WO1991000051A1 - Steerable highly elongated guidewire - Google Patents

Steerable highly elongated guidewire Download PDF

Info

Publication number
WO1991000051A1
WO1991000051A1 PCT/US1990/003343 US9003343W WO9100051A1 WO 1991000051 A1 WO1991000051 A1 WO 1991000051A1 US 9003343 W US9003343 W US 9003343W WO 9100051 A1 WO9100051 A1 WO 9100051A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
distal
guidewire
body
portion
distal end
Prior art date
Application number
PCT/US1990/003343
Other languages
French (fr)
Inventor
De Toledo Fernando Alvarez
Original Assignee
Boston Scientific Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • A61M2025/09058Basic structures of guide wires
    • A61M2025/09083Basic structures of guide wires having a coil around a core
    • A61M2025/09091Basic structures of guide wires having a coil around a core where a sheath surrounds the coil at the distal part
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • A61M2025/09133Guide wires having specific material compositions or coatings; Materials with specific mechanical behaviours, e.g. stiffness, strength to transmit torque
    • A61M2025/09141Guide wires having specific material compositions or coatings; Materials with specific mechanical behaviours, e.g. stiffness, strength to transmit torque made of shape memory alloys which take a particular shape at a certain temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • A61M2025/09166Guide wires having radio-opaque features
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • A61M2025/09175Guide wires having specific characteristics at the distal tip

Abstract

A steerable guidewire (10) of length in excess of 350 centimeters for use in gastro-intestinal procedures includes an elongated distal body (14) having distal and proximal ends. An elongated handle (12) extends proximally of the proximal end of the distal body. At least a distal end region of the distal body, including the distal end portion (16), is formed of a flexible, kink-resistant material, e.g. a super-elastic material. A flexible distal tip (20) formed of a radiopaque material, e.g. a platinum coil (19), is ball welded to the distal end of the elongated distal body. A plastic sleeve (32) is disposed closely about the distal end of the body and the distal tip joined thereto. The guidewire is constructed in a manner whereby substantially all of an angular rotational force applied to the handle outside of a patient's body is transmitted to the distal tip within the body.

Description

STEERABLE HIGHLY ELONGATED GUIDEWIRE Background of the Invention This invention relates to medical devices formed from elongated wires and coils used as guidewires, e.g., for navigating narrow passageways of a body.

Generally, the distal end of a guidewire is introduced into a body by a physician, e.g., through a puncture opening, and its progress is observed by a radioscope. The physician manipulates the tip of the guidewire through tortuous aspects of the body passageways to a site to be treated. A catheter or other medical device is advanced over the guidewire to the treatment site and the guidewire is then removed, leaving the catheter in place. In order for the physician to have a maximum degree of control over the guidewire, and to ensure the patient's safety, it is important that the guidewire be as small in diameter as possible, particularly in the tip region, but not so small as to create a danger of the tip breaking loose in the body. It is also important that the guidewire be smooth to allow ready advancement and retraction within the passageways; that the distal tip of the guidewire be highly flexible to permit negotiation of difficult turns within the body; that the distal tip be visible by radioscope; that the guidewire be stiff enough axially to be advanced by pressure from the proximal end outside the body without kinking, i.e., turning back upon itself; and that the guidewire have good steerability or torgue response, i.e., the tip-to-handle turn ratio should be as close to 1:1 as possible, without whipping. Most prior art guidewires compromise these desired features, e.g., trading tip flexibility for good torgue response.

Fuji Teru o Co. Ltd., EP 0 141 006 describes a guidewire having a rigid body portion, a flexible distal end portion, and a tapered portion in between the body and distal portions. At least portions of the body and/or distal end are formed of a super elastic metal member, e.g., a NiTi alloy (Nitinol) . A coating, e.g., an elastomer, containing a radiopaque material, e.g., barium, is disposed over the length of the guidewire so that the position of the guidewire in a blood vessel can be determined. This coating is fixed to the distal end portion so that the guidewire may be flexibly deformed within the coating.

Samson U.S. 4,538,622 describes a guidewire having a proximal portion formed of stainless steel wire secured at its distal end to a first coil formed of stainless steel, which in turn is secured at its distal end to a second coil formed of a radiopaque material, e.g., platinum. The distal end of the second coil terminates in a rounded tip.

Leary U.S. 4,545,390 describes a guidewire having a main wire or rod formed of a material that may have a high degree of radiopacity and which tapers evenly at its distal end. A coil made of a radiopaque material, e.g., a platinum/tungsten alloy, fitted over the tapered portion extends slightly beyond the distal end of the main wire or rod, and terminates in a ball weld. Summary of the Invention

According to one aspect of the invention, a steerable guidewire of length in excess of the order of about 350 centimeters and sufficient for use in gastro¬ intestinal procedures comprises an elongated distal body portion having a distal end and a proximal end, an elongated handle portion extending proximally of the proximal end of said distal body portion, at least a distal end region of said distal body portion, including said distal end, being formed of a flexible, kink- resistant material comprising a super-elastic material, a flexible distal tip portion ball welded to said distal end of said elongated distal body portion, said distal tip portion being formed of a radiopaque material comprising platinum, and a plastic sleeve disposed closely about said distal end region of said distal body portion and said distal tip portion joined thereto, said guidewire constructed in a manner whereby substantially all of an angular rotational force applied to said handle portion outside of a patient's body is transmitted to the distal tip portion within the body.

Preferred embodiments of the invention may include one or more of the following features. The ratio of angular rotation force applied to the handle to angular rotation of the distal tip portion is of the order of about 1:1. The plastic sleeve is formed of heat shrinkable material. The plastic sleeve is formed of polyamide material. The steerable guidewire comprises a wire coil disposed over said body portion and said tip portion. The length of said guidewire is of the order of about 450 centimeters.

A guidewire of this invention includes the advantages of: use of a super elastic material, such as Nitinol wire, in the body portion in conjunction with a radiopaque tip portion provides a guidewire which is flexible, kink-resistant, and visible with a radioscope; when the body portion of the guidewire is advanced through a passageway, it is curved and restored without plastic deformation, making it easier to accommodate tortuous routes to a treatment site; and the body portion is elastic and presses against passageway walls without recoiling out of the passageway, and thus holds the distal portion in place and facilitates advancement of a catheter.

Still other advantages include the following. The guidewire is sufficiently small in diameter and sufficiently long for gastro-intestinal use; the ball weld joint provides the necessary strength between the tip and body portions so that the platinum coil does not break away from the Nitinol wire; the sleeve provides sufficient smoothness to allow the guidewire to be advanced and retracted readily; the sleeve also aids in torque transmission from proximal to distal ends of the guidewire; the platinum coil tip is radiopaque as well as flexible; and the handle portion provides the necessary stiffness to advance and retract the guidewire without kinking, and sufficient torque to turn the guidewire without whipping.

These and other features and advantages will be seen from the following description of a presently preferred embodiment, and from the claims.

Description of the Preferred Embodiment We first briefly describe the drawings. Drawinσs

Fig. 1 is a generally schematic view, partially in section, of a guidewire of the invention;

Fig. 2 is a longitudinal view of the distal end of the guidewire partially in section;

Fig. 2A is a similar view of the joint region between adjacent portions of the guidewire, specifically between body and handle;

Fig. 3 is a schematic view showing a guidewire of the invention employed in the gastro-intestinal region of a human body; and

Fig. 4 is a schematic view of the distal portion of an alternate embodiment of the guidewire of the invention.

Referring to Figs. 1 and 2, guidewire 10, approximately 450 cm in length, has a handle portion 12 (approximately 400 cm in length) , a body portion 14 (approximately 40 cm in length) , and a distal portion 16 (approximately 10 cm in length) , including a distal tip region 20 (approximately 3 to 5 cm in length) . The guidewire terminates distally in a rounded ball tip element 22. The total length of guidewire 10 makes it suitable for use in the gastro-intestinal region of the body. A guidewire of this length is also useful as an exchange wire because when it is inserted into a body and advanced through a passageway an equal or greater length of guidewire 10 remains outside the body to allow a second device, e.g., a catheter (74, Fig. 3), to be advanced over the guidewire.

Handle portion 12 is formed of stainless steel wire 17, which provides sufficient stiffness to allow the physician to push guidewire 10 through a passageway and also to prevent its recoil from the body passage. Body portion 14 is a solid wire 18 formed of super elastic, flexible, and kink-resistant material, for example, a nickel-titanium system commonly referred to as NITINOL (an acronym for "Nickel-Titanium Naval Ordinance") .

Other alloys exhibiting the desired properties include, e.g., Silver-Cadmium (Ag-Cd) , Gold-Cadmium (Au-Cd) , Gold- Copper-Zinc (Au-Cu-Zn) , Copper-Zinc (Cu-Zn) , Copper-Zinc- Aluminum (Cu-Zn-Al) , Copper-Zinc-Tin (Cu-Zn-Sn) , Copper- Zinc-Xenon (Cu-Zn-Xe) , Iron Beryllium (Fe3Be) , Iron- Platinum (Fe,Pt) , Indium-Thallium (In-Tl) and Titanium- Nickel (Ti-Ni) (Schetsky, L. McDonald, "Shape Memory Alloys", Encyclopedia of Chemical Technology (3rd ed.), John Wiley & Sons, 1982, vol. 20, pp. 726-736); also Nickel-Titanium-Vanadium (Ni-Ti-V) , Copper-Tin (Cu-Sn) and Iron-Nickel-Titanium-Cobalt (Fe-Ni-Ti-Co) . Tip portion 16 is a tapered continuation of the Nitinol wire 18 of body portion 14 and has mounted about its distal extremity, in distal tip region 20, a radiopaque, flexible platinum coil 19, which allows the guidewire to make a 90° turn in a passageway of 1/8 to 1/4 inch radius without breakage or permanent deformation of the tip. Platinum coil 19 is fitted over the distal end portion 21 of Nitinol wire 18 and joined to guidewire 10 only at its distal end to the ball weld tip 22, as described below; the proximal portion of the coil 19 floating freely about the distal tapered portion 21 of the body portion. The proximal end of Nitinol wire 18 is joined to the distal end of stainless steel wire 17 at joint 24. Referring to Fig. 2A, the proximal end 23 of wire 18 and distal end 25 of wire 17 extend into coupling sleeve 24 and are joined together therein, e.g., by crimping of the sleeve as shown in Fig. 2, or by spot welding or adhesive, e.g., cyanoacrylate (27, Fig. 2A) . Sleeve 32, 34 formed of a suitable material, e.g. a shrink sleeve of polytetrafluroethylene (PTFE) or polyethylene or a sleeve of polyamide material or other suitable plastic material, is disposed over body and tip portions 14, 16, and over handle portion 12. Body portion 14 of guidewire 10 is formed of solid Nitinol wire 18 normally equal in diameter at its proximal end to the diameter of stainless steel wire 17, and generally having an outer diameter. A, e.g., 0.023 inch. The distal portion of Nitinol wire 18 in the distal tip region 20 is tapered, reaching an outer diameter B, e.g., 0.007 to 0.012 inch and preferably 0.010 inch, in the distal tip region 20, about 3 to 5 centimeters in length. Platinum coil 19 of tip portion 16, having an outer diameter, C, e.g., 0.018 inch, and an inner diameter approximately that of the outer diameter of the Nitinol wire in region 20, i.e., diameter B, is fitted over the wire in region 20 and ball welded to the Nitinol wire 18 at the distal tip 22. Sleeves 32, 34 have thickness of about 0.005 to 0.006 inch, increasing the dieimeter of body portion 14 to D, e.g., 0.035 inch. The coupling sleeve 24 lies between the opposed ends of sleeves 32, 34 and preferably is not covered. The diameter of tip portion 16 is increased to an outer diameter E, e.g., 0.028 inch, where the sleeve 32 covers the distal coil 19, then tapers distally over the rounded tip 22.

Platinum coil 19 of distal tip region 20 is a single or multi-filar coil of flat or round wire, and can be tweaked, i.e., the individual coils can be spaced apart, to make the tip portion 20 more flexible.

Platinum coil 19 is fitted over necked down region 21 and ball welded to the distal end of Nitinol wire 18 at distal tip 22. Parameters for the ball welding include, e.g., using tungsten inert gas to plasma arc weld tip 22 using a chill clamp fixture, a weld current of less than 1.25 amps, and a weld time of 0.08 seconds. Stainless steel wire 17 of handle portion 12 is then crimped, spot welded or glued to the proximal end 23 of Nitinol wire 18 of body portion 14 using coupling sleeve 24, and sleeves 32, 34 disposed over tip and body portions 16 and 14 by standard procedure.

Referring to Fig. 3, guidewire 10 can be used for treatment of gastro-intestinal ailments. Generally, a physician inserts the distal end, i.e., rounded tip 22, of guidewire 10 into a body. Axial pressure is applied to the proximal portion, i.e., handle 14, of guidewire 10 to advance or retract guidewire 10. The rounded tip 22 of guidewire 10 is steered by rotating handle 14 to direct rounded tip 22 to various passageways. In the figure, guidewire 10 is shown inserted through a puncture opening in a stomach 60, and advanced through a duodenum 62, to a duodenal papilla 64, and into a bile duct 66 at which point the physician can direct rounded tip 22 of guidewire 10 through a cystic duct, as shown by arrow 68, to a gallbladder 70, or into a hepatic duct, as shown by arrow 72. A catheter 74 can then be advanced over guidewire 10, and guidewire 10 removed when catheter 74 is in place.

Other embodiments are within the following claims. For example, a wire coil 40 may be disposed over the tip and body portions of a guidewire 10 (Fig. 4) . A sleeve as described above may be further disposed thereabout. What is claimed is:

Claims

1. A steerable guidewire of length in excess of the order of about 350 centimeters and sufficient for use in gastro-intestinal procedures, said guidewire comprising: an elongated distal body portion having a distal end and a proximal end, an elongated handle portion extending proximally of the proximal end of said distal body portion, at least a distal end region of said distal body portion, including said distal end, being formed of a flexible, kink-resistant material comprising a super- elastic material, a flexible distal tip portion ball welded to said distal end of said elongated distal body portion, said distal tip portion being formed of a radiopaque material comprising platinum, and a plastic sleeve disposed closely about said distal end region of said distal body portion and said distal tip portion joined thereto, said guidewire constructed in a manner whereby substantially all of an angular rotational force applied to said handle portion outside of a patient's body is transmitted to the distal tip portion within the body.
2. The steerable guidewire of claim 1 wherein the ratio of angular rotation force applied to the handle to angular rotation of the distal tip portion is of the order of about 1:1.
3. The steerable guidewire of claim 1 wherein said plastic sleeve is formed of heat shrinkable material.
4. The steerable guidewire of claim 1 wherein said plastic sleeve is formed of polyamide material.
5. The steerable guidewire of claim 1 comprising a wire coil disposed over said body portion and said tip portion.
6. The steerable guidewire of claim 1 wherein the length of said guidewire is of the order of about 450 centimeters.
PCT/US1990/003343 1989-06-28 1990-06-13 Steerable highly elongated guidewire WO1991000051A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US37434889 true 1989-06-28 1989-06-28
US374,348 1989-06-28

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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0515201A1 (en) * 1991-05-21 1992-11-25 C.R. Bard, Inc. Superelastic formable guidewire
EP0519604A2 (en) * 1991-06-18 1992-12-23 Scimed Life Systems, Inc. Intravascular guide wire and method of manufacture thereof
US5241970A (en) * 1991-05-17 1993-09-07 Wilson-Cook Medical, Inc. Papillotome/sphincterotome procedures and a wire guide specially
US5259393A (en) * 1992-05-13 1993-11-09 Cordis Corporation Guidewire having controlled radiopacity tip
US5353808A (en) * 1992-03-04 1994-10-11 Cordis Corporation Guidewire having distally located marker segment
EP0714315A1 (en) * 1993-08-16 1996-06-05 Boston Scientific Corporation Zebra exchange guide wire
EP0754430A2 (en) * 1995-06-30 1997-01-22 Terumo Kabushiki Kaisha Ultrasonic imaging catheter
US5622184A (en) * 1994-11-29 1997-04-22 Applied Medical Resources Corporation Guidewire and method of manufacture
EP0838230A2 (en) * 1996-10-22 1998-04-29 Terumo Kabushiki Kaisha Guide wire
US5836893A (en) * 1996-03-08 1998-11-17 Scimed Life Systems, Inc. Intravascular guidewire
EP0911055A1 (en) * 1997-10-27 1999-04-28 Cordis Corporation Guidewire with outer sheath
US5924998A (en) * 1997-03-06 1999-07-20 Scimed Life System, Inc. Guide wire with hydrophilically coated tip
US6056702A (en) * 1998-10-02 2000-05-02 Cordis Corporation Guidewire with outer sheath
US6093157A (en) * 1997-10-22 2000-07-25 Scimed Life Systems, Inc. Radiopaque guide wire
US6132388A (en) * 1997-10-16 2000-10-17 Scimed Life Systems, Inc. Guide wire tip
US6251086B1 (en) 1999-07-27 2001-06-26 Scimed Life Systems, Inc. Guide wire with hydrophilically coated tip
US6340441B1 (en) 1998-03-13 2002-01-22 Scimed Life Systems, Inc. Multi-layer guide wire and method of manufacture therefor
US7022086B2 (en) 2002-05-21 2006-04-04 Scimed Life Systems, Inc. Guidewire with encapsulated marker

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0141006A1 (en) * 1983-09-16 1985-05-15 Terumo Kabushiki Kaisha Guide wire for catheter
US4545390A (en) * 1982-09-22 1985-10-08 C. R. Bard, Inc. Steerable guide wire for balloon dilatation procedure
GB2180454A (en) * 1985-09-18 1987-04-01 Bard Inc C R Catheter exchange method and means therefor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4545390A (en) * 1982-09-22 1985-10-08 C. R. Bard, Inc. Steerable guide wire for balloon dilatation procedure
EP0141006A1 (en) * 1983-09-16 1985-05-15 Terumo Kabushiki Kaisha Guide wire for catheter
GB2180454A (en) * 1985-09-18 1987-04-01 Bard Inc C R Catheter exchange method and means therefor

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5241970A (en) * 1991-05-17 1993-09-07 Wilson-Cook Medical, Inc. Papillotome/sphincterotome procedures and a wire guide specially
US5368049A (en) * 1991-05-21 1994-11-29 C. R. Bard, Inc. Superelastic formable guidewire with malleable cladding
EP0515201A1 (en) * 1991-05-21 1992-11-25 C.R. Bard, Inc. Superelastic formable guidewire
EP0519604A2 (en) * 1991-06-18 1992-12-23 Scimed Life Systems, Inc. Intravascular guide wire and method of manufacture thereof
US6409682B1 (en) 1991-06-18 2002-06-25 Scimed Life Systems, Inc. Intravascular guide wire and method for manufacture thereof
US5452726A (en) * 1991-06-18 1995-09-26 Scimed Life Systems, Inc. Intravascular guide wire and method for manufacture thereof
EP0519604A3 (en) * 1991-06-18 1993-04-14 Scimed Life Systems, Inc. Intravascular guide wire and method of manufacture thereof
US5353808A (en) * 1992-03-04 1994-10-11 Cordis Corporation Guidewire having distally located marker segment
US5259393A (en) * 1992-05-13 1993-11-09 Cordis Corporation Guidewire having controlled radiopacity tip
EP1208868A3 (en) * 1993-08-16 2003-11-26 Boston Scientific Corporation Zebra exchange guide wire
EP0714315A4 (en) * 1993-08-16 1996-09-11 Boston Scient Corp Zebra exchange guide wire
EP0714315A1 (en) * 1993-08-16 1996-06-05 Boston Scientific Corporation Zebra exchange guide wire
EP1208868A2 (en) * 1993-08-16 2002-05-29 Boston Scientific Corporation Zebra exchange guide wire
US5622184A (en) * 1994-11-29 1997-04-22 Applied Medical Resources Corporation Guidewire and method of manufacture
EP0754430A3 (en) * 1995-06-30 1997-06-11 Terumo Corp Ultrasonic imaging catheter
US5738100A (en) * 1995-06-30 1998-04-14 Terumo Kabushiki Kaisha Ultrasonic imaging catheter
EP0754430A2 (en) * 1995-06-30 1997-01-22 Terumo Kabushiki Kaisha Ultrasonic imaging catheter
US5836893A (en) * 1996-03-08 1998-11-17 Scimed Life Systems, Inc. Intravascular guidewire
EP0838230A3 (en) * 1996-10-22 1998-06-10 Terumo Kabushiki Kaisha Guide wire
US6001068A (en) * 1996-10-22 1999-12-14 Terumo Kabushiki Kaisha Guide wire having tubular connector with helical slits
EP0838230A2 (en) * 1996-10-22 1998-04-29 Terumo Kabushiki Kaisha Guide wire
EP1325763A3 (en) * 1996-10-22 2003-08-20 Terumo Kabushiki Kaisha Guide wire
EP1325763A2 (en) * 1996-10-22 2003-07-09 Terumo Kabushiki Kaisha Guide wire
US6656134B2 (en) 1997-03-06 2003-12-02 Scimed Life Systems, Inc. Guide wire with hydrophilically coated tip
US5924998A (en) * 1997-03-06 1999-07-20 Scimed Life System, Inc. Guide wire with hydrophilically coated tip
US7115101B2 (en) 1997-03-06 2006-10-03 Scimed Life Systems, Inc. Guide wire with hydrophilically coated tip
US6132388A (en) * 1997-10-16 2000-10-17 Scimed Life Systems, Inc. Guide wire tip
US6093157A (en) * 1997-10-22 2000-07-25 Scimed Life Systems, Inc. Radiopaque guide wire
EP0911055A1 (en) * 1997-10-27 1999-04-28 Cordis Corporation Guidewire with outer sheath
US6340441B1 (en) 1998-03-13 2002-01-22 Scimed Life Systems, Inc. Multi-layer guide wire and method of manufacture therefor
US6056702A (en) * 1998-10-02 2000-05-02 Cordis Corporation Guidewire with outer sheath
US6251086B1 (en) 1999-07-27 2001-06-26 Scimed Life Systems, Inc. Guide wire with hydrophilically coated tip
US7022086B2 (en) 2002-05-21 2006-04-04 Scimed Life Systems, Inc. Guidewire with encapsulated marker

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