WO1990002573A1 - Tubular articles - Google Patents

Tubular articles Download PDF

Info

Publication number
WO1990002573A1
WO1990002573A1 PCT/GB1989/001048 GB8901048W WO9002573A1 WO 1990002573 A1 WO1990002573 A1 WO 1990002573A1 GB 8901048 W GB8901048 W GB 8901048W WO 9002573 A1 WO9002573 A1 WO 9002573A1
Authority
WO
WIPO (PCT)
Prior art keywords
article
antimicrobial agent
triclosan
latex
natural rubber
Prior art date
Application number
PCT/GB1989/001048
Other languages
French (fr)
Inventor
Richard Milner
Original Assignee
Smith & Nephew Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB888820945A priority Critical patent/GB8820945D0/en
Priority to GB8820945.7 priority
Priority to PCT/GB1989/000978 priority patent/WO1990001956A1/en
Priority to GBPCT/GB89/00978 priority
Application filed by Smith & Nephew Plc filed Critical Smith & Nephew Plc
Priority claimed from AT89910154T external-priority patent/AT102053T/en
Publication of WO1990002573A1 publication Critical patent/WO1990002573A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/02Contraceptive devices; Pessaries; Applicators therefor for use by males
    • A61F6/04Condoms, sheaths or the like, e.g. combined with devices protecting against contagion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B42/00Surgical gloves; Finger-stalls specially adapted for surgery; Devices for handling or treatment thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/202Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with halogen atoms, e.g. triclosan, povidone-iodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents

Abstract

Tubular articles such as condoms or catheters are rendered antimicrobially effective by incorporating therein an effective amount of a non-ionic sparingly water soluble antimicrobial agent. Preferably the antimicrobial is triclosan and the tubular article is a condom made from natural rubber latex. A method of manufacturing the tubular articles is described in which the antimicrobial agent is incorporated into the material forming the article before the article is formed.

Description

TUBULAR ARTICLES

This invention relates to tubular articles such as condoms or catheters rendered antimicrobially effective by incorporating therein an effective amount of a non-ionic sparingly water soluble antimicrobial agent such as triclosan into the material such as natural rubber from which the article is made.

For many elastomeric tubular articles which are used in the medical or veterinary sciences it is often desirable to treat them so they can prevent the passage of bacteria or virus or even have a microbiocidal effect at least at their surfaces. Such articles include catheters such a urethral catheters, condoms, wound drains, endotracheal tubes and the like. Heretofore such articles have been treated with antimicrobial agents by washing with a solution of the agent or by treating it with a cream or lubricating oil or powders which contain an antimicrobial agent.

It would be useful if the aforementioned articles could be manufactured with the antimicrobial agent in situ. Unfortunately it has proved to be extremely difficult to produce articles made of rubbers such as natural rubber latex or the like incorporating an antimicrobial agent. For example, the agents have tendency to destabalise the materials from which the article is formed, for example by causing gelling of a latex. However, a method has now been discovered which allows articles to be formed which incorporate an antimicrobially effective amount of an agent which reduces the tendency for bacteria to grow on the surface of the article and then improves the barrier properties of the article against transmission of bacteria and even of viruses such as the HIV and hepatitis B virus.

The present invention provides a method for the manufacture of an antimicrobially effective tubular article which comprises including an antimicrobially effective amount of a non-ionic sparingly water soluble antimicrobial agent into the article prior to forming the article.

The present invention also provides an antimicrobial tubular article which contains a non-ionic sparingly water soluble antimicrobial agent.

The antimicrobial agent is non-ionic at neutral pH values and only sparingly soluble in water. By sparingly water soluble it is meant that the antimicrobial agent has a solubility in water at 20°C of less than O.lgm/litre, preferably less than 0.05gm/litre.

The article material will contain (ie within its body as opposed to residing only on its surface) an antimicrobially effective amount of antimicrobial agent. Suitably the article material may contain from 0.1 to 10% w/w of antimicrobial agent, more suitably 1 to 5% w/w and preferably about 1.0%ww.

The material which forms the article can be any one of those which are conventionallly used for forming such articles especially condoms and include natural rubber, polyvinyl chloride and polyurethane. The use of a natural rubber latex to form the article material is preferred. The use of a non-ionic sparingly soluble antimicrobial agent in a natural rubber latex article offers a method of overcoming many of the potential problems which could occur with natural rubber latex articles if they are susceptible to penetration by virus such as those responsible for AIDS and Hepatitis B.

From the foregoing it will be appreciated that in a preferred aspect this invention provides a natural rubber latex tubular article which contains a non-ionic, sparingly soluble antimicrobial agent. The preferred antimicrobial agent is 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan).

Thus in a preferred aspect the present invention provides a natural rubber latex tubular article which contains 2,4 4'-trichloro-2'-hydroxydiphenyl ether.

These antimicrobial agents are particularly suitable for incorporation into catheters and condoms formed from natural rubber latex. It has been observed that natural rubber latices may be coagulated by ionic antimicrobial agent. If articles formed from natural rubber latices are to be treated with such antimicrobial agentsin the prior art, it is only after the rubber has been vulcanised that this can be achieved. The nature of the surface of cured rubber articles is such as to be not readily coated or impregnated with for example an antimicrobial agent. Methods of overcoming this problem have included coating the article with the antimicrobial agent in a binding agent modifying the rubber surface to make it responsive to binding the antimicrobial agent or by treating the surface with a solvent to cause the rubber to swell and then impregnating with the antimicrobial agent in the same or another solvent and finally removing the solvent. These processes are difficult to carry out and do not give a consistent product. Surprisingly it has been found that non-ionic, sparingly water soluble antimicrobial agents do not coagulate natural rubber latex. This enables the antimicrobial agent to be uniformly mixed with the rubber latex in the fluid pre-cured state which makes manufacture of rubber articles made therefrom easier as it requires no post-cure operations on the article and can also provide a more consistent product. The low solubility of the antimicrobial agent means that it is not removed during the leaching step in the tubular article manufacturing process yet the antimicrobial agent is found to be effectively released from both the inside and outside of the article under conditions of which simulate wear.

Suitable non-ionic, sparingly soluble antimicrobial agents include phenol derivatives such as chlorophene, dichlσroxylenol, hexachloraphane; diphenyl derivatives, halogenated hydroxy diphenyl derivatives such as diphenyl ethers for example 2,4,4'-trichloro-2'-hydroxy diphenyl ether (triclosan); and agents such as diacetylamino-azotoluene and triclocarban. The preferred antimicrobial agent is triclosan.

The articles containing antimicrobial agent may be prepared by mixing the required amount of agent with the article material, for example an aqueous dispersion such as a natural rubber latex. The agent may have been previously formed into a dispersion by mixing with a little of the latex or by mixing with water and dispersing agents. The rest of the latex may be gradually mixed with this dispersion until a homogenous mixture results. The article is then formed in the usual manner.

Thus, a former may be first dipped into a coagulant solution and allowed to dry. Thereafter the coated former is dipped into the latex, removed, dried and immersed in a leaching bath. After drying the article may then be 'cured'. Alternatively, condoms or catheters may be prepared by conventional processes not employing coagulatants, for example acid gellation or heat gellation as well as multivalent cation gellation. Condoms are most aptly prepared by the conventional double dipping process.

In a process described above the antimicrobial agent may be distributed through the whole of the article material if desired so that the agent may be released from both the inside and the outside of the article. However, it may be desirable for some purposes to have the agent available only on the inside or wearer-contacting surface of the article. The agent may be present therefore in the material which forms the last coat on the former, that is becomes the inside of the article when the article is removed from the former. Thus with a condom the vaginal flora is less likely to be disturbed. Reversing the method when producing a catheter means that a product can be produced where most of the antibacterial agent can be available on the outside of the catheter.

It will be understood that in a preferred aspect this invention provides a thin polymer condom which contains 2,4,4 - trichloro - 21 - hydroxydiphenyl ether (triclosan) .

Such condoms incorporating a non-ionic sparingly water soluble antimicrobial agent offer the user a higher degree of protection from common infecting organisms that might penetrate through any discontinuity in the condom.

The present invention provides a method of reducing the risk of infection which comprises using thin polymer condom which contain 2,4,4 - trichloro - 21 - hydroxydiphenyl ether (triclosan). The condom contains an antimicorbially effective amount of triclosan. The triclosan provides a protection for the period of use by improving the barrier property of the condom, for example with respect to HIV. In a further preferred aspect the present invention provides a condom which contains a non-ionic, sparingly water soluble antimicrobial agent and which has at least on the inside surface thereof a powder containing triclosan.

The powder may contain an antimicrobially effective amount of triclosan. The powder may suitably contain from 0.1 to 10% w/w of triclosan, more suitably may contain from 0.5 to 8% w/w and preferably contains about 1% w/w.

The powder containing an antimicrobially effective amount of triclosan may be obtained by methods which comprise mixing of the ingredients. Suitable methods include (a) mixing a solution of triclosan in acetone with the powder, drying, grinding and sieving the resulting powder to remove large particles and (b) mixing the dry powders together.

The powder containing triclosan may be coated onto the inside of the condom incorporating the non-ionic, sparingly water soluble antimicrobial agent such as triclosan itself in the way lubricating powders are conventionally applied. The article according to this invention may also contain a further antibacterial agent is desired, for example chlorhexidine digluconate.

The following examples illustrate the invention.

EXAMPLE 1

A condom former of glass is thoroughly washed using dilute acid or alkali solutions. The former is rinsed in s'oft water and dried. The former is dipped into the natural rubber latex. The former is removed and the latex coating dried and evenly distributed over the former by rotation and agitation of the former. The former is then dipped a second time into the latex since a second layer of latex reduces the chance of any pin-holes remaining in the final product. The former is removed and the second coat dried. The article is then leached in a tank of warm water at 70βC for two minutes. After leaching the former is dipped in an aqueous solution containing 10% w/w of chlorhexidine digluconate for 20 seconds and then removed and shaken to remove any adhering water droplets.

The rubber latex contained 1% by weight of triclosan. This was prepared as follows:-

The hydroxy halogenated biphenyl ether 2,4,4*-trichloro-21-hydroxy diphenyl ether (triclosan) was incorporated into a natural rubber latex by mixing triclosan (21g) with a small quantity of latex to form a paste. The latex was gradually diluted with more latex until the required concentration was achieved. The final latex formulation was:-

Latex (42%) 4940g Triclosan 21g

EXAMPLE 2

The procedure of Example 1 was repeated omitting the chlorhexidine step.

EXAMPLE 3

The procedure of Example 2 was repeated but the triclosan was incorporated into the first latex only, EXAMPLE 4

A catheter is prepared by a multiple dipping process whereby a former of appropriate size is repeatedly dipped in a bath of pre-vulcanised rubber latex to build up layers of rubber to give the required wall thickness. The final latex dip incorporated 1% triclosan (based on solids content of latex).

Claims

1 A method for the manufacture of an antimicrobially effective tubular article which comprises including an antimicrobially effective amount of a non-ionic sparingly water soluble antimicrobial agent into the article material prior to forming the article.
2 A method as claimed in claim 1 wherein the antimicrobial agent is
2,4,4*-trichloro-21-hydroxydiphenyl ether.
3 A method as claimed in claim 2 wherein the article ' is a condom.
4 A method as claimed in claim 2 wherein the article is a catheter.
5 A method as claimed in any claims 1 to 4 wherein the material is a natural rubber latex.
6 A tubular article which includes an antimicrobially effective amount of a non-ionic sparingly water soluble antimicrobial agent. An article as claimed in claim 6 wherein the animicrobial agent in
2,4,4*-trichloro-21-hydroxydiphenyl ether.
An article as claimed in claim 7 which is a condom.
An article as claimed in claim 8 which is a cathete .
An article as claimed in any of claims 6 to 9 wherein the material is natural rubber.
PCT/GB1989/001048 1988-08-24 1989-09-06 Tubular articles WO1990002573A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB888820945A GB8820945D0 (en) 1988-09-07 1988-09-07 Medical articles
GB8820945.7 1989-05-17
PCT/GB1989/000978 WO1990001956A1 (en) 1988-08-24 1989-08-23 Antimicrobial articles, their preparation and use
GBPCT/GB89/00978 1989-08-23

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE89910154A DE68913549D1 (en) 1988-09-07 1989-09-06 Tubular objects.
AT89910154T AT102053T (en) 1988-09-07 1989-09-06 Rohrfoermige belongings.
GB9023372A GB2243835B (en) 1988-09-07 1990-10-26 Tubular articles

Publications (1)

Publication Number Publication Date
WO1990002573A1 true WO1990002573A1 (en) 1990-03-22

Family

ID=26294356

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1989/001048 WO1990002573A1 (en) 1988-08-24 1989-09-06 Tubular articles

Country Status (3)

Country Link
DE (1) DE68913549D1 (en)
GB (1) GB2243835B (en)
WO (1) WO1990002573A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663035A1 (en) * 1990-06-08 1991-12-13 De Benne Jacques Process for incorporating an active principle into a membrane and products thus obtained
EP0761243A1 (en) * 1995-09-08 1997-03-12 Union Carbide Chemicals And Plastics Company, Inc. Biostatic coatings and processes
WO1997014447A1 (en) * 1995-10-13 1997-04-24 Paul Kenneth Priscott Biomaterials for use in medical applications
AU712132B2 (en) * 1995-10-13 1999-10-28 Paul Kenneth Priscott Improvements in implantable medical devices
US7993390B2 (en) 2002-02-08 2011-08-09 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
US8105520B2 (en) 2002-02-08 2012-01-31 Boston Scientific Scimed, Inc, Implantable or insertable medical device resistant to microbial growth and biofilm formation

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2263114A (en) * 1991-12-19 1993-07-14 Yad Hygiene Products Limited Biocidal rubber latex products and methods of making same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0141628A1 (en) * 1983-10-29 1985-05-15 Unitika Ltd. Antimicrobial latex composition shaped article produced therefrom, and method of manufacturing a shaped article
EP0147970A1 (en) * 1983-12-12 1985-07-10 Rohm And Haas Company Microbiocidal or antimicrobial biomedical devices
US4592920A (en) * 1983-05-20 1986-06-03 Baxter Travenol Laboratories, Inc. Method for the production of an antimicrobial catheter
EP0229862A2 (en) * 1986-01-24 1987-07-29 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Medical instrument
FR2623087A1 (en) * 1987-03-13 1989-05-19 Medic 44 Sarl Active male and/or female condom device

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT124873T (en) * 1988-04-23 1995-07-15 Smith & Nephew Surgical gloves.
AT130767T (en) * 1988-08-24 1995-12-15 Smith & Nephew Inc Antimicrobial objects, their production and their use.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4592920A (en) * 1983-05-20 1986-06-03 Baxter Travenol Laboratories, Inc. Method for the production of an antimicrobial catheter
EP0141628A1 (en) * 1983-10-29 1985-05-15 Unitika Ltd. Antimicrobial latex composition shaped article produced therefrom, and method of manufacturing a shaped article
EP0147970A1 (en) * 1983-12-12 1985-07-10 Rohm And Haas Company Microbiocidal or antimicrobial biomedical devices
EP0229862A2 (en) * 1986-01-24 1987-07-29 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Medical instrument
FR2623087A1 (en) * 1987-03-13 1989-05-19 Medic 44 Sarl Active male and/or female condom device

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663035A1 (en) * 1990-06-08 1991-12-13 De Benne Jacques Process for incorporating an active principle into a membrane and products thus obtained
EP0761243A1 (en) * 1995-09-08 1997-03-12 Union Carbide Chemicals And Plastics Company, Inc. Biostatic coatings and processes
WO1997014447A1 (en) * 1995-10-13 1997-04-24 Paul Kenneth Priscott Biomaterials for use in medical applications
AU712132B2 (en) * 1995-10-13 1999-10-28 Paul Kenneth Priscott Improvements in implantable medical devices
US7993390B2 (en) 2002-02-08 2011-08-09 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
US8105520B2 (en) 2002-02-08 2012-01-31 Boston Scientific Scimed, Inc, Implantable or insertable medical device resistant to microbial growth and biofilm formation
US8481138B2 (en) 2002-02-08 2013-07-09 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
US9034346B2 (en) 2002-02-08 2015-05-19 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation

Also Published As

Publication number Publication date
GB9023372D0 (en) 1991-01-09
GB2243835B (en) 1993-07-14
GB2243835A (en) 1991-11-13
DE68913549D1 (en) 1994-04-07

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