WO1991000059A1 - Equipment for obtaining medical, pharmacological or other data by nuclear and echographic magnetic resonance - Google Patents

Equipment for obtaining medical, pharmacological or other data by nuclear and echographic magnetic resonance Download PDF

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Publication number
WO1991000059A1
WO1991000059A1 PCT/FR1990/000496 FR9000496W WO9100059A1 WO 1991000059 A1 WO1991000059 A1 WO 1991000059A1 FR 9000496 W FR9000496 W FR 9000496W WO 9100059 A1 WO9100059 A1 WO 9100059A1
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Prior art keywords
probe
characterized
ultrasound
ultrasonic
installation according
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PCT/FR1990/000496
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French (fr)
Inventor
François TRANQUART
Marceau Berson
Alain Lepape
Léandre Pourcelot
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Institut National De La Sante Et De La Recherche Medicale
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radiowaves
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radiowaves involving electronic or nuclear magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64

Abstract

The invention relates to equipment for investigation into medical, biological and analogue data, of the kind which includes an ultra-sonic analysis apparatus (120) containing a probe (100) for the detection of ultrasonic transmission and reception, and an apparatus for analysis by nuclear magnetic resonance (170). Said apparatus has means (181) for establishing an essentially constant magnetic field and a probe (182) for detecting the transmission or reception of a radio-frequency electromagnetic field, the ultra-sonic probe being located close to said radio-frequency field probe. The equipment is characterized by the fact that it includes rhythming means (175) which alternatively activate the transmission/reception of ultrasounds and the transmission/reception of the radio-frequency field, as well as means (140) for insulating, by galvanization, the ultrasonic probe during activation of the radio-frequency field transmission/detection.

Description

INSTALLATION FOR OBTAINING NUCLEAR MAGNETIC RESONANCE OF MEDICAL ULTRASOUND DATA, OR OTHER PHARMACOLOGICAL.

The present invention relates generally to the field of imaging and spectroscopy for medical applications, and more generally relates to a new method of medical investigation and a new apparatus for its implementation.

For years, nuclear magnetic resonance (NMR) has emerged as a preferred tool for the study of physical and chemical parameters (spectroscopy) and morphological (imaging) in particular biological, medical and industrial applications.

But in view of the low sensitivity of NMR phenomenon and the current inability to achieve real-time imaging and spectroscopy, this technique can not in practice be sufficient in itself, especially when studying rapidly changing phenomena such as cardiac movements and blood flow. Thus, especially in biomedical applications, it is now essential to compare the NMR data to functional parameters to properly interpret the results.

For example, imaging can now combine nuclear magnetic resonance imaging (MRI) with heart spectroscopy, NMR acquisitions by synchronizing with the signal

1'électrocardiogramme.

But the joint measurement of cardiac work can currently only be achieved by measuring the intraventricular pressure left, this is not sufficient for the correct evaluation of contractile properties of the myocardium.

Moreover, 1'échographie type time / motion (TM) or two-dimensional proved for many years its ability to assess for example the parameters of myocardial function such as ventricular volume, stroke volume, the ejection fraction, fiber shortening rate, the rate of thickening infarction, etc ..

already known in the prior art, by the French Patent Publication No. 2507321, a diagnostic apparatus which comprises on the one hand ultrasonic pulse emitting means and detection and recording of reflections from interfaces between tissues, supplemented by means of processing and display of the information gathered (i.e. an ultrasound machine), and secondly means for identifying tissues by the phenomenon of nuclear magnetic resonance (NMR ), ultrasound and NMR data being processed simultaneously.

More specifically, Figure 1 of this patent application shows that the patient's body is arranged in a uniform magnetic field B0 established by appropriate coils 11, and the transmission / ultrasound detection and antenna for generating the RF excitation field Bl NMR phenomenon are incorporated into a common set of portable detection 20.

Such equipment is known, however, unable to give satisfactory results. Indeed, the simple fact of providing the ultrasonic means in close proximity to the generating antenna Bl excitation field and this field can have immediate consequence of making the NMR data collected by this coil unusable. Specifically, the radiofrequency field Bl, an order of frequency of 20 to 200 MHz, is extremely sensitive to the presence in the vicinity of magnetic materials (field strains) or electrical (antenna effect), and these anomalies created by the presence of the ultrasonic probe does not provide a spectroscopy or NMR imaging medically usable.

The present invention aims to overcome these drawbacks of the prior art and to propose an apparatus which combines the techniques of NMR and ultrasound so practically usable.

To this end, the present invention relates to an installation for the investigation of medical, biological, and the like, comprising an ultrasonic testing apparatus comprising a transmitting probe / receiving ultrasound and an analytical apparatus by nuclear magnetic resonance having means for establishing a substantially constant magnetic field and a transmitting-receiving sensor of a radio frequency electromagnetic field, the ultrasonic probe being disposed in the vicinity of said RF field probe, the installation being characterized in that it comprises timing means for alternately activate the transmission / reception of ultrasound and the transmission / reception of the radio frequency field, and means for galvanically isolating the ultrasonic probe during the activation of the transmission / detection field radio frequency.

Preferred but not limiting aspects of the installation of the present invention are:

- the timing means comprises a link for a synchronization signal between each analysis apparei_l processing module by nuclear magnetic resonance and a processing module of the apparatus of ultrasonic analysis.

- the electrical isolation means comprises a pneumatic switch adapted when open to provide significant ent deviates contacts. - the ultrasonic analyzer operates an ultrasound time / high frequency or a Doppler motion transmission.

- nuclear magnetic resonance spectroscopy analysis apparatus operates by phosphorus 31 or carbon 13 or imaging, including the proton.

- the installation can be used for investigation on metabolic and mechanical vitro data on a member such as an animal heart perfused and stimulated contained in a tube accommodated in the probe of the nuclear magnetic resonance apparatus, in which case the ultrasonic probe is an ultrasonic probe arranged in the tube and adapted to transmit and receive ultrasound according to a viewing direction substantially inclined with respect to the tube axis.

- for example, the ultrasonic probe is disposed vertically near one of the tube walls and has at its lower end a piezoelectric transducer as a whole inclined with respect to a horizontal plane.

- alternatively, the ultrasonic probe is disposed vertically near one of the tube walls and has at its lower end a piezoelectric transducer disposed horizontally as a whole and is provided below the sensor an acoustic mirror comprising a inclined reflecting surface.

- in another variant, the ultrasonic probe is arranged horizontally - * _ years the tube and is at least partially embedded in a sidewall thereof.

- the timing means define alternately a nuclear magnetic resonance phase comprising an excitation and a resultant ultrasonic acquisition and analysis phase comprising an exciting and acquisition resulting, for example with respective durations of 400 ms and 600 s.

Other aspects, objects and advantages of the present invention will become more apparent from reading the following detailed description given by way of example and with reference to the accompanying drawings, wherein: Figure 1 is a view of overall schematic of an apparatus according to one possible embodiment of the present invention, Figure 2 is a detail view in axial section of a part of the apparatus of Figure 1, Figure 3 is an enlarged view enlarged view of a detail of Figure 2, Figure 4 is a view similar to Figure 2, a first alternative embodiment, FIG 5 is a view similar to Figure 3 of that variant, Figure 6 is a view similar to Figure 2 of a second embodiment, Figure 7 is a view similar to Figure 3 of this second embodiment, Figure 8 is a representation in block diagram form an example of the part electronics of the apparatus échographi as used in the invention, Figure 9 is a schematic representation of a record obtained with the apparatus of the invention, and Figure 10 is a timing chart schematically illustrating the operation of the apparatus of 1'invention.

We first show that, from one figure to another, elements or identical or similar parts are designated by the same reference numbers.

Referring firstly to Figure 1, there shown an apparatus for the metabolism study of an isolated rat heart perfused and C, by a combination of NMR spectroscopy phosphorus 31 and an ultrasound "time -movement". This technique will result validated by pharmacological studies in conditions of cardiac hypoxia one hand and under the action of a positive inotropic agent in the other activity.

The apparatus comprises an ultrasound probe 100 disposed as will be seen further in the vicinity of the magnetic core of the NMR apparatus, a coaxial cable 110 connects the sensor 100 to an ultrasound unit time / movement 120, operating at frequencies highest in the order of 10 to 20 MHz, a recorder 130, e.g., optical fiber type (device "Visicorder" (trademark) manufactured by Hewlett-Packard company) or the type video recorder, and a switch 140 to external control. All above is associated with one of a rat heart study C system comprising a stimulator 150, a pressure sensor 160, an infusion system 165 and an NMR spectrometer 170.

The pacemaker 150 is connected to the heart of rat C by conventional liquid two electrodes 151, 152. The pressure sensor 160 is adapted to measure the intra-left ventricular pressure (PVG) of the core by being connected by a pipe 161, and delivers an output signal to an oscilloscope or analoque 162 providing a measure of said pressure. Finally, the infusion system 165 includes a reservoir 166 cte perfusion medium, a peristaltic pump 167, a recepient 168 for collecting the perfusate and tubing 169 connecting with the core C and the LP perfusion medium.

The NMR device is used in the present example a type of AM200 spectrometer manufactured by Bruker corporation, operating with a constant magnetic field Bo of 4.7 Teslas. The assembly 180 transmission / detection of the spectrometer is equipped with a probe 182 ultinoyaux 20 mm associated with a superconducting magnet 181 for the establishment of the constant electric field Bo. The probe consists of an excitation antenna 182 type saddle, for applying pulses (B_ field) and receiving nuclear magnetic resonance signals. The frequency is, for example 81.13 MHz for phosphorus 31. The shield 111 of coaxial cable 110 of the ultrasonic probe 100 is connected at 185 to the enclosure 184 which houses the NMR antenna 182 and the tube 183.

The isolated rat heart C LP immersed in a perfusion fluid within a test tube 183 associated with the probe 182, with a diameter of 20 mm. Preferably, the NMR parameters are close to those usually used for the study of the heart, namely:

- pulse duration: 14 s;

- delay between pulses: 1 s; ~ Duration of acquisition of NMR signals: 315 ms.

As indicated in the introduction, the introduction of the probe. ultrasound 100 and the power cable 110 in the sensitive volume of the probe

NMR will cause substantial disruption of the NMR acquisition because of the following:

- if the probe and / or cable comprise magnetic materials, they will disturb the homogeneity of the magnetic field Bo and Bi and NMR detection; - due to the presence of conductive elements

(Cables) leading to the outside of the field area, an inevitable antenna effect will lead to the Apparitio of interference signals in the radio frequency signals of NMR. Both these phenomena contribute to a significant degradation of the signal / noise ratio of the NMR signal acquisition.

In accordance with an essential aspect of the invention, the ultrasonic probe and its cable are devoid of any magnetic material. In addition, there are provided switching means 140 for electrical isolation of the cable 110 to avoid interference to the excitation signals and NMR acquisition for their appearance.

These means switches must meet the following conditions:

- they must be a perfect circuit breaker, and to this end provide the open state a substantial contact spacing, for example of the order of 1 cm; they must be easily operable from outside.

In a first embodiment, these switching means are constituted by a pneumatic switch. Such a switch can meet the above criteria by allowing a relatively high operating frequency, of the order of 2 Hz.

The switch 140 must be located as close as possible to the ultrasound probe 100 within the access hole of the NMR probe 180; a minimum distance of 10 cm on the inside of this hole must be respected.

Furthermore, according to another essential aspect of the invention, and in combination with the fact that the ultrasound probe 100 is inoperative during the excitation phases and of NMR acquisition, investigative phase ultrasound and NMR s' perform alternately in an interlaced mode. Specifically, the switch 140 is open during the excitation / acquisition NMR phases and is closed for ultrasound recordings outside the NMR activity period. To this end, the pneumatic switch 140 is slaved to the NMR spectrometer 170 by an appropriate control signal on a control line 173, providing the necessary synchonisation. Referring now to Figure 10, which illustrates the interleaving of the signals * ultrasound and nuclear magnetic resonance, NMR excitation pulse, denoted NMRI, with a duration of 14 microseconds in this example, is triggered by a cardiac gating (the pulse), which allows a perfect alignment of the cardiac cycle.

Taking into account the fact that a delay of about 1 second between pulses NMRI (TRMN period) is required to avoid partial saturation peaks of phosphorylated compounds, and a delay slightly less than 0.4 seconds (duration TACQ ) is required for the acquisition of NMR (rated URMN signals), one thus has a period of about 0.6 second (period TECHO) for performing an ultrasound recording. Appropriate timing by the spectrometer

NMR 170 is provided via line 175 (Figure 1) between the latter and the ultrasound system 120, such that the ultrasound acquisition intervene at the end of each period TACO, thus avoiding any overlapping between NMR signals and the signals ultrasonic echography.

As indicated, the ultrasound technique used in this example is the technique called "time / motion", which allows to follow the evolution over time of the movements of the walls of the heart valves e and dimensions of these walls and heart cavities.

The rat heart C is, as already indicated placed in the test tube 183 of 20 mm diameter, itself introduced into the central passage of the NMR probe 182.

In this configuration, the problem is to position the ultrasonic sensor facing the heart. In addition, because of heart dimensions (of the order of a centimeter) and thereof walls (of the order of 3 to 4 mm), it is necessary to have a good resolution not only laterally but especially axially for evaluating thicknesses. For this purpose, use is advantageously a high ultrasound frequency, for example of the order of 10 to 20 MHz.

Given the dimensions indicated above and infusion-related requirements (presence of small pipes infusion and pressure-sensing and pacing electrodes in the tube 172a relatively narrow), the core C is in practice only little inclined relative to the vertical axis A of the system. It follows that an ultrasound sensor introduced into the tube so as to emit an ultrasound beam parallel to the axis A could be usefully employed as the ultrasound information collected according to a direction substantially parallel to said axis are of interest limit.

In accordance with another important aspect of the present invention uses a sensor placed near the wall of the tube 183 and adapted to allow a target sufficiently inclined relative to the longitudinal axis AC of the heart.

We will describe below three possible solutions to the probe 100.

Firstly with reference to Figures 2 and 3, there is illustrated a probe 100 donation τ t the transducer 101 is inclined by an angle α, for example about 15-45 °, relative to the horizontal, so as to obtain a direction of incidence (viewing direction V) proper to collect information on the movement and dimensions of the walls of the heart chambers, is ie sufficiently obliquely to the longitudinal axis AC of the heart. Apart from this feature, the probe 100 can be performed relatively conventional manner and include a tube 102, e.g., less than or equal to 15 mm and a diameter of the order of 4 mm, made of a non-magnetic material such as plastic or copper, to the lower end of which is fixed the inclined transducer 101.

The transducer 101 is shaped like a spherical cup to ensure focusing of the ultrasound beam in a focal point F located preferably at a distance of the order of 10 to 15 mm from said transducer. The transducer is constituted for example of a conventional piezoelectric material PZT (lead mixture, zirconate and titanate) and has silver electrodes.

It is also conceivable to use as piezoelectric material polyvinylidene fluoride

(PVDF), which has an electro-acoustic yield less but better impulse response. In 103 is shown a thin protection plate and adaptation, stuck on the outer surface of the transducer. A damping material 104 is housed inside the tube 102 behind the transducer 101.

Its thickness is for example about 10 mm. Finally a small bronze tube 105 has a diameter slightly smaller than that of tube 102 and extends rearwardly thereof along a length of the order of 15 cm. The tube 105 serves as a portion of sheath for electrical son reliefe 106 to the transducer 101 and second handling means for moving and guiding the probe 100 according to the position of the heart

C into the tube 183.

There is shown in Figures 4 and 5 a second embodiment of the probe 100 to inclined aiming. The probe 100 is here an ordinary probe, that is to say it exhibits as such a viewing direction Vo confused with its axis oriented substantially vertically here. This probe is associated with an acoustic mirror 107 of triangular section, the reflecting face 107a is inclined at an angle Θ for example of the order of 40 to 60 ° relative to the horizontal, so as to return the beam ultrasound in the viewing direction V inclined towards the core C.

Structurally, the probe 100 of Figure 5 is identical to that of Figure 3, the only differences being of geometric order.

The acoustic mirror 107 is made of a material known for its good qualities of acoustic reflection, including glass, poly methyl ethacrylate, copper, etc .. The mirror 107 can be secured to the probe by an appropriate mechanical connection such that one or more struts (not shown). Preferably, the distance between the transducer 101 and the point P on the face 107a to the vertical of the center 0 of the transducer is preferably chosen sufficiently large so that said face 107a can reflect all of the ultrasound beam.

There is shown in Figures 6 and 7 another alternative embodiment, wherein the probe 100 is of reduced length and disposed perpendicularly to the axis of the tube 183. In the case where the latter has a substantial wall thickness, e.g. 2 mm, the probe can be partially * incorporated in the thickness of this wall. For example, the probe may have a diameter D of 2 mm and a length L of 3 mm, with a transducer 101 having a thickness of about 0.2 mm and a thickness of absorbent material 104 of the order of 2.8 mm. The latter proves sufficient thickness with a conventional piezoelectric material (PZT) to the extent that the frequency is high (of the order of 20 MHz). Indeed, at such frequencies, the ultrasound absorption is very strong and the rear wave emitted in the material 104, which may degrade the axial resolution of the probe, can be fully attenuated over a very short distance. It is noted, however, that can also be used as the piezoelectric material PDFV which require a high acoustic impedance absorbent material (resonance λ / 4), can accommodate a small thickness for this material . In this embodiment, the two electric son 106 connecting with the transducer 101 are preferably bonded to the inner wall of the tube 183 before being connected to a coaxial cable via a suitable miniature connector (not shown). There is shown in Figure 8 the block diagram of the ultrasound unit time / movement 120.

A logical sequencer 121 standalone or synchronized by a signal from the NMR spectrometer 170 to the alternating sequence RMN / ultrasound driver 120 and the control module 122 especially a transmitting circuit for exciting the probe 100 with a pulse of short duration (in order to optimize the axial resolution of the probe) and large amplitude (150 volts). The echoes received by said probe is applied to the input of a receiving circuit 123 comprising a preamplifier 123a, 123b a logarithmic amplifier and a detector 123c The output of circuit 123 is applied to a first input of a summing amplifier 124 , "of which a second input receives from the sequencer logic 121 of the timing reference pulses and deep, spaced for example 0.5 seconds and 2.6 microseconds (2 mm), respectively, and of which a third input may receive the signals pacemaker synchronization 150. the circuit 124 thus provides to the recorder 130 the useful signals, ie the ultrasound echoes, the pulses of the time marker and depth or distance as well as pacemaker pulses.

The presence of pacemaker pulses to perform the measurements on the recording time / movement established by the recorder 130 at selected times according to the heart stimulation condition.

Finally, the module 120 comprises a time base triggered 125 by the sequencer 121 and which provides the horizontal scanning of the recorder.

Experimental results

The heart of rat C, isolated and perfused has validated the technique of the present invention. The evolution of intra-left ventricular pressure

(PVG) has been considered the gold standard of the contractile function.

First will be described with reference to Figure 9 the parameters that according to the invention on the recording time / movement provided by the recorder 130 and an example of which is shown in the same figure.

In this figure, S and D respectively denote the phases of diastole and systole ventricular. The percentage of systolic thickening is equal to (Ed-Es) / Ed, the speed of systolic contraction (VCS) is equal to the ratio a / t, while the sine of the angle θ of the slope protosystolique is equal to c / 1.

Furthermore, different .degrés myocardial hypoxia were obtained by controlled reduction of the infusion rate.

A 50% of this flow causes a 50% decrease of the PVG 58% of the speed of systolic contraction. When this flow is reduced by 75%, the PVG 75% lower while also systolic contraction rate decreases by 61%. Variations of these cardiac parameters and others, obtained by the combination of the ultrasound analysis and NMR analysis are presented in Table I below. In particular, this table shows the relative change (relative to a reference 10 ml / min for the perfusion rate) metabolic and mechanical parameters (except pH: absolute value) when the flow is reduced to 5 ml / min (reduction 50% or moderate hypoxia) and 2.5 ml / min (75% reduction, or severe hypoxia).

TABLE I

Flow rate (ml / min) 10 2.5

P PH pCr ATP PVG Sin

S / S + D

VCS

Thickening

Figure imgf000017_0001

(*) Not calculable

Another model phar acologique was used to implement an agent for positive inotropic activity, namely isoprenaline, to a final concentration of 4.10 ~ 3 mg / ml. Variations of the same parameters as above are presented in Table II below. The first column corresponds to the reference conditions (medium without isoprenaline perfused at 10 ml / min, while the other three columns show the relative variations of parameters (except pH) respectively after 2 minutes, 6 minutes and 10 minutes. TABLE II

without with isoprenaline (4.10- 3 mg / ml) n isoprenaline 2 6 min 10 min

Figure imgf000018_0001

Although there has been described above a pharmacological activity in vitro on isolated rat heart stimulated perfused, it is understood that the scope of the present invention extends beyond this specific context.

In particular, one may combine an ultrasound Doppler technique or a technique and NMR interlaced under in vivo spectroscopy and NMR 1'imagerie. More generally, the NMR apparatus may be of the type for imaging the whole body or comprise a surface coil for micro-imaging or spectroscopy applications. In the latter case, the ultrasonic probe can be placed on the patient in any suitable place, for example adjacent to the NMR excitation antenna aiming bias the organ studied. In all cases, the electrical isolation of the ultrasonic probe is carried out for the excitation / acquisition NMR phases, so that the disturbances are minimized regardless of the positioning of the ultrasonic probe. As a corollary, it is also realized in this case the sequencing interlaced NMR and ultrasound acquisitions.

Moreover, although there have been described above switches pneumatic means for isolating the ultrasonic probe, any other means fulfilling the same function can be used. In particular, electronic or optoelectronic means may be used.

Finally be mentioned that 1'invention can be applied with ultrasound techniques of any type. It was mentioned above 1'échographie time / movement, but also can be used, for example, the Doppler technique, in particular for measuring blood flow or similar speeds. Finally skilled in the art to imagine any other variant or modification within the spirit of 1'invention.

Claims

1. Installation for the investigation of medical, biological, and the like, of the type comprising an ultrasound analysis apparatus comprising a probe (100) transmitting / receiving ultrasound and an analytical apparatus by nuclear magnetic resonance comprising means (181) for establishing a substantially constant magnetic field and a probe (182) transceiving a radio frequency electromagnetic field, the ultrasonic probe being disposed in the vicinity of said RF field probe, the installation being characterized in that it comprises timing means for alternately activating 1'émission / reception of ultrasound and the transmission / reception of the radio frequency field, and means (140) for electrically isolating the ultrasonic probe during the activation of the emission / detection of the radiofrequency field.
2. Installation according to claim 1, characterized in that the timing means comprises a link (175) for a synchronization signal between a processing module (170) of the analysis apparatus by nuclear magnetic resonance and a module processing (120) of the ultrasonic analyzer.
3. Installation according to one of claims 1 and 2, characterized in that the electrical isolation means comprises a pneumatic switch (140) adapted when ouvert- 'to ensure a large contact gap.
4. Installation according to one of claims 1 to 3, characterized in that the ultrasonic testing apparatus (120) operates a time ultrasound / high frequency movement.
5. Installation according to one of claims 1 to 3, characterized in that the ultrasonic testing apparatus (120) operates by Doppler effect.
6. Installation according to one of the preceding claims, characterized in that the apparatus for nuclear magnetic resonance analysis (170) operates according to a technique selected from the group spectroscopy phosphorus 31, carbon 13 spectroscopy and NMR imaging.
7. Installation according to one of the preceding claims for the investigation on metabolic and mechanical vitro data on a member such as an animal heart (C) and stimulated infused contained in a tube (183) housed in the probe ( 182) of the nuclear magnetic resonance apparatus, characterized in that the ultrasonic probe is an ultrasonic probe which transmits and receives ultrasound in a viewing direction (V) substantially inclined with respect to the axis (a) of tube.
8. Installation according to claim 7, characterized in that the ultrasound probe (100) is arranged vertically near one of the tube walls (183) and in that it comprises at its lower end a piezoelectric transducer ( 101) inclined as a whole relative to a horizontal plane.
9. Installation according to claim 7, characterized in that the ultrasound probe (100) is arranged vertically near one of the tube walls (183), in that it comprises at its lower end a transducer ^ pi ézo- electrical connector (101) disposed horizontally as a whole and in that it is provided below the sensor an acoustic mirror (107) having an inclined reflecting surface (107a).
10. Installation according to claim 7, characterized in that the ultrasound probe (100) is disposed horizontally in the tube (183) and is at least partially embedded in a sidewall thereof.
11. Installation according to one of the preceding claims, characterized in that the timing means alternately define a nuclear magnetic resonance phase comprising an excitation and a resultant ultrasonic acquisition and analysis phase comprising an excitation and resulting acquisition.
12. Installation according to Claim 11, characterized in that the nuclear magnetic resonance phase has a duration of around 400 ms and the ultrasonic analysis phase has a duration of about 600 ms.
PCT/FR1990/000496 1989-07-03 1990-01-17 Equipment for obtaining medical, pharmacological or other data by nuclear and echographic magnetic resonance WO1991000059A1 (en)

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Cited By (8)

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EP0649117A2 (en) * 1993-10-15 1995-04-19 George S. Allen Method for providing medical images
US8932237B2 (en) 2010-04-28 2015-01-13 Insightec, Ltd. Efficient ultrasound focusing
US9177543B2 (en) 2009-08-26 2015-11-03 Insightec Ltd. Asymmetric ultrasound phased-array transducer for dynamic beam steering to ablate tissues in MRI
US9289154B2 (en) 2009-08-19 2016-03-22 Insightec Ltd. Techniques for temperature measurement and corrections in long-term magnetic resonance thermometry
US9541621B2 (en) 2009-11-10 2017-01-10 Insightec, Ltd. Techniques for correcting measurement artifacts in magnetic resonance thermometry
US9623266B2 (en) 2009-08-04 2017-04-18 Insightec Ltd. Estimation of alignment parameters in magnetic-resonance-guided ultrasound focusing
US9852727B2 (en) 2010-04-28 2017-12-26 Insightec, Ltd. Multi-segment ultrasound transducers
US9981148B2 (en) 2010-10-22 2018-05-29 Insightec, Ltd. Adaptive active cooling during focused ultrasound treatment

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Publication number Priority date Publication date Assignee Title
US6735461B2 (en) 2001-06-19 2004-05-11 Insightec-Txsonics Ltd Focused ultrasound system with MRI synchronization

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FR2507321A1 (en) * 1981-06-04 1982-12-10 Instrumentarium Oy diagnostic apparatus for the determination of the structure and quality of tissue
EP0074588A1 (en) * 1981-09-04 1983-03-23 Hitachi, Ltd. Imaging apparatus using nuclear magnetic resonance
EP0088620A2 (en) * 1982-03-05 1983-09-14 Olympus Optical Co., Ltd. An ultrasonic probe for diagnostic examination of the interior of body cavities
EP0145173A1 (en) * 1983-10-17 1985-06-19 Electro-Biology, Inc Modification of blood-circulatory dynamics within a living body

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507321A1 (en) * 1981-06-04 1982-12-10 Instrumentarium Oy diagnostic apparatus for the determination of the structure and quality of tissue
EP0074588A1 (en) * 1981-09-04 1983-03-23 Hitachi, Ltd. Imaging apparatus using nuclear magnetic resonance
EP0088620A2 (en) * 1982-03-05 1983-09-14 Olympus Optical Co., Ltd. An ultrasonic probe for diagnostic examination of the interior of body cavities
EP0145173A1 (en) * 1983-10-17 1985-06-19 Electro-Biology, Inc Modification of blood-circulatory dynamics within a living body

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0649117A2 (en) * 1993-10-15 1995-04-19 George S. Allen Method for providing medical images
EP0649117A3 (en) * 1993-10-15 1996-01-31 George S Allen Method for providing medical images.
US5590215A (en) * 1993-10-15 1996-12-31 Allen; George S. Method for providing medical images
US9623266B2 (en) 2009-08-04 2017-04-18 Insightec Ltd. Estimation of alignment parameters in magnetic-resonance-guided ultrasound focusing
US9289154B2 (en) 2009-08-19 2016-03-22 Insightec Ltd. Techniques for temperature measurement and corrections in long-term magnetic resonance thermometry
US9177543B2 (en) 2009-08-26 2015-11-03 Insightec Ltd. Asymmetric ultrasound phased-array transducer for dynamic beam steering to ablate tissues in MRI
US9541621B2 (en) 2009-11-10 2017-01-10 Insightec, Ltd. Techniques for correcting measurement artifacts in magnetic resonance thermometry
US8932237B2 (en) 2010-04-28 2015-01-13 Insightec, Ltd. Efficient ultrasound focusing
US9852727B2 (en) 2010-04-28 2017-12-26 Insightec, Ltd. Multi-segment ultrasound transducers
US9981148B2 (en) 2010-10-22 2018-05-29 Insightec, Ltd. Adaptive active cooling during focused ultrasound treatment

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