleic acid hybrid construct for translocating an exogenous nucleic acid into a target cell and nucleus |
ES2249760T3 (en) | 1993-01-26 | 2006-04-01 | The Trustees Of The University Of Pennsylvania (A Corporation Of Pennsylvania) | COMPOSITIONS AND PROCEDURES OF ADMINISTRATION OF GENETIC MATTERS. |
ES2320883T3 (en) | 1993-01-26 | 2009-05-29 | The Trustees Of The University Of Pennsylvania (A Corporation Of Pennsylvania) | COMPOSITIONS AND METHODS FOR THE ADMINISTRATION OF GENETIC MATERIAL. |
US7001759B1 (en) | 1993-01-26 | 2006-02-21 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
ATE251913T1 (en) | 1997-05-21 | 2003-11-15 | Univ Leland Stanford Junior | COMPOSITION AND METHOD FOR DELAYING TRANSPORT THROUGH BIOLOGICAL MEMBRANES |
US5891994A (en) | 1997-07-11 | 1999-04-06 | Thymon L.L.C. | Methods and compositions for impairing multiplication of HIV-1 |
US8038984B2 (en) | 1998-06-20 | 2011-10-18 | Washington University | Membrane-permeant peptide complexes for treatment of sepsis |
US7306784B2 (en) | 1998-06-20 | 2007-12-11 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
US6589503B1 (en) | 1998-06-20 | 2003-07-08 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
WO1999067284A2 (en) * | 1998-06-20 | 1999-12-29 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
US7229961B2 (en) | 1999-08-24 | 2007-06-12 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into ocular tissues |
CA2381425A1 (en) | 1999-08-24 | 2001-03-01 | Cellgate, Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
US6669951B2 (en) | 1999-08-24 | 2003-12-30 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
US6730293B1 (en) | 1999-08-24 | 2004-05-04 | Cellgate, Inc. | Compositions and methods for treating inflammatory diseases of the skin |
US6399067B1 (en) | 2000-04-28 | 2002-06-04 | Thymon L.L.C. | Methods and compositions for impairing multiplication of HIV-1 |
KR100379577B1 (en) * | 2000-07-26 | 2003-04-08 | 최수영 | Cell-transducing HIV-1 Tat-glutamate dehydrogenase fusion protein, polynucleotide coding the fusion protein, expression vector of the fusion protein and the transducing method of the fusion protein |
KR100379578B1 (en) * | 2000-07-26 | 2003-04-08 | 최수영 | Cell-transducing HIV-1 Tat-C3 transferase fusion protein, expression vector of the fusion protein and the analysing method of Rho protein using the fusion protein |
ATE437647T1 (en) | 2001-02-16 | 2009-08-15 | Cellgate Inc | TRANSPORTER WITH SPACED ARGININE PARTICLES |
JP2003009883A (en) * | 2001-07-05 | 2003-01-14 | Mitsubishi Pharma Corp | Apoptosis inducer of mast cell |
KR100495138B1 (en) * | 2001-07-31 | 2005-06-14 | 학교법인 한림대학교 | Plant cell transducing domain-cargo molecule complex |
DE10212867B4 (en) * | 2002-03-22 | 2005-07-21 | Hans Prof. Dr. Wolf | Use of urea-adjuvated polypeptides for diagnosis, prophylaxis and therapy |
KR100472939B1 (en) * | 2002-05-24 | 2005-03-18 | 학교법인 한림대학교 | Cell-transducing HIV-1 Tat-pyridoxal kinase fusion protein and use of the fusion protein |
AU2003254066B2 (en) | 2002-07-19 | 2009-08-27 | The Regents Of The University Of California | Dendrimers as molecular translocators |
KR100472937B1 (en) * | 2002-07-25 | 2005-03-10 | 학교법인 한림대학교 | Cell-transducing HIV-1 Tat-cytosine deaminase fusion protein and use of the fusion protein |
US7183066B2 (en) * | 2002-09-27 | 2007-02-27 | Allergan, Inc. | Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins |
JP2008535783A (en) | 2005-02-15 | 2008-09-04 | サイモン・エル・エル・シー | Methods and compositions for attenuating HIV-1 proliferation |
WO2006094200A2 (en) * | 2005-03-03 | 2006-09-08 | The Trustees Of Boston College | Method of obtaining a desired localization for cellular imaging with the use of peptidoconjugates |
US7935816B2 (en) | 2007-10-25 | 2011-05-03 | Gene Tools, Llc | Molecular transporter compositions comprising dendrimeric oligoguanidine with a triazine core that facilitate delivery into cells in vivo |
JP6124791B2 (en) | 2010-09-22 | 2017-05-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate | Therapeutic application of Smad7 |
CA2904329C (en) | 2013-03-08 | 2021-11-30 | The Regents Of The University Of Colorado, A Body Corporate | Ptd-smad7 therapeutics |
KR101835554B1 (en) | 2014-06-24 | 2018-04-19 | 서울대학교 산학협력단 | Composition comprising C/EBF for promoting differentiation or stability of induced regulatroy T cell and method therefor |
EP3615575A4 (en) | 2017-04-28 | 2021-01-13 | Auckland Uniservices Limited | Methods of treatment and novel constructs |
US20210046153A1 (en) * | 2018-05-03 | 2021-02-18 | University Of Utah Research Foundation | Oca-b peptide conjugates and methods of treatment |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0243204A2 (en) * | 1986-04-24 | 1987-10-28 | Cetus Oncology Corporation | Infective drug delivery system |
WO1988005077A1 (en) * | 1986-12-29 | 1988-07-14 | Battelle Memorial Institute | A method of modifiying the metabolism of eukaryotic cells upon incorporation therein of foreign sequences of nucleic acids by means of an internalizing vector |
EP0388758A1 (en) * | 1989-03-16 | 1990-09-26 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Protein-polycation conjugate |
-
1990
- 1990-12-21 CA CA002071214A patent/CA2071214C/en not_active Expired - Lifetime
- 1990-12-21 ES ES91903111T patent/ES2091916T3/en not_active Expired - Lifetime
- 1990-12-21 JP JP91503306A patent/JPH05505102A/en active Pending
- 1990-12-21 EP EP91903111A patent/EP0506884B1/en not_active Expired - Lifetime
- 1990-12-21 WO PCT/US1990/007607 patent/WO1991009958A2/en active IP Right Grant
- 1990-12-21 DE DE69028412T patent/DE69028412T2/en not_active Expired - Lifetime
- 1990-12-21 AT AT91903111T patent/ATE142266T1/en not_active IP Right Cessation
- 1990-12-21 AU AU71829/91A patent/AU658818B2/en not_active Expired
- 1990-12-21 DK DK91903111.2T patent/DK0506884T3/en active
-
1996
- 1996-10-24 GR GR960402831T patent/GR3021474T3/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0243204A2 (en) * | 1986-04-24 | 1987-10-28 | Cetus Oncology Corporation | Infective drug delivery system |
WO1988005077A1 (en) * | 1986-12-29 | 1988-07-14 | Battelle Memorial Institute | A method of modifiying the metabolism of eukaryotic cells upon incorporation therein of foreign sequences of nucleic acids by means of an internalizing vector |
EP0388758A1 (en) * | 1989-03-16 | 1990-09-26 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Protein-polycation conjugate |
Non-Patent Citations (3)
Title |
---|
Cell, vol. 55, 23 December 1988, Cell Press A.D. Frankel et al.: "Cellular uptake of the tat proteine from human immuno-deficiency virus", pages 1189-1193 * |
Cell. Mol. Biol., vol. 28, no. 1, 1982 Pergamon Press Ltd (GB) J.C. Stavridis et al.: "Use of transferrin as a gene-carrier to the erythroid cells of the marrow", pages 15-18 * |
Patents Abstracts of Japan, vol. 12, no. 344 (C-528)(3191), 16 September 1988; & JP-A_63102682 (MEDEISA SHINYAKU K.K.) 7 May 1988 * |
Also Published As
Publication number | Publication date |
---|---|
DE69028412T2 (en) | 1997-03-27 |
ATE142266T1 (en) | 1996-09-15 |
WO1991009958A2 (en) | 1991-07-11 |
CA2071214A1 (en) | 1991-06-22 |
EP0506884A1 (en) | 1992-10-07 |
AU658818B2 (en) | 1995-05-04 |
GR3021474T3 (en) | 1997-01-31 |
AU7182991A (en) | 1991-07-24 |
CA2071214C (en) | 2006-06-06 |
EP0506884B1 (en) | 1996-09-04 |
DK0506884T3 (en) | 1996-11-04 |
JPH05505102A (en) | 1993-08-05 |
DE69028412D1 (en) | 1996-10-10 |
ES2091916T3 (en) | 1996-11-16 |
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