WO1990003802A3 - Technetium imaging agents - Google Patents

Technetium imaging agents Download PDF

Info

Publication number
WO1990003802A3
WO1990003802A3 PCT/US1989/004446 US8904446W WO9003802A3 WO 1990003802 A3 WO1990003802 A3 WO 1990003802A3 US 8904446 W US8904446 W US 8904446W WO 9003802 A3 WO9003802 A3 WO 9003802A3
Authority
WO
WIPO (PCT)
Prior art keywords
imaging agents
technetium
technetium imaging
glucarate
infarcted
Prior art date
Application number
PCT/US1989/004446
Other languages
French (fr)
Other versions
WO1990003802A2 (en
Inventor
Harvey J Berger
Ban An Khaw
Koon Yan Pak
H William Strauss
Original Assignee
Centocor Inc
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc, Gen Hospital Corp filed Critical Centocor Inc
Priority to DE68922858T priority Critical patent/DE68922858T2/en
Priority to EP89912027A priority patent/EP0438502B1/en
Publication of WO1990003802A2 publication Critical patent/WO1990003802A2/en
Publication of WO1990003802A3 publication Critical patent/WO1990003802A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Method using technetium-99m imaging agents for the study, detection or diagnosis of ischemic, infarcted or diseased tissue. The imaging agents comprise a complex of technetium-99 m and glucarate.
PCT/US1989/004446 1988-10-07 1989-10-05 Technetium imaging agents WO1990003802A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE68922858T DE68922858T2 (en) 1988-10-07 1989-10-05 TECHNOLOGY-BASED IMAGING AGENTS.
EP89912027A EP0438502B1 (en) 1988-10-07 1989-10-05 Technetium imaging agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/254,961 US4952393A (en) 1987-04-02 1988-10-07 Organ infarct imaging with technetium labelled glucarate
US254,961 1988-10-07

Publications (2)

Publication Number Publication Date
WO1990003802A2 WO1990003802A2 (en) 1990-04-19
WO1990003802A3 true WO1990003802A3 (en) 1990-06-14

Family

ID=22966255

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/004446 WO1990003802A2 (en) 1988-10-07 1989-10-05 Technetium imaging agents

Country Status (6)

Country Link
US (1) US4952393A (en)
EP (1) EP0438502B1 (en)
JP (1) JP2925205B2 (en)
AT (1) ATE122896T1 (en)
DE (1) DE68922858T2 (en)
WO (1) WO1990003802A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116598A (en) * 1990-10-29 1992-05-26 Mallinckrodt Medical, Inc. N4 technetium-99 m complexes for use as radiopharmaceuticals
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
JP2901787B2 (en) * 1991-07-15 1999-06-07 日本メジフィジックス株式会社 Nuclear magnetic resonance contrast agent
JP2894879B2 (en) * 1991-10-04 1999-05-24 日本メジフィジックス株式会社 Diagnostic contrast agent
DE69426035T2 (en) * 1993-07-28 2001-05-17 Diatide, Inc. RADIO-MARKED GLUCANE
WO2005042766A2 (en) * 2003-10-31 2005-05-12 Molecular Targeting Technologies, Inc. Technetium-99m glucarate methods of use for monitoring tissues
GB0416062D0 (en) * 2004-07-19 2004-08-18 Amersham Plc Improved N4 chelator conjugates
CA2724462A1 (en) 2008-03-10 2009-09-17 Mcw Research Foundation, Inc. 99mtc-labeled 19 amino acid containing peptide for use as phosphatidylethanolamine binding molecular probe and radiopharmaceutical

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4027005A (en) * 1974-06-07 1977-05-31 New England Nuclear Corporation Diagnostic agents
US4372941A (en) * 1980-09-05 1983-02-08 Ryan James W Novel radioassay procedure
US4431626A (en) * 1981-05-27 1984-02-14 The Regents Of The University Of California Tc-99m Labeled carrier for imaging
DE3331159A1 (en) * 1983-08-30 1985-03-14 Hoechst Ag, 6230 Frankfurt N- (4-AMINOBENZOYL) AMINODICARBONIC ACIDS FOR THE STABILIZATION OF TECHNETIUM-99M PREPARATIONS, STABILIZED INJECTION PREPARATIONS AND METHOD FOR THEIR PRODUCTION
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Journal of Nuclear Medicine, Volume 16, No. 11, 1975, D.J. ROSSMAN et al.: "Detection and Size Estimation of Acute Myocardial Infarction using 99mTc-Glucoheptonate", pages 980-985 *
STN International (Karlsruhe), File BIOSIS, AN 85:244954, L.L.-Y. HWANG et al.: "Extraction of Technetium-V from Radiopharma-Ceuticals", see the whole Abstract, & Int. J. Appl. Radiat. Isot. 35 (9), 1984, 825-830 *
STN International (Karlsruhe), File BIOSIS, AN 89:417301, K.Y. PAK et al.: "Visualization of Experimental Tumor Model Application of a New Technetium-99m Labeled Compound", see the whole Abstract, & 36th Annual Meeting of the Society for Nuclear Medicine, St. Louis, Missouri, USA, June 13-16, 1989, J. Nucl. Med. 30 (5 Suppl.), 1989, 906 *
STN International (Karlsruhe), File BIOSOS, AN 89-417280, T. UEHARA et al.: "Technetium - 99m - Glucarate - a Marker of Acute Cerebral Damage", see the whole Abstract, & 36th Annual Meeting of the Society for Nuclear Medicine, St. Louis, Missouri, USA, June 13-16, 1989, J. Nucl. Med., 30 (5 Suppl.), 1989, 901 *
The International Journal of Radiation and Isotopes, Volume 36, No. 6, June 1985, Pergamon Press Ltd, (Oxford, GB), L.L.-Y. HWANG et al.: "Complexes of Technetium with Polyhydric Ligands", pages 475-480 *

Also Published As

Publication number Publication date
JP2925205B2 (en) 1999-07-28
US4952393A (en) 1990-08-28
DE68922858T2 (en) 1996-02-08
EP0438502B1 (en) 1995-05-24
WO1990003802A2 (en) 1990-04-19
JPH04502453A (en) 1992-05-07
DE68922858D1 (en) 1995-06-29
ATE122896T1 (en) 1995-06-15
EP0438502A1 (en) 1991-07-31

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