WO1988004659A3 - Novel cc-1065 analogs - Google Patents

Novel cc-1065 analogs Download PDF

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Publication number
WO1988004659A3
WO1988004659A3 PCT/US1987/003227 US8703227W WO8804659A3 WO 1988004659 A3 WO1988004659 A3 WO 1988004659A3 US 8703227 W US8703227 W US 8703227W WO 8804659 A3 WO8804659 A3 WO 8804659A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
analogs
compounds
novel
useful
Prior art date
Application number
PCT/US1987/003227
Other languages
French (fr)
Other versions
WO1988004659A2 (en
Inventor
Robert C Kelly
David G Martin
Paul A Aristoff
Original Assignee
Upjohn Co
Robert C Kelly
David G Martin
Paul A Aristoff
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Robert C Kelly, David G Martin, Paul A Aristoff filed Critical Upjohn Co
Priority to MX9203200A priority Critical patent/MX9203200A/en
Priority to DE3750612T priority patent/DE3750612T2/en
Priority to EP88901185A priority patent/EP0340243B1/en
Publication of WO1988004659A2 publication Critical patent/WO1988004659A2/en
Publication of WO1988004659A3 publication Critical patent/WO1988004659A3/en
Priority to KR88701019A priority patent/KR960009264B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Fire Alarms (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Silicon Polymers (AREA)
  • Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
  • Emergency Protection Circuit Devices (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Design And Manufacture Of Integrated Circuits (AREA)
  • Reduction Or Emphasis Of Bandwidth Of Signals (AREA)
  • Forms Removed On Construction Sites Or Auxiliary Members Thereof (AREA)
  • Control Of Driving Devices And Active Controlling Of Vehicle (AREA)

Abstract

2-Acyl-4,5,8,8a-tetrahydro-4-oxycyclopropan[c]pyrrol(3,2-e) indole derivatives of Formula (I'). The compounds of Formula (I') are useful as uv light absorber substances, as chemical intermediates and as prodrugs of known spirocyclopropylpyrroloindole CC-1065 analogs. Representative Formula (I') compounds have been shown to possess useful ranges of antitumor activity in standard laboratory animal tests.
PCT/US1987/003227 1986-12-19 1987-12-11 Novel cc-1065 analogs WO1988004659A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
MX9203200A MX9203200A (en) 1986-12-19 1987-12-11 CC ANALOGS. 1065 NOVELTIES.
DE3750612T DE3750612T2 (en) 1986-12-19 1987-12-11 CC-1065 ANALOG.
EP88901185A EP0340243B1 (en) 1986-12-19 1987-12-11 Cc-1065 analogs
KR88701019A KR960009264B1 (en) 1986-12-19 1988-08-19 Novel cc-1065 analogs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94463386A 1986-12-19 1986-12-19
US944,633 1986-12-19

Publications (2)

Publication Number Publication Date
WO1988004659A2 WO1988004659A2 (en) 1988-06-30
WO1988004659A3 true WO1988004659A3 (en) 1988-08-11

Family

ID=25481770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/003227 WO1988004659A2 (en) 1986-12-19 1987-12-11 Novel cc-1065 analogs

Country Status (9)

Country Link
EP (1) EP0340243B1 (en)
JP (1) JP2598819B2 (en)
KR (1) KR960009264B1 (en)
AT (1) ATE112279T1 (en)
AU (1) AU617304B2 (en)
DE (1) DE3750612T2 (en)
HK (1) HK1000510A1 (en)
MX (1) MX9203200A (en)
WO (1) WO1988004659A2 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987006265A1 (en) * 1986-04-17 1987-10-22 Kyowa Hakko Kogyo Co., Ltd. Novel compounds dc-88a and dc-89a1 and process for their preparation
JP2562935B2 (en) * 1988-04-28 1996-12-11 明治製菓株式会社 Antitumor substance SF2582 derivative
US4994578A (en) * 1987-11-27 1991-02-19 Meiji Seika Kaisha, Ltd. Certain anti-tumor duocarmycin antibiotics from streptomyces
JP2642165B2 (en) * 1988-07-22 1997-08-20 協和醗酵工業株式会社 Novel DC-89 compound and method for producing the same
US5084468A (en) * 1988-08-11 1992-01-28 Kyowa Hakko Kogyo Co., Ltd. Dc-88a derivatives
KR0137959B1 (en) * 1988-09-12 1998-05-15 로버트 에이. 아미테이지 Novel cc-1065 analogs having two cpi sub-units
US5008271A (en) * 1988-10-21 1991-04-16 Kyowa Hakko Kogyo Co., Ltd. DC-88A derivatives
US5187186A (en) * 1989-07-03 1993-02-16 Kyowa Hakko Kogyo Co., Ltd. Pyrroloindole derivatives
JP2510335B2 (en) * 1989-07-03 1996-06-26 協和醗酵工業株式会社 DC-88A derivative
WO1991016324A1 (en) * 1990-04-25 1991-10-31 The Upjohn Company Novel cc-1065 analogs
US5214065A (en) * 1990-06-11 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivatives
US5248692A (en) * 1990-06-11 1993-09-28 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives as anti-tumor agents
US5258383A (en) * 1991-06-28 1993-11-02 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives
EP0563475B1 (en) * 1992-03-25 2000-05-31 Immunogen Inc Cell binding agent conjugates of derivatives of CC-1065
US5248691A (en) * 1992-09-03 1993-09-28 Eli Lilly And Company Furanoindolines
WO1995026964A1 (en) * 1994-04-01 1995-10-12 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivative
DE69533277T2 (en) * 1994-04-22 2005-07-21 Kyowa Hakko Kogyo Co., Ltd. DC-89 DERIVAT
AU693283B2 (en) * 1994-11-29 1998-06-25 Kyorin Pharmaceutical Co. Ltd. Acrylamide derivatives and process for producing the same
GB9516943D0 (en) * 1995-08-18 1995-10-18 Cancer Soc Auckland Div Nz Inc Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
US6130237A (en) * 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
WO1998011101A2 (en) * 1996-09-12 1998-03-19 Cancer Research Campaign Technology Limited Condensed n-aclyindoles as antitumor agents
AU757510C (en) 1998-08-27 2003-09-11 Medimmune Limited Pyrrolobenzodiazepines
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
AU2002303929B9 (en) * 2001-05-31 2007-01-25 E. R. Squibb & Sons, L.L.C. Cytotoxins, prodrugs, linkers and stabilizers useful therefor
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
EP2121667B1 (en) 2007-02-21 2016-06-08 E. R. Squibb & Sons, L.L.C. Chemical linkers with single amino acids and conjugates thereof
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
BRPI0921687A8 (en) 2008-11-03 2022-11-08 Syntarga Bv COMPOUND, CONJUGATE, USE OF A COMPOUND, PHARMACEUTICAL COMPOSITION, PROCESS FOR PREPARING A PHARMACEUTICAL COMPOSITION, METHOD FOR TREATING A MAMMAL IN NEED THEREOF, AND, METHOD FOR TREATING OR PREVENTING A TUMOR IN A MAMMAL.
PL3056203T3 (en) 2010-04-21 2018-06-29 Syntarga B.V. Conjugates of cc-1065 analogs and bifunctional linkers
PT3092010T (en) 2014-01-10 2018-09-28 Synthon Biopharmaceuticals Bv Method for purifying cys-linked antibody-drug conjugates

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0154445A1 (en) * 1984-02-21 1985-09-11 The Upjohn Company Analogues of antibiotic cc-1065

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0154445A1 (en) * 1984-02-21 1985-09-11 The Upjohn Company Analogues of antibiotic cc-1065

Also Published As

Publication number Publication date
EP0340243B1 (en) 1994-09-28
MX9203200A (en) 1992-09-01
JP2598819B2 (en) 1997-04-09
KR890700127A (en) 1989-03-02
WO1988004659A2 (en) 1988-06-30
DE3750612D1 (en) 1994-11-03
JPH02502005A (en) 1990-07-05
AU1229088A (en) 1988-07-15
HK1000510A1 (en) 1998-04-03
AU617304B2 (en) 1991-11-28
KR960009264B1 (en) 1996-07-16
DE3750612T2 (en) 1995-03-02
EP0340243A1 (en) 1989-11-08
ATE112279T1 (en) 1994-10-15

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